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  • genes
  • This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in the stimulation of hypoxia-induced genes such as VEGF. (wikipedia.org)
  • essential
  • In the following 4 years, Fisher showed that the transactivator gene tat was essential for virus replication, that truncation of the 3' open reading frame disrupts virus cytopathogenicity, and that sor (now called vif) is required for efficient cell to cell transmission of HIV virus. (wikipedia.org)
  • found
  • Tat acts by binding to an RNA stem-loop structure, the trans-activating response element (TAR), found at the 5′ ends of nascent HIV-1 transcripts. (wikipedia.org)
  • protein
  • Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. (genecards.org)
  • Recent studies in kidney demonstrate that low density lipoprotein receptor-related protein 1 (LRP1)-dependent signaling by tissue-type plasminogen activator (t-PA) is an essential regulator of the myofibroblast phenotype after injury. (pitt.edu)
  • The general scheme of electron flow in the CPR/P450 system is: The ubiquitous electron-transport protein cytochrome b5 can serve as an effector (activator or inhibitor) of P450s. (wikipedia.org)
  • The ability of the retrovirus to bind to its target host cell using specific cell-surface receptors is given by the surface component (SU) of the Env protein, while the ability of the retrovirus to enter the cell via membrane fusion is imparted by the membrane-anchored trans-membrane component (TM). (wikipedia.org)
  • cells
  • The sodium salt of crocetin, transcrocetinate sodium (INN, also known as trans sodium crocetinate or TSC) is an experimental drug that increases the movement of oxygen from red blood cells into hypoxic (oxygen-starved) tissues. (wikipedia.org)