• This study provides some evidence that, when the immune system is not mobilized against the rtTA transactivator, the tetR-regulatable system is able to support long-term transgene regulation in the context of an rAAV in nonhuman primates. (asm.org)
  • We and others have found persistent Epo regulation in mice after a single i.m. injection of an rAAV vector harboring the tetracycline-dependent transactivator (rtTA) ( 3 ) or the tetracycline-repressed transactivator (tTA) ( 24 ) and the Epo cDNA. (asm.org)
  • The utility of this system lies in the assumption that the tetracycline transactivator (TTA) acts as an inert control element and does not contribute to phenotypes under study. (jneurosci.org)
  • The tetracycline transactivator system offers unparalleled flexibility to spatially restrict and temporally control transgenes in vivo using a readily available, systemically delivered drug. (jneurosci.org)