By injecting the antibodies in a subcutaneous slow-release delivery formulation in the tumor area, we show that an eight-fold lower dose of antibody is as effective in inducing tumor eradication as systemic delivery. (aacrjournals.org)
Available data also do not indicate whether Tdap-induced transplacental maternal antibodies provide early protection against pertussis to infants or interfere with an infant's immune responses to routinely administered pediatric vaccines. (whale.to)
A CPS-tetanus toxoid conjugate administrated i.n. induced a strong serum IgG but only a weak mucosal IgA response, while CPS-rCTB conjugates elicited high IgG as well as IgA antibodies in both serum and the lungs after i.n. immunization. (gu.se)
A recent study reported toxoid fusions with STa toxoid (STa P13F ) fused at the N- or C-terminus, or inside the A subunit of LT R192G elicited neutralizing antitoxin antibodies, and suggested application of toxoid fusions in ETEC vaccine development (Liu et al. (illinois.edu)
Data from this study indicated that toxoid fusion 3xSTa A14Q -tmLT is safe and can induce neutralizing antitoxin antibodies, and provided helpful information for vaccine development against ETEC diarrhea. (illinois.edu)
Excitingly, by combining both second and third lines of investigation, we succeeded in inducing cross-clade neutralizing antibodies in mice, guinea pigs, and rhesus macaques (Xu 2018 Nat Med. (nih.gov)
Thus, among children with high exposure, the can induce an increase in IgG and IgG4 antibodies with a odds of sensitisation to mite rather than cat was 4·0 decrease in IgE antibodies,16,17 and that expression of the (99% CI 1·49-10·00). (cdc.gov)
Immunity9
a) Vaccine: A suspension of live (usually attenuated) or inactivated microorganisms (e.g., bacteria, viruses, or rickettsiae) or fractions thereof administered to induce immunity and prevent infectious disease or its sequelae. (cdc.gov)
Immunization is a more inclusive term denoting the process of inducing or providing immunity artificially by administering an immunobiologic. (cdc.gov)
Then, another breakthrough is that the addition of tetanus toxoid to glycopeptide conjugate resulted in a glycopeptide-TT vaccine induced dual (double) antibody-dependent protective immunity without the need for adjuvant, which is feasible for human use. (lsuhsc.edu)
Our research goal is to further develop the first "universal" multi-epitope vaccine protects against all the medically significant Candida species in addition to C. albicans, as well as address the fundamental question concerning vaccine induced immunity in high-risk immunocompromised populations. (lsuhsc.edu)
An optimally effective GBS vaccine should induce both mucosal and systemic immunity. (gu.se)
New combination vaccines should induce similar or superior levels of neutralizing antibody in serum for individual protection against paralytic disease and mucosal immunity that effectively decreases viral replication in the intestine and pharynx for population protection against transmission of poliovirus. (who.int)
Finally, using subunit influenza vaccine, we demonstrated that daily vaccination by microneedle patch induced a potent, balanced humoral immunity with an increased memory response compared to bolus vaccination. (cdc.gov)
Rate of patients with persistence of cell-mediated immunity induced by COVID-19 approved vaccines (at least three doses) after standard induction immuno-chemotherapy. (who.int)
It is the only vaccine currently available that can induce the mucosal immunity necessary to interrupt virus circulation. (who.int)
An initial dose of BOOSTRIX is administered 5 years or more after the last dose of the Diphtheria and TetanusToxoids and Acellular Pertussis (DTaP) series or 5 years or more after a dose of Tetanus and DiphtheriaToxoids Adsorbed (Td). (nih.gov)
Severe allergic reaction (e.g., anaphylaxis) after a previous dose of any tetanus toxoid-, diphtheria toxoid-, or pertussis antigen-containing vaccine or to any component of BOOSTRIX. (nih.gov)
In an earlier study in adults, the new vaccine was safe and induced significantly higher pertussis toxoid-specific antibody responses compared with the widely used Tdap vaccine. (medscape.com)
Tetanus toxoid protein1
It is composed of the tetanus toxoid protein conjugated to the capsular polysaccharide of the H. influenzae type b bacteria. (justaaa.com)
Vaccines4
Immunobiologic: Immunobiologics include antigenic substances, such as vaccines and toxoids, or antibody-containing preparations, such as globulins and antitoxins, from human or animal donors. (cdc.gov)
Three of the peptide carriers also turned out to be excellent vaccines by themselves in that they induced protection against candidiasis. (lsuhsc.edu)
Tdap-induced transplacental maternal antibody will have a negative impact on an infant's protective immune response to later-administered routine pediatric DTaP or to conjugate vaccines containing tetanus toxoid or diphtheria toxoid. (whale.to)
Anaphylactic reactions2
Equine DAT can induce anaphylactic reactions (a toxoid. (cdc.gov)
Background: Epidemiological data on drug-induced anaphylactic reactions are limited in India and are largely depending on studies from developed countries. (ijccm.org)
Systemic2
the dose depends with toxin-induced systemic symptoms. (cdc.gov)
Oral administration of antigen is a long recognized method of inducing systemic immune tolerance. (jci.org)
Antibody5
We have used a protein-based vaccine, tetanus toxoid (TT), together with the mucosal adjuvant cholera toxin (CT), for oral immunization of mice to study the nature of antigen-specific Th cell subsets induced in Peyer's patches (PP) of the gastrointestinal (GI) tract and in the spleen (SP) during peak antibody responses. (silverchair.com)
Active immunization is the production of antibody or other immune responses through the administration of a vaccine or toxoid. (cdc.gov)
This administration method is associated with very low serum levels of antibody, which decreases the risk of treatment-induced side effects. (aacrjournals.org)
All four mucosal routes also induced antibody responses to CPS in distant mucosal tissues. (gu.se)
Although antibody responses 1 month after vaccination were significantly higher with TdaPTgen or PTgen than with the licensed comparator Tdap vaccine, no conclusions can be drawn about the persistence of vaccine-induced immunogenicity on the basis of these results," the researchers note. (medscape.com)
Mucosal1
I.n. immunization was usually the most efficient way to obtain strong anti-CPS responses in both serum and mucosal tissues including both the lungs and the vagina.Priming with pure GBS CPS III alone or with GBS CPS III-rCTB conjugate induced comparable levels of specific IgG and IgA in serum, lungs and vagina. (gu.se)
Vaccination5
Vaccination currently denotes the physical act of administering any vaccine or toxoid. (cdc.gov)
The conjugates when administrated subcutaneously induced only IgG responses in serum, lung and vagina, while intranasal (i.n.) vaccination also elicited specific anti-CPS IgA responses in the lungs and vagina. (gu.se)
Rectal vaccination induced high specific IgA in the vagina and the intestine, and oral administration in the lungs and rectum. (gu.se)
studied the immune for problems other than vaccination, while response to diphtheria and tetanus toxoid those aged 7-8 years and 11-12 years were components of a combined diphtheria teta- chosen from 4 primary schools in Gaza. (who.int)
Protein3
It consists of the receptor binding domain of the SARS-CoV-2 spike protein conjugated chemically to tetanus toxoid. (wikipedia.org)
Despite widespread uses of tetanus toxoid (TT) as a vaccine, model antigen and protein carrier, TT epitopes have been poorly characterized. (listlabs.com)
Here, we investigated whether in MS patients oral myelin treatment, containing both myelin basic protein (MBP) and proteolipid protein (PLP), induced antigen specific MBP or PLP reactive T cells that either secreted IL4, TGF-beta1, or alternatively did Th1 type sensitization occur as measured by IFN-gamma secretion. (jci.org)
The immune responses induced by these antigenic proteins were evaluated by measuring the extent and duration of the skin reaction, known at the delayed-type hypersensitivity response (DTH). (outsourcing-pharma.com)
With these epitopes, we created a TT epitope pool, which allowed us to characterize TT responses directly ex vivo using a cytokine-independent Activation Induced Marker (AIM) assay. (listlabs.com)
Recent studies have shown that TT can also induce a series of γδ T cell responses to Mycobacteria. (creative-biolabs.com)
Vaccinations following this profile also improved immune responses to tetanus toxoid and subunit influenza vaccine but not a live-attenuated viral vaccine, measles vaccine. (cdc.gov)
Antigen1
In this study, we generated a different STa toxoid (STa A14Q ) and a triple-mutant LT toxoid (LT S63K/R192G/L211A , tmLT), constructed a toxoid fusion (3xSTa A14Q -tmLT) that carried 3 copies of STa A14Q for further facilitation of anti-STa immunogenicity, and assessed antigen safety and immunogenicity in a murine model to explore its potential for ETEC vaccine development. (illinois.edu)
Antitoxin1
b) Toxoid: A modified bacterial toxin that has been made nontoxic, but retains the ability to stimulate the formation of antitoxin. (cdc.gov)
Immune response3
The preliminary results from the 20 patient study, conducted by Daniel Libraty at the University of Massachusetts Medical School, evaluated the immune response induced by using the SonoPrep device to allow the transdermal delivery of tetanus toxoid and Candida albicans , a form of yeast that can act as a pathogen in humans. (outsourcing-pharma.com)
A DTH skin immune response was induced in 90 per cent of the SonoPrep treated patients and the duration of the DTH skin reaction was similar in the treatment group versus the control group. (outsourcing-pharma.com)
Shikha Barman, director of transdermal drug development at Sontra, explained that SonoPrep allows an immune response to be induced by activating the Langerhan cells in the epidermis. (outsourcing-pharma.com)
Bacterial2
The major focus of this research is the molecular pathogenesis of invasion and inflammation induced by Streptococcus pneumoniae, the leading invasive bacterial pathogen of children. (stjude.org)
Bacterial Peptidoglycan Traverses the Placenta to Induce Neuroproliferation and Aberrant Postnatal Behavior. (stjude.org)
Immunogenicity1
Data from the phase 3 study confirmed the lot consistency, immunogenicity, safety, and tolerability of a toxoid-based Clostridioides difficile vaccine. (ajmc.com)
Pathogenesis1
In this study, we evaluated the contribution of newly recruited neutrophils and monocytes and resident alveolar macrophages to the pathogenesis of PLY-induced lung injury. (aai.org)
Anaphylaxis6
Aim: The aim was to analyze the published studies of drug-induced anaphylaxis reported from India in relation with causative drugs and other clinical characteristics. (ijccm.org)
Drug-induced anaphylaxis: Case/non-case study based on an Italian pharmacovigilance database. (ijccm.org)
Severe drug-induced anaphylaxis: Analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010. (ijccm.org)
Cetirizine-induced anaphylaxis: A rare adverse drug reaction. (ijccm.org)
Amoxicillin/clavulinic acid-induced anaphylaxis during anesthesia. (ijccm.org)
Cefotaxime-induced near-fatal anaphylaxis in a neonate: A case report and review of literature. (ijccm.org)
Fractions1
Both large and small molecular size fractions of CPS III-rCTB conjugates induced high, almost comparable levels of CPS specific IgG in serum, lungs and vagina that were generally superior to those obtained with a mixture of CPS III and rCTB. (gu.se)
Dose3
For management of a tetanus-prone wound, a dose of BOOSTRIX may be administered if at least 5 years have elapsed since previous receipt of a tetanus toxoid-containing vaccine. (nih.gov)
If Guillain-Barré syndrome occurred within 6 weeks of receipt of a prior vaccine containing tetanus toxoid, the risk of Guillain-Barré syndrome may be increased following a subsequent dose of tetanus toxoid-containing vaccine, including BOOSTRIX. (nih.gov)
Persons who experienced an Arthus-type hypersensitivity reaction following a prior dose of a tetanus toxoid-containing vaccine should not receive BOOSTRIX unless at least 10 years have elapsed since the last dose of a tetanus toxoid-containing vaccine. (nih.gov)
Mice1
Blockade of PLY-induced alveolar leukocyte trafficking by pretreatment of mice with anti-CD18 plus anti-CD49d Abs or depletion of circulating neutrophils did not attenuate the increase in lung permeability observed in response to intratracheal PLY. (aai.org)
Cells2
1. The pre-B-cell receptor provides an important signal that induces transition of pro-B cells to pre-B. (justaaa.com)
Continuous ligation of LILRB1 modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-mediated cell death, and inhibited secretion of cytokines IL-10, IL-12p70, and TGF-β. (ashpublications.org)
Addition1
In addition, PLY also induced a decrease in the resident alveolar macrophage population, and the recruitment of peripheral blood neutrophils and monocytes into the alveolar space. (aai.org)
Cell1
Specifically, 4,860 short-term T cell lines were generated to either MBP, PLP, or tetanus toxoid (TT) from 34 relapsing-remitting MS patients: 17 orally treated with bovine myelin daily for a minimum of 2 yr as compared to 17 nontreated patients. (jci.org)
Children1
Children continue to die mainly from preventable or easily treatable conditions such as acute respiratory infections (inducing pneumonia), diarrhea and malaria. (unicef.org)
Type1
Contains two major Rotavirus serotypes, four major E. coli pilus antigens (K88, K99, F41 and 987P) and C. perfringens type C toxoid. (merck-animal-health-usa.com)