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BordetellaBordetella pertussisBordetella bronchisepticaBordetella InfectionsBordetella parapertussisVirulence Factors, BordetellaBordetella aviumPertussis VaccineCholera ToxinAdenylate Cyclase ToxinHemagglutininsT-2 ToxinPertussis ToxinTetanus ToxinRhinitis, AtrophicBacterial ProteinsBotulinum Toxins, Type AMarine ToxinsAntibodies, BacterialCeanothusMolecular Sequence DataShiga Toxin 2Bacterial Outer Membrane ProteinsAdhesins, BacterialAdenylate CyclaseShiga Toxin 1ToxoidsGene Expression Regulation, BacterialAntigens, BacterialGenes, BacterialAntitoxinsHemolysin ProteinsVirulenceDNA, BacterialVaccines, AcellularChild, OrphanedAmino Acid SequenceNasopharynxAgglutininsLeukocytosisEnterotoxinsDermotoxinsCytotoxinsBase SequenceTurbinatesBacterial AdhesionPolypyrimidine Tract-Binding ProteinMice, Inbred BALB CTurkeysSpecies SpecificityLymphocytosisEndotoxinsEscherichia coliAnimals, SucklingBacterial VaccinesClostridium difficilePasteurella multocidaVirulence FactorsMycotoxinsRespiratory SystemHemolysisDiphtheria-Tetanus-Pertussis VaccineSwine DiseasesAdenosine Diphosphate RiboseAgglutination TestsImmunizationBacillus anthracisHemagglutinationNasal CavityImmunoglobulin GFimbriae, BacterialPolymerase Chain ReactionNeuromuscular AgentsTracheostomyRespiratory Tract InfectionsTransglutaminasesEnzyme-Linked Immunosorbent AssayLungBifidobacteriales InfectionsScorpionsCulture MediaRabbitsMutationCloning, MolecularRicinDNA Transposable ElementsLipopolysaccharidesNeurotoxinsClostridium botulinumBacteriological TechniquesSwineCell LineCyclic AMPPasteurella InfectionsEscherichia coli ProteinsEnterobactinElectrophoresis, Polyacrylamide Gel
ParapertussisCyaABacterium Bordetella pertussisCoughDermonecroticBacterial ToxinAntibodiesEffects of pertussis toxinAdenylate cyclaseBacteriaDiphtheria ToxinBronchiseptica infectionInhibitorsCorynebacteriumProducesSpeciesRespiratoryPertussis vaccineSubunitProteinsVaccinesKnown bacterialProteinExotoxinInactivatesFilamentousExtracellularAerobicVibrioInfectionAssayCytotoxicELISAGramColiContrastPulmonary1906GenesDiseaseSymptoms
Parapertussis9
  • Bordetella parapertussis shows the most similarity to B. pertussis and was therefore used for research determining the role of PT in causing the typical symptoms of whooping cough. (wikipedia.org)
  • Other Bordetella species, such as Bordetella parapertussis ( 3 ) and Bordetella holmesii ( 4 ), can cause diseases similar to pertussis, albeit usually with much less severe symptoms than typical whooping cough caused by B. pertussis . (frontiersin.org)
  • B. bronchiseptica" is closely related to "Bordetella pertussis" and "Bordetella parapertussis", causing pertussis or whooping cough in humans [2]. (kenyon.edu)
  • Specific diagnostic tools were applied for the first time in a Tunisian prospective study in order to get a first estimation of the prevalence of Bordetella pertussis/parapertussis infections and to evaluate their use to determine the epidemiologic characteristics of these infections in Tunisian infants. (pasteur.fr)
  • All except 1 NPAs were negative by conventional culture, whereas PCR gave positive signals for 126 specimens (21%): B. pertussis, B. parapertussis, and Bordetella spp. (pasteur.fr)
  • The pathogenic bacteria Bordetella pertussis and Bordetella parapertussis cause pertussis (whooping cough) and pertussis-like disease, respectively, both of which are characterized by paroxysmal coughing. (bvsalud.org)
  • Here, we show that a toxin we named deacylating autotransporter toxin (DAT) of B. parapertussis inactivates heterotrimeric Gi GTPases through demyristoylation of their α subunits and contributes to cough production along with Vag8 and LPS. (bvsalud.org)
  • The most common causative organism is Bordetella pertussis (see the image below), though Bordetella parapertussis also has been associated with this condition in humans. (medscape.com)
  • Bordetella parapertussis also has been associated with whooping cough in humans. (medscape.com)
CyaA7
  • Bordetella pertussis, the causative agent of whooping cough, secretes among various toxins an adenylate cyclase (CyaA) that displays a unique mechanism of cell invasion, which involves a direct translocation of its N-terminal catalytic domain (AC, 400 residues) across the plasma membrane of the eukaryotic targeted cells. (pasteur.fr)
  • The adenylate cyclase (CyaA) of Bordetella pertussis is able to deliver CD8(+) T cell epitopes into the cytosol of CD11b(+) dendritic cells (DC) following its specific interaction with the alpha(M)beta(2) integrin (CD11b/CD18). (ox.ac.uk)
  • Indeed, we previously showed that CyaA toxins carrying a single cytotoxic T lymphocyte (CTL) epitope can induce efficient protective and therapeutic antitumor immunity in mice. (ox.ac.uk)
  • In particular, the bacterium produces the CyaA toxin. (pasteur.fr)
  • Scientists from the Institut Pasteur are investigating CyaA, one of the major toxins of Bordetella pertussis. (pasteur.fr)
  • Its virulence factor adenylate cyclase toxin (CyaA) plays an important role in the course of infection. (uni-wuerzburg.de)
  • Adenylate cyclase toxin (CyaA) of Bordetella pertussis binds to CD11b/CD18 on macrophages and dendritic cells (DC) and confers virulence to the bacteria by subverting innate immune responses of the host. (tcd.ie)
Bacterium Bordetella pertussis5
Cough8
  • Whether the effects of pertussis toxin are responsible for the paroxysmal cough remains unknown. (wikipedia.org)
  • Bordetella pertussis is the agent responsible for whooping cough, a disease that is currently on the rise. (pasteur.fr)
  • Pertussis or whooping cough, mainly caused by Bordetella pertussis , is a severe respiratory disease that can affect all age groups but is most severe and can be life-threatening in young children. (frontiersin.org)
  • The main causative agent of whooping cough is Bordetella pertussis ( 2 ), a gram negative coccobacillus which is able to colonize the human upper respiratory tract by attaching to the ciliated cells. (frontiersin.org)
  • A type of bacteria called Bordetella pertussis causes whooping cough. (clevelandclinic.org)
  • The human pathogen Bordetella pertussis targets the respiratory epithelium and causes whooping cough. (uni-wuerzburg.de)
  • The CDC would like to keep the American population ignorant about this startling fact: Our current pertussis epidemic is caused by a deadly new strain of Bordetella pertussis bacterium (ptxP3) and its emergence is directly connected to the whooping cough vaccine. (wakeup-world.com)
  • Pertussis or whooping cough is a highly public of Iran and the results of this tion of vaccination history was done contagious, vaccine-preventable res- study, together with future studies in by observation of each student's vac- piratory disease caused by Bordetella other parts of the country, could help to cination card. (who.int)
Dermonecrotic2
Bacterial Toxin2
Antibodies1
Effects of pertussis toxin1
  • The effects of pertussis toxin on endothelin-1 and noradrenaline coupling to inositol phosphate (IP) formation was investigated in cultured aortic smooth muscle cells from 14 week SHR and WKY rats. (strath.ac.uk)
Adenylate cyclase3
Bacteria5
  • these organisms produced significantly more toxin than did bacteria in phase I from other species, or those in phases III and IV. (microbiologyresearch.org)
  • Pertussis is primarily a toxin-mediated disease in which toxins produced by the bacteria are responsible for the majority of its clinical features. (canada.ca)
  • Bordetella produces a pertussis toxin (Ptx) and filamentous hemagglutinin (Fha) A) These help the bacteria to attach to and destroy the respiratory epithelium resulting in a build-up of mucus 3. (slideserve.com)
  • ADP-ribosyltransferases including toxins secreted by Vibrio cholera, Pseudomonas aerurginosa, and other pathogenic bacteria inactivate the function of human target proteins by attaching ADP-ribose onto a critical amino acid residue. (indexindex.com)
  • In this study, we analyzed three bacterial toxins and five culture supernatants of selected bacteria with known toxicity as model agents exposed to the lung epithelial cell line NuLi-1. (biomedcentral.com)
Diphtheria Toxin1
  • Upon request, the laboratory can test for the presence of diphtheria toxin by the Elek assay for C. diphtheriae and C. ulcerans isolates. (cdc.gov)
Bronchiseptica infection1
Inhibitors1
  • Treatments with pertussis-toxin, inhibition of phospholipase C and protein kinase C inhibitors and chelation of free cytosolic calcium did not change the bradykinin-induced inhibition of phosphotyrosine kinase. (nih.gov)
Corynebacterium2
  • CDC is actively researching new laboratory methods to better identify and characterize other Bordetella and Corynebacterium species. (cdc.gov)
  • A toxin-mediated disease caused by Corynebacterium diphtheriae 2. (slideserve.com)
Produces2
Species1
Respiratory2
  • Respiratory specimens were analysed by RT-PCR for rhinovirus, enterovirus and respiratory syncytial virus and by PCR for adenovirus, Chlamydia pneumoniae , Mycoplasma pneumoniae and Bordetella pertussis . (bmj.com)
  • Bordetella pertussis is a gram- negative bacterium that is responsible for the highly contagious respiratory disease known as pertussis. (cdc.gov)
Pertussis vaccine2
  • The acellular pertussis vaccine components are purified from Bordetella pertussis by salt precipitation, ultracentrifugation, and ultrafiltration. (cdc.gov)
  • There is evidence that individuals that vaccinated with acellular Bordetella pertussis vaccine, which are commonly used in developed countries since the middle 90s, can become asymptomatically infected and then transmit pertussis to susceptible individuals. (cdc.gov)
Subunit1
  • They include both the hydrolysis resistant GTP analogs, GTP-γ-S and GDP-β-S, that hold the Gα subunit in active and inactive conformations, respectively, and various bacterial toxins. (sigmaaldrich.com)
Proteins2
  • Bacterial toxins can be single proteins or oligomeric protein complexes that are organized with distinct AB structure-function properties. (springer.com)
  • Pasteurella multocida toxin (PMT, produced by Pasteurella multocida ) offers the possibility to discriminate between Gα q and Gα 11 proteins, since it stimulates inositol phosphate formation in a strictly Gα q -dependent manner. (sigmaaldrich.com)
Vaccines6
  • Current pertussis vaccines protect against disease, but not against colonization by and transmission of Bordetella pertussis , whereas natural infection protects against both. (mdpi.com)
  • Whole-cell pertussis vaccines in the United States have been and continue to be prepared from suspensions of killed Bordetella pertussis whole bacterial cells. (cdc.gov)
  • So, we get vaccines for our dogs against Bordetella . (cdc.gov)
  • We do get vaccines for our dogs against Bordetella . (cdc.gov)
  • The mutation rate of a virus is considerably higher than that of a bacterium, meaning that in this case, in our case, Bordetella pertussis does not evolve that fast except for the antigen genes that are used in the commercial vaccines. (cdc.gov)
  • Acellular (a) pertussis (P) vaccines contain semipurified or purified components of Bordetella pertussis . (msdmanuals.com)
Known bacterial1
  • The position-sensitive iterative database search program PSI-BLAST connected the mammalian ARTs with most known bacterial ADP-ribosylating toxins. (indexindex.com)
Protein3
  • Bacterial toxins also catalyze the non-covalent modification of host protein function or can modify host cell properties through direct protein-protein interactions. (springer.com)
  • 3D representation of pertussis toxin, made up of 6 complex protein subunits. (whoopingcough.net)
  • It was concluded that SHR cells do not appear to have an alteration in endothelin-1 activated, pertussis toxin sensitive G-protein coupling to IP formation or in the dependence of inositol phosphate formation on extracellular calcium. (strath.ac.uk)
Exotoxin1
  • Pertussis toxin is an exotoxin with six subunits (named S1 through S5-each complex contains two copies of S4). (wikipedia.org)
Inactivates2
  • Pertussis toxin (PTX, produced by Bordetella pertussis ) irreversibly inactivates most members of the Gα i family by uncoupling them from their cognate receptors. (sigmaaldrich.com)
  • We previously reported that pertussis toxin (PTx), which inactivates heterotrimeric GTPases of the Gi family through ADP-ribosylation of their α subunits, causes coughing in combination with Vag8 and lipid A in B. pertussis infection. (bvsalud.org)
Filamentous2
  • After purification, filamentous hemagglutinin (FHA) and pertussis toxin (PT) are combined to obtain a 1:1 ratio and are then treated with formaldehyde to inactivate PT. (cdc.gov)
  • high-school students aged 6-17 years in toxin, filamentous haemagglutinin and There are reports from a large number Ahvaz, south-west Islamic Republic of pertussis toxin) were measured using a of countries that the incidence of per- Iran from October 2010 to June 2011. (who.int)
Extracellular1
  • Pertussis toxin preincubation followed by removal of extracellular calcium reduced further the endothelin responses by similar amounts in SHR and WKY cells, but SHR stimulated IP formation remained significantly decreased compared to WKY. (strath.ac.uk)
Aerobic2
  • Bordetella pertussis is a Gram-negative aerobic bacterium. (canada.ca)
  • Bordetella pertussis is a Gram-negative , aerobic , non-motile, non-spore-forming coccobacillus . (wikidoc.org)
Vibrio1
  • Cholera toxin (CTX, produced by Vibrio cholerae ) is responsible for the infectious gastro-enteritis known as cholera. (sigmaaldrich.com)
Infection4
  • Bacterial toxins damage the host at the site of bacterial infection or distant from the site. (springer.com)
  • The virulence of Bordetella bronchiseptica in gnotobiotic piglets was studied by intranasal infection with 11 cultures derived from eight strains isolated from pigs (4), dogs (2), a human subject and a monkey. (microbiologyresearch.org)
  • Intranasal infection with Bordetella bronchiseptica in gnotobiotic piglets. (microbiologyresearch.org)
  • RÉSUMÉ Si la coqueluche est une infection évitable par la vaccination, l'immunité induite par le vaccin ne dure pas toute la vie et des doses de rappel sont recommandées en fonction de l'épidémiologie de la maladie dans le pays. (who.int)
Assay1
  • Each toxin resulted in a different but specific impedance profile over time according to their mode of action, whereas viability assay showed the metabolic activity of the cells at a chosen time point without revealing any information on their mode of action. (biomedcentral.com)
Cytotoxic1
  • We confirmed concentration dependent cytotoxic effects of the selected toxins in NuLi-1 cells over a period of up to 48 h. (biomedcentral.com)
ELISA1
  • Using a Bordetella IgG ELISA kit, pertussis-IgG was detected in 301 (47.0%) students. (who.int)
Gram1
  • Bordetella bronchiseptica", stain RB50, is a small (0.4 by 8.0 um), gram negative, rod shaped beta-proteobacteria belonging to the Bordetellae family. (kenyon.edu)
Coli1
  • Yamasaki S, Sato T, Hidaka Y, Ozaki H, Ito H, Hirayama T, Takeda Y, Sugimura T, Tai A, Shimonishi Y (1990) Structure-activity relationship of Escherichia coli heat-stable enterotoxin: Role of Ala residue at position 14 in toxin-receptor interaction. (springer.com)
Contrast1
Pulmonary1
  • Another example, the alpha-toxin of Staphylococcus aureus is also involved in pneumonia and attacks pulmonary epithelial cells. (biomedcentral.com)
19062
Genes1
  • However, "B. bronchiseptica" has the genes to express the toxin which shows that "B. bronchiseptica" is closely related to "B. pertussis" [4]. (kenyon.edu)
Disease1
  • Pertussis is primarily a toxin-mediated disease. (wikidoc.org)
Symptoms1
  • Bordetella pertussis positive individuals had lower FEV 1 /FVC (77.1% v 80.7%, p = 0.012) and more asthma symptoms than B pertussis negative cases. (bmj.com)