Toxicological implications of enzyme induction and inhibition. Medical search. Frequent questions

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Anatomy10

Liver Microsomes, Liver Cells, Cultured Cell Line Hepatocytes Cell-Free System Cell Line, Tumor Tumor Cells, Cultured T-Lymphocytes Fibroblasts

Organisms7

Rats, Inbred Strains Rats, Inbred F344 Rats, Sprague-Dawley Mice, Inbred C57BL Mice, Inbred BALB C Mice, Knockout Mice, Transgenic

Diseases2

Liver Neoplasms, Experimental Disease Models, Animal

Chemicals and Drugs57

Antipyrine Glucaric Acid Phenobarbital Glutethimide Adipates Heparinoids Cytochrome P-450 Enzyme System Carbamazepine Tyrosine Transaminase Tryptophan Oxygenase Tetrahydrocortisone Barbital Toxaphene Xenobiotics Primidone NAD(P)H Dehydrogenase (Quinone)beta-Naphthoflavone gamma-Glutamyltransferase 17-Hydroxycorticosteroids Phenytoin Dactinomycin Cytochrome P-450 CYP2B1 RNA, Messenger Cycloheximide Aniline Hydroxylase Aminopyrine N-Demethylase Rifampin Isothiocyanates Polychlorinated Biphenyls Oxygenases Hydrocortisone Anticonvulsants Cytochrome P-450 CYP3A Mixed Function Oxygenases Aryl Hydrocarbon Hydroxylases Ornithine Decarboxylase Cytochrome P-450 CYP1A1 Glucuronosyltransferase Leucine Dexamethasone Anticarcinogenic Agents Carboxy-Lyases Glutathione Transferase Oxidoreductases Alkaline Phosphatase Glucose Isoenzymes Transcription Factors DNA-Binding Proteins Recombinant Proteins Enzyme Inhibitors NF-kappa B DNA Cytokines Tumor Necrosis Factor-alpha Interferon-gamma Membrane Proteins

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

FIGLU Test Metabolic Clearance Rate Organ Size Liver Neoplasms, Experimental Reverse Transcriptase Polymerase Chain Reaction Blotting, Western Remission Induction Induction Chemotherapy Transfection Models, Biological Disease Models, Animal Flow Cytometry

Phenomena and Processes31

Enzyme Induction Half-Life Drug Interactions Metabolic Detoxication, Drug Kinetics Biotransformation Time Factors Dose-Response Relationship, Drug Metabolic Clearance Rate Organ Size Signal Transduction Gene Expression Regulation Apoptosis Embryonic Induction Base Sequence Transcription, Genetic Promoter Regions, Genetic Mutation Amino Acid Sequence Cell Differentiation Gene Expression Up-Regulation Transfection Cell Division Protein Binding Transcriptional Activation Phosphorylation Gene Expression Regulation, Enzymologic Cell Survival Enzyme Activation Cell Proliferation

Information Science3

Molecular Sequence Data Base Sequence Amino Acid Sequence

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Information Science

Enzyme Induction Antipyrine Glucaric Acid Phenobarbital Glutethimide Liver Adipates Heparinoids Microsomes, Liver FIGLU Test Cytochrome P-450 Enzyme System Carbamazepine Tyrosine Transaminase Tryptophan Oxygenase Tetrahydrocortisone Barbital Toxaphene Xenobiotics Half-Life Primidone NAD(P)H Dehydrogenase (Quinone)beta-Naphthoflavone gamma-Glutamyltransferase 17-Hydroxycorticosteroids Phenytoin Dactinomycin Drug Interactions Cytochrome P-450 CYP2B1 RNA, Messenger Cycloheximide Aniline Hydroxylase Aminopyrine N-Demethylase Metabolic Detoxication, Drug Kinetics Biotransformation Rifampin Isothiocyanates Time Factors Cells, Cultured Polychlorinated Biphenyls Oxygenases Dose-Response Relationship, Drug Hydrocortisone Anticonvulsants Cytochrome P-450 CYP3A Mixed Function Oxygenases Aryl Hydrocarbon Hydroxylases Ornithine Decarboxylase Cell Line Rats, Inbred Strains Hepatocytes Cytochrome P-450 CYP1A1 Metabolic Clearance Rate Glucuronosyltransferase Leucine Dexamethasone Organ Size Anticarcinogenic Agents Liver Neoplasms, Experimental Carboxy-Lyases Glutathione Transferase Rats, Inbred F344 Oxidoreductases Cell-Free System Molecular Sequence Data Signal Transduction Alkaline Phosphatase Gene Expression Regulation Rats, Sprague-Dawley Glucose Apoptosis Embryonic Induction Isoenzymes Base Sequence Mice, Inbred C57BL Transcription, Genetic Transcription Factors Promoter Regions, Genetic DNA-Binding Proteins Mutation Amino Acid Sequence Cell Line, Tumor Cell Differentiation Tumor Cells, Cultured Gene Expression Mice, Inbred BALB C Reverse Transcriptase Polymerase Chain Reaction Blotting, Western Remission Induction Up-Regulation Induction Chemotherapy Transfection Mice, Knockout Models, Biological Cell Division Protein Binding Transcriptional Activation Disease Models, Animal Recombinant Proteins Phosphorylation

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