• Results demonstrated that during 14 days of the experiment, neither mortality and sublethal effects as signs of toxicity were detected. (ugm.ac.id)
  • All the rats were examined daily for signs of toxicity and mortality, and were subjected to detailed clinical examination before initiation of the study and weekly thereafter during the exposure period. (phytojournal.com)
  • 1500 mg/kg per day for 90 days did not harmful to the environment than synthetic produce any signs of toxicity, mortality, insecticides, new evidence indicates that changes in tissue weight, pathology or se- these products may pose a risk to certain rum and blood parameters [ 8 ]. (who.int)
  • Cardiac arrest has occurred after convulsions resulting from systemic toxicity, presumably following unintentional intravascular injection. (nih.gov)
  • The observed systemic toxicity does not warrant scheduling. (tga.gov.au)
  • In conclusion, a single intramuscular dose of C4 produced no acute or chronic systemic toxicity or inflammation in rats, suggesting that C4 may be toxicologically safe for clinical use in cancer brachytherapy. (hindawi.com)
  • Similarly, no evidence of local or systemic toxicity was seen in 4-week and 25-week dermal toxicity studies in the rat. (europa.eu)
  • However, we take into account the dose for animal testing for reproductive and developmental toxicity and carcinogenicity testing. (cdc.gov)
  • In a study of developmental toxicity in rats, maternal (liver) toxicity was seen at the top (limit) dose of 1000 mg/kg bw/d. (tga.gov.au)
  • In a study of developmental toxicity in rabbits, marked maternal toxicity (that included a bodyweight loss over GD 6-9) was seen at the top (limit) dose of 1000 mg/kg bw/d, and skeletal malformations were seen in 1, 1, and 4 foetuses (4 litters) at 0, 300 and 1000 mg/kg bw/d, respectively. (tga.gov.au)
  • flammable, respiratory sensitizer/target organ toxicity, and irritant. (uwm.edu)
  • The pictograms tell us that the material is flammable, a respiratory sensitizer/target organ toxicity, and an irritant. (uwm.edu)
  • Most patients who overdose on acetaminophen will initially be asymptomatic, as clinical symptoms of end-organ toxicity do not manifest until 24-48 hours after an acute ingestion. (medscape.com)
  • Potential long-term toxicity of repeated orally administered doses of artemether in rats. (ajtmh.org)
  • Three groups were orally administered with Picrorhiza Kurroa extract at doses of 200 mg/kg, 1000 mg/kg or 2000 mg/kg body weight and observed daily for 14 days. (phytojournal.com)
  • Based on the results of the dose-range finding study (28-day repeated toxicity), GST was orally administered to rats at doses of 0, 500, 1000, and 2000 mg/kg B.W/day for 90-day and reversibility of effects of 2000 mg/kg bw/day was assessed after 4 weeks. (eaht.org)
  • Cadmium Toxicity: What Health Effects Are Associated With Acute High-Dose Cadmium Exposure? (cdc.gov)
  • describe the health effects of acute high-dose cadmium exposure. (cdc.gov)
  • ONTOX will deliver a generic strategy to create innovative new approach methodologies to predict systemic repeated dose toxicity effects that, when combined with tailored exposure assessment, will enable human risk assessment. (fhi.no)
  • The seriousness of the exposure depends upon the oral toxicity of the material and the amount swallowed. (ufl.edu)
  • Acute toxicity is due to short-term exposure and happens within a relatively short period of time, whereas chronic exposure is due to repeated or long-term exposure and happens over a longer period. (ufl.edu)
  • However, the toxicity studies on TiO 2 NPs have focused on inhalation and skin exposure and study on oral exposure has been limited. (eaht.org)
  • At these moderately toxic exposure levels in a 90-day toxicity setting in rats, the read-across substance, DIPE, demonstrated a No Observed Adverse Effect Concentration (NOAEC) via the inhalation route of exposure of 3300 ppm (equivalent to 13800 mg/m 3 ). (europa.eu)
  • The Tier 2 process for occupational exposure banding also assesses the sufficiency of toxicity data to ensure that adequate information is available to reliably band a chemical. (cdc.gov)
  • Information is given on sources of depleted uranium exposure, the likely routes of acute and chronic intake, the potential health risks from both the radiological and chemical toxicity standpoints and future research needs. (who.int)
  • Previous studies have shown that C4 does not affect anisotropy or volumetric dosimetry when placed adjacent to radioactive seeds, nor does it alter the T1 positive-contrast signal after exposure to high doses of radiation [ 6 ]. (hindawi.com)
  • Responses of birds to single high-dose exposure to MCs were evaluated in fourteen-day old Japanese quail males ( Coturnix coturnix japonica) with average body weight of 50 g which were randomly divided into five groups. (nel.edu)
  • No mortality occurred during the period of five days post exposure in both control and MCs-exposed groups and this high-dose experiment failed to provide data to compute the LD50. (nel.edu)
  • Nevertheless, marked sub-lethal effects were recognised in the damage of liver that included dose-dependent changes in the body/liver ratios and morphological changes ranging from mild vacuolar dystrophy to focal liver necroses in the highest exposure group. (nel.edu)
  • Though maximum cyanobacterial biomass dose rates that could be administered to birds of the size were used in the present experiment and more pronounced hepatic lesions than after exposure to environmentally relevant doses were observed, birds would probably have survived unless killed for histopathology on day 5 of exposure. (nel.edu)
  • C57BL/6) and MMP-9-/- mice were exposed to varying doses (10 or 40 microg) of MWCNTs via oropharyngeal aspiration and serum was collected at 4 and 24 h post-exposure. (cdc.gov)
  • What determines the nature and level of risk and harm to any given person depends on the timing, dose, and toxicity of the pesticide exposure. (stonyfield.com)
  • Simulated and noticed exposure after dental dosing showed sufficient contract. (healthy-nutrition-plan.com)
  • however, up to 10% of individuals with severe lithium toxicity develop chronic neurologic sequelae. (medscape.com)
  • You need to pay attention to these chronic toxicities. (medscape.com)
  • Toxicity is usually divided into two types, acute or chronic, based on the number of exposures to a poison and the time it takes for toxic symptoms to develop. (ufl.edu)
  • Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: approaches to dose selection. (elsevierpure.com)
  • Further, whether leakage of the C4 solution from the capsules after prostate brachytherapy would potentiate systemic inflammatory effects or produce acute or chronic toxicity is unknown. (hindawi.com)
  • 12-month carcinogenicity screening studies in the rat and mouse demonstrate that urea is of very low chronic toxicity by the oral route. (europa.eu)
  • Urea is of low toxicity following chronic administration to the mouse. (europa.eu)
  • It is concluded that urea is of very low chronic toxicity. (europa.eu)
  • The 0.5 mg/kg dose led to d4T-TP of 13.2 (12.7C13.7) fmol/106 cells, slightly greater than the adult dosage of 20 mg b.we.d. [11.5 (11.2C11.9) fmol/106 cells], which includes excellent antiviral effectiveness and substantially much less toxicity. (healthy-nutrition-plan.com)
  • Therefore, the objective of this study was to obtain data on avian high-dose toxicity of MCs and compute LD50, if possible, following the natural oral route of administration. (nel.edu)
  • Based on this finding, we will continue to conduct further study to assess the repeated-dose acute oral toxicity. (ugm.ac.id)
  • Intramuscular loading dose of quinine for falciparum malaria: pharmacokinetics and toxicity. (ox.ac.uk)
  • Herein, we report the pharmacokinetics, dosimetry and toxicity analysis of 177Lu-EDTMP in patients (phase-0/I study). (nih.gov)
  • A study of the pharmacokinetics, biodistribution, and acute toxicity of C4 demonstrated rapid, dual-route elimination and lack of toxicity after injection of the C4 solution into the prostate and periprostatic tissues [ 7 ]. (hindawi.com)
  • Given a sufficient dose however, hemorrhagic gastroenteritis, liver and kidney necrosis, cardiomyopathy, and metabolic acidosis can occur (Newman-Taylor 1998). (cdc.gov)
  • Uncommon: Pancreatitis (dose related, less common in children than adults), increased liver enzymes, and retinal depigmentation. (cdc.gov)
  • In the United States, acetaminophen toxicity has replaced viral hepatitis as the most common cause of acute liver failure. (medscape.com)
  • To investigate the neem active constituent nimbolide for the evidence of acute toxicity and its protective effects against carbon tetrachloride (CCl 4 ) induced liver toxicity in rats. (ijpsr.com)
  • Rare case reports document liver toxicity. (msdmanuals.com)
  • High-dose methotrexate (HDMTX) plays an important role in the treatment of acute lymphoblastic leukemia (ALL) although there is great inter-patient variability in the efficacy and toxicity of MTX. (oncotarget.com)
  • Symptomatic and structural efficacy with and without optimal MTX dose was assessed by generalised logistic regression with adjustment for appropriate variables. (bmj.com)
  • Halving the paediatric dosage would significantly decrease the threat of mitochondrial toxicity without diminishing antiviral efficacy. (healthy-nutrition-plan.com)
  • This is a two-part study in which the first phase will evaluate escalating doses of the therapy, and the second phase will explore the safety and efficacy of the recommended dose. (precisionmedicineonline.com)
  • In addition to dose, for carcinogenicity testing we look for tumors in more than one species and sex. (cdc.gov)
  • If doses producing an adverse effect are many time the MRHD, we usually do not consider them in our evaluation. (cdc.gov)
  • Neonatal dose: Under evaluation in Pediatric AIDS Clinical Trial Group protocol 332. (cdc.gov)
  • A regulatory design 90-day toxicity study in rats (Dalbey and Feuston, 1996) was conducted via the inhalation route with a vaporised sample of commercial grade DIPE for 6 hours/day and 5 days/week. (europa.eu)
  • Previous studies using oral administration of environmentally relevant doses of cyanobacterial biomass containing microcystins. (nel.edu)
  • Previous studies using oral administration of environmentally relevant doses of cyanobacterial biomass containing microcystins (MCs) induced only sub-lethal effects in experimental birds. (nel.edu)
  • They pointed to weight gain in that paper, but what about the even more common toxicities, like rash and diarrhea ? (medscape.com)
  • The toxicity information for some of the health effects listed above may be categorical in nature (presence/absence of genotoxicity or skin irritation, for example) while other outcomes are expressed through quantitative information and/or potency data. (cdc.gov)
  • The objective of this study was to assess the single dose oral toxicity of nano formulation of Picrorhiza Kurroa extract in Wistar Rats, at a dosage of 200, 1000 or 2000 mg/kg body weight. (phytojournal.com)
  • The aim of this study is to evaluate the dosemetric parameters and acute toxicity of dose-escalated whole pelvis (WP) Intensity Modulated Radiation Therapy (IMRT) and volumetric modulated arc therapy (VMAT) prostate boost following neoadjuvant and concomitant with androgen deprivation therapy in high-risk prostate cancer patients. (scirp.org)
  • This research aimed to evaluate toxicity and safety of consuming chloroform extract of S. trifasciata leaf (CESTL) in acute phase using female Wistar rats as model animal. (ugm.ac.id)
  • Hence the purpose of this study was to evaluate the potential inflammatory toxicity of C4 in the target organs and systemically. (hindawi.com)
  • Objective To evaluate the symptomatic and structural impact of optimal MTX dose in patients with early RA in daily clinical practice over 2 years. (bmj.com)
  • Avian high-dose toxicity of cyanobacterial biomass. (nel.edu)
  • I think the literature shows that most patients have dose reductions anyway, and the literature that's out there comparing lower doses shows very little change in overall outcomes. (medscape.com)
  • According to Brazilian research, patients who take Topamax in lower doses along with sodium divalproate can still find it to be an effective treatment against migraine prophylaxis. (gregjoneslaw.com)
  • Since both may have effects on different neurotransmitter systems involved in migraine and even contrary effects on weight, the possibility of combining them in lower doses is attractive," Dr. Abouch Valenty Krymchantowski told Reuters Health by email. (gregjoneslaw.com)
  • A dose-rate-based version of the 80-mCi rule is derived and used to demonstrate application of this rule to pediatric patients and to adult male patients. (snmjournals.org)
  • Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric. (oncotarget.com)
  • Pediatric usual dose: In combination with other antiretrovirals: 90 mg per m2 of body surface area every 12 hours. (cdc.gov)
  • Pediatric dose: 4 mg per kg of body weight twice daily. (cdc.gov)
  • Pediatric dose: 1 mg per kg of body weight every 12 hours (up to weight of 30 kg). (cdc.gov)
  • Pediatric usual dose: 0.01 mg per kg of body weight every 8 hours. (cdc.gov)
  • In the present study, nano formulation of Picrorhiza Kurroa extract has not caused any mortality or any symptoms of toxicity at and up to a dose of 2000 mg/kg body weight (Limit Dose), under the conditions of the study. (phytojournal.com)
  • Some plants contain chemicals that can cause symptoms similar to digitalis toxicity if they are eaten. (medlineplus.gov)
  • Contact your provider if you are taking a digitalis medicine and you have symptoms of toxicity. (medlineplus.gov)
  • There were no toxicological effects as evidenced by signs of mortality, behavior, diet consumption and tissue weights, however, some hematological parameters showed alterations in their value at higher dose level. (ijpsr.com)
  • Cadmium ingested in high doses irritates the gastric epithelium. (cdc.gov)
  • For high risk prostate cancer, the treatment volumes and even dose levels are still a controversial issue. (scirp.org)
  • Dose escalation in two phases utilizing Simultaneous integrated boost (SIB) combined with ADT in high risk prostate cancer patient is feasible and associated with acceptable acute GI and GU toxicity. (scirp.org)
  • Hence, there is increased interest in radiation dose escalation combined with androgen deprivation in high risk prostate cancer patients [6] [7]. (scirp.org)
  • An ongoing GETUG-AFU-18 phase III trial is evaluating the impact of dose escalation in combination with 3-year androgen deprivation treatment on 5-year biochemical or clinical control in high-risk prostate cancer patients [8]. (scirp.org)
  • Toxicity occurs frequently, since this population is at high risk for overdose. (medscape.com)
  • Generally, the doses are too high. (medscape.com)
  • While rare major abnormalities to the heart and major vessels were seen in one and two foetuses (2 litters) at the mid and high dose respectively, the findings were seen at the same incidence in studies from the laboratories historical database with the exception of incomplete caudal vena cava with persistent cardinal vein. (tga.gov.au)
  • However, the singular occurrence of this finding at the mid- and high-dose was considered likely incidental to treatment. (tga.gov.au)
  • In clinical signs, compound-colored stool was observed in all animals of treatment group (low: day 14 or 15, middle: day 8, high: day 8) and continuously observed up to the end of administration or day 1 of recovery period (high dose group). (eaht.org)
  • In all patients plasma quinine concentrations exceeded the high minimum inhibitory concentration for Plasmodium falciparum malaria prevalent in Thailand within four hours of the start of treatment but did not cause toxicity other than mild cinchonism. (ox.ac.uk)
  • Digitalis toxicity can be caused by high levels of digitalis in the body. (medlineplus.gov)
  • Best Dose is recommended for areas of high infestation. (springtimeinc.com)
  • Surprisingly high doses of lidocaine are well tolerated when delivered subcutaneously by the tumescent technique. (liposuction.com)
  • The safety of such high doses has yet to be well documented by rigorous pharmacologic studies involving a large number of patients. (liposuction.com)
  • No clear toxicity was seen in dogs administered high doses of urea by subcutaneous injection over a period 45 days. (europa.eu)
  • Both male and female mice were treated with low and high doses of THJ-2201. (springeropen.com)
  • A high level of toxicity was observed, with slight differences between organisms. (who.int)
  • PURPOSE: To compare anatomical and functional dose-volume parameters as predictors of acute radiation-induced lung toxicity (RILT) in patients with lung tumors treated with stereotactic body radiation therapy (SBRT). (nevinmanimala.com)
  • Dose volume parameters in patients with and without acute RILT were compared. (nevinmanimala.com)
  • ROC curves assessing the ability of dose-volume parameters to discriminate between patients with and without acute RILT were generated and area under the curves (AUC) were calculated. (nevinmanimala.com)
  • CONCLUSION: The predictive value of PET perfusion-based functional parameters outperforms the standard CT-based dose-volume parameters for the risk of grade ≥2 acute RILT. (nevinmanimala.com)
  • Severe radiation-induced lung toxicity, expected at normal lung absorbed doses of 25-27 Gy, is avoided, probably because most of the local electron dose is delivered to tumor tissue instead of to normal lung parenchyma. (snmjournals.org)
  • This was recognized to be a surrogate for red bone marrow absorbed dose and was intended to decrease the likelihood of severe marrow depression, the dose-limiting toxicity in radioiodine therapy of thyroid cancer. (snmjournals.org)
  • In a study of intramuscular injection of quinine eight adults with moderately severe falciparum malaria resistant to chloroquine were treated with quinine dihydrochloride, being given a loading dose of 20 mg salt (16.7 mg base)/kg followed by three or four eight hourly maintenance doses of 10 mg salt (8.3 mg base)/kg injected into the anterior thigh. (ox.ac.uk)
  • When intravenous infusion is not possible an intramuscular quinine loading dose is an effective means of starting treatment in patients with moderately severe falciparum malaria who cannot swallow tablets. (ox.ac.uk)
  • Unusual (more severe): Peripheral neuropathy (dose related), electrolyte abnormalities, and hyperuricemia. (cdc.gov)
  • The therapeutic dose is 300-2700 mg/d with desired serum levels of 0.6-1.2 mEq/L. (medscape.com)
  • For the phase-I study, 21 patients with metastatic prostate cancer were given a therapeutic dose of 177Lu- EDTMP (692-5550MBq). (nih.gov)
  • Procedure referred to OECD Guidelines for the Testing of Chemicals, Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure with single-dose administration of 2000 mg/kg bw. (ugm.ac.id)
  • The fixed-dose procedure (FDP), proposed in 1992 by the British Toxicology Society, is a method to assess a substance's acute oral toxicity. (wikipedia.org)
  • Therefore, it can be concluded that no-observed-adverse-effect-level (NOAEL) for single-dose oral administration of CESTL with the dose 2000 mg/kg bw and can be classified in the hazard of Category 5 based on Globally Harmonized System of Classification and Labelling of Chemicals (GHS). (ugm.ac.id)
  • Acute grade 1 toxicity for Gastrointestinal (GI) and Genitourinary (GU) were 65% and 35% respectively, while Grade 2 toxicity was 30% for both. (scirp.org)
  • When toxicity data are present for a given endpoint, a weighted score based on that health endpoint is assigned. (cdc.gov)
  • Note: The NOAEL/BMDL (or, in some cases lowest observed adverse effect level) are used in this analysis, NOT the agency RfD or MRL, because of differences in purpose and dose adjustments. (cdc.gov)
  • In the absence of preferred NOAEL/BMDL values from such agency authenticated toxicity benchmarks, clearly documented NOAELs/BMDLs from one or more of a suite of designated information sources can be used (Rank 2 or second-level sources). (cdc.gov)
  • Metformin reduces insulin doses in type 1 diabetes, but does not reduce the rate of glycated hemoglobin (HbA 1c), nor is it clear whether the benefit is sustained beyone 1 year or has any benefit to cardiovascular or other key clinical outcomes. (greenmedinfo.com)
  • The assumption of uniform energy deposition in the lungs leads to substantially overestimated absorbed doses. (snmjournals.org)
  • Acute radiation toxicities were reported during the radiation course and the following 3 months. (scirp.org)
  • The Proctitis and frequency were the commonest acute toxicity and were maximal during the 5th week of radiation therapy. (scirp.org)
  • Dose escalation can be achieved with either 3-Dimensional Conformal Radiation Therapy (3-DCRT) or with intensity-modulated Radiation Therapy (IMRT). (scirp.org)
  • This study provides a detailed characterization of the dose-dependent impact of ionizing radiation on skin cells (45, 60, or 80 grays). (mdpi.com)
  • Along with estimating radiation dose values to certain critical organs, we have also proposed an MTD for 177Lu-EDTMP that correlated well with toxicity data. (nih.gov)
  • Humans, obviously, cannot be used as test subjects, so toxicity testing is done with animals and plants. (ufl.edu)
  • Single-dose Acute Oral Toxicity Study of Chloroform Extract of Snake Plant ( Sansevieria trifasciata Prain. (ugm.ac.id)
  • Therefore, the aim of this study was to obtain safety data for new TiO 2 powder, GST produced through sludge recycling of the sewage treatment plant through repeated-dose toxicity in Sprague-Dawley (SD) rats in according to the OECD test guideline (TG 408). (eaht.org)
  • In a phase-0 study, the biokinetics of skeletal and non-skeletal uptake of 177Lu-EDTMP was assessed in 6 patients with metastatic prostate cancer using tracer doses (172.7-206.9MBq). (nih.gov)
  • A Japanese study* proves that garlic toxicity is almost impossible to reach. (springtimeinc.com)
  • Dose - 1/2 lb (equal to about 78 cloves) per 100 lbs body weight is the amount force-fed to study dogs each day for seven straight days. (springtimeinc.com)
  • One study with 10 patients concluded that tumescent anesthesia with a lidocaine dose of 55 mg/kg is safe for liposuction.1 We have personally performed tumescent liposuction on more than 400 patients using lidocaine doses in the range of 50-60 mg/kg without evidence of lidocaine toxicity. (liposuction.com)
  • No evidence of toxicity was seen in this study at dose levels of up to 45000 ppm. (europa.eu)
  • Group allotment in hepatoprotective activity study included vehicle, CCl 4 (1ml/kg), Silymarin (100 µg/kg/day) + CCl 4 and graded doses of nimbolide (100 and 200µg/ kg/ day) + CCl 4 . (ijpsr.com)
  • The study start date was July 18, and as of Dec. 2, no dose-limiting toxicity or adverse immune reactions were observed in the six outpatient subjects with locally advanced or metastatic solid tumors. (precisionmedicineonline.com)
  • In this work, the 80-mCi activity retention limit is used to derive lung-absorbed doses and dose rates. (snmjournals.org)
  • The resulting dose-rate-based limits make it possible to account for patient-specific differences in lung geometry. (snmjournals.org)
  • With this definition, the 80-mCi rule was generalized by calculating the activity required to yield a dose rate equal to DRC using lung-to-lung S factor values corresponding to different reference phantoms. (snmjournals.org)
  • the photon-only portion, which better reflects the dose to normal lung parenchyma, ranged from 4.9 to 55 Gy. (snmjournals.org)
  • At a lung meeting I recently attended, one of the patient advocates who was attending there pointed out how this 1+ toxicity is really disruptive to persons, knowing that they're going to have frequent bowel movements beyond what they normally do, and it really changes their life. (medscape.com)
  • Reabsorption of lithium is increased and toxicity is more likely in patients who are hyponatremic or volume depleted, both of which are possible consequences of diuretic therapy. (medscape.com)
  • By the way, in the paper about weight loss with alectinib, half the patients had a dose reduction. (medscape.com)
  • The level of toxicity reflects a continuum from relatively nontoxic to production of toxic effects in patients at low doses (for example, a few milligrams or less). (cdc.gov)
  • Only transient toxicity was observed in 14/21 patients, of which 6 had baseline toxicity. (nih.gov)
  • Beyond the MTD, a significantly higher number of patients displayed grade 3-4 toxicity. (nih.gov)
  • Note: may need higher dose in patients with central nervous system disease. (cdc.gov)
  • Need to decrease dose in patients with renal impairment. (cdc.gov)
  • We believe many doctors and CML patients will find this treatment, if approved, to be a welcome addition, offering a distinct adverse event profile and a convenient once-daily dosing regimen. (aol.com)
  • Results Within the first year of follow-up, 314 patients (53%) with RA received MTX as a first DMARD (mean dose 12.2±3.8 mg/week). (bmj.com)
  • After six weeks of the patients taking the lower-dose combination of the drugs, 27 patients reported that they experienced less side effects and that their headaches continued to improve. (gregjoneslaw.com)
  • In the latter case, clearly specified quantitative benchmarks, such as median lethal doses (LD50s) for acute toxicity and no- observed-adverse-effect levels (NOAELs), or equivalent point of departure such as benchmark dose lower confidence limit (BMDL), for STOT-RE, are used. (cdc.gov)
  • Digitoxin blood level may be lowered with repeated doses of charcoal, given after gastric lavage . (medlineplus.gov)
  • Mean estimated red marrow dose was 0.80±0.15mGy/MBq while mean total-body dose was 0.16±0.04mGy/MBq. (nih.gov)
  • Lidocaine Toxicity Lidocaine Toxicity with Tumescent Liposuction A Case Report of Probable Drug Interactions JEFFREY A. KLEIN, MD NORMA KASSARJDIAN, MD We report a case of mild lidocaine toxicity. (liposuction.com)
  • Drawing the dose volume histograms (DVHs) was done for planning target volumes (PTVs), including Prostate PTV & nodal PTV, and organs at risk including rectum, bladder, femoral heads, and bowel bag for the plans. (scirp.org)
  • The DVH analysis showed good coverage of PTVs and organs at risk doses were acceptable. (scirp.org)
  • Nimbolide showed dose dependent hepatoprotective in nature which was further substantiated by marked decrease in incidence of hepatocellular necrosis on histopathological and transmission electron microscopic analysis. (ijpsr.com)
  • People may also develop digitalis toxicity if they have other risk factors. (medlineplus.gov)
  • A low level of potassium in the body can increase the risk of digitalis toxicity. (medlineplus.gov)
  • Blood drawn at 23:48 p.m. had a plasma lidocaine concentration of 6.3 mg/L by immunoassay (IA), and confirmed by gas chromatography (GC) to be 6.1 mg/L. Lidocaine plasma levels greater than 6 mg/L are associated with an increased risk of toxicity. (liposuction.com)
  • [ 1 ] It has an excellent safety profile when administered in proper therapeutic doses, but hepatotoxicity can occur after overdose or when misused in at-risk populations. (medscape.com)
  • How well a person does depends on the severity of the toxicity and if it has caused an irregular heart rhythm. (medlineplus.gov)
  • Conclusion - In my opinion, it is extremely unlikely that any dog would ever voluntarily eat the amount of raw garlic necessary to reach the minimum toxic dose. (springtimeinc.com)
  • Conclusion Optimal MTX dose is more efficacious than non-optimal dose for remission and function in early arthritis in daily practice, with no impact on radiological progression over 2 years. (bmj.com)
  • En conclusion, l'utilisation d'huile de margousier, substance plutôt inoffensive pour l'environnement, est une alternative au larvicide d'anophèle. (who.int)
  • To the best of my knowledge, that was the first documented case of tumescent liposuction totally by local anesthesia where a standard dose of lidocaine, widely recognized as safe, has led to potentially toxic plasma lidocaine concentrations. (liposuction.com)
  • Excretion was rapid with the majority of the administered dose eliminated in the urine (11% in males and 48% in females) and bile (85 - 88%) within 48 hours after administration. (tga.gov.au)