• Concurrent chemoradiotherapy with 3x-weekly cisplatin is recommended if patient refuses surgery. (medscape.com)
  • If cisplatin cannot be administered, then cetuximab concurrent to radiotherapy. (medscape.com)
  • radiotherapy (based on initial stage) Ā± cisplatin/cetuximab (based on induction chemotherapy [ICT] toxicity). (medscape.com)
  • If the main objective is organ preservation, consider concomitant radiotherapy (RT) (with cisplatin or cetuximab). (medscape.com)
  • concomitant RT (with cisplatin or cetuximab) or consider surgery followed by radiotherapy. (medscape.com)
  • For concomitant chemoradiotherapy with 3x-weekly cisplatin, several studies have demonstrated benefit in locoregional control and overall survival over radiotherapy alone with a significant increase in acute and chronic toxicity. (medscape.com)
  • Determine the toxicity and response to cisplatin, paclitaxel and radiation therapy in these patients. (knowcancer.com)
  • Background The aim of this study was to evaluate toxicity, compliance, recurrence and the survival of weekly and triweekly cisplatin-based concomitant chemoradiation in treatment of cervical cancer. (bmj.com)
  • Materials and Methods The databases were searched from 1995 until 2015 to identify eligible studies on weekly versus triweekly cisplatin chemoradiotherapy. (bmj.com)
  • Weekly cisplatin regimen significantly reduced the incidence of Hematologic toxicity. (bmj.com)
  • Conclusions Weekly cisplatin regimen had the similar therapeutic effect as the triweekly cisplatin regimen but with less hematologic toxicity. (bmj.com)
  • Therefore, we recommend the weekly cisplatin 30 to 40 mg/m 2 chemoradiotherapy as the strong candidate for the optimal cisplatin dose and dosing schedule in the treatment of locally advanced cervical cancer. (bmj.com)
  • Nedaplatin a cisplatin analog was developed to reduce the toxicity of cisplatin whereas it can be cross-resistant with cisplatin in some circumstances. (antiviralbiologic.com)
  • Although cisplatin-based chemotherapy is the first-line treatment for locoregionally advanced nasopharyngeal carcinoma [3 4 the medical software of cisplatin has been limited due to its toxicity and acquired resistance developed during TCS 5861528 the therapy. (antiviralbiologic.com)
  • Nedaplatin is the second generation of platinum complex which was developed to reduce toxicities such as nephrotoxicity and gastrointestinal toxicity generally seen in cisplatin-treated individuals [5]. (antiviralbiologic.com)
  • We investigated long-term treatment outcomes and the feasibility of chemoradiotherapy consisting of daily-low-dose 5-fluorouracil and cisplatin (LDFP) chemotherapy plus radiotherapy for Stage I-II squamous cell esophageal cancer. (elsevierpure.com)
  • LDFP chemotherapy, as continuous infusion of 200 mg/m 2 5-fluorouracil combined with one hour infusion of 4 mg/m 2 cisplatin, was administered on the same days as radiotherapy. (elsevierpure.com)
  • Title:-Weekly Cisplatin vs. Three-weekly Cisplatin in Concurrent Chemoradiotherapy of Locally Advanced Head and Neck Squamous Cell Carcinoma-Evaluation of Short Term Response and Toxicity. (gov.bd)
  • Received weekly cisplatin 40 mg m2 for 5 to 6 cycles as concurrent chemotherapy with radiation therapy. (who.int)
  • If participants cannot tolerate toxicity, must have received at least 4 cycles of cisplatin. (who.int)
  • The study investigators noted that disease recurrence is common in patients with loco-regional advanced NPC achieving remission following first-line treatment with the standard of care, concurrent cisplatin-radiotherapy with or without induction chemotherapy. (ogkologos.com)
  • Radiotherapy was given 3 weeks after the first treatment cycle concurrently with weekly cisplatin 20mg/m(2) on day 1 and etoposide 50mg/m(2) on day 4 within 5-6 weeks, followed by three courses of irinotecan 60mg/m(2) on days 1, 8, and 15 and cisplatin 60mg/m(2) on day 1 of a 4-week cycle. (ogologos-giassas.com)
  • The chemoradiotherapy regimen consisted of cisplatin (50 mg/m 2 ) on days 1 and 29 concurrent with volume-directed external-beam radiation therapy, followed by carboplatin given at a dose to achieve an area under the concentration-time curve (AUC) of 5-6 plus paclitaxel (175 mg/m 2 every 21 days for four cycles). (medscape.com)
  • With concurrent paclitaxel and cisplatin with radiotherapy, two year survival rates of 26% were seen. (wikidot.com)
  • Intensity Modulated Radiotherapy (IMRT)for Whole Pelvic Radiation Therapy (WPRT) is considered superior to 3D conformal radiotherapy in dose distribution to targets and to spare normal tissue as (BM) supported by many dosimetric studies [ 7 ]. (oncologyradiotherapy.com)
  • Purpose Intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) have been adopted for radiotherapy treatment of anal canal carcinoma (ACC) due to better conformality, dose homogeneity and normal-tissue sparing compared to 3D-CRT. (ucalgary.ca)
  • Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy? (biomedcentral.com)
  • Intensity-modulated radiation therapy in advanced head and neck patients treated with intensive chemoradiotherapy: preliminary experience and future directions. (uchicago.edu)
  • Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy. (uchicago.edu)
  • Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: toxicity and clinical outcome. (uchicago.edu)
  • Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: toxicity and clinical outcome. (uchicago.edu)
  • A multi-institutional acute gastrointestinal toxicity analysis of anal cancer patients treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy. (uchicago.edu)
  • Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience. (uchicago.edu)
  • Title:-A Comparative Study of Cardiac Toxicity Analysis in Hypo-Fractionated Vs. Conventional Fractionated Adjuvant Radiotherapy in Post Mastectomy Left Breast Carcinoma. (gov.bd)
  • Concurrent chemoradiotherapy is still the mainstay of HNSCCs treatment, especially in unresectable ones, which has been associated with variable individual clinical outcomes despite similar clinical-pathological features (Nogueira et al. (researchsquare.com)
  • 2004 ). One problem with cancers, especially HNSCCs, is the unpredictability of treatment outcomes, both in terms of tumor response and host toxicity. (researchsquare.com)
  • Our findings demonstrate that a non-operative approach with high-dose radiotherapy and concurrent chemoradiotherapy can result in favorable outcomes. (mskcc.org)
  • Background: Induction chemotherapy (IC) in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) often compromises compliance with subsequent chemoradiotherapy (CRT), which negatively affects outcomes. (elsevierpure.com)
  • The goal of this study was to compare outcomes and toxicity of preoperative SF-SRS with multifraction (3-5 fractions) SRS (MF-SRS) in a large international multicenter cohort (XXX). (qxmd.com)
  • Daily Step Counts Predict Outcomes for Locally Advanced Non-Small Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy was presented at the 2019 ASTRO Annual Meeting. (roinstitute.org)
  • Due to the poor outcomes with surgery and systemic therapy, radiotherapy may be considered even when there has been previous high dose radiotherapy to the neck. (wikidot.com)
  • Concomitant radiotherapy and cetuximab have shown a benefit in locoregional control and overall survival compared to radiotherapy alone with a better toxicity profile compared to chemotherapy. (medscape.com)
  • She cited several studies whose findings show high rates of disease-free survival and PFS with no grade ā‰„4 toxicities in patients with recurrent prostate cancer treated with SBRT. (cyberknifemiami.com)
  • Chemoradiotherapy with LDFP provided favorable long-term survival with acceptable toxicity for Stage I-II squamous cell esophageal cancer. (elsevierpure.com)
  • Baseline FPG level is an independent predictor of survival in our cohort of patients with locally advanced NSCLC treated with concurrent chemoradiotherapy. (biomedcentral.com)
  • Influence of concurrent capecitabine based chemoradiotherapy with bevacizumab on the survival rate, late toxicity and health- related quality life in locally advanced rectal cancer. (radioloncol.com)
  • That study showed improved progression-free and overall survival in the chemoradiotherapy arm. (medscape.com)
  • For this study, Matei and colleagues hypothesized that systemic chemotherapy and tumor volume-directed radiotherapy would improve recurrence-free survival and overall survival in comparison with systemic chemotherapy alone for patients with surgically staged III/IVA uterine cancer. (medscape.com)
  • According to Sandeep Samant, MD , Chief of Head and Neck Surgery at Northwestern Medicine and symposium Chair, "The goal of deintensification is to reduce late toxicity, while maintaining high survival and normal functioning related to swallowing, saliva, and taste. (ascopost.com)
  • The goal of deintensification is to reduce late toxicity, while maintaining high survival and normal functioning related to swallowing, saliva, and taste. (ascopost.com)
  • Although physical parameters such as the mean lung dose are used in clinical practice, they are not suited for individualised radiotherapy. (maastrichtuniversity.nl)
  • Hounsfield unit (HU) changes before versus three months post-radiotherapy were correlated per voxel with the radiotherapy dose in 95 lung cancer patients. (maastrichtuniversity.nl)
  • Conclusions Chemoradiotherapy treatment of ACC using IMRT vs HT results in differences in dose homogenity and normal-tissue sparing, but no significant differences in toxicities. (ucalgary.ca)
  • By building on the proven concept of conventional chemoradiation for patients with locally advanced NSCLC with a subsequent radiation dose intensification to residual disease with SBRT concurrent with immunotherapy, we hope address the issues of metastatic and local failures. (frontiersin.org)
  • Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
  • Fractionated radiotherapy was performed with a total dose of 60 Gy delivered in 2 Gy per fraction. (elsevierpure.com)
  • Split-course radiotherapy (RT) was administered to a total dose of 40 Gy, with a 2-week treatment break. (cancernetwork.com)
  • Ninety-five percent patients completed a full-dose chemoradiotherapy as planning. (biomedcentral.com)
  • 20 Gy was identified as the most likely clinically meaningful dose threshold for toxicity. (ox.ac.uk)
  • Stereotactic body radiotherapy for multisite extracranial oligometastases: final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease. (uchicago.edu)
  • Results from their pilot study suggested that step counts may serve as dynamic predictors of short-term hospitalization risk during chemoradiotherapy, and with his Innovative Projects in Radiation Oncology award, Dr. Ohri explored whether physical activity could also be used as a treatment. (roinstitute.org)
  • On the other hands, researches have been conducted to find molecular markers for predicting the development of treatment-induced acute or chronic toxicity before initiation of treatment (Venkatesh et al. (researchsquare.com)
  • Feasibility and acute toxicity of hypofractionated radiation in large-breasted patients. (uchicago.edu)
  • Acute toxicity is significant with our current treatments," Dr. Agrawal said. (ascopost.com)
  • Patients must have recovered from all acute toxicities from previous therapy, excluding alopecia and toxicities related to prior therapy. (genentech-clinicaltrials.com)
  • Aim: The main objective of this study was evaluation of bone marrow sparing IMRT versus standard IMRT as a planning limitation in cervical cancer therapy receiving concurrent chemo radiotherapy for evaluation of the response of treatment,toxicity profile and quality of life of both radiotherapy treatment modalities. (oncologyradiotherapy.com)
  • Evaluation of bone marrow sparing IMRT versus standard IMRT as a planning limitation in cervical cancer therapy cases receiving concurrent chemo radiotherapy. (oncologyradiotherapy.com)
  • To date, only one published study compares dosimetric parameters of IMRT vs HT in ACC, but there are no published data comparing toxicities. (ucalgary.ca)
  • Toxicity associated with radiation therapy is decreased by placing the patient in the prone position on a belly board, however for patients who cannot tolerate prone positioning, IMRT decreases the volume of normal tissue irradiated. (biomedcentral.com)
  • Therefore, knowing the genetic variations (polymorphisms) will be effective in predicting the response to treatment, and accordingly, we can determine which patients will benefit from chemo- or radiotherapy (Ansell et al. (researchsquare.com)
  • Concurrent chemo-radiotherapy is the usual treatment for locally advanced cervical cancer. (oncologyradiotherapy.com)
  • We investigated the outcome and the prognostic factors of patients with locally advanced esophageal cancer who were treated with concurrent chemo-radiotherapy. (e-roj.org)
  • This study has shown that results of concurrent chemo-radiotherapy in patients with locally advanced esophageal cancer is comparable to those of other studies. (e-roj.org)
  • Title:- Comparative Study on the Effects of 70 GY Three-Dimensional Conformal Radiotherapy (3 DCRT) and Concurrent Chemo-radiotherapy woth 60 GY in Stage III Nonsmall Cell Lung Cancer. (gov.bd)
  • This combination of chemotherapy and radiotherapy has a special role in tumor down staging and in sphincter preservation for lower rectal tumors. (wjgnet.com)
  • Collected activity data by providing patients with a Garmin VivofitĀ® activity tracker to wear throughout their standard course of chemotherapy and radiotherapy. (roinstitute.org)
  • By examining the SNPs, it is possible to make predictions about the patient's response to treatment or development of toxicity after treatment, and if necessary, make changes in the patient's treatment regimen. (researchsquare.com)
  • Concomitant with radiation, fluorouracil based chemotherapy remains the standard, and although toxicity is decreased with continuous infusion fluorouracil, oral capecitabine is non-inferior to the continuous infusion regimen. (biomedcentral.com)
  • In 2004, a randomized trial from Germany was published establishing a regimen of preoperative chemoradiotherapy and surgery followed by additional cycles of chemotherapy alone as the standard of care for clinical stages T3 or T4, or for node-positive rectal cancer [ 3 ]. (biomedcentral.com)
  • Consolidation chemotherapy with IP following concurrent EP plus TRT is a safe and with acceptable toxicity regimen and deserves further phase III testing in patients with LS-SCLC. (ogologos-giassas.com)
  • Therefore, we designed this randomized trial to explore whether a combined regimen of oxaliplatin-added chemoradiotherapy and a concomitant boost to the primary tumor would further lead to a better clinical outcome. (biomedcentral.com)
  • Preliminary scientific outcome data show up encouraging with advantageous normal tissues toxicity results evaluating with traditional data of concurrent chemoradiation plus cetuximab. (healthy-nutrition-plan.com)
  • BACKGROUND AND PURPOSE: To determine if suppression of active bone marrow, as defined on FDG PETCT, is seen in on-treatment imaging of anal cancer patients receiving concurrent chemoradiation. (ox.ac.uk)
  • A web-based search of all original articles about the impact of gene polymorphisms on toxicity and response to therapy in HNSCCs was done until September 2021 using international English language databases including Google Scholar, Scopus, PubMed and Web of science. (researchsquare.com)
  • 1 Early clinical studies of the EGFR monoclonal antibody in combination with radiotherapy primarily included head and neck squamous cell carcinoma, and the study of its combination with radiation therapy for NSCLC was performed relatively late. (dovepress.com)
  • Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
  • Background - Mucosal head and neck squamous cell cancers are often managed with multimodality treatment which can be associated with significant toxicity. (ices.on.ca)
  • METHODS AND MATERIALS: Scans from 26 patients participating in the ART trial (full title: Anal squamous cell carcinoma: Investigation of functional imaging during chemoRadioTherapy), a single center observational study with FDG PETCT prior to radiotherapy and at fraction 8-10 of concurrent chemoradiation were analysed. (ox.ac.uk)
  • Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma. (uchicago.edu)
  • Over the decades Dr. Morrison has been involved in trials of fractionation, radiation protectors, induction and concurrent chemotherapy, and proton beam therapy. (mdanderson.org)
  • OBJECTIVES: I. Assess the efficacy and role of amifostine as a cytoprotection agent with concurrent chemoradiotherapy in advanced, previously irradiated or metastatic head and neck cancer. (knowcancer.com)
  • Title:-Comparative Study of Two Hypofractionated Palliative Radiotherapy Schedule (24 GY/3 Frractions Vs. 30 GY/10 Fractions) in Locally Advanced Head Neck Cancer. (gov.bd)
  • Other clinical studies from the United States, Europe, and Asia have also influenced the treatment strategies for operable rectal cancer, as various approaches using preoperative or postoperative radiotherapy, with or without chemotherapy, have been examined. (biomedcentral.com)
  • A concomitant boost to oxalipatin-combined preoperative chemoradiotherapy demonstrated a slightly higher pCR rate but delayed incision healing after surgery. (biomedcentral.com)
  • Patients who received preoperative RT in the study had superior local control and reduced toxicity compared with patients in the postoperative group. (biomedcentral.com)
  • CONCLUSION: The effect of concurrent chemoradiation in suppression of active bone marrow is seen in on-treatment FDG PETCT scans. (ox.ac.uk)
  • A number of studies of radiotherapy combined with targeted therapy in non-small-cell lung carcinoma have been completed or are ongoing. (dovepress.com)
  • Radiotherapy combined with targeted therapy has considerably furthered the study of non-small-cell lung carcinoma (NSCLC) under the joint efforts of the two disciplines, yielding both exciting results and worrisome reports. (dovepress.com)
  • Background: This phase 2 prospective randomized double-arm study carried out at Clinical Oncology Department Tanta University, Radiotherapy Department, NCI, Cairo University and Gharbia cancer society through the period from May 2018 to December 2019 and enrolled 60 patients with cervical carcinoma. (oncologyradiotherapy.com)
  • Title:- Comparative Study of Concurrent Chemoradiotherapy Vs Only Radiotherapy in Locally Advanced Carcinoma Cervix to Asses the Clinical Outcome & Toxicity of Patients in Our Clinical Setting. (gov.bd)
  • He has been actively involved in both the clinical implementation of stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) and related translational and clinical research, as well as the integration of SRS and SBRT into other systemic therapies. (uchicago.edu)
  • Daily Step Counts to Predict Hospitalizations During Concurrent Chemoradiotherapy for Solid Tumors was presented at the 2019 ASCO Quality Care Symposium. (roinstitute.org)
  • Our objectives were to compare dosimetry and toxicities between these modalities. (ucalgary.ca)
  • The investigators wrote that, to their knowledge, this is the first randomised phase III study to assess the efficacy and safety of adding metronomic capecitabine as an adjuvant therapy to chemoradiotherapy in patients with high-risk locoregionally advanced NPC. (ogkologos.com)
  • Grade 3 neutropenia reported during radiotherapy was significantly difference (p=0.004) as 25% of patients in group A against 0% in group B. (oncologyradiotherapy.com)
  • Grade 2+ hematological and non-hematological toxicities were similar. (ucalgary.ca)
  • Patient underwent bilateral ante grade stenting and completed concurrent chemoradiotherapy. (jpalliativecare.com)
  • Griffiths said the treatment was well tolerated, with only 3 incidences of grade 3/4 toxicities: 2 patients developed small bowel obstruction and 1 experienced rectovaginal fistula. (cyberknifemiami.com)
  • No grade 4 toxicity or treatment-related death was seen. (elsevierpure.com)
  • An estimated 80% of patients will have grade 3 toxicity with current treatments, and up to 25% to 60% will "continue to suffer from grade 3 toxicity. (ascopost.com)
  • Two hundred forty six patients with esophageal cancer that were treated by radiotherapy between January 1994 and July 2007. (e-roj.org)
  • Methods and materials This is a retrospective study of 35 ACC patients treated with radical chemoradiotherapy at two tertiary cancer institutions from 2008-2010. (ucalgary.ca)
  • Title:- Comparative Study of Hypofractioned Palliative Radiotherapy (17 GY in 2 Fractions) with Conventional Fractionation (30 GY in 10 Fractions) in Inoperable Locally Advanced Non-Small Cell Lung Cancer in Terms of Symptom Control and Toxicities. (gov.bd)
  • In this article, we review the data surrounding the use of chemotherapy (CT) and chemoradiotherapy (CRT) in patients with resectable pancreatic cancer. (cancernetwork.com)
  • While presenting results on behalf of colleagues, Jun Ma of the Sun Yat-sen University Cancer Center in Guangzhou, China explained that metronomic chemotherapy refers to frequent and regular administration over long time periods of chemotherapeutic drugs at substantially lower doses than typically prescribed, and is a strategy that delivers low toxicity and good compliance. (ogkologos.com)
  • We aim to determine the prognostic value of fasting plasma glucose (FPG) and diabetes mellitus in patients with locally advanced non-small cell lung cancer (NSCLC) treated with concurrent chemoradiotherapy. (biomedcentral.com)
  • In this study, we determine the prognostic value of fasting plasma glucose (FPG) and Type 2 Diabetes Mellitus (T2DM) in patients with stage III non-small cell lung cancer treated with concurrent chemoradiotherapy. (biomedcentral.com)
  • Background/Aim: Radiotherapy of locally advanced lung cancer often requires high doses potentially leading to pneumonitis. (iiarjournals.org)
  • The majority of patients with small-cell lung cancer (SCLC) receive radiotherapy in combination with chemotherapy. (iiarjournals.org)
  • Also, many patients with locally advanced non-small-cell lung cancer (NSCLC) receive radiotherapy, if they are not candidates for surgery. (iiarjournals.org)
  • However, the comparator was external-beam radiotherapy, and the study reaffirmed the role of chemotherapy for treating high risk endometrial cancer," she said. (medscape.com)
  • Nitin Ohri, MD, and his team at the Montefiore Einstein Center for Cancer Care and Albert Einstein College of Medicine conducted a randomized clinical trial to determine if giving cancer patients daily customized step count goals as measured and guided through fitness trackers could improve their ability to tolerate concurrent chemoradiotherapy. (roinstitute.org)
  • Cardiac Dosing Predicts Activity Decline During Concurrent Chemoradiation for Locally Advanced Lung Cancer was presented at the 2018 ASTRO Annual Meeting. (roinstitute.org)
  • His clinical interests include breast cancer, limited metastatic disease, immunotherapy, and technologic improvements in the delivery of radiotherapy. (uchicago.edu)
  • Is postmastectomy radiotherapy useful in elderly women with high-risk breast cancer? (uchicago.edu)
  • This is a multicenter, double-blind, placebo-controlled, randomized, phase II study to investigate the efficacy and safety of Atezolizumab with or without Tiragolumab as consolidation therapy in participants with limited stage small cell lung cancer who have not progressed during/after chemoradiotherapy. (genentech-clinicaltrials.com)
  • The combination of radiotherapy and targeted therapy is an important approach in the application of targeted therapy in clinical practice, and represents an important opportunity for the development of radiotherapy itself. (dovepress.com)
  • Targeted therapy in combination with radiotherapy has a bright future. (dovepress.com)
  • Differences in the experimental results prompted this summary for a more comprehensive and rational understanding of radiotherapy combined with targeted therapy. (dovepress.com)
  • This retrospective review of the literature indicates that numerous drugs have been used for targeted therapy and that the studies of radiotherapy combined with targeted therapy are diverse and complicated by their variable quality. (dovepress.com)
  • Findings were categorized by type of treatment (radiotherapy, chemotherapy, targeted therapy, or combination therapy). (researchsquare.com)
  • such integration of ablative radiotherapy and immunotherapy along with advancing the search for biomarkers is currently Dr. Chmura's focus. (uchicago.edu)
  • Title:- Palliative Effect of Radiotherapy In 8 GY single Fraction Versus 30 GY In Ten Fractions For Painful Bone Metastases. (gov.bd)
  • There is a single randomised controlled trial comparing salvage surgery alone versus salvage surgery with chemoradiotherapy. (wikidot.com)