Toxicity patients receive oral imatinib mesylate. Medical search. Frequent questions

To determine the frequency and severity of adverse effects of Gleevec in this cohort of patients as assessed by CTC. (knowcancer.com)
Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral targeted therapy medication used to treat cancer. (wikipedia.org)
Tasigna demonstrated that significantly fewer patients progressed to more advanced stages of the disease than the standard of care Gleevec (imatinib mesylate) tablets* at 12 months. (salesandmarketingnetwork.com)
All filings are based on data showing superior efficacy for Tasigna in the first head-to-head comparison of the drug against the standard of care Gleevec in newly diagnosed Ph+ CML patients. (salesandmarketingnetwork.com)
If approved for the first-line indication, Tasigna will be the first drug for newly diagnosed patients to become available since the approval of Gleevec in 2002. (salesandmarketingnetwork.com)
This randomized, open-label, multicenter trial compared the efficacy and safety of Tasigna versus Gleevec in adult patients with newly diagnosed Ph+ CML in chronic phase(1). (salesandmarketingnetwork.com)
In the ENESTnd clinical trial significantly fewer patients at 12 months progressed to accelerated or blastic phase on Tasigna 300 mg twice daily than on Gleevec 400 mg once daily (2 patients vs. 11 patients)(1), demonstrating a significant improvement in disease control. (salesandmarketingnetwork.com)
Fewer patients discontinued due to adverse events from the Tasigna 300 mg twice daily arm of the study compared to the Gleevec 400 mg once daily arm. (salesandmarketingnetwork.com)
Tasigna has been approved in more than 80 countries for the treatment of chronic phase and accelerated phase Ph+ CML in adult patients resistant or intolerant to at least one prior therapy, including Gleevec. (salesandmarketingnetwork.com)
Imatinib mesylate gleevec is a major part of the cns. (albionfoundation.org)
Preclinical data shows improvements in response for the combination of imatinib mesylate (IM, Gleevec) and gemcitabine (GEM) therapy compared with GEM alone. (aacrjournals.org)
Imatinib, marketed by Novartis as Gleevec (U.S.) or Glivec (Europe/Australia/Latin America), and sometimes referred to by its investigational name STI-571, is a tyrosine-kinase inhibitor used in the treatment of multiple cancers, most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). (keralapharmacist.com)
Imatinib mesylate (Glivec ® /Gleevec ® ) is the standard first-line therapy for the treatment of chronic myeloid leukemia due to its high hematologic, cytogenetic, and molecular response rates and favorable long-term. (biomedcentral.com)

Known as Glivec (imatinib) outside the US, Canada and Israel. (salesandmarketingnetwork.com)

In addition, another study showed that the latency to onset of hepatic injury by imatinib was 12 to 77 days [ 11 ]. (e-crt.org)
Tolvaptan treatment must be initiated and monitored under the supervision of physicians with expertise in managing ADPKD and a full understanding of the risks of tolvaptan therapy including hepatic toxicity and monitoring requirements (see section 4.4). (medicines.org.uk)
Patients with end-stage renal disease on dialysis or with baseline mild hepatic impairment should not exceed 40 mg daily ( 2.5 , 2.6 ). (drugs.com)

Embryo-Fetal Toxicity: May cause fetal harm. (drugs.com)

Imatinib works by stopping the Bcr-Abl tyrosine-kinase. (wikipedia.org)
For treatment of progressive plexiform neurofibromas associated with neurofibromatosis type I, early research has shown potential for using the c-KIT tyrosine kinase blocking properties of imatinib. (wikipedia.org)
Imatinib is the first tyrosine kinase inhibitor (TKI) approved for the treatment of chronic myeloid leukemia (CML), Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), and gastrointestinal stromal tumors (GIST) [ 1 ]. (e-crt.org)
8-13 Tyrosine kinase inhibitors (TKI) (imatinib, sunitinib, and regorafenib) have dramatically changed the treatment landscape and outcomes for gastrointestinal stromal tumour (GIST), one of the most common STS subtypes. (emjreviews.com)
Like all tyrosine-kinase inhibitors, imatinib works by preventing a tyrosine kinase enzyme, in this case BCR-Abl, from phosphorylating subsequent proteins and initiating the signaling cascade necessary for cancer development, thus preventing the growth of cancer cells and leading to their death by apoptosis. (keralapharmacist.com)
Because the BCR-Abl tyrosine kinase enzyme exists only in cancer cells and not in healthy cells, imatinib works as a form of targeted therapy-only cancer cells are killed through the drug's action. (keralapharmacist.com)
Imatinib is a 2-phenyl amino pyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. (keralapharmacist.com)
As this is now a constitutively active tyrosine kinase, imatinib is used to decrease bcr-abl activity. (keralapharmacist.com)
Imatinib also inhibits the abl protein of non-cancer cells but cells normally have additional redundant tyrosine kinases which allow them to continue to function even if abl tyrosine kinase is inhibited. (keralapharmacist.com)

Locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate. (nih.gov)

The incidence of septal defects, suggesting a depressed patient about her plans, it is unusual in children, this condition causes increased flow and hypoxia include alter-ations in the absence of systemic infection, especially with antibiotic-resistant bacteria, should be assessed at well-child visits starts at one or both and is ultimately required to maintain this level. (albionfoundation.org)
One study demonstrated that imatinib mesylate was effective in patients with systemic mastocytosis, including those who had the D816V mutation in c-Kit.However, since imatinib binds to tyrosine kinases when they are in the inactive configuration and the D816V mutant of c-Kit is constitutively active, imatinib does not inhibit the kinase activity of the D816V mutant of c-Kit. (keralapharmacist.com)

EAST HANOVER, N.J., Feb. 19 -- (Healthcare Sales & Marketing Network) -- Novartis announced today that Tasigna (nilotinib) 200 mg capsules has been granted priority review by the US Food and Drug Administration (FDA) for the treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase. (salesandmarketingnetwork.com)

Pandey SK, Ghosh S, Maiti P, Haldar C. Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer. (springer.com)
Toxicity of Anticancer Drugs The therapeutic index for cancer chemotherapeutic agents is usually low and the cells of the bone marrow and the gastrointestinal tract are usually the most sensitive normal cells. (present5.com)
Various therapeutic options, including imatinib, are available to treat desmoid tumor. (e-crt.org)
Our results show that HES1 , regulated by NOTCH2 , as an indicator of sensitivity to imatinib, and an important therapeutic consideration for desmoid tumor. (e-crt.org)
The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. (ashpublications.org)
In Section III, Dr. Martin Tallman describes the evaluation and management of patients with acute promyelocytic leukemia, a notable example of therapeutic progress in a molecularly defined entity of leukemia. (ashpublications.org)

According to a small trial, imatinib is an effective drug in some patients with aggressive fibromatosis. (wikipedia.org)

Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. (knowcancer.com)
Incomplete surgical resection leaves patients at increased risk for local recurrence and progression. (medscape.com)
Therefore, the identification of risk factors for imatinib-induced hepatotoxicity could reduce the occurrence of hepatotoxicity, thereby preventing progression to chronic liver disease and/or acute liver failure. (e-crt.org)

Thus, close liver function monitoring is recommended, especially in patients with liver impairment or using PPIs. (e-crt.org)

We retrospectively evaluated the records of 177 patients receiving imatinib from October 2012 to September 2017. (e-crt.org)

With gene-wise functional analyses, we detected a significant correlation between recurrent NOTCH2 noncoding mutations and clinical response to imatinib. (e-crt.org)
This fact explains why many BCR-ABL mutations can cause resistance to imatinib by shifting its equilibrium toward the open or active conformation. (keralapharmacist.com)

Preliminary results in colorectal cancer (CRC) patients enrolled in the GATTO study, a phase I study of Tomuzotuximab in combination with Gatipotuzumab in patients with EGFR positive solid tumors. (postersessiononline.eu)

In patients with clinically localized prostate cancer, the National Comprehensive Cancer Network (NCCN) strongly discourages the use of NADT before RP outside of a clinical trial. (medscape.com)
The regulatory submissions are based on data from the ENESTnd (Evaluating Nilotinib Efficacy and Safety in Clinical Trials of Newly Diagnosed Ph+ CML Patients) Phase III clinical trial. (salesandmarketingnetwork.com)
The first clinical trials of Tasigna began 21 months after its discovery, with the drug receiving its first regulatory approval in the second-line indication in 2007(3). (salesandmarketingnetwork.com)
Although imatinib-induced hepatotoxicity may aggravate the patient's clinical condition and alter the treatment plan, the underlying mechanism of and factors influencing imatinib-induced hepatotoxicity have rarely been investigated. (e-crt.org)
Hepatotoxicity of imatinib could aggravate the patient's clinical condition and alter the patient's treatment plan. (e-crt.org)
Segaert S, Van Cutsem E. Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors. (medscape.com)
Here, we describe potential roles of NOTCH2 and HES1 in clinical response to imatinib at genome and transcriptome levels. (e-crt.org)
Prescribe JUXTAPID only to patients with a clinical or laboratory diagnosis consistent with HoFH. (drugs.com)
This has important clinical implications as, in contrast to advanced-stage NSCLC, chemotherapy can also be offered to patients with SCLC and a poor or bad performance status (World Health Organization performance status of 2-3), since a rapid amelioration of the patient's symptoms and general condition can be expected together with an improved outcome 7 . (ersjournals.com)

This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
Multicenter phase I/II study of nivolumab combined with paclitaxel plus ramucirumab as the second-line treatment in patients with advanced gastric cancer. (postersessiononline.eu)

The purpose of this study is to evaluate the rate of complete MRD response by flow cytometry after 4 weekly doses of daratumumab-hyaluronidase (Day 29) among patients with MRD positive T-ALL in hematologic morphologic complete remission or complete remission with incomplete hematologic recovery. (mayo.edu)
A previous report showed that high doses of Mg reduce microalbuminuria in traumatic critically ill patients at 36 hour, after infusion [8]. (trpv-antagonist.com)
Patients may down-titrate to lower doses based on tolerability. (medicines.org.uk)
Severe congestive cardiac failure is an uncommon but recognized side effect of imatinib and mice treated with large doses of imatinib show toxic damage to their myocardium. (keralapharmacist.com)

Imatinib was effective and well tolerated for advanced desmoid tumor treatment. (e-crt.org)
Once the patient was fit for Surgery, wide excision of tumor and reconstruction with ipsilateral non-vascularised proximal fibula was performed. (jbstjournal.com)
We studied 5 consecutive cases of GCT involving the distal radius operated by en-bloc resection of tumor followed by reconstruction with ipsilateral non-vascularized fibular graft with a minimum 1 year follow-up. (jbstjournal.com)

Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. (wikipedia.org)
On 1 February 2012, imatinib was approved for use after the surgical removal of KIT-positive tumors to help prevent recurrence. (wikipedia.org)

For participants who cannot swallow tablets or who are receiving less than a 10 mg dose, a capsule with small ponatinib minitablets inside will be provided. (ucsf.edu)

The FDA first granted approval for advanced GIST patients in 2002. (wikipedia.org)

Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. (ucsf.edu)

This partially randomized phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. (mayo.edu)
Now this priority review designation brings us one step closer to offering patients who are newly diagnosed with Ph+ CML in the chronic phase a promising new treatment option. (salesandmarketingnetwork.com)
It is the largest global randomized comparison of two oral therapies ever conducted in newly diagnosed Ph+ CML patients. (salesandmarketingnetwork.com)
This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. (ucsf.edu)

Discontinue JUXTAPID for clinically significant liver toxicity ( 2.4 , 5.1 ). (drugs.com)
All patients presented with pain and swelling over distal end radius and were assessed clinically and radiographically. (jbstjournal.com)

Gastrointestinal adverse reactions occur in 93% of patients and could affect absorption of concomitant oral medications ( 5.5 ). (drugs.com)

The goals of this study are to help make chemotherapy more effective in treating the patient's leukemia as demonstrated by fewer patients with leukemia minimal residual disease (MRD) while also trying to reduce the amount of body fat that chemotherapy causes the patient to gain in the first month. (ucsf.edu)

We conclude by emphasizing the need to inform patients and physicians about herb-drug interactions and how to advise patients on appropriate use of herbal supplements to minimize the risk for interactions. (cancernetwork.com)
Advise patients not to visit anyone who has a respiratory infection. (studylib.net)

In humans, ehrlichia sennetsu is responsible for pneumonia, including rhodococcus equi, an aerobic gram-negative bacilli as causes of death odds ratio is nearly for patients who present with massive thrombosis of renal hypertension in children. (albionfoundation.org)

Small cell lung cancer (SCLC) is an aggressive malignant disease, with the majority of patients presenting with distant metastasis at diagnosis. (ersjournals.com)

The purpose of this study is to compare relapse-free survival between participants with FLT3/ITD AML in first morphologic complete remission (CR1) who undergo hematopoietic stem cell transplant (HCT) and are randomized to receive gilteritinib or placebo beginning after the time of engraftment for a two year period. (mayo.edu)
No patients in the study had a prolongation of the QT interval >500 milliseconds(1). (salesandmarketingnetwork.com)
The purpose of this study was to investigate factors affecting on the incidence of hepatotoxicity within 90 days after starting imatinib treatment and time to onset of imatinib-induced hepatotoxicity. (e-crt.org)
The findings of this study suggest that the use of PPIs and presence of liver disease or HBV were associated with imatinib-induced hepatotoxicity. (e-crt.org)
Therefore, the aim of the present study was to evaluate the association between serum Mg and microalbuminuria in diabetic patients in China. (trpv-antagonist.com)
This is a retrospective study conducted in 5 consecutive patients of GCT of distal radius. (jbstjournal.com)
Informed consent from the patient was taken and approval from the institutional review board was obtained for the study. (jbstjournal.com)
The International Association for the Study of Lung Cancer defines limited-stage SCLC (LS-SCLC) as: "disease restricted to one hemithorax with regional lymph node metastases, including hilar, ipsilateral and contralateral mediastinal, and ipsilateral and contralateral supraclavicular nodes and should also include patients with ipsilateral pleural effusion independent of whether cytology is positive or negative" 2 . (ersjournals.com)

Specifically adult patients with unresectable, recurrent and/or metastatic dermatofibrosarcoma protuberans (DFSP). (wikipedia.org)

3) specific combinations of high-resolution computed tomography and surgical lung biopsy patterns in patients subjected to surgical lung biopsy [ 1 , 4 ]. (ersjournals.com)
The patient was admitted to surgical c. (biomedcentral.com)

Due in part to the development of imatinib and related drugs, the five-year survival rate for people with chronic myeloid leukemia increased from 31% in 1993, to 59% in 2009, to 70% in 2016. (wikipedia.org)
However, the NCCN notes that androgen deprivation therapy before, during, and/or after radiation prolongs survival in selected patients who are receiving radiation therapy only. (medscape.com)
If left untreated, patients with SCLC rarely survive longer than a few months 5 , but chemotherapy dramatically prolongs survival compared to the best supportive care 6 . (ersjournals.com)

In this article, we describe the mechanisms via which interactions between herbs and prescription drugs may occur, and highlight four popular herbs and a medicinal mushroom commonly used by cancer patients, along with reports of their interactions with standard drugs. (cancernetwork.com)
We highlight four popular herbs and a medicinal mushroom commonly used by cancer patients-turmeric, green tea, ginger, ashwagandha, and reishi mushroom-along with reports of their interactions with standard drugs. (cancernetwork.com)
It was defined as "the effect of herbs, other plants, or plant extracts on the activity, metabolism, or toxicity of drugs. (cancernetwork.com)
The objectives in combination chemotherapy have been to limit the toxicity of individual agents and to evade drug resistance by exposing the cancer cell to drugs with different modes of action simultaneously. (present5.com)
When patients develop resistance, multiple drugs with different pathways of entry and different cellular targets are used. (savedelicious.com)
Imatinib has been cited as the first of the exceptionally expensive cancer drugs, costing $92,000 a year. (keralapharmacist.com)

14-16 Imatinib, cediranib, and pexidartinib have also demonstrated activity in some of the rarest, chemo-refractory STS subtypes, including dermatofibrosarcoma protuberans, 17,18 alveolar soft part sarcoma (ASPS), 19 and tenosynovial giant cell tumour. (emjreviews.com)
Dr. Tallman focuses on the molecular genetics of APL, current curative treatment strategies and approaches for patients with relapsed and refractory disease. (ashpublications.org)

Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette smoking, with patients often presenting with metastatic disease at the time of diagnosis. (ersjournals.com)

Withhold STIVARGA in patients with worsening or severe infections. (nih.gov)
Withhold and then reduce or discontinue STIVARGA depending on severity and persistence of dermatologic toxicity. (nih.gov)

Starting from 2011, it became clear that CML patients who continue to respond to imatinib have the same or almost the same life expectancy as the general population. (wikipedia.org)

However, the molecular mechanism of why imatinib works remains unclear. (e-crt.org)

This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). (ucsf.edu)
Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens. (ucsf.edu)

Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. (ucsf.edu)
In patients, primary or acquired resistance to chemotherapy is associated with the expression of P-gp. (ashpublications.org)

Once the patient was medically fit, surgery (ORIF with resection of distal end of radius and reconstruction with ipsilateral non vascularised proximal fibula along with plate and 2 k-wires) was performed. (jbstjournal.com)

The U.S. Food and Drug Administration (FDA) has approved imatinib as first-line treatment for Philadelphia chromosome-positive CML, both in adults and children. (wikipedia.org)
Nursing Interventions/Patient Teaching Evaluation Monitor labs (CBC, blood urea nitrogen [BUN], creatinine, liver panel, and electrolytes) before drug administration and during treatment. (studylib.net)
Provide drug information verbally and in print to the patient/family/caregiver. (studylib.net)
Teach patients to take cyclophosphamide early in the day to prevent accumulation of drug in the bladder during the night. (studylib.net)
Doctors and patients complain that this is excessive, given that its development costs have been recovered many times over, and that the costs of synthesizing the drug are orders of magnitude lower. (keralapharmacist.com)

BCRP substrates: Monitor patients closely for symptoms of increased exposure to BCRP substrates. (nih.gov)

Patients with liver disease or hepatitis B virus (HBV) carriers had a more than 8-fold higher risk of hepatotoxicity and a 5.2-fold increased hazard of hepatotoxicity compared to those without liver disease or HBV. (e-crt.org)
Patients with body weight under 55 kg had a 2.2-fold higher risk for occurrence of hepatotoxicity. (e-crt.org)
400 mg had a 2.3-fold increased hazard of time to reach hepatotoxicity compared to those with an imatinib dose ≤ 400 mg. (e-crt.org)
Permanent imatinib discontinuation due to hepatotoxicity is necessary in 0.5% of patients [ 6 ]. (e-crt.org)
However, the factors for imatinib-induced hepatotoxicity have rarely been investigated. (e-crt.org)

Patients must avoid grapefruit juice ( 4 , 5.6 , 7.1 ). (drugs.com)

A decreased WBC count puts patient at high risk for acquiring an infection. (studylib.net)
Cervical lymphadenitis can be infused so that an effective antistaphylococcal antibiotic while awaiting transplantation increases overall mortality despite some improvement among high-risk patients such as human chorionic choriocarcinomas usually uterine, gonadtropin hcg teratoma, islet cell antibodies and t concentrations generally become normal and problem pregnancies. (albionfoundation.org)
Several studies have confirmed that these patients may present with an acute case of classic nodular basal cell carcinoma demonstrates intermediate risk. (albionfoundation.org)
However, the risk of toxicity is greater in this group than in patients with good performance status. (ersjournals.com)

ergoloid mesylates increases effects of pseudoephedrine by pharmacodynamic synergism. (medscape.com)
For patients with achlorhydria, administration with an acidic beverage (i.e., cola) significantly increases the oral bioavailability. (pdr.net)

Imatinib works by binding close to the ATP binding site of bcr-abl, locking it in a closed or self-inhibited conformation, and therefore inhibiting the enzyme activity of the protein semi-competitively. (keralapharmacist.com)

RP is most likely to cure patients with organ-confined disease. (medscape.com)
Including long-term ventilation, ter heide h neonatal marfan syndrome has been approved for use in patients with progressive neuromuscular disease. (albionfoundation.org)
Among 20 patients, four (20%) had a partial response and 14 (66.7%) had stable disease, 11 of which continued for ≥ 1 year. (e-crt.org)

Encourage patients to drink at least 2 L of fluid per day to promote The patient is free from infection. (studylib.net)

In this regard, imatinib was one of the first cancer therapies to show the potential for such targeted action, and is often cited as a paradigm for research in cancer therapeutics. (keralapharmacist.com)

It is also used to maintain remission in chronic phase CML patients. (wikipedia.org)

Various adverse effects of imatinib have been reported. (e-crt.org)
001). Selleckchem LDC000067 Adverse events in the cataract surgeries were reported in 22.2% (70/316) and 36.5% (38/104) of hydrogel bandage patients and corneal shield patients, respectively (P = .0045). (inhibitorlibrary.com)

Anatomy8

Diseases25

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes16

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science1

Health Care7

Gleevec13

Glivec1

Hepatic3

Embryo-fetal toxicity1

Tyrosine kinase9

Sunitinib1

Systemic2

Novartis1

Therapeutic6

Aggressive fibromatosis1

Progression3

Impairment1

20171

Mutations2

Solid Tumors1

Clinical9

Multicenter2

Doses4

Tumor3

Tumors2

Tablets1

GIST1

Chemotherapy alone in treating1

Newly diagnosed4

Clinically2

Gastrointestinal1

Patient's1

Advise2

Hypertension1

Distant metastasis1

Study8

Recurrent1

Surgical2

Survival3

Drugs6

Refractory2

Metastatic1

Stivarga2

Life expectancy1

Mechanism1

Treatment regimens2

Resistance to chemotherapy2

Medically1

Drug5

Substrates1

HEPATOTOXICITY5

Grapefruit juice1

Risk4

Increases2

Activity1

Disease3

Fluid1

Therapies1

Chronic phase1

Adverse2