Cell AggregationTorsades de PointesToxicity TestsPlatelet Aggregation InhibitorsErythrocyte AggregationBlood PlateletsPhosphoric Diester HydrolasesToxicity Tests, AcuteAdenosine DiphosphateDose-Response Relationship, DrugAmyloidPlatelet ActivationReceptor AggregationProtein Foldingalpha-SynucleinLong QT SyndromeTime FactorsProtein BindingLethal Dose 50Amyloid beta-PeptidesKineticsBleeding TimeThrombinMutationPeptidesFibrinogenProtein DenaturationAmino Acid SequenceProtein MultimerizationThromboxane A2Antineoplastic Combined Chemotherapy ProtocolsPlatelet Membrane GlycoproteinsDrug Administration ScheduleMolecular Sequence DataAntineoplastic AgentsToxicity Tests, ChronicRabbitsThromboxane B2DNA Breaks, Single-StrandedPlatelet Function TestsSolubilityDNA Topoisomerases, Type IMolecular ChaperonesCollagenGlycolatesCircular DichroismCells, CulturedTreatment OutcomeCell SurvivalProtein Structure, QuaternaryPeptide FragmentsScattering, RadiationCell LineAntibodies, MonoclonalProtein ConformationCamptothecinAspirinDrug Evaluation, PreclinicalProtein Structure, SecondaryRecombinant ProteinsInclusion BodiesDrug-Related Side Effects and Adverse ReactionsModels, BiologicalHydrogen-Ion ConcentrationThiazolesDogsNeurodegenerative DiseasesPhenethylaminesMicroscopy, ElectronModels, MolecularMicroscopy, Electron, TransmissionNeoplasmsDisease Models, AnimalReceptors, Purinergic P2Y12TemperatureBlood Platelet DisordersAnti-Arrhythmia AgentsInfusions, IntravenousBenzamidinesApyraseAdministration, OralPlatelet CountCalciumCisplatinRistocetinStructure-Activity RelationshipSerotoninThrombosisNo-Observed-Adverse-Effect LevelFluorouracilSulfonamidesNerve Tissue ProteinsSynucleinsProteinsElectrocardiographyAlzheimer DiseaseThrombocytopeniaCongo RedCell Line, TumorMaximum Tolerated Dose