• The most serious and life-threatening side effect of chemotherapy is myelosuppression, or damage to the bone marrow, resulting in reduced white blood cells, red blood cells and platelets. (wraltechwire.com)
  • Chemotherapy-induced myelosuppression may lead to increased risks of infection, severe anemia, and/or bleeding. (wraltechwire.com)
  • By contrast, trilaciclib provides the first proactive approach to myelosuppression through a unique mechanism of action that helps protect the bone marrow from damage by chemotherapy. (wraltechwire.com)
  • In clinical trials, the addition of trilaciclib to extensive-stage small cell lung cancer chemotherapy treatment regimens reduced myelosuppression and improved clinical outcomes. (wraltechwire.com)
  • G1 is proud to deliver COSELA to patients and their families as the first and only therapy to help protect against chemotherapy-induced myelosuppression. (wraltechwire.com)
  • GTHX ), a commercial-stage oncology company, today announced that the U.S. Food and Drug Administration (FDA) has approved COSELA™ (trilaciclib) for injection to decrease the incidence of chemotherapy-induced myelosuppression in adult patients when administered prior to a platinum/etoposide-containing regimen or topotecan-containing regimen for extensive-stage small cell lung cancer (ES-SCLC). (g1therapeutics.com)
  • While undergoing chemotherapy, many patients experience significant myelosuppression, become fatigued and susceptible to infection, and often require transfusions and growth factor administrations," said Jared Weiss, M.D., Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, NC. (lumiraventures.com)
  • Myelosuppression is the result of damage to bone marrow stem cells and is one of the most common side effects of chemotherapy. (lumiraventures.com)
  • In clinical trials, trilaciclib significantly reduced chemotherapy-induced myelosuppression, and patients receiving trilaciclib experienced fewer dose delays/reductions, infections, hospitalizations, and need for rescue therapies compared to patients receiving chemotherapy alone. (lumiraventures.com)
  • The authors of the above-mentioned study on Burkitt lymphoma cells and chemotherapy suggest that including antioxidants in the treatment protocol may enhance chemotherapy-induced apoptosis and phagocytosis. (pinestreetfoundation.org)
  • 2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
  • Antioxidant and apoptosis-inducing activities of ellagic acid. (nutrimedical.com)
  • BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)
  • For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
  • Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
  • CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
  • Treatment with E/PCF-NPs under irradiation induced 4T1 cell apoptosis in approximately 93.6% cells. (dovepress.com)
  • RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
  • Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
  • People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. (peacehealth.org)
  • The chemotherapy drug cisplatin may cause kidney damage, resulting in depletion of calcium and phosphate. (peacehealth.org)
  • The chemotherapy drug cisplatin may cause depletion of sodium due to kidney damage which sometimes occurs in people treated with cisplatin. (peacehealth.org)
  • Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
  • Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
  • Taiwanese researchers found that si jun zi decoction can alleviate toxicity induced by cisplatin , a chemotherapy medication. (preventcancer.news)
  • Cisplatin-based highly emetogenic chemotherapy (HEC) regimens, which are key treatments for some of malignant tumors, were conventionally administered after an antiemetic premedication with dexamethasone plus a 5-hydroxytryptamine 3 receptor antagonist (5-HT 3 RA) such as ondansetron or granisetron. (medscape.com)
  • However, when they performed a similar experiment in genetically altered mice that lack the naturally occurring hemopexin protein, the hemopexin-deficient mice demonstrated increased doxorubicin cardiac toxicity compared to wild type mice. (appliedradiationoncology.com)
  • Chemotherapy with streptozocin (STZ) in combination with 5-FU or doxorubicin (Dox) represents a standard of care for patients with metastatic pancreatic neuroendocrine neoplasms (pNEN). (cancerindex.org)
  • The combination of doxorubicin with ifosfamide is more effective, exhibiting higher response rates than doxorubicin alone, but is associated with severe short- and long-term toxicities, including cardiomyopathy and bone marrow suppression ( 11 - 13 ). (spandidos-publications.com)
  • Further, the utility of the first-line cytostatic doxorubicin is limited by dose-related and cumulative myocardial toxicity, especially in elderly patients with pre-existing cardiac disease ( 14 ). (spandidos-publications.com)
  • Cancers such as doxorubicin are commonly used in cancer leukaemia, colorectal, breast, lung, and so on are chemotherapy. (who.int)
  • Though studies have examined the cost-effectiveness of adjuvant goserelin with radiotherapy for locally advanced prostate cancer, few have compared the cost-effectiveness of adjuvant goserelin to adjuvant chemotherapy alone in premenopausal breast cancer. (biomedcentral.com)
  • Moreover, estrogens also ameliorated hematopoietic suppression induced by caner radiotherapy or chemotherapy in the clinic [7,8]. (biomedgrid.com)
  • As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
  • Skin toxicity is a common side effect of radiotherapy for solid tumors. (biomedcentral.com)
  • Skin toxicity is a common side effect of external beam radiotherapy in patients suffering from solid cancers. (biomedcentral.com)
  • Moreover, clinical management of radiation-induced skin toxicity often requires radiotherapy treatment gaps, thereby reducing the probability of loco-regional tumor control [ 2 ]. (biomedcentral.com)
  • 2,3] The majority employ them as adjuncts to chemotherapy or other cancer treatments to alleviate symptoms and to prevent recurrence. (cancernetwork.com)
  • However, there is potential for exercise to alleviate some of the vascular toxicity of chemotherapy, and the evidence for this is provided. (bioscientifica.com)
  • Therefore, to understand the self-regulation and defense mechanisms of heart tissue under the oxidative stress may provide us new approaches to alleviate the clinical cardiotoxicity of chemotherapy. (uky.edu)
  • BOSTON, Aug. 01, 2022 (GLOBE NEWSWIRE) -- Aileron Therapeutics (Nasdaq: ALRN), a chemoprotection oncology company that aspires to make chemotherapy safer and thereby more effective to save more patients' lives, today outlined its strategy to strengthen the company's Phase 1b chemoprotection trial of ALRN-6924 in patients with p53-mutated breast cancer. (aileronrx.com)
  • There are currently no available therapies to protect patients from chemotherapy-induced toxicities before they occur," said Raj Malik, M.D., Chief Medical Officer and Senior Vice President, R&D. "If approved, trilaciclib would be the first proactively administered myelopreservation therapy that is intended to make chemotherapy safer and reduce the need for rescue interventions, such as growth factor administrations and blood transfusions. (lumiraventures.com)
  • however, standard of care chemotherapy regimens are highly myelosuppressive and can lead to costly hospitalizations and rescue interventions," said Jack Bailey, Chief Executive Officer at G1 Therapeutics. (wraltechwire.com)
  • 1,2 Similarly, there are increased risks of congestive heart failure in adults treated with anthracycline-based chemotherapy regimens, which in current practice includes patients with breast cancer, leukemia, lymphoma, sarcoma, and other cancer types. (ajmc.com)
  • 2. As is the case with other anthracyclines the use of idarubicin Hydrochloride can cause myocardial toxicity leading to congestive heart failure. (nih.gov)
  • Curcumin protects bleomycin-induced lung injury in rats. (greenmedinfo.com)
  • The present study was designed to determine the protective effects of curcumin against bleomycin (BLM)-induced inflammatory and oxidant lung injury. (greenmedinfo.com)
  • Data analogous to those with H2O2-mediated cytotoxicity were obtained in studies of bleomycin-engendered DNA strand breakage and cell damage, i.e., brief treatment of BT-20 cells with both hemin or FeSO4 significantly increases their sensitivity to bleomycin (100 micrograms/ml), whereas treatment followed by 24 h incubation with media alone significantly protects against bleomycin toxicity. (mtak.hu)
  • Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. (peacehealth.org)
  • Taurine has been shown to be depleted in people taking chemotherapy. (peacehealth.org)
  • It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements. (peacehealth.org)
  • Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy. (peacehealth.org)
  • The approval of COSELA is based on data from three randomized, placebo-controlled trials that showed patients receiving COSELA prior to the start of chemotherapy had clinically meaningful and statistically significant reduction in the duration and severity of neutropenia. (g1therapeutics.com)
  • However, when one looks more closely at the existing published science on how antioxidants and chemotherapy combine, the true answer is not so definitive. (pinestreetfoundation.org)
  • The overwhelming majority of studies find a favorable interaction between antioxidants and chemotherapy, providing evidence that antioxidants can decrease chemotherapy side effects, increase treatment effectiveness, and decrease resistance to chemotherapy. (pinestreetfoundation.org)
  • A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)
  • 4. It is recommended that idarubicin hydrochloride be administered only under the supervision of a physician who is experienced in leukemia chemotherapy and in facilities with laboratory and supportive resources adequate to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity. (nih.gov)
  • Chemotherapy induced mucositis is a common side effect of drug toxicity with up to 80% of patients having symptoms during their treatment (Dodd et al 2000, Lalla and Patterson 2006). (ukessays.com)
  • However, it induces severe and dose-limiting cardiac toxicity. (uky.edu)
  • It also has severe limitations on the dosage of chemotherapeutic agents that can be administered to a patient, thus, limiting the effective range of chemotherapy. (justia.com)
  • However, the accumulation of evidence suggests that immunotherapy also induces severe and complex neurologic immune-related adverse events (ir-AEs) and even leads to immunotherapy-related death, which arouses the concern of clinicians. (hindawi.com)
  • RESEARCH TRIANGLE PARK - Patients undergoing treatment for lung cancer will soon have access to a treatment that prevents damage to their bones and immune system from chemotherapy that has won FDA approval for Triangle-based G1 Therapeutics . (wraltechwire.com)
  • The approval of trilaciclib (Cosela) is an important advance in the treatment of patients with extensive-stage small cell lung cancer receiving chemotherapy," said Dr. Jeffrey Crawford, Geller Professor for Research in Cancer in the Department of Medicine and Duke Cancer Institute, in a statement. (wraltechwire.com)
  • These complications impact patients' quality of life and may also result in chemotherapy dose reductions and delays. (wraltechwire.com)
  • One example is a human study in which researchers discovered that higher levels of the antioxidant selenium in the blood of patients with aggressive B-cell non-Hodgkin's lymphoma correlated with increased achievable doses of anthracycline based chemotherapy, better treatment response, achievement of long term remission, and longer overall survival. (pinestreetfoundation.org)
  • Using antioxidants during chemotherapy is an important and controversial question among health care providers, patients, and their support teams. (pinestreetfoundation.org)
  • In this retrospective study at one hospital, the records of 152 patients with stage Ia to IIIa ER + breast cancer who received goserelin or chemotherapy were reviewed. (biomedcentral.com)
  • Protecting cancer patients from chemotherapy-induced toxicities remains a critical unmet need. (aileronrx.com)
  • We look forward to the continued clinical investigation of this potentially transformative therapy to prevent multiple chemotherapy-induced side effects and help patients fight cancer more effectively. (aileronrx.com)
  • Cardiac toxicity is more common in patients who have received prior anthracyclines or who have pre-existing cardiac disease. (nih.gov)
  • In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy. (peacehealth.org)
  • Research suggests that it can be used to treat malignant tumors in the digestive tract and to improve the immune function and quality of life of patients after chemotherapy. (preventcancer.news)
  • RESEARCH TRIANGLE PARK, N.C., Aug. 17, 2020 (GLOBE NEWSWIRE) - G1 Therapeutics, Inc. (Nasdaq: GTHX), a clinical-stage oncology company, today announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for trilaciclib for small cell lung cancer (SCLC) patients being treated with chemotherapy and granted Priority Review with a Prescription Drug User Fee Act (PDUFA) action date of February 15, 2021. (lumiraventures.com)
  • The trilaciclib NDA was supported by compelling myelopreservation data from three randomized, double-blind, placebo-controlled clinical trials in which trilaciclib was administered prior to chemotherapy treatment in patients with SCLC. (lumiraventures.com)
  • Preventing bone marrow damage proactively is an opportunity to improve the quality of life of patients receiving chemotherapy for small cell lung cancer and reduce costly rescue interventions. (lumiraventures.com)
  • In 2019, trilaciclib received FDA Breakthrough Therapy Designation, and, in June 2020, G1 submitted the NDA based on myelopreservation data from three randomized, double-blind, placebo-controlled clinical trials in which trilaciclib was administered prior to chemotherapy in patients with small cell lung cancer (SCLC). (lumiraventures.com)
  • As we saw in patients, plasma hemopexin was elevated in mice within 24 hours after completion of chemotherapy and was strongly associated with subsequent cardiac function. (appliedradiationoncology.com)
  • These findings serve as the basis for future investigations to develop hemopexin as both a biomarker and a protective therapy for patients at risk of chemotherapy-related heart toxicity," said Dr Asnani, who is also an associate member of the Cancer Research Institute at BIDMC. (appliedradiationoncology.com)
  • Streptozocin-Based Chemotherapy in Patients with Advanced Neuroendocrine Neoplasms--Predictive and Prognostic Markers for Treatment Stratification. (cancerindex.org)
  • The aim of this study was a retrospective evaluation of the clinicopathological characteristics of pNEN patients receiving STZ-based chemotherapies and to identify predictive and prognostic markers. (cancerindex.org)
  • STZ-based chemotherapy is an effective and well-tolerated treatment option in patients with well differentiated neuroendocrine neoplasms. (cancerindex.org)
  • The aim of the present study was to determine the status of STZ usage in Japan and to evaluate the effectiveness and safety of STZ chemotherapy in Japanese NET patients. (cancerindex.org)
  • The main recipients of STZ chemotherapy were middle-aged patients with pancreatic NET and unresectable liver metastases. (cancerindex.org)
  • Tea extracts are an efficient, broadly available treatment option for patients suffering from acute radiation-induced skin toxicity. (biomedcentral.com)
  • This often leads to the occurrence of moist skin desquamation (RTOG grade ≥ 2 skin toxicity) [ 1 ], which causes discomfort and compromises patients' quality of life during and immediately after treatment. (biomedcentral.com)
  • Patients with grade 2+ skin toxicity mostly suffer from skin disintegrity and symptoms caused by inflammation in the irradiated areas. (biomedcentral.com)
  • Prompt recognition and management of cardiotoxicity during chemotherapy is critical in order to ensure that patients can continue to receive these important treatments. (ajmc.com)
  • They also outline that information should be available to make patients aware of particular hygiene needs that may be required as a result of specific treatments such as chemotherapy. (ukessays.com)
  • Among all the treatment side effects and complications that cancer patients face, OM ranks as one of the most troublesome, causing significant concern for the majority of patients receiving chemotherapy. (ukessays.com)
  • Bruce and Quinn (2007) highlighted the fact that patients consider OM to be the most difficult treatment related toxicity to endure. (ukessays.com)
  • To date, there are no effective and well-tolerated cytostatics for the palliative treatment of patients who are not suitable for aggressive anthracycline-based chemotherapy. (spandidos-publications.com)
  • The goal of this seminar is to increase your knowledge of asbestos toxicity and your ability to evaluate potentially exposed patients. (cdc.gov)
  • Chemotherapy-induced nausea and vomiting (CINV) is a non-hematologic toxicity of chemotherapy that severely impairs the quality of life of patients and reduces their treatment compliance. (medscape.com)
  • [ 8 ] In patients receiving moderately emetogenic chemotherapy (MEC), better CINV control was obtained with palonosetron than with a first-generation 5-HT 3 RA, [ 9 ] which supports current guideline recommendations for palonosetron use as a part of antiemetic premedication for MEC. (medscape.com)
  • Due to its high antioxidant content, GSE can help prevent disease and protect against oxidative stress, tissue damage, and inflammation. (healthline.com)
  • It has long been known that oxidative stress is an essential mechanism by which chemotherapy works to treat cancer. (pinestreetfoundation.org)
  • On the other hand, the decreased levels of antioxidants (or oxidative stress) that are caused by many chemotherapy treatments correlates with increased side effects. (pinestreetfoundation.org)
  • It may provide novel insight into the role of Mrp1 in oxidative stress regulation, and thereby give us critical information regarding the potential adverse sequelae of introduction of MRP1 inhibitors as adjuncts to clinical chemotherapy of multidrug resistant tumors. (uky.edu)
  • To address this, we employed clinically approved drugs Zoledronate (ZOL) and IL-2 to induce anti-TB Vγ2Vδ2 T-effector cells as adjunctive immunotherapy against MDR-TB infection of macaques. (bvsalud.org)
  • The research has now progressed from animal studies to human trials, with the safety of using a 5 day FMD in combination with a variety of cancer treatments (including chemotherapy, endocrine therapy and immunotherapy) and across a range of cancer types having now been established(4).This study also explored some of the mechanisms by which an FMD may improve treatment outcomes. (getmeback.uk)
  • The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
  • Although the mechanism of DOX cardiac toxicity has not been completely elucidated, it is believed that the superoxide anion and other reactive oxygen species (ROS) generated by DOX contributes significantly to cardiac pathology. (uky.edu)
  • A team led by researchers at Beth Israel Deaconess Medical Center (BIDMC) has identified a protein linked with the onset of anthracycline-associated cardiac toxicity. (appliedradiationoncology.com)
  • In two studies conducted in women undergoing treatment for breast cancer, levels of a protein known as hemopexin circulating in the blood were associated with increased cardiac toxicity. (appliedradiationoncology.com)
  • These findings, published in Science Advances, suggest the body produces the protein as a protective measure against the therapy-induced cardiac toxicity. (appliedradiationoncology.com)
  • Given the increasing burden of both heart failure and cancer in the aging population, the development of new biomarkers and heart-protective strategies is essential to minimizing the impact of cancer therapy-associated cardiac toxicity," said senior and corresponding author Aarti Asnani, MD, a cardiologist and director of the Cardio-Oncology Program at BIDMC. (appliedradiationoncology.com)
  • Having established a clear link between anthracycline-induced cardiac toxicity and increased hemopexin levels, the scientists sought to determine hemopexin's functional role. (appliedradiationoncology.com)
  • Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • Radiation-induced inflammation is mainly caused by activation of NF-κB, a preformed dimeric transcription factor sequestered in the cytosol by its inhibitor molecules of the IκB-family. (biomedcentral.com)
  • Bacterial cell wall components can then induce inflammation further. (ukessays.com)
  • Although these cellular-suicide mechanisms may protect the organism in some physiologic settings, such as by preventing cancer, the double-edged sword is that these same DNA-damage response pathways that help prevent cancer can also contribute to debilitating disease processes. (the-scientist.com)
  • We consider the most likely mechanisms of endothelial toxicity to be through direct damage and dysfunction of the endothelium. (bioscientifica.com)
  • Along with the traditional approaches of chemotherapy, a revolution in the understanding of the molecular mechanisms that underlie many common cancers has led to the development of targeted pathway inhibitors, many of which inhibit tyrosine kinases. (ajmc.com)
  • In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)
  • The long-term goal of the present application is to investigate the role of Mrp1 in protecting against DOX-induced cardiotoxicity. (uky.edu)
  • The goal of the research is to better understand the basis of cardiotoxicity - damage to the heart caused by chemotherapy drugs - and inform the discovery of new methods of prevention for chemotherapy-induced heart failure. (vcuhealth.org)
  • Radiation-induced dermatitis (RID) is a cutaneous reaction that occurs because of damage by ionising radiation. (eviq.org.au)
  • r r Radiation induced fibrosis (RIF) resulting from chronic dermatitis can manifest in many ways such as skin induration (the skin becoming thicker and harder due to an inflammatory process induced by radiation) and retraction/inversion (skin scarring resulting in pulling of the nearby skin), lymphoedema and restriction of joint motion. (eviq.org.au)
  • In clinical practice, the use of an assessment tool can aid in the assessment of a patient's skin reaction, for example, the eviQ radiation-induced dermatitis assessment tool . (eviq.org.au)
  • In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy, though such effects have not yet been studied in humans. (peacehealth.org)
  • This effect of Vitamin c may have some therapeutic implications for radiation-induced injuries. (biomedgrid.com)
  • Radioprotectors are given prior to exposure to ionizing radiation to reduce harmful effects, including radiation-induced lethality [1]. (biomedgrid.com)
  • In recent years, natural substances such as SH groups and cysteine have been investigated for their effectiveness in protecting from radiation damage [2]. (biomedgrid.com)
  • In this study, we explored the effect of topically-applied tea extracts on the duration of radiation-induced skin toxicity. (biomedcentral.com)
  • Radiation technique has improved dramatically with the introduction of linear accelerators, thereby reducing skin toxicity. (biomedcentral.com)
  • In the past, many clinical efforts have been made to attenuate skin toxicity in radiation therapy or to delay its onset, but in many countries there is no "gold standard" in skin care during and after radiation treatment. (biomedcentral.com)
  • To date, the majority of previous studies have aimed to prevent or attenuate skin reactions but did not focus on the duration of radiation-induced skin toxicity, if present. (biomedcentral.com)
  • Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity: possible role in chemotherapy efficacy. (mtak.hu)
  • The patient demographics, tumor characteristics, context of STZ chemotherapy, and patient outcome were collected and assessed. (cancerindex.org)
  • Compared to chemotherapy or photothermal treatment alone, the combined treatment in vitro significantly inhibited the survival rate of 4T1 cells to 17.7%, induced ROS generation, and reduced NAD + /NADH significantly. (dovepress.com)
  • Tetrazolium reduction and resazurin assays are the mainstay of routine in vitro toxicity batteries. (cdc.gov)
  • It is the first and only therapy designed to help protect bone marrow (myeloprotection) when administered prior to treatment with chemotherapy," G1 says. (wraltechwire.com)
  • Goserelin therapy results in better survival and higher utility-weighted life-years, and is more cost-effective than TC or TEC chemotherapy. (biomedcentral.com)
  • It is the first and only therapy designed to help protect bone marrow (myeloprotection) when administered prior to treatment with chemotherapy. (g1therapeutics.com)
  • Trilaciclib is a first-in-class investigational therapy designed to preserve bone marrow and immune system function during chemotherapy and improve patient outcomes. (lumiraventures.com)
  • Trilaciclib is a first-in-class investigational therapy designed to improve outcomes for people with cancer treated with chemotherapy. (lumiraventures.com)
  • E/PCF-NPs show enhanced anti-cancer effects due to synergistic effects of chemotherapy with photothermal therapy and may be potential therapeutic agents for cancer treatment. (dovepress.com)
  • The seven-year, $5.4 million award will fund Salloum's research program, Managing Cardiac Toxicities of Cancer Therapy. (vcuhealth.org)
  • There are data suggesting that early recognition of chemotherapy-induced cardiomyopathy and prompt initiation of medical therapy can promote recovery of cardiac function. (ajmc.com)
  • Dr Asnani and colleagues studied 30 women diagnosed with breast cancer and scheduled to undergo treatment with anthracycline chemotherapies. (appliedradiationoncology.com)
  • The findings suggest the body may produce hemopexin as a protective response to anthracycline-induced cardiac damage. (appliedradiationoncology.com)
  • Therefore, GSE likely protected against further heart damage. (healthline.com)
  • Moreover, DNA damage is responsible for many of the toxicities incurred in treatment, including bone marrow suppression, hair loss, and gastrointestinal toxicites. (the-scientist.com)
  • Myeloprotection is a novel approach of protecting HSPCs in the bone marrow from chemotherapy-induced damage. (wraltechwire.com)
  • In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
  • In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)
  • However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
  • In a far-reaching analysis of for liver diseases reported in Pharmaceutical Biology in May 2011, concluded that milk thistle is effective in protecting the liver from damage caused by hepatitis, cirrhosis and other liver ailments. (superfoods-scientific-research.com)
  • Studies have also shown that ellagic acid may protect against chromosome damage and reduce the effects of chemically induced hepatic structural degeneration. (nutrimedical.com)
  • We will also study the mitochondrial damage induced by DOX and the role of Mrp1 during this process. (uky.edu)
  • RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
  • Cell exposure to chemotherapy causes DNA damage and generates reactive oxygen species (ROS), which are able to injure cells, tissues and blood vessels. (ukessays.com)
  • At that time, data were insufficient to assess the efficacy of ZDV as a prophylactic agent in humans or the toxicity of this drug in persons not infected with HIV. (cdc.gov)
  • In order to investigate the effectiveness of HePC ointment as a topical anti-leishmanial preparation, we tested its efficacy on experimentally induced lesions in hamsters. (who.int)
  • There has been no phase III study of comparing the efficacy of first- and second-generation 5-HT 3 receptor antagonists in the triplet regimen with dexamethasone and aprepitant for preventing chemotherapy-induced nausea and vomiting after highly emetogenic chemotherapy (HEC). (medscape.com)
  • Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
  • The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
  • In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
  • By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
  • These data suggest that curcumin treatment reduces the development of BLM-induced inflammatory and oxidant activity. (greenmedinfo.com)
  • ALRN-6924 will be administered at 1.2 mg/kg on 3 consecutive days in each treatment cycle, Days 0, 1 and 2, while chemotherapy will be administered on Day 1. (aileronrx.com)
  • Bax expression was induced and caspase-3 was activated by ellagic acid treatment. (nutrimedical.com)
  • Treatment was well tolerated with less than 10% grade 3 and 4 toxicities. (cancerindex.org)
  • Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
  • In this article, we turn our focus to lymphoma, conducting a systematic search for published research that would support or discourage the use of antioxidants in combination with chemotherapy. (pinestreetfoundation.org)
  • This approach can help reduce some chemotherapy-related toxicity, making chemotherapy safer and more tolerable, while also reducing the need for reactive rescue interventions. (wraltechwire.com)
  • However, the inherent toxicity of these agents in radioprotectors calls for further studies of safer and more effective radioprotectors [9,10]. (biomedgrid.com)
  • Often, people who undergo chemotherapy develop aversions to certain foods, sometimes making it permanently difficult to eat those foods. (peacehealth.org)
  • Ellagic acid has demonstrated DNA-protecting properties, including the ability to bind to toxins and neutralize them. (nutrimedical.com)
  • Helps protect liver cells from toxins. (butterflyayurveda.com)
  • The importance of these pathways in cancer prevention is illustrated by the fact that individuals who inherit mutations in any one of the many genes that participate in these stress-induced signal transduction pathways have a very high incidence of cancer. (the-scientist.com)
  • The DIRECT trial(5) looked at the effect of the FMD on outcomes of standard neoadjuvant chemotherapy (FEC-T or AC-T) given to 131 women with stage II-III HER2 negative breast cancer. (getmeback.uk)
  • Recent promising studies demonstrate that immune checkpoint inhibitors (ICI) can induce objective intracranial response. (abta.org)
  • The toxicity data of protein kinase inhibitors in humans is also well established [5]. (who.int)
  • The temperature elevation and thermal toxicity of nanoparticles were studied. (dovepress.com)
  • Chemotherapy decreases estrogen levels due to cytotoxic effects on the ovaries. (biomedcentral.com)
  • I've been interested in this topic for a very long time largely because of the background of allogeneic transplant that we were aware that we would induce infertility in men and women in those days because we used total body irradiation. (medscape.com)
  • Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)
  • Salloum has been conducting research on topics such as how hydrogen sulfide protects the heart and how a pregnancy hormone called relaxin could have protective effects on the heart. (vcuhealth.org)
  • The high turnover rate of the non - keratinized squamous epithelia cells that make up the oral mucosa, every ten to fourteen days, increase the vulnerability of these cells to the effects of chemotherapy. (ukessays.com)
  • It aids in the recovery process from Hepatitis A and B, drug and alcohol addiction, the after-effects of chemotherapy, and a lethargic liver. (butterflyayurveda.com)
  • EGCG, TCD or GSH all showed certain chemoprevention effects against the joint toxicity induced by the multi-heavy metal mixture and indicated alleviation and the potential mechanism that also included the promotion of excretion of metals to which animals were exposed. (cdc.gov)
  • This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
  • More specifically, in one aspect, the invention features methods of inducing differential stress resistance in a subject with cancer. (justia.com)
  • In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)
  • Herbs, however, contain biologically active compounds and can potentially interact with prescription medications, including chemotherapy drugs. (cancernetwork.com)
  • The survival of irradiated mice protected by Vitamin c was significantly increased and statistically higher than that of mice pre-treated with oral administration. (biomedgrid.com)
  • Cutaneous lesions were experimentally induced by inoculation with leishmania promastigotes in 60 golden hamsters. (who.int)
  • All abovementioned results were similar to those in mice protected by Vitamin c , but the protecting actions of Vitamin c on promoting recovery of nucleated cells and leukocyte counts were significantly higher than those of Vitamin c . (biomedgrid.com)
  • Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
  • Taking niacinamide by mouth while undergoing chemotherapy doesn't seem to benefit people with brain tumors. (medlineplus.gov)
  • The drug called Cosela is injected before a patient receives chemotherapy being used to fight small cell lung cancer. (wraltechwire.com)
  • COSELA will help change the chemotherapy experience for people who are battling ES-SCLC. (wraltechwire.com)
  • Absorption may occur after skin or eye exposure to liquid or vapor nitrogen mustard and may cause systemic toxicity. (cdc.gov)
  • Therefore, curcumin offers the potential for a novel pharmacological approach in the suppression of drug or chemical-induced lung injury. (greenmedinfo.com)