Toxicity of chemotherapy cell protected from chemotherapy induced. Medical search. Frequent questions

As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
Skin toxicity is a common side effect of radiotherapy for solid tumors. (biomedcentral.com)
Skin toxicity is a common side effect of external beam radiotherapy in patients suffering from solid cancers. (biomedcentral.com)
Moreover, clinical management of radiation-induced skin toxicity often requires radiotherapy treatment gaps, thereby reducing the probability of loco-regional tumor control [ 2 ]. (biomedcentral.com)
Moreover, estrogens also ameliorated hematopoietic suppression induced by caner radiotherapy or chemotherapy in the clinic [7,8]. (biomedgrid.com)
While healthy cells are protected from DNA damage induced by reactive oxygen species, malignant cells are protected against chemo- or radiotherapy. (genengnews.com)
However, in many cases, chemotherapy or radiotherapy alone cannot achieve a satisfactory therapeutic outcome, namely the complete remission of tumors, and induces severe side effects at therapeutically effective doses. (biomedcentral.com)
Recently, treatment outcomes have been improved in conjunction with a reduction in toxicity through technological innovations such as intensity modulated radiotherapy or stereotactic body radiotherapy. (springer.com)

E/PCF-NPs show enhanced anti-cancer effects due to synergistic effects of chemotherapy with photothermal therapy and may be potential therapeutic agents for cancer treatment. (dovepress.com)
Honey can decrease the side effects of chemotherapy on reproductive system and prevent sterility. (greenmedinfo.com)
PMID: 29791311 Abstract Title: Protective effects of persian honey, Apis Mellifera Meda Skorikov on side effects of chemotherapy and ischemia/reperfusion induced testicular injury. (greenmedinfo.com)
Abstract: Introduction The aim of the present study was to survey the protective effect of pretreatment with Persian honey on amelioration of side effects of chemotherapy and ischemia/reperfusion induced testicular injury. (greenmedinfo.com)
The high turnover rate of the non - keratinized squamous epithelia cells that make up the oral mucosa, every ten to fourteen days, increase the vulnerability of these cells to the effects of chemotherapy. (ukessays.com)
Myelosuppression is the result of damage to bone marrow stem cells and is one of the most common side effects of chemotherapy. (lumiraventures.com)
Our results prompted further exploration of the feasibility of innovative therapeutic approaches aimed at reducing the clinical side effects of chemotherapy," noted the researchers. (genengnews.com)
It aids in the recovery process from Hepatitis A and B, drug and alcohol addiction, the after-effects of chemotherapy, and a lethargic liver. (butterflyayurveda.com)
The results of this study suggest that fasting may mitigate some of the harmful effects of chemotherapy," said co-author Tanya Dorff , assistant professor of clinical medicine at the USC Norris Comprehensive Cancer Center and Hospital. (usc.edu)

For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
Taiwanese researchers found that si jun zi decoction can alleviate toxicity induced by cisplatin , a chemotherapy medication. (preventcancer.news)
The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. (peacehealth.org)
Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
Previously, we discovered that successful functional knockout (KO) of the NRF2 gene in chemo-resistant lung cancer cells significantly increased the anticancer activity of cisplatin, carboplatin, and vinorelbine in both cell culture and mouse models. (genengnews.com)
Also cisplatin accumulation shows toxicity to normal tissues. (biomedcentral.com)
HemoHIM itself did not inhibit melanoma cell growth in vitro , and did not disturb the effects of cisplatin in vitro . (biomedcentral.com)
In melanoma-bearing mice treated with cisplatin, HemoHIM administration also increased the activity of NK cells and Tc cells and the IL-2 and IFN-γ secretion from splenocytes, which seemed to contribute to the enhanced efficacy of cisplatin by HemoHIM. (biomedcentral.com)
HemoHIM may be a beneficial supplement during cisplatin chemotherapy for enhancing the anti-tumor efficacy and reducing the toxicity of cisplatin. (biomedcentral.com)
Cisplatin-based highly emetogenic chemotherapy (HEC) regimens, which are key treatments for some of malignant tumors, were conventionally administered after an antiemetic premedication with dexamethasone plus a 5-hydroxytryptamine 3 receptor antagonist (5-HT 3 RA) such as ondansetron or granisetron. (medscape.com)

When oxidative stress levels are reduced in cancer cells, their growth is more easily controlled through a process called apoptosis. (pinestreetfoundation.org)
During apoptosis, cells are removed by the immune system before they lose their cell wall, thus avoiding an inflammatory response to the dying cells. (pinestreetfoundation.org)
The authors of the above-mentioned study on Burkitt lymphoma cells and chemotherapy suggest that including antioxidants in the treatment protocol may enhance chemotherapy-induced apoptosis and phagocytosis. (pinestreetfoundation.org)
2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
In this study, it was found that oxidative stress inhibited apoptosis by depleting cells of their energy source, which is called adenosine triphosphate (ATP). (pinestreetfoundation.org)
Antioxidant and apoptosis-inducing activities of ellagic acid. (nutrimedical.com)
BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)
For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
The cell viability, reactive oxygen species (ROS) levels, ratios of oxidized nicotinamide adenine dinucleotide to its reduced form (NAD + /NADH), apoptosis assays, and cellular uptake of E/PCF-NPs were determined on 4T1 cells. (dovepress.com)
Treatment with E/PCF-NPs under irradiation induced 4T1 cell apoptosis in approximately 93.6% cells. (dovepress.com)
The long-circulating and higher tumor accumulation of E/PCF-NPs resulted in complete ablation of breast tumor tissue through the enhanced photothermal effect by NIR laser irradiation-mediated cell apoptosis. (dovepress.com)
Specifically, cytotoxicity and apoptosis will be measured to determine the effect of Mrp1 on cell sensitivity of DOX. (uky.edu)
RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
Detection of single- and double-stranded DNA breaks at the early stages of apoptosis was performed using the in-situ cell death detection kit. (greenmedinfo.com)
Discussion Pretreatment with honey protect testis against chemotherapy and testicular IR injury, increase FSH and LH and testosterone and decrease the cellular damage and apoptosis. (greenmedinfo.com)
The resulting damage cannot be overcome by the antioxidant system to protect the cell from oxidative damage, leading to necrosis, apoptosis, or autophagy of the target cell and tissue ( 10 , 11 ). (spandidos-publications.com)
With each subsequent mitosis, the cumulative effects of unrepaired DNA result in apoptosis (cell death) of these tumor cells. (medscape.com)
Role of PDL-1 in NSCLC chemoresistance was assessed using CRISPR/Cas9 knockdown and various functional assays including MTT, cell invasion, sphere formation, and cell apoptosis. (cdc.gov)
Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)

Acquisition of these mutations by normal cells can lead to microscopic abnormalities starting years before detectable tumors appear. (abta.org)
Brain tumors in general are derived mostly from glial cells, astrocytes and oligodendrocytes, but not neurons. (abta.org)
We speculate that acute exposure of tumors to iron (e.g., derived from heme-proteins in hemorrhagic cancerous lesions) may increase sensitivity of some cancer cells, particularly those relatively low in endogenous ferritin, to oxidant-mediated lysis. (mtak.hu)
In contrast, repeated, more chronic, ex posure may result in resistance of various tumors to oxidant-producing immune effector cells or chemotherapeutic agents, an effect derived from their increased synthesis and accumulation of the intracellular iron scav enger, ferritin. (elsevierpure.com)
Research suggests that it can be used to treat malignant tumors in the digestive tract and to improve the immune function and quality of life of patients after chemotherapy. (preventcancer.news)
Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
It may provide novel insight into the role of Mrp1 in oxidative stress regulation, and thereby give us critical information regarding the potential adverse sequelae of introduction of MRP1 inhibitors as adjuncts to clinical chemotherapy of multidrug resistant tumors. (uky.edu)
Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
Overexpression of p62 is likely related to tumorigenesis and has been observed in many types of tumors ( 13 , 21 - 23 ), such as chemotherapy-resistant epithelial cell carcinoma ( 24 ). (spandidos-publications.com)
Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
Yet, researchers at the ChristianaCare's Gene Editing Institute have discovered that a mutation unique to certain cancer tumors may serve as a potential signal for safely deploying CRISPR gene editing enzymes to disarm DNA that makes cancer cells resistant to treatment, without affecting healthy cells. (genengnews.com)
The researchers are now conducting tests in animals to further confirm selective targeting of NRF2 in squamous cell tumors and to assess any concerns in order to lay the foundation for a clinical trial in patients. (genengnews.com)
The trial would test whether using CRISPR to knock out the NRF2 gene in squamous cell carcinoma lung cancer tumors improves the efficacy of conventional chemotherapy and radiation treatments. (genengnews.com)
The cancers produce tumors that are frequently protected by the NRF2 gene. (genengnews.com)
Like squamous cell tumors, they also have mutations that create a protospacer adjacent motif (PAM) site that can serve as a target for keeping CRISPR edits focused exclusively on tumors. (genengnews.com)
Taking niacinamide by mouth while undergoing chemotherapy doesn't seem to benefit people with brain tumors. (medlineplus.gov)

The most serious and life-threatening side effect of chemotherapy is myelosuppression, or damage to the bone marrow, resulting in reduced white blood cells, red blood cells and platelets. (wraltechwire.com)
Chemotherapy-induced myelosuppression may lead to increased risks of infection, severe anemia, and/or bleeding. (wraltechwire.com)
By contrast, trilaciclib provides the first proactive approach to myelosuppression through a unique mechanism of action that helps protect the bone marrow from damage by chemotherapy. (wraltechwire.com)
In clinical trials, the addition of trilaciclib to extensive-stage small cell lung cancer chemotherapy treatment regimens reduced myelosuppression and improved clinical outcomes. (wraltechwire.com)
G1 is proud to deliver COSELA to patients and their families as the first and only therapy to help protect against chemotherapy-induced myelosuppression. (wraltechwire.com)
GTHX ), a commercial-stage oncology company, today announced that the U.S. Food and Drug Administration (FDA) has approved COSELA™ (trilaciclib) for injection to decrease the incidence of chemotherapy-induced myelosuppression in adult patients when administered prior to a platinum/etoposide-containing regimen or topotecan-containing regimen for extensive-stage small cell lung cancer (ES-SCLC). (g1therapeutics.com)
While undergoing chemotherapy, many patients experience significant myelosuppression, become fatigued and susceptible to infection, and often require transfusions and growth factor administrations," said Jared Weiss, M.D., Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, NC. (lumiraventures.com)
In clinical trials, trilaciclib significantly reduced chemotherapy-induced myelosuppression, and patients receiving trilaciclib experienced fewer dose delays/reductions, infections, hospitalizations, and need for rescue therapies compared to patients receiving chemotherapy alone. (lumiraventures.com)

Chemotherapy with streptozocin (STZ) in combination with 5-FU or doxorubicin (Dox) represents a standard of care for patients with metastatic pancreatic neuroendocrine neoplasms (pNEN). (cancerindex.org)
Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. (oncotarget.com)
Cancers such as doxorubicin are commonly used in cancer leukaemia, colorectal, breast, lung, and so on are chemotherapy. (who.int)

Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity: possible role in chemotherapy efficacy. (mtak.hu)
However, whether the efficacy of PDT depends on the expression level of p62 in colorectal cancer cell lines is not known. (spandidos-publications.com)
At that time, data were insufficient to assess the efficacy of ZDV as a prophylactic agent in humans or the toxicity of this drug in persons not infected with HIV. (cdc.gov)
In order to investigate the effectiveness of HePC ointment as a topical anti-leishmanial preparation, we tested its efficacy on experimentally induced lesions in hamsters. (who.int)
There has been no phase III study of comparing the efficacy of first- and second-generation 5-HT 3 receptor antagonists in the triplet regimen with dexamethasone and aprepitant for preventing chemotherapy-induced nausea and vomiting after highly emetogenic chemotherapy (HEC). (medscape.com)

Tea extracts are an efficient, broadly available treatment option for patients suffering from acute radiation-induced skin toxicity. (biomedcentral.com)
Dox-induced over-production of reactive oxygen and nitrogen species (ROS and RNS) such as superoxide, hydrogen peroxide, hydroxyl radical and peroxynitrite has been proposed to be the main cause of Dox-induced acute cardiomyocyte toxicity and cell death by damaging various molecular constituents and organelles [ 9 - 12 ]. (oncotarget.com)

Due to its high antioxidant content, GSE can help prevent disease and protect against oxidative stress, tissue damage, and inflammation. (healthline.com)
5 Conversely, p53 induction by oxidative damage may help reduce the development of atherosclerosis, perhaps by suppressing the growth or enhancing the death of cells involved in causing atherosclerotic lesions. (the-scientist.com)
It has long been known that oxidative stress is an essential mechanism by which chemotherapy works to treat cancer. (pinestreetfoundation.org)
Taking a deeper look into the research literature yields many examples where oxidative stress on cancer cells has been shown to be counterproductive. (pinestreetfoundation.org)
However, when oxidative stress levels go up, cancer cell death happens through a slower, messier, and less effective pathway called pyknosis or necrosis. (pinestreetfoundation.org)
Additionally, the ability of the body to "clean up" the resulting cellular debris from cancer cell death is also inhibited by oxidative stress. (pinestreetfoundation.org)
The body's house-cleaning cells (called monocyte-derived macrophages) cannot function optimally under conditions of oxidative stress (i.e. low oxygen levels). (pinestreetfoundation.org)
On the other hand, the decreased levels of antioxidants (or oxidative stress) that are caused by many chemotherapy treatments correlates with increased side effects. (pinestreetfoundation.org)
Therefore, to understand the self-regulation and defense mechanisms of heart tissue under the oxidative stress may provide us new approaches to alleviate the clinical cardiotoxicity of chemotherapy. (uky.edu)
Oxidative stress has been shown to correlate with increasing protein toxicity, linking loss of protein, accumulation of ROS, and protein aggregate formation. (spandidos-publications.com)

Our goal for this interim data will be to further support our belief that ALRN-6924 has a protective effect against severe chemotherapy-induced anemia and thrombocytopenia. (aileronrx.com)
It also has severe limitations on the dosage of chemotherapeutic agents that can be administered to a patient, thus, limiting the effective range of chemotherapy. (justia.com)
However, it induces severe and dose-limiting cardiac toxicity. (uky.edu)
Here we report a severe life-threatening complication of treatment with streptozotocin in a patient with pancreatic island-cell carcinoma. (cancerindex.org)
However, the accumulation of evidence suggests that immunotherapy also induces severe and complex neurologic immune-related adverse events (ir-AEs) and even leads to immunotherapy-related death, which arouses the concern of clinicians. (hindawi.com)

In this study, we explored the effect of topically-applied tea extracts on the duration of radiation-induced skin toxicity. (biomedcentral.com)
To date, the majority of previous studies have aimed to prevent or attenuate skin reactions but did not focus on the duration of radiation-induced skin toxicity, if present. (biomedcentral.com)
Radiation-induced inflammation is mainly caused by activation of NF-κB, a preformed dimeric transcription factor sequestered in the cytosol by its inhibitor molecules of the IκB-family. (biomedcentral.com)
Abstract: CONTEXT: Effects of a radioprotective, standardized leaf extract (code SBL-1) from traditional medicinal plant, sea buckthorn [Hippophae rhamnoides L. (Elaeagnaceae)], on neurotransmitters and brain injuries in rats showing radiation-induced conditioned taste aversion (CTA), are not known. (greenmedinfo.com)
This effect of Vitamin c may have some therapeutic implications for radiation-induced injuries. (biomedgrid.com)
Radioprotectors are given prior to exposure to ionizing radiation to reduce harmful effects, including radiation-induced lethality [1]. (biomedgrid.com)

Patients with grade 2+ skin toxicity mostly suffer from skin disintegrity and symptoms caused by inflammation in the irradiated areas. (biomedcentral.com)
Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)
Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
Elimination of senescent cells can counter chronic inflammation, said Steven N. Austad, director of aging studies at the University of Alabama at Birmingham. (qualitycounts.com)
Bacterial cell wall components can then induce inflammation further. (ukessays.com)
The major focus of this research is the molecular pathogenesis of invasion and inflammation induced by Streptococcus pneumoniae, the leading invasive bacterial pathogen of children. (stjude.org)

A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
Pembrolizumab (Keytruda), a humanized monoclonal anti-PD-1 antibody, is the first anti-PD-1 antibody approved by the FDA for the treatment of patients with unresectable or metastatic melanoma, non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma, cervical cancer, colorectal cancer, and gastric/gastroesophageal junction cancer [ 4 - 10 ]. (hindawi.com)
Undifferentiated prostate cancer, squamous cell carcinoma, and ductal transitional carcinoma also occur infrequently. (msdmanuals.com)
Global burden of HPV-attributable squamous cell carcinoma of the anus in 2020, according to sex and HIV status: A worldwide analysis. (who.int)

The approval of COSELA is based on data from three randomized, placebo-controlled trials that showed patients receiving COSELA prior to the start of chemotherapy had clinically meaningful and statistically significant reduction in the duration and severity of neutropenia. (g1therapeutics.com)

However, when one looks more closely at the existing published science on how antioxidants and chemotherapy combine, the true answer is not so definitive. (pinestreetfoundation.org)
The overwhelming majority of studies find a favorable interaction between antioxidants and chemotherapy, providing evidence that antioxidants can decrease chemotherapy side effects, increase treatment effectiveness, and decrease resistance to chemotherapy. (pinestreetfoundation.org)
A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)

Chemotherapy induced mucositis is a common side effect of drug toxicity with up to 80% of patients having symptoms during their treatment (Dodd et al 2000, Lalla and Patterson 2006). (ukessays.com)
4. It is recommended that idarubicin hydrochloride be administered only under the supervision of a physician who is experienced in leukemia chemotherapy and in facilities with laboratory and supportive resources adequate to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity. (nih.gov)

This approach can help reduce some chemotherapy-related toxicity, making chemotherapy safer and more tolerable, while also reducing the need for reactive rescue interventions. (wraltechwire.com)
Although the mechanism of DOX cardiac toxicity has not been completely elucidated, it is believed that the superoxide anion and other reactive oxygen species (ROS) generated by DOX contributes significantly to cardiac pathology. (uky.edu)
Cell exposure to chemotherapy causes DNA damage and generates reactive oxygen species (ROS), which are able to injure cells, tissues and blood vessels. (ukessays.com)
PDT uses a modality-based photosensitizer, which selectively affects cancer cells, using excitation and light-absorption in the presence of oxygen to produce a high concentration of reactive oxygen species (ROS), such as singlet oxygen and other free radicals ( 7 - 9 ). (spandidos-publications.com)
ABSTRACT The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. (who.int)
With intact cells, the to radiation killing compared with well formation of oxygen reactive intermediates oxygenated healthy cells [ 2,3,7-9 ]. (who.int)

To address this, we employed clinically approved drugs Zoledronate (ZOL) and IL-2 to induce anti-TB VÎ³2VÎ´2 T-effector cells as adjunctive immunotherapy against MDR-TB infection of macaques. (bvsalud.org)
The research has now progressed from animal studies to human trials, with the safety of using a 5 day FMD in combination with a variety of cancer treatments (including chemotherapy, endocrine therapy and immunotherapy) and across a range of cancer types having now been established(4).This study also explored some of the mechanisms by which an FMD may improve treatment outcomes. (getmeback.uk)
The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)

Compared to chemotherapy or photothermal treatment alone, the combined treatment in vitro significantly inhibited the survival rate of 4T1 cells to 17.7%, induced ROS generation, and reduced NAD + /NADH significantly. (dovepress.com)
Tetrazolium reduction and resazurin assays are the mainstay of routine in vitro toxicity batteries. (cdc.gov)

Silymarin may protect the liver from toxic chemicals and have been tested for their potential to make chemotherapy more effective or less toxic as well as to slow or stop the growth of cancer cells. (superfoods-scientific-research.com)
There are currently no available therapies to protect patients from chemotherapy-induced toxicities before they occur," said Raj Malik, M.D., Chief Medical Officer and Senior Vice President, R&D. "If approved, trilaciclib would be the first proactively administered myelopreservation therapy that is intended to make chemotherapy safer and reduce the need for rescue interventions, such as growth factor administrations and blood transfusions. (lumiraventures.com)

We are pleased with the continued progress of the dose-optimization portion of our Phase 1b clinical trial in which we treat small cell lung cancer patients with ALRN-6924 twenty-four hours before topotecan, a standard chemotherapy. (aileronrx.com)
The CRISPR-directed gene editing strategy could advance as an effective augmentative therapy to approach patients with locally advanced lung cancer, especially where the current standard of care has failed and there may be resistance to standard chemotherapy. (genengnews.com)

Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
They also outline that information should be available to make patients aware of particular hygiene needs that may be required as a result of specific treatments such as chemotherapy. (ukessays.com)

however, standard of care chemotherapy regimens are highly myelosuppressive and can lead to costly hospitalizations and rescue interventions," said Jack Bailey, Chief Executive Officer at G1 Therapeutics. (wraltechwire.com)
In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)

The stabilized helical structure of our peptides allows the design of cell-permeating therapeutic agents with large molecular surfaces for optimal target binding properties, resulting in drug candidates like ALRN-6924. (aileronrx.com)
Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)
Chemotherapy has been one of the major therapeutic modalities commonly used for the treatment for a variety of cancer patients. (biomedcentral.com)
Our finding supports PDL-1 in CAFs as a chemotherapy response biomarker and as a drug delivery and therapeutic target for chemoresistant NSCLC. (cdc.gov)
Metronidazole selectively radiosensitizes of metronidazole (in a range of therapeutic hypoxic cells without influencing the ra- concentrations) on PMN-generated free diation response of normal well-oxygenated radicals during phagocytosis activity in cells [ 5,7-9 ]. (who.int)

Mechanisms by which Dox promotes cardiac damage and cardiomyocyte cell death have been investigated extensively, but a definitive picture has yet to emerge. (oncotarget.com)
Dox is a mitochondrial toxin, and mitochondrial damage is central to Dox-induced cardiac dysfunction and cell death [ 8 ]. (oncotarget.com)
Cardiac toxicity is more common in patients who have received prior anthracyclines or who have pre-existing cardiac disease. (nih.gov)

The DIRECT trial(5) looked at the effect of the FMD on outcomes of standard neoadjuvant chemotherapy (FEC-T or AC-T) given to 131 women with stage II-III HER2 negative breast cancer. (getmeback.uk)
RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
Trilaciclib is a first-in-class investigational therapy designed to preserve bone marrow and immune system function during chemotherapy and improve patient outcomes. (lumiraventures.com)
Trilaciclib is a first-in-class investigational therapy designed to improve outcomes for people with cancer treated with chemotherapy. (lumiraventures.com)

One example is a human study in which researchers discovered that higher levels of the antioxidant selenium in the blood of patients with aggressive B-cell non-Hodgkin's lymphoma correlated with increased achievable doses of anthracycline based chemotherapy, better treatment response, achievement of long term remission, and longer overall survival. (pinestreetfoundation.org)
Using antioxidants during chemotherapy is an important and controversial question among health care providers, patients, and their support teams. (pinestreetfoundation.org)
RESEARCH TRIANGLE PARK - Patients undergoing treatment for lung cancer will soon have access to a treatment that prevents damage to their bones and immune system from chemotherapy that has won FDA approval for Triangle-based G1 Therapeutics . (wraltechwire.com)
The approval of trilaciclib (Cosela) is an important advance in the treatment of patients with extensive-stage small cell lung cancer receiving chemotherapy," said Dr. Jeffrey Crawford, Geller Professor for Research in Cancer in the Department of Medicine and Duke Cancer Institute, in a statement. (wraltechwire.com)
These complications impact patients' quality of life and may also result in chemotherapy dose reductions and delays. (wraltechwire.com)
Silymarin increases the activity of SOD in red blood cells (erythrocytes) and white blood cells (lymphocytes) formed in the lymphatic tissue in patients with liver disease. (superfoods-scientific-research.com)
In this trial, ALRN-6924 is being evaluated as an agent to protect cancer patients against chemotherapy-induced toxicity, a concept known as myelopreservation or chemoprotection. (aileronrx.com)
Streptozocin-Based Chemotherapy in Patients with Advanced Neuroendocrine Neoplasms--Predictive and Prognostic Markers for Treatment Stratification. (cancerindex.org)
The aim of this study was a retrospective evaluation of the clinicopathological characteristics of pNEN patients receiving STZ-based chemotherapies and to identify predictive and prognostic markers. (cancerindex.org)
STZ-based chemotherapy is an effective and well-tolerated treatment option in patients with well differentiated neuroendocrine neoplasms. (cancerindex.org)
The aim of the present study was to determine the status of STZ usage in Japan and to evaluate the effectiveness and safety of STZ chemotherapy in Japanese NET patients. (cancerindex.org)
The main recipients of STZ chemotherapy were middle-aged patients with pancreatic NET and unresectable liver metastases. (cancerindex.org)
This often leads to the occurrence of moist skin desquamation (RTOG grade ≥ 2 skin toxicity) [ 1 ], which causes discomfort and compromises patients' quality of life during and immediately after treatment. (biomedcentral.com)
Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)
Among all the treatment side effects and complications that cancer patients face, OM ranks as one of the most troublesome, causing significant concern for the majority of patients receiving chemotherapy. (ukessays.com)
Bruce and Quinn (2007) highlighted the fact that patients consider OM to be the most difficult treatment related toxicity to endure. (ukessays.com)
To treat patients with colorectal cancer, an approach that selectively targets cancer cells without damaging normal cells and which minimizes the risk of perforating the intestinal barrier is needed ( 2 ). (spandidos-publications.com)
G1 launching expanded access program (EAP) for patients with small cell lung cancer in the U.S. (lumiraventures.com)
RESEARCH TRIANGLE PARK, N.C., Aug. 17, 2020 (GLOBE NEWSWIRE) - G1 Therapeutics, Inc. (Nasdaq: GTHX), a clinical-stage oncology company, today announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for trilaciclib for small cell lung cancer (SCLC) patients being treated with chemotherapy and granted Priority Review with a Prescription Drug User Fee Act (PDUFA) action date of February 15, 2021. (lumiraventures.com)
The trilaciclib NDA was supported by compelling myelopreservation data from three randomized, double-blind, placebo-controlled clinical trials in which trilaciclib was administered prior to chemotherapy treatment in patients with SCLC. (lumiraventures.com)
Preventing bone marrow damage proactively is an opportunity to improve the quality of life of patients receiving chemotherapy for small cell lung cancer and reduce costly rescue interventions. (lumiraventures.com)
In 2019, trilaciclib received FDA Breakthrough Therapy Designation, and, in June 2020, G1 submitted the NDA based on myelopreservation data from three randomized, double-blind, placebo-controlled clinical trials in which trilaciclib was administered prior to chemotherapy in patients with small cell lung cancer (SCLC). (lumiraventures.com)
Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)
In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy. (peacehealth.org)
One of the challenges of using CRISPR in cancer patients is ensuring it can distinguish between a malignant cell and a healthy cell. (genengnews.com)
Studies of cellular (nucleated blood and bone marrow cells) drug concentrations in leukemia patients have shown that peak cellular idarubicin concentrations are reached a few minutes after injection. (nih.gov)
Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
It may be seen in greater than 90% of patients older than 60 years who have been successfully treated with combination chemotherapy and whole-brain radiation. (medscape.com)
Chemotherapy-induced nausea and vomiting (CINV) is a non-hematologic toxicity of chemotherapy that severely impairs the quality of life of patients and reduces their treatment compliance. (medscape.com)
[ 8 ] In patients receiving moderately emetogenic chemotherapy (MEC), better CINV control was obtained with palonosetron than with a first-generation 5-HT 3 RA, [ 9 ] which supports current guideline recommendations for palonosetron use as a part of antiemetic premedication for MEC. (medscape.com)

Irradiated Ce6 produced singlet oxygen which rapidly induces tumor cell death. (spandidos-publications.com)

Moreover, DNA damage is responsible for many of the toxicities incurred in treatment, including bone marrow suppression, hair loss, and gastrointestinal toxicites. (the-scientist.com)
It is the first and only therapy designed to help protect bone marrow (myeloprotection) when administered prior to treatment with chemotherapy," G1 says. (wraltechwire.com)
To date, approaches have included the use of growth factor agents to accelerate blood cell recovery after the bone marrow injury has occurred, along with antibiotics and transfusions as needed. (wraltechwire.com)
Myeloprotection is a novel approach of protecting HSPCs in the bone marrow from chemotherapy-induced damage. (wraltechwire.com)
It is the first and only therapy designed to help protect bone marrow (myeloprotection) when administered prior to treatment with chemotherapy. (g1therapeutics.com)
It kills both, including important hematopoietic stem and progenitor cells (HSPCs) in the bone marrow that produce white blood cells (immune cells that help fight infection), red blood cells (cells that carry oxygen from the lungs to the tissues), and platelets (cells that prevent bleeding from cancer, surgeries, chronic diseases, and injuries). (g1therapeutics.com)
Exogenous remodeling of lung resident macrophages protects against infectious consequences of bone marrow-suppressive chemotherapy. (stjude.org)
Concentrations of idarubicin and idarubicinol in nucleated blood and bone marrow cells are more than a hundred times the plasma concentrations. (nih.gov)

We will also study the mitochondrial damage induced by DOX and the role of Mrp1 during this process. (uky.edu)

Recent promising studies demonstrate that immune checkpoint inhibitors (ICI) can induce objective intracranial response. (abta.org)
In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
Immune checkpoint inhibitors (ICIs) are antibodies that target crucial signaling pathways, such as programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), to improve the activation of T cells and enhance the immune response to cancer cells. (hindawi.com)
The toxicity data of protein kinase inhibitors in humans is also well established [5]. (who.int)

IONPs-PAA-PEG-MAN nanodecoy exhibits preferential uptake in macrophages to significantly increase drug uptake with sustained high drug contents in host cells. (bvsalud.org)
Macrophages are immune cells that have the ability to engulf and digest foreign and harmful substances, including cancer cells. (preventcancer.news)

Data analogous to those with H2O2-mediated cytotoxicity were obtained in studies of bleomycin-engendered DNA strand breakage and cell damage, i.e., brief treatment of BT-20 cells with both hemin or FeSO4 significantly increases their sensitivity to bleomycin (100 micrograms/ml), whereas treatment followed by 24 h incubation with media alone significantly protects against bleomycin toxicity. (mtak.hu)

p62 is a multifunctional protein that mediates cell signaling pathways, autophagy and tumorigenesis, and participates in important regulation processes at the intersection between autophagy and cancer. (spandidos-publications.com)
Autophagy contributes to the prolonged survival of tumor cells, whereas defects in autophagy play a critical role in tumorigenesis ( 15 , 16 ). (spandidos-publications.com)
A recent study showed that the hypoxic environment produced by PDT can induce autophagy in tumor cells ( 17 ). (spandidos-publications.com)
This suggests that autophagy is a form of adaptation of the nutritional environment of rapidly growing tumor cells in response to hypoxia. (spandidos-publications.com)
Autophagy, regarded generally as a protective mechanism that maintains cell viability by recycling unwanted and damaged cellular constituents, is nevertheless subject to dysregulation having detrimental effects for the cell. (oncotarget.com)
Here we will review Dox-induced cardiotoxicity and cell death in the broad context of the autophagy and mitophagy processes. (oncotarget.com)

2. As is the case with other anthracyclines the use of idarubicin Hydrochloride can cause myocardial toxicity leading to congestive heart failure. (nih.gov)

In their study, the researchers investigated the effectiveness of si jun zi in inhibiting the metastasis of colorectal cancer cells to the liver. (preventcancer.news)
The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
In recent years, natural substances such as SH groups and cysteine have been investigated for their effectiveness in protecting from radiation damage [2]. (biomedgrid.com)
Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)

Therefore, GSE likely protected against further heart damage. (healthline.com)
Thus, we must rely on the elegant mechanisms our cells have developed to repair damage. (the-scientist.com)
All somatic eukaryotic cells arrest progression through the cell cycle when their DNA is damaged, presumably because optimal repair of the damage would be a mechanistic challenge if the cell continued to replicate DNA or segregate chromosomes. (the-scientist.com)
Multicellular organisms can also deal with DNA damage through programmed cell death. (the-scientist.com)
The DNA- damage response gene, p53 , is an important mediator of this cell-death pathway. (the-scientist.com)
Although these cellular-suicide mechanisms may protect the organism in some physiologic settings, such as by preventing cancer, the double-edged sword is that these same DNA-damage response pathways that help prevent cancer can also contribute to debilitating disease processes. (the-scientist.com)
Milk thistle inhibits the factors responsible for liver damage and stimulates the growth of new liver cells to replace damaged ones. (superfoods-scientific-research.com)
Neutralizes liver cell damage caused by toxins and strengthens the liver cells' outer membranes to prevent future harm. (superfoods-scientific-research.com)
In a far-reaching analysis of for liver diseases reported in Pharmaceutical Biology in May 2011, concluded that milk thistle is effective in protecting the liver from damage caused by hepatitis, cirrhosis and other liver ailments. (superfoods-scientific-research.com)
Studies have also shown that ellagic acid may protect against chromosome damage and reduce the effects of chemically induced hepatic structural degeneration. (nutrimedical.com)
As these drugs cause damage to cells they are termed cytotoxic. (justia.com)
ROS cause further cell damage and stimulate expression of transcription factors that lead to tissue injury and cell death. (ukessays.com)
Hematopoietic cells and peripheral blood cells are known to be sensitive to radiation, and low doses of radiation can cause damage. (biomedgrid.com)
In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)
However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
Toxic effects of Dox include cardiomyocyte damage and apoptotic and necrotic cell death [ 5 ]. (oncotarget.com)
While chemotherapy saves lives, it causes significant collateral damage to the immune system. (usc.edu)

It could be deduced that the uncertainly radioprotective action against death is induced by a possible process of enhanced regeneration of the leukocyte stem cells due to not only strengthened radioresistance and increased numbers of remained leukocyte cells, but also enhanced post-irradiation repair or promoted proliferation of the leukocyte stem cells. (biomedgrid.com)
However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)
Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)

We hypothesize that engineering of clumped-clustered BCG into nanoscale particles would improve safety and also facilitate the antigen-presenting-cell (APC)'s uptake and the following processing/presentation for better anti-TB protective immunity. (bvsalud.org)
Their study is published in Molecular Cancer Research in an article titled, " Kinetics of Nuclear Uptake and Site-Specific DNA Cleavage during CRISPR-Directed Gene Editing in Solid Tumor Cells . (genengnews.com)

In contrast, repeated, more chronic, exposure effector cells or chemotherapeutic agents, an effect derived from their increased synthesis and accumulation of the intracellular iron scavenger, ferritin. (mtak.hu)

nevertheless, large increases in overall ferritin content of iron-exposed cells result. (mtak.hu)
Pretreat ment of BT-20 and Caco-2 cells with hemin or FeSO 4 rapidly increases H-ferritin mRNA but only slightly increases L-ferritin iiiUN V: neverthe less, large increases in overall ferritin content of iron-exposed cells result. (elsevierpure.com)
The Gene Editing Institute has done multiple tests in animals to establish that disabling NRF2 with CRISPR increases sensitivity to chemotherapy. (genengnews.com)
Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. (medscape.com)
Either increases toxicity of the other by pharmacodynamic synergism. (medscape.com)

In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy, though such effects have not yet been studied in humans. (peacehealth.org)

Here, we hypothesized that enhancing protective VÎ³2VÎ´2 T-effector cells could improve treatment outcome of MDR-TB. (bvsalud.org)
We found that adjunctive ZOL/IL-2 administrations during TB drugs treatment of MDR-TB-infected macaques significantly expanded VÎ³2VÎ´2 T cells and enhanced/sustained VÎ³2VÎ´2 T-effector subpopulation producing anti-TB cytokines until week 21. (bvsalud.org)
Bax expression was induced and caspase-3 was activated by ellagic acid treatment. (nutrimedical.com)
Treatment was well tolerated with less than 10% grade 3 and 4 toxicities. (cancerindex.org)
In the past, many clinical efforts have been made to attenuate skin toxicity in radiation therapy or to delay its onset, but in many countries there is no "gold standard" in skin care during and after radiation treatment. (biomedcentral.com)
Photodynamic therapy (PDT) is a treatment that involves photosensitizing agents and light to kill cancer cells. (spandidos-publications.com)
From a clinical perspective, the well-known toxicity of chemotherapy often remains a serious barrier to successful treatment and even enrollment in clinical trials. (genengnews.com)

pharmacogenomics of chemotherapy-induced toxicity in pediatric leukemia. (mskcc.org)

I've been interested in this topic for a very long time largely because of the background of allogeneic transplant that we were aware that we would induce infertility in men and women in those days because we used total body irradiation. (medscape.com)

In this article, we turn our focus to lymphoma, conducting a systematic search for published research that would support or discourage the use of antioxidants in combination with chemotherapy. (pinestreetfoundation.org)

In mice, fasting cycles then "flipped a regenerative switch": changing the signaling pathways for hematopoietic stem cells, which are responsible for the generation of blood and immune systems, the research showed. (usc.edu)
We could not predict that prolonged fasting would have such a remarkable effect in promoting stem cell-based regeneration of the hematopoietic system," said corresponding author Valter Longo , the Edna M. Jones Professor of Gerontology and the Biological Sciences at the USC Davis School of Gerontology , and director of the USC Longevity Institute. (usc.edu)

Single-strand breaks are easily fixed, but double-strand breaks require the complex mechanisms of nonhomologous end-joining and homologous recombination, the latter only being useful in late S, G 2 or M phases of the cell cycle, when homologous chromosomes are present in the cell. (the-scientist.com)
3 Such cellular-suicide mechanisms can eliminate cells that could present problems for the whole organism because of alterations in the DNA or difficulties in dealing with stressful stimuli. (the-scientist.com)
The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)

Streptozotocin-induced diabetic ketoacidosis in a patient with metastatic islet-cell carcinoma. (cancerindex.org)
Ehrlich ascites carcinoma (EAC) cells were administered into the mice by subcutaneous injection. (techscience.com)

Cytokines are signaling molecules used by immune cells to mediate immune responses. (preventcancer.news)
We used a Cr 51 -release assay to measure the activity of NK/Tc cell and ELISA to evaluate the production of cytokines. (biomedcentral.com)

Behavioral examination As well as curcumins result on pathological and molecular changes induced by mutant huntingtin we also examined the results of curcumin to the early behavioral deficits in KI mice. (pdgfreceptor.com)

WATERTOWN, Mass. , April 22, 2020 (GLOBE NEWSWIRE) -- Aileron Therapeutics (NASDAQ:ALRN) today announced plans to report interim results from their Phase 1b/2 clinical trial of ALRN-6924 in small cell lung cancer (SCLC). (aileronrx.com)

The drug called Cosela is injected before a patient receives chemotherapy being used to fight small cell lung cancer. (wraltechwire.com)
In June 2020, G1 announced a co-promotion agreement with Boehringer Ingelheim for trilaciclib in small cell lung cancer in the U.S. and Puerto Rico. (lumiraventures.com)
Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)

We wondered whether hemoglobin derived from extravasated RBC deposits heme-derived iron into the tumor, which could modulate the sensitivity of cancer cells to oxidant-mediated injury. (mtak.hu)
A brief exposure (1 h) of 51Cr-radiolabeled breast cancer cells (BT-20) but not colon cancer cells (Caco-2) to hemin (10 microM) or FeSO4 (10 microM) significantly enhances cytotoxicity mediated by 0.5 mM hydrogen peroxide (H2O2). (mtak.hu)
A brief exposure (1 h) of 51 Cr-radiolabeled breast cancer cells (BT-20) but not colon cancer cells (Caco-2) to hemin (10 μM) or Fe-SO 4 (10 μM) significantly enhances cytotoxicity mediated by 0.5 mM hydrogen peroxide (H 2 O 2 ). (elsevierpure.com)
Luckily, researchers from Nanjing University of Chinese Medicine have found a traditional Chinese medicine that can stop cancer cells from spreading . (preventcancer.news)
They found that the herbal formula activates the body's innate immune system, allowing it to respond quickly to the presence of cancer cells and stop them from spreading to other sites. (preventcancer.news)
Using mice transplanted with human colorectal cancer cells, they studied the anti-metastasis activities of the modified si jun zi decoction and compared it to the anti-cancer drug, 5-fluorouracil. (preventcancer.news)
Based on these findings, which were published in the journal BMC Complementary and Alternative Medicine , the researchers concluded that the modifified si jun zi decoction inhibits colorectal cancer metastasis by stimulating the body's innate immune system , which helps it clear away cancer cells in the vascular system in time. (preventcancer.news)
Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body. (medindia.net)
Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
The present study aimed to examine the role of p62 expression levels in chlorin e6‑based PDT in colorectal cancer cells. (spandidos-publications.com)
Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy. (peacehealth.org)

Absorption may occur after skin or eye exposure to liquid or vapor nitrogen mustard and may cause systemic toxicity. (cdc.gov)

Unfortunately, scientists have yet to be able to locate specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib). (justia.com)
By outlining how prolonged fasting cycles - periods of no food for two to four days at a time over the course of six months - kill older and damaged immune cells and generate new ones, the research also has implications for chemotherapy tolerance and for those with a wide range of immune system deficiencies, including autoimmunity disorders. (usc.edu)
When you starve, the system tries to save energy, and one of the things it can do to save energy is to recycle a lot of the immune cells that are not needed, especially those that may be damaged," Longo said. (usc.edu)

Ginger (Zingiber officinale) can be helpful in alleviating nausea and vomiting caused by chemotherapy. (peacehealth.org)

tizer drug, especially for hypoxic cells [ 9 ]. (who.int)

The importance of these pathways in cancer prevention is illustrated by the fact that individuals who inherit mutations in any one of the many genes that participate in these stress-induced signal transduction pathways have a very high incidence of cancer. (the-scientist.com)

The survival of irradiated mice protected by Vitamin c was significantly increased and statistically higher than that of mice pre-treated with oral administration. (biomedgrid.com)
After administration of Vitamin c , enhanced CD4 and CD8 cells, numbers of NK cells and CD4 and CD8 cells in mice were found and lymphocytes numbers was higher than in irradiated control group. (biomedgrid.com)
Stimulated recovery of leukocyte, lymphocytes, and NK cells counts were observed in mice pre-treated with Vitamin c . (biomedgrid.com)
All abovementioned results were similar to those in mice protected by Vitamin c , but the protecting actions of Vitamin c on promoting recovery of nucleated cells and leukocyte counts were significantly higher than those of Vitamin c . (biomedgrid.com)
Vitamin c also reduced the frequency of micronucleated reticulocytes and provided cell protection in the reproductive system, thus increasing the survival rate of subletically irradiated mice [18,19]. (biomedgrid.com)
In both mice and a Phase 1 human clinical trial, long periods of not eating significantly lowered white blood cell counts. (usc.edu)

RUNX1-positive leukemia cells in preclinical models. (lu.se)

Endometrium-derived epithelial cells (Ishikawa) showed no response to the natural compound by using a cell viability assay (MTT). (nutrimedical.com)

Overexpression of p62 may contribute to colorectal cancer cell death. (spandidos-publications.com)

Anatomy4

Organisms1

Diseases83

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment79

Phenomena and Processes12

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science3

Health Care29

Radiotherapy8

Effects of chemotherapy9

Cisplatin12

Apoptosis21

Tumors16

Myelosuppression8

Doxorubicin3

Efficacy5

Acute2

Oxidative10

Severe5

Radiation-induced6

Inflammation6

Squamous4

Start of chemotherapy1

Antioxidants and chemotherapy3

Drug toxicity2

Reactive6

Immunotherapy5

Vitro2

Make chemotherapy2

Standard chemotherapy2

Treatments2

Regimens2

Therapeutic5

Cardiac3

Outcomes4

Patients30

Tumor cell1

Bone8

Mitochondrial damage1

Inhibitors4

Macrophages2

Bleomycin1

Autophagy6

Myocardial1

Effectiveness6

Damage18

Proliferation3

Uptake2

Accumulation1

Increases5

Decrease1

Treatment7

Pediatric1

Irradiation1

Lymphoma1

Hematopoietic2

Mechanisms4

Carcinoma2

Cytokines2

Molecular1

Therapeutics1

Lung3

Cancer cells11

Systemic1

Immune cells3

Nausea1

Hypoxic1

Incidence1

Mice6

Leukemia1

Epithelial1

Colorectal1