CisplatinChemotherapyEfficacyAntineoplastic chemotherapeuticAnticancerCutaneous toxicityRadiationCardiac toxicitySelective toxicityAgentsSevereTreatmentsMedicationNanoparticlesEvaluateSystemicTreatmentPatientsRenalSymptomsDose-dependentPathwaysCumulativeDrugDrugsPrevalentContrastTargetsAgentPhaseCancer cellsMajorManagementReduceStudiesEvidenceSide effects
Cisplatin6
- Pt NPs anticancer activity was tested performing cell viability experiments with TNBC and comparing with a common chemotherapeutic drug (cisplatin). (aiche.org)
- The results showed no apparent toxicity of Pt NPs for healthy cells in contrast to cisplatin. (aiche.org)
- The treatment consisted of one chemotherapeutic agent liposome-entrapped cisplatin analog: L-NDDP. (survivingmesothelioma.com)
- Cisplatin injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. (globalrph.com)
- Cumulative renal toxicity associated with cisplatin is severe. (globalrph.com)
- Chemotherapeutic (antineoplastic) medications, particularly those containing platinum ( cisplatin and carboplatin ), can cause tinnitus and hearing loss. (msdmanuals.com)
Chemotherapy3
- As the major drawback of chemotherapy is the toxicity, cell viability experiments were also performed on fibroblasts. (aiche.org)
- Cancer chemotherapy has long relied on generalized and nonspecific treatments that often involve substantial patient toxicity. (ajmc.com)
- In order to achieve a more effec- were recommended postoperative radiation and adjuvant tive and individualised chemotherapeutic treatment of breast chemotherapy. (lu.se)
Efficacy8
- It is a subset of the broader field of pharmacogenomics, which is the area of study aimed at understanding how genetic variants influence drug efficacy and toxicity. (wikipedia.org)
- In clinical settings, it has commonly been observed that the same types and doses of treatment can result in substantial differences in efficacy and toxicity across patients. (wikipedia.org)
- Thus, the application of pharmacogenomics within the field of cancer can offer key advantages for personalizing cancer therapy, minimizing treatment toxicity, and maximizing treatment efficacy. (wikipedia.org)
- These all contribute to understanding variations in drug efficacy and toxicity between patients. (wikipedia.org)
- The ability to perform whole-genome analysis for cancer patients can aid in identifying markers of predisposition to drug toxicity and efficacy. (wikipedia.org)
- The aim is to to improve drug efficacy and/or reducing toxicity. (ncl.ac.uk)
- The need for new chemotherapeutic agents with increased efficacy and decreased toxicity has led to the development of novel biologicals, such as antibody therapy, for the treatment of cancer [ 6 ]. (hindawi.com)
- However, many of these drugs exhibit shortcomings such as poor efficacy, high toxicity, and tolerance. (bvsalud.org)
Antineoplastic chemotherapeutic2
- Describe administration guidelines, monitoring and precautions for antineoplastic chemotherapeutic and biotherapeutic agents. (aphon.org)
- Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. (bvsalud.org)
Anticancer3
- Common anticancer chemotherapeutic agents causing drug-induced thrombotic microangiopathy via immune-mediated mechanism or dose-dependent toxicity or both [ 4 , 7 ]. (hindawi.com)
- Interest has grown in natural compounds for the development of anticancer drugs, due to their low toxicity and higher tolerance in patients ( 6 ). (spandidos-publications.com)
- Epidermal growth factor receptor (EGFR) inhibitors are part of an emerging class of anticancer medicines known as "targeted therapy," which target pathways more specific to neoplastic proliferation than traditional chemotherapeutic agents. (medscape.com)
Cutaneous toxicity1
- Hand-foot syndrome is a potentially dose-limiting cutaneous toxicity. (oncologynurseadvisor.com)
Radiation3
- 5. Evaluate patients with common chemotherapeutic and radiation toxicities. (utmb.edu)
- The researchers also identified the chemokine CXCL10 in circulating blood as a novel biomarker for radiation-induced cardiac toxicity. (mskcc.org)
- From the perspective of cancer, DNA damage causes the disease, but it is also used to treat the disease via radiation and many chemotherapeutic agents. (the-scientist.com)
Cardiac toxicity3
- Memorial Sloan Kettering Cancer Center (MSK) researchers have discovered that innate immune signaling drives late cardiac toxicity after DNA-damaging cancer therapies. (mskcc.org)
- Further, they found that suppressing this signaling pathway with an experimental STING antagonist effectively prevented cardiac toxicity in mouse models. (mskcc.org)
- Use of the chemotherapeutic agent Adriamycin is complicated by its potentially lethal cardiac toxicity. (mapi.com)
Selective toxicity1
- The selective toxicity of 2-chloro-2΄-deoxy-β-D-adenosine towards certain normal and malignant lymphocyte and monocyte populations is based on the relative activities of deoxycytidine kinase and deoxynucleotidase. (nih.gov)
Agents8
- Cardiovascular toxicity of the first line cancer chemotherapeutic agents: doxorubicin, cyclophosphamide, streptozotocin and bevacizumab. (nel.edu)
- [6] Their targeting ability was believed to limit side effects for cancer patients and give a wider therapeutic window than other chemotherapeutic agents, although this promise hasn't yet been realized in the clinic. (wikipedia.org)
- Thus, 2-chloro-2΄-deoxy- β -D-adenosine can be distinguished from other chemotherapeutic agents affecting purine metabolism in that it is cytotoxic to both actively dividing and quiescent lymphocytes and monocytes, inhibiting both DNA synthesis and repair. (nih.gov)
- It is recommended that bleomycin be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. (nih.gov)
- Thus, evidence exists for the use of phytochemicals as novel chemotherapeutic agents. (hindawi.com)
- However, the need for more agents with this level of success for the management of chemotherapeutic pain has resulted in other avenues of investigation [ 11 ], including phytochemicals and other natural products [ 12 ]. (hindawi.com)
- 1 These are becoming more prevalent with increased use of targeted therapies in addition to traditional chemotherapeutic agents. (oncologynurseadvisor.com)
- in contrast, EGFR inhibitors (EGFRIs) target pathways more specific to survival of neoplastic cells, thus belonging to a new class of chemotherapeutic agents - so-called "targeted therapy. (medscape.com)
Severe3
- This can include choosing drugs that target specific mutations within cancer cells, identifying patients at risk for severe toxicity to a drug, and identifying treatments that a patient is most likely to benefit from. (wikipedia.org)
- however, severe neurological toxicity has been reported rarely following treatment with standard cladribine dosing regimens. (nih.gov)
- Pulmonary fibrosis is the most severe toxicity associated with bleomycin. (nih.gov)
Treatments3
- In summary this work provides a new treatment for TNBC based on Pt NPs with no apparent toxicity for healthy cells, overcoming one of the major drawbacks of current treatments. (aiche.org)
- However, because of distant metastasis, chemotherapeutic resistance and poor tolerance, these treatments can fail. (spandidos-publications.com)
- The use of long-term cancer treatments has caused an unexpected constellation of side effects to emerge-most notably the cutaneous toxicities. (oncologynurseadvisor.com)
Medication1
- The occurrence of some EGFRIassociated cutaneous toxicities is actually associated with clinical response to the medication. (medscape.com)
Nanoparticles2
- The temperature elevation and thermal toxicity of nanoparticles were studied. (dovepress.com)
- Targeted nanoparticles represent an approach to minimize dose-limiting toxicities associated with chemotherapeutics. (aacrjournals.org)
Evaluate1
- The aim of this review was to evaluate the impact of SNPs on toxicity and response to therapy in HNSCCs. (researchsquare.com)
Systemic1
- Absorption may occur after skin or eye exposure to liquid or vapor nitrogen mustard and may cause systemic toxicity. (cdc.gov)
Treatment14
- Additionally, the germline genome affects toxicity reactions to a specific treatment due to its influence on drug exposure. (wikipedia.org)
- Their results, published in the Journal of Experimental Medicine on March 6, 2023, identify a targetable mechanism for one of the most challenging treatment-related late toxicities in cancer survivors. (mskcc.org)
- AOH1996 can suppress tumour growth as a monotherapy or combination treatment in cell and animal models without resulting in toxicity. (independent.co.uk)
- By examining the SNPs, it is possible to make predictions about the patient's response to treatment or development of toxicity after treatment, and if necessary, make changes in the patient's treatment regimen. (researchsquare.com)
- 2004 ). One problem with cancers, especially HNSCCs, is the unpredictability of treatment outcomes, both in terms of tumor response and host toxicity. (researchsquare.com)
- On the other hands, researches have been conducted to find molecular markers for predicting the development of treatment-induced acute or chronic toxicity before initiation of treatment (Venkatesh et al. (researchsquare.com)
- We have identified childhood cancer patient subpopulations who benefit from TDM treatment approaches with specific, commonly-used chemotherapeutics. (ncl.ac.uk)
- Therefore, new treatment options need to be developed for TNBC with low toxicity to healthy cells. (aiche.org)
- Treatment resistance for infectious diseases is growing quickly, and chemotherapeutic toxicity in cancer means that vaccines must be made right away to save humanity. (researchgate.net)
- Moreover, DNA damage is responsible for many of the toxicities incurred in treatment, including bone marrow suppression, hair loss, and gastrointestinal toxicites. (the-scientist.com)
- Although HFS and HFSR do not involve life-threatening toxicities, the syndromes have a significant impact on treatment schedules and quality of life in treated patients. (oncologynurseadvisor.com)
- Change from Baseline in the grade of toxicity secondary to cancer-treatment (if applicable) according to the CTCAE v5.0 scale. (who.int)
- Currently, chemotherapeutic drugs are widely used for the treatment of osteosarcoma. (bvsalud.org)
- By any metric, cancer is one trialize their innovation have led to chemotherapeutic treatment delivery of the most technocentric global dis- a global cancer research effort that schedules to reduce toxicity without ease domains. (who.int)
Patients5
- Variations in toxicity and response to therapy are observed among patients despite similar clinicopathologic characteristics which are attributed to single nucleotide polymorphisms (SNPs). (researchsquare.com)
- Serious neurological toxicity (including irreversible paraparesis and quadraparesis) has been reported in patients who received LEUSTATIN Injection by continuous infusion at high doses (4 to 9 times the recommended dose for Hairy Cell Leukemia). (nih.gov)
- Its occurrence is higher in elderly patients and in those receiving greater than 400 units total dose, but pulmonary toxicity has been observed in young patients and those treated with low doses. (nih.gov)
- 3 Of the cutaneous toxicities experienced by patients, hand-foot syndromes (HFS)-also known as palmar-plantar erythrodysesthesia, palmar-plantar erythema, acral erythema, and Burgdorf's reaction -are becoming among the most common. (oncologynurseadvisor.com)
- Not only can these toxicities severely affect patients' quality of life, but in some specific instances, they can be associated with increased response to therapy. (medscape.com)
Renal1
- azilsartan increases toxicity of lithium by decreasing renal clearance. (medscape.com)
Symptoms1
- Dosage and duration of calcium folinate rescue primarily depend on the type and dosage of methotrexate therapy, the occurrence of toxicity symptoms, and the individual excretion capacity for methotrexate. (janusinfo.se)
Dose-dependent1
- PIs could cause DTMA either by an immune mechanism or dose-dependent/cumulative toxicity. (hindawi.com)
Pathways1
- One of the major chemotherapeutic advances over the past decade has been the discovery and deployment of targeted therapies directed at cancer-specific molecules and signaling pathways. (ajmc.com)
Cumulative2
- Here, we report the first case of ixazomib-induced DTMA due to cumulative toxicity rather than immune-mediated mechanism. (hindawi.com)
- In this article, we discuss the precipitating factors for cumulative toxicity of ixazomib, resulting in DTMA, diagnostic workup, and management of DTMA. (hindawi.com)
Drug5
- In June 2010, after evidence accumulated showing no evidence of benefit and significant toxicity, the U.S. Food and Drug Administration (FDA) forced the company to withdraw it. (wikipedia.org)
- The initial basic science work with the drug showed good results, although there was a lot of concern regarding the potential for toxicity. (ophthalmologytimes.com)
- On hospital admission, toxicity from his chemotherapeutic regimen, in particular Ara-C, was raised as a potential etiology for the patient's altered mental status (AMS), but was considered unlikely since he had not been administered this drug in the past 2 weeks and had not had any prior episodes of AMS in association with this drug. (cdc.gov)
- To test the compounds, the researchers used amounts of chemotherapeutic that would not kill these multi-drug resistant cancers if the pumps were not blocked. (smu.edu)
- URACIL and the chemotherapeutic drug, 5-FLUOROURACIL. (bvsalud.org)
Drugs4
- It was defined as "the effect of herbs, other plants, or plant extracts on the activity, metabolism, or toxicity of drugs. (cancernetwork.com)
- 7. These and similar experiments on pneumococcus meningitis suggest that in chemotherapeutic investigations certain drugs may be injected into serous cavities in amounts exerting distinct bactericidal activity in vivo without producing local irritation or general toxic effects. (rupress.org)
- So it was incredibly gratifying that we were able to identify molecules that can inhibit that mechanism in the cancer cells, thereby bolstering the effectiveness of chemotherapeutic drugs. (smu.edu)
- Laboratory studies have demonstrated that many chemotherapeutic drugs are teratogenic (can interfere with the development of a fetus), often in more than one animal species. (cdc.gov)
Prevalent1
- The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Contrast1
- These examples are in contrast with examples of progress in chemotherapeutics. (hindawi.com)
Targets1
Agent1
- MMC is a chemotherapeutic agent that cross-links DNA and generates free radicals. (ophthalmologytimes.com)
Phase2
- Doxorubicin's maximum toxicity occurs during the S phase of cell cycle. (medscape.com)
- The investigational chemotherapeutic is currently in a Phase 1 clinical trial in humans at City of Hope. (independent.co.uk)
Cancer cells1
- Unfortunately, in the cancer cells that don't die, the chemotherapeutic often changes the cell, which then adapts to protect itself by aggressively multiplying the production of its defensive pumps. (smu.edu)
Major1
- Other major dose-related toxicities are myelosuppression, nausea, and vomiting. (globalrph.com)
Management1
- Since the early 1980's, management of PCP has become increasingly successful, and several effective chemotherapeutic regimens are available (1). (cdc.gov)
Reduce1
- In recent years, important advances have been made in understanding which patient subpopulations are athighest risk for developing PCP and in the design of chemotherapeutic regimens that can reduce the frequency of this illness. (cdc.gov)
Studies2
- Recent studies indicate that Pt NPs can be used as a therapy for cancer showing a limited toxicity to healthy cells. (aiche.org)
- See more studies on Chemotherapeutic and. (naturalnews.com)
Evidence1
- After a 10-year follow-up there has been no evidence of endothelial toxicity. (ophthalmologytimes.com)
Side effects1
- When toxicities are discussed, the owner should be given criteria by which to distinguish mild side effects from those that can be life threatening. (vin.com)