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  • tumour
  • The aim of this thesis was to develop PKPD models of anticancer drugs for tumour effects and haematological toxicity, which is the most frequent dose-limiting toxicity. (diva-portal.org)
  • The possibility to implant hollow fibres filled with tumour cells in immunocompetent rats was investigated for simultaneous assessment of PK, tumour response and haematological toxicity. (diva-portal.org)
  • 4 ] performed a meta-analysis of 13 trials (n = 9,528) considering several different toxicities, varying tumour types, stages of disease, and thresholds of NCI CTCAE classification and concluded that neutropenia or leukopenia experienced during chemotherapy was associated with improved survival. (biomedcentral.com)
  • dosage
  • Refractory secondary leukemia is more common when such drugs are given in combination with DNA-damaging antineoplastics, when patients have been heavily pretreated with cytotoxic drugs, or when epirubicin dosage has been escalated. (thefreedictionary.com)
  • survival
  • This study aims to investigate 13 common chemotherapy toxicities and their association with relapse-free survival and breast cancer-specific survival. (biomedcentral.com)
  • Cox proportional-hazards modelling was used to analyse the association between chemotherapy-related toxicities and both breast cancer-specific survival and relapse-free survival. (biomedcentral.com)
  • The largest study [ 3 ] (n = 750), showed that patients with grade 2 or 3 neutropenia, on the National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) scale, had a 10 % absolute survival advantage at 5 years compared to those with no neutropenia (multivariable P = 0.037). (biomedcentral.com)
  • Trial results showed that the two groups did not differ significantly regarding disease-free and overall survival, and had similar rates of toxicities. (ascopost.com)
  • Neutropenia
  • There were two toxicity-related deaths, one patient due to grade 4 febrile neutropenia and the other due to congestive heart failure. (hindawi.com)
  • occur
  • Myocardial toxicity, manifested in its most severe form by potentially fatal congestive heart failure (CHF), may occur either during therapy with epirubicin or months to years after termination of therapy. (nih.gov)
  • Cardiac toxicity, including fatal congestive heart failure (CHF), may occur either during therapy with Epilem RU or months to years after termination of therapy. (sdrugs.com)
  • Cardiac toxicity, including fatal congestive heart failure (CHF), may occur either during therapy or months to years after therapy ends. (thefreedictionary.com)
  • cancer
  • The team combined several important cancer-fighting components on the nanodiamond surface, including Epirubicin, a highly toxic but widely used chemotherapy drug that is often administered in combination with other cancer drugs. (scitechdaily.com)
  • rats
  • The developed hollow fibre model in immunocompetent rats was successfully applied to monitor PK, toxicity and the time course of antitumour effects. (diva-portal.org)
  • leukemia
  • Because of its toxicity, Epirubicin, when administered alone can cause serious side effects, such as heart failure and reduced white blood cell count, and it has been linked to an increased risk for leukemia. (scitechdaily.com)