Chemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
DisopyramideMexiletineAnti-Arrhythmia AgentsFlecainideProcainamideQuinidinePyridinesOrosomucoidParasympatholyticsTocainideCross CirculationLidocaineToxicity TestsEncyclopedias as TopicSodium ChannelsMyocardial Contraction
DigoxinDrug toxicityAmiodaroneNorpaceCardiacProcainamideAnticholinergicArrhythmiasConcomitantObstructiveAcuteAdditive effectsConcentrationsIntravenousMedicationsVentricularDrugsSymptomsReproductiveTheophyllineAllergicBeta-blockerLiverAntiarrhythmicIntervalRiskPatientsPatientPotentialCombinationReduceMain
Digoxin5
  • digoxin: serum levels of digoxin enhanced, leading to toxicity. (dalilaldwaa.com)
  • Chronic verapamil treatment can increase serum digoxin levels by 50% to 75% during the first week of therapy leading to digitalis toxicity. (canadian-rxpharmacy.com)
  • drug toxicity (digoxin, figure 4). (rjmatthewsmd.com)
  • J., effect of digoxin toxicity or outcome. (elastizell.com)
  • In this context, a regularly prescribed renally eliminated medication (e.g. digoxin, dabigatran or metformin) may need to be temporarily withheld or dose reduced in order to avoid high serum levels and toxicity. (aneskey.com)
Drug toxicity4
  • A thorough knowledge of this class of drugs is necessary for differentiating drug toxicity from primary disease. (medscape.com)
  • Serum drug concentrations are not likely to be helpful to the emergency physician treating a patient with acute antidysrhythmic drug toxicity, but concentrations of quinidine, lidocaine, and propafenone can be measured in the acute care setting. (medscape.com)
  • Persistent episodes may be caused by drug toxicity, low potassium levels, and lung disease. (rjmatthewsmd.com)
  • This may be due to underlying pathology, insensitivity of the pathogen or drug toxicity. (pillintrip.com)
Amiodarone3
  • goserelin increases toxicity of amiodarone by QTc interval. (medscape.com)
  • For example, when taken with antiarrhythmics, grapefruit pectin can cause increased plasma concentrations of amiodarone, quinidine and disopyramide. (nutrawiki.org)
  • Increased amiodarone concentrations in plasma can cause thyroid or pulmonary toxicity and liver injury among others, while increased quinidine and disopyramide can be cardiotoxic (toxic to the heart). (nutrawiki.org)
Norpace1
  • Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication used in the treatment of ventricular tachycardia. (wikipedia.org)
Cardiac4
  • Antidysrhythmics alter the propagation and mechanisms of cardiac rhythms, making toxicity from these agents highly lethal. (medscape.com)
  • Additionally, the patients receiving these drugs may have a lower dysrhythmic threshold resulting from underlying cardiac conditions as well as other comorbidities, making them more suscpetible to toxicity. (medscape.com)
  • Disopyramide depresses the increase in sodium permeability of the cardiac myocyte during Phase 0 of the cardiac action potential, in turn decreasing the inward sodium current. (wikipedia.org)
  • Cardiac toxicity / convulsions. (southsudanmedicaljournal.com)
Procainamide1
  • Concomitant treatment with quinidine, disopyramide, procainamide, phenothiazines, antihistamines, monoamine oxidase inhibitors and tricyclic antidepressants can prolong the QTc-interval and increase the risk of ventricular arrhythmias. (oushodsheba.com)
Anticholinergic2
  • Disopyramide also has an anticholinergic effect on the heart which accounts for many adverse side effects. (wikipedia.org)
  • The anticholinergic effect of drugs such as tri- and tetracyclic antidepressants, antihistamines, quinidine, amantadine, antipsychotics (e.g. butyrophenones, phenothiazines), disopyramide and other anticholinergics (e.g. tiotropium, ipratropium, atropine-like compounds) may be intensified by Buscopan. (janusinfo.se)
Arrhythmias2
Concomitant1
  • In case of theophylline toxicity and/or elevated serum theophylline levels, the dose of theophylline should be reduced while the patient is receiving concomitant erythromycin therapy.There have been published reports suggesting that when oral erythromycin is given concurrently with theophylline there is significant decrease in erythromycin serum concentrations. (drugcentral.org)
Obstructive3
  • Disopyramide administration for obstructive HCM has a IB recommendation in the 2020 American Heart Association/American College of Cardiology Foundation guidelines for treatment of obstructive HCM. (wikipedia.org)
  • This combination increases acceptance of higher disopyramide dosing, important since there is a dose-response correlation in obstructive HCM, higher doses yielding lower gradients. (wikipedia.org)
  • Although dual-chamber pacing has been used with caution in diabetes mellitus, hypothyroidism, nephrotic syndrome, hus miscellaneous agents allopurinol ain cimetidine ain, decreased creatinine secretion disopyramide obstructive uropathy from renal insufficiency, hypokalemia requiring simulta-neous potassium supplementation, and nutrition. (elastizell.com)
Acute1
  • The first and most important diagnostic tool in acute antidysrhythmic toxicity is electrocardiography. (medscape.com)
Additive effects1
  • disopyramide) may have additive effects when used in combination. (madinamerica.com)
Concentrations1
  • conversely, food or one of its components may affect bioavailability and half-life, circulating plasma concentrations of drugs resulting in an increased risk of toxicity and its adverse effects, or therapeutic failure. (mdpi.com)
Intravenous1
  • Disopyramide is available in both oral and intravenous forms, and has a low degree of toxicity. (wikipedia.org)
Medications1
  • The American Family Physician (AFP) states that grapefruit, in general, can increase the risk of toxicity and adverse effects of many medications. (nutrawiki.org)
Ventricular3
  • Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. (wikipedia.org)
  • Disopyramide does not act as a blocking agent for beta or alpha adrenergic receptors, but does have a significant negative inotropic effect on the ventricular myocardium. (wikipedia.org)
  • Disopyramide is used for preventing and restoring atrial and ventricular extrasystole and tachycardia in order to prevent atrial flutter and arrhythmia. (chemicalbook.com)
Drugs1
  • Tofranil may elevate a patient's risk for serotonin toxicity, especially if the patient is also taking other drugs that raise serotonin levels, including ecstasy, St. John's wort, or certain other antidepressants. (prostate.net)
Symptoms4
  • Many investigators and clinicians believe that disopyramide controlled release is the most potent agent available for reducing resting pressure gradients and improving symptoms. (wikipedia.org)
  • When used in patients resistant to beta-blockade, disopyramide is effective in 60% of cases, reducing symptoms and gradient to the extent that invasive procedures such as surgical septal myectomy are not required. (wikipedia.org)
  • Patients should be monitored for clinical symptoms of colchicine toxicity (See WARNINGS).Erythromycin has been reported to increase the systemic exposure (AUC) of sildenafil. (drugcentral.org)
  • Adverse reactions include poor appetite, abnormal fatigue or weakness, nausea or vomiting (prodromal symptoms of liver toxicity) and dark urine, yellow eyes or skin (liver toxicity). (hongqipharma.com)
Reproductive1
  • Animal studies are insufficient with respect to reproductive toxicity (see section 5.3). (janusinfo.se)
Theophylline1
  • Do not administer erythromycin with lovastatin or simvastatin (See CONTRAINDICATIONS).Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase of serum theophylline levels and potential theophylline toxicity. (drugcentral.org)
Allergic1
  • Special emphasis is done to discuss recommendations to cope with undesirable events that may arise during anesthesia (vasovagal syncope, anesthetic toxicity, anaphylactic and allergic reactions). (intechopen.com)
Beta-blocker1
  • See also Beta-Blocker Toxicity and Calcium Channel Blocker Toxicity , as those topics are not covered in this article. (medscape.com)
Liver1
  • 2. Liver toxicity is the main adverse reaction of this product. (hongqipharma.com)
Antiarrhythmic1
  • showed that pyridostigmine used in combination with disopyramide substantially alleviates vagolytic side effects without compromising antiarrhythmic efficacy. (wikipedia.org)
Interval1
  • Disopyramide prolongs the PR interval by lengthening both the QRS and P wave duration. (wikipedia.org)
Risk1
  • Coadministration of alpelisib (BCRP substrate) with a BCRP inhibitor may increase alpelisib concentration, which may increase the risk of toxicities. (medscape.com)
Patients1
  • 4. Nervous system toxicity: Peripheral neuritis is more common in patients with slow acetylation, and it is obviously related to the dose. (hongqipharma.com)
Patient1
  • Some clinicians prescribe pyridostigmine sustained release (marketed in the US as Mestinon Timespan) to every patient begun on disopyramide. (wikipedia.org)
Potential1
  • Another concern about disopyramide has been the hypothetical potential for inducing sudden death from its type 1 anti-arrhythmic effects. (wikipedia.org)
Combination1
  • Animal studies using beclometasone dipropionate and formoterol combination showed evidence of toxicity to reproduction after high systemic exposure. (oushodsheba.com)
Reduce1
Main1
  • Disopyramide, despite its efficacy, has one main side effect that has limited its use in the US, though it has seen wider application in Canada, UK and Japan. (wikipedia.org)