• Information on benzo(a)pyrene (BaP), an indicator species for polycyclic aromatic hydrocarbons (PAHs), for use in responding to chemical incidents. (www.gov.uk)
  • Also relative to human AHR, the Neandertal AHR exhibited 150-1000 times greater sensitivity to induction of Cyp1a1 and Cyp1b1 expression by PAHs (e.g. benzo(a)pyrene). (oregonstate.edu)
  • Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. (biomedcentral.com)
  • Selected compounds included nitrated polycyclic aromatic hydrocarbons (nitro-PAHs), the PAHs retene and benzo[a]pyrene, and the pharmaceuticals acetaminophen and flutamide. (oregonstate.edu)
  • Among the PAHs in the inks is benzo(a)pyrene, a compound identified in an Environmental Protection Agency toxicity report as "among the most potent and well-documented skin carcinogens. (infinityhealthwellness.com)
  • The diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene is a potent mutagen and possibly the ultimate carcinogenic form of benzo(a)pyrene. (lookformedical.com)
  • However, soil tests conducted this past summer proved the material in Pawtucket and the dirt shipped to Plainfield Pike contained toxins, including two times the acceptable levels of carcinogenic aromatic hydrocarbons and four times the acceptable levels of benzo(a)pyrene, another carcinogen. (ecori.org)
  • We previously demonstrated that co-exposing pre-steatotic hepatocytes to benzo[a]pyrene (B[a]P), a carcinogenic environmental pollutant, and ethanol, favored cell death. (lih.lu)
  • There are few examples of algae degrading aromatic compounds [ 5 , 6 ] examined the effects of the chlorophyte alga, Selenstrum capriconutum , on benzo pyrene. (omicsonline.org)
  • Additionally, the AOS eliminated biomarker responses of municipal wastewater that has been experimentally contaminated (spiked) with compounds (benzo[a]pyrene and 17β-estradiol) known to negatively affect those organisms. (waterworld.com)
  • Uses, beyond tissue-specific cell ablation, are possible for the hepatocyte-specific zebrafish line, including investigations of the role of nitroreductase in the toxicity of nitrated compounds. (oregonstate.edu)
  • Test compounds were selected based on: their ability to undergo nitroreduction, known importance of hepatic metabolism to toxicity, and known pharmaceutical hepatotoxins. (oregonstate.edu)
  • The results suggest a range of potential roles of the liver in the toxicity of these compounds, and highlight the additional uses of this transgenic model in toxicity testing. (oregonstate.edu)
  • Previous tests with model toxic compounds (copper and benzo[a]pyrene) were done, and catalase (CAT), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PDH) and glutathione-S-transferase (GST) responded, being considered potential biomarkers of contamination in tadpoles. (unesp.br)
  • Although the potential toxicity of most of these undesirable compounds is real, poisoning risks are rather limited due to the efficient elimination during oil-refining steps, careful conditioning, choice of efficient packaging and industrial quality control management. (ocl-journal.org)
  • Genotoxicity of the compounds was determined using the comet assay, and toxicity determined via the cell viability assay. (cdc.gov)
  • Lentinan inhibits oxidative stress and inflammatory cytokine production induced by benzo(a)pyrene in human keratinocytes. (greenmedinfo.com)
  • Optical spectral repetitive scan analysis during the oxidative metabolism of benzo(a)pyrene by liver microsomal suspensions reveals the time-dependent formation of an intermediate(s) of which the visible spectra resemble those of several benzo(a)pyrene phenols. (lookformedical.com)
  • Meanwhile, production of oxidative stress and altered expression of mrp1 and cyp1a could be important components of such joint toxicity . (zju.edu.cn)
  • These documents provide information on the health effects of exposure, the chemical's toxicity and material for responding to a chemical incident. (www.gov.uk)
  • Co-Exposure of Phenanthrene and the cyp-Inducer 3-Methylchrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae. (uib.no)
  • Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. (oregonstate.edu)
  • Exposure to benzo[a]pyrene during development resulted in transgenerational inheritance of neurobehavioral and physiological deficiencies. (oregonstate.edu)
  • However, more definitive studies regarding specific pathways that are involved with nanoparticle internalization, inflammatory responses and toxicity are warranted before proper guidelines regarding nanoparticle exposure are established. (cdc.gov)
  • This approach included new exposure land uses for public open space, suggested modifications to the exposure parameters, and set the toxicity value at low risk rather than the minimal risk adopted in the derivation of other GACs. (envchemgroup.com)
  • To obtain the S4UL, the CLEA model is used to estimate the average daily exposure from benzo[a]pyrene in soil, which is equivalent to its toxicity value. (envchemgroup.com)
  • This CSEM focuses on the toxicity of polycyclic aromatic hydrocarbons. (cdc.gov)
  • Take the Initial Check to assess your current knowledge about the toxicity of polycyclic aromatic hydrocarbons. (cdc.gov)
  • These results are indicative of a region-specific attack on the carcinogen by the cell monooxygenases which is distinct from the liver attack of microsomal enzymes on benzo(a)pyrene. (lookformedical.com)
  • For example, benzo[a]pyrene is a proven human carcinogen and is classed as a non-threshold contaminant. (envchemgroup.com)
  • The effect of inhibitors on the spectrophotometric assay correlates well with the results obtained from benzo(a)pyrene metabolite analysis using high-pressure liquid chromatography. (lookformedical.com)
  • Differences in benzo(a)pyrene metabolite pattern have been shown by rodent liver microsomes (Sprague-Dawley) and rodent embryo cells from Syrian hamsters and NIH Swiss mice. (lookformedical.com)
  • During the acute toxicity test tadpoles showed. (unesp.br)
  • This study succeeded on both fronts, demonstrating that water treated by the AOS technology was non-toxic to certain aquatic organisms typically used for testing whole effluent toxicity for the EPA's National Pollutant Discharge Elimination System (NPDES) Permits Program, such as Daphnia and rainbow trout, as well as zebrafish embryos. (waterworld.com)
  • Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing. (oregonstate.edu)
  • The resulting CYP1A1/CYP1B1 enzymes are responsible for PAH first pass metabolism, which can result in the generation of toxic intermediates and perhaps AHR-associated toxicities. (oregonstate.edu)
  • An epoxide hydrase inhibitor, 1,1,1-trichloropropene-2,3-oxide, enhanced phenol formation regardless of the source of liver microsomes, and 7,8-benzoflavone inhibited control and 3-methylcholanthrene-induced microsomal metabolism of benzo(a)pyrene, 7,8-Benzoflavone did not effect benzo(a)pyrene metabolism by liver microsomes from phenobarbital-pretreated rats. (lookformedical.com)
  • Differences in benzo(a)pyrene metabolism between rodent liver microsomes and embryonic cells. (lookformedical.com)
  • Benzo(a)anthracene (PubChem CID: 5954) vegetable oils and examined the identity through the fatty acids profiles. (bvsalud.org)
  • For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). (cdc.gov)
  • Chrysene is estimated to have about 1% of the toxicity of benzo(a)pyrene. (wikipedia.org)
  • Interindividual UGT variability likely plays an important role in drug efficacy and xenobiotic toxicity, as well as in hormonal regulation and certain diseases, which in some cases may be amenable to therapeutic manipulations including gene therapy. (aspetjournals.org)
  • Several of these fungal polysaccharides have been averaged over all other psychiatric morbidity these should be reported to reduce the genotoxic effect of cyclophosphamide-induced toxicity by withania somnifera on benzo a pyrene-dna adduct nair et al. (familytreecounseling.com)
  • The goal of this research is to study the effect of benzo-alpha-pyrene (BαP) as a pollutant on the plasma levels of cortisol, thyroxin (T4), and triiodothyronine (T3) hormones, and the T3/T4 ratio in the yellowfin sea bream, Acanthopagrus latus. (ac.ir)
  • Benzo[a]pyrene (B[a]P), one typical environmental pollutant, the toxicity mechanisms, and potential prevention remain perplexing. (bvsalud.org)
  • Target tissues for carcinogenicity in mice exposed to benzo[a]pyrene via the diet were the forestomach, oesophagus and tongue. (europa.eu)
  • Coconut, safflower, evening primrose, Benzo(b)fluoranthene (PubChem CID: 9153) and linseed oils marketed in São Paulo (Brazil) were investigated totaling 69 samples. (bvsalud.org)
  • It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. (cdc.gov)
  • In a preclinical study published in the journal Frontiers in Pharmacology , researchers from the USA investigated the potential chemopreventive effects of a mushroom - Ganoderma lucidum (GL)-derived commercial product named GLSF in vitro and in mice with lung carcinogenesis induced by two tobacco smoke carcinogens, namely benzo[a]pyrene (B[a]P) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). (news-medical.net)
  • Whereas there remains much to learn about the potential biological relevance of UGTs, deficient glucuronidation can result in either elevated tissue concentrations and direct toxicity of substrates, as with the endobiotic bilirubin, or, alternatively, enhanced bioactivation of substrates to toxic reactive intermediates, as in the case of acetaminophen and benzo[ a ]pyrene. (aspetjournals.org)
  • The hepatic nuclear fraction isolated from 3-methylcholanthrene (MC)-treated rats contained enhanced levels of cytochrome P-450 and aryl hydrocarbon hydroxylase [benzo(a)pyrene (BP) monooxygenase], whereas the activities of epoxide hydrase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and the concentration of cytochrome b5 were not altered. (lookformedical.com)
  • Benzo[a]pyrene (B[a]P) is a well-known genotoxic polycylic aromatic compound whose toxicity is dependent on signaling via the aryl hydrocarbon receptor (AHR). (oregonstate.edu)
  • However, pretreating the mice with GLSF was found to reduce B[a]P-induced lung toxicity (with an efficacy comparable to curcumin), as demonstrated by the improved histology of the harvested lung tissue samples, as well as lower LDH activity, malondialdehyde levels, and inflammatory cell infiltration in them. (news-medical.net)
  • Our multi-specifics antibodies show in vivo efficacy while sustaining a good toxicity profile as in comparison with T cell engagers. (ehd.org)
  • The direct spectrophotometric observation of benzo(a)pyrene phenol formation by liver microsomes. (lookformedical.com)
  • Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA. (lookformedical.com)
  • Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[a]pyrene and ethynylestradiol: insights into anti-estrogenic effects. (uib.no)
  • Photo-enhanced toxicity of crude oil on early developmental stages of Atlantic cod (Gadus morhua). (uib.no)
  • Lastly, these supports were also found to be significantly cytotoxic to macrophages, and research is ongoing to determine if the mechanism of silver nanoparticle toxicity is similar to bacteria. (cdc.gov)
  • They found that mice treated with GLSF had lower B[a]P-induced lung toxicity and reduced NNK-induced lung tumor development. (news-medical.net)
  • Benzo[a]pyrene ( BaP ) acts as an indicator species for PAH contamination. (www.gov.uk)
  • A comparison of two methods for fractionating complex mixtures in preparation for toxicity analysis. (tamu.edu)
  • These results suggest that activation and detoxification of benzo(a)pyrene may be species and tissue variable, and susceptibility and resistence to malignant transformation may be predicted on induction of a fortuitous combination of intermediate metabolic steps. (lookformedical.com)
  • It was found that the concentration of oil in the soil of 200 g/kg and above has a toxic effect on microorganisms: the toxicity index was 38 units, the decomposition rate of benzo [a] pyrene significantly decreases. (rudn.ru)
  • In a subacute toxicity test, following B[a]P treatment, mice showed a dose-dependent slowdown in body weight gain and abnormalities in behavioral and cognitive function and which were alleviated by ASP co-treatment. (bvsalud.org)
  • Virtually safe' dermal dose of benzo[a]pyrene, related to a risk level of 10E-5 (human). (europa.eu)
  • Toxicity assessment of urban marine sediments from Western Norway using a battery of stress-activated receptors and cell-based bioassays from fish. (uib.no)
  • The lung toxicity was measured using lactate dehydrogenase (LDH) activity assay, lipid hydroperoxide (LPO) assay, histology, and immunohistology analysis. (news-medical.net)
  • The neutral and A1 fractions contained the highest levels of tPAHs and benzo[a]pyrene (BaP) but failed to induce a positive response in the Salmonella/microsome assay with concentrations containing as much as 1800 and 2500 ng BaP/plate, respectively. (tamu.edu)
  • Taking 24 hpf death and 48 hpf cardiac edema as endpoints, the toxicities of CdSO 4 and ANF were significantly enhanced by each other. (zju.edu.cn)
  • It is possible that this compound carries a high toxicity for these organisms, since the fipronil can be incorporated into aquatic environments during the rainy season, coinciding with the time of amphibian's reproduction and occurrence of tadpoles in aquatic environment in our region. (unesp.br)
  • Prevalence of impared lung function in rubber manufacturing factory employees uncovered to benzo(a)pyrene and respirable particulate matter. (ehd.org)
  • Transcriptome responses in copepods Calanus finmarchicus, Calanus glacialis and Calanus hyperboreus exposed to phenanthrene and benzo[a]pyrene. (uib.no)
  • This communication sought to further investigate nanoparticle/cell interactions, ensuing toxicity and cellular responses within biological systems. (cdc.gov)
  • Here, the intracellular mechanisms underlying this toxicity were studied. (lih.lu)
  • The findings provide scientific evidence for further study on the organ toxicity and mechanisms of B[a]P. (bvsalud.org)
  • This study aimed to test the acute toxicity of Regent®800WG in tadpoles at different stages of development in order to establish the LC50 (96h) for these organisms as well as the effect of sub lethal concentrations on the development and on some biochemical system on tadpoles, such as antioxidant defense systems, esterase activity and lipid peroxidation. (unesp.br)
  • However the research of contaminants is part of multiple controls conducted by fat and oil industry to verify the conformity of products placed on the market in relation to regulations such as the European commission regulation EC No. 1881/2006 setting maximum levels for some contaminants in food as lead, some mycotoxins, dioxins, polychlorobiphenyls, benzo[a]pyrene. (ocl-journal.org)
  • In the absence of regulation, the detection of contaminants must be addressed in partnership with authorities according to the toxicity of molecules. (ocl-journal.org)
  • The limit of detection ranged from 15 to 96 ng for benzoa]pyrene and indeno1,2,3-cd]pyrene, respectively. (who.int)
  • The yeast Saccharomyces cerevisiae are convenient eukaryotic model to determining the toxicity of various pollutants, including heavy metals. (rudn.ru)
  • the terms used were postnatal development, toxicity, rodents and physical and reflexological parameters. (bvsalud.org)
  • Fire toxicity of insulation materials plays a pivotal role in fire safety as they are one of the most prevalent materials within a modern house. (backtoearth.co.uk)
  • Built a series of toxicity of heavy metal salts with respect to the test functions of S. cerevisiae basically coincided. (rudn.ru)
  • Further, oxidant-induced toxicity in the normal population may facilitate the clonal expansion of the more resistant initiated cell during promotion 2,5,29 . (bvsalud.org)
  • In 2017 the EPA published updated toxicity values for one type of prevalent petroleum contaminant, benzo[a]pyrene (BaP), in its IRIS database (Integrated Risk Information System). (nwtoxiccommunities.org)
  • Additional pattern changes were found in mouse and hamster embryo secondary cultures with a reduction of the K-region metabolites and a marked increase in 9-hydroxybenzo(a)-pyrene. (lookformedical.com)
  • GoLocalProv recently reported that RIDOT director Peter Alviti downplayed the toxicity of the material during a Sept. 10 radio interview. (ecori.org)
  • When 3-hydroxybenzo(a)pyrene was used as a standard for comparison of activity, the rates of formation of phenols were compared when measured by fluorometric, spectrophotometric, or high-pressure liquid chromatographic analytical techniques. (lookformedical.com)
  • This report presents key data and expert opinions on the toxicity and intake of Benzo a pyrene (BaP). (eugris.info)