It inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. (nih.gov)
Benzoic3
The chemical name for probenecid is 4-[(dipropylamino) sulfony1] benzoic acid. (nih.gov)
Probenecid is the generic name for 4-[(dipropyl-amino)sulfonyl] benzoic acid. (nih.gov)
Probenecid is uricosuric and renal tubular transport blocking agent.Probenecid is the generic name for 4-[(dipropyl-amino)sulfonyl] benzoic acid. (drugcentral.org)
Toxic1
There is a close line between the plasma concentrations of the therapeutic and toxic effect, therefore a high risk for toxicity. (wikipedia.org)
Function2
Measurable changes in proximal tubule function, such as decreased clearance of para-aminohippuric acid also occur over a period of years and precede overt kidney failure. (testcatalog.org)
Because the suggestions for drug screening process in antineoplastic remedies need evaluation of individual tumors xenotransplanted into immune-compromised 4-Aminohippuric Acid mice (5), the function from the immune system continues to be neglected (6), producing studies centered on the interplay between disease fighting capability and dying cells required. (treatmentforprostatecancer.info)
Years1
Hypersensitivity to probenecid.Children under years of age.Not recommended in persons with known blood dyscrasias or uric acid kidney stones.Therapy with probenecid should not be started until an acute gouty attack has subsided. (drugcentral.org)
Therapeutic1
There is a close line between the plasma concentrations of the therapeutic and toxic effect, therefore a high risk for toxicity. (wikipedia.org)
Amino3
DCVC, in contrast, was not transported by the organic anion system, but may be transported by one or more amino acid systems. (nih.gov)
Cyclosporine, the active principle in Cyclosporine Capsules USP MODIFIED, is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. (nih.gov)
Probenecid is uricosuric and renal tubular transport blocking agent.Probenecid is the generic name for 4-[(dipropyl-amino)sulfonyl] benzoic acid. (drugcentral.org)
Urine1
Alkalization of the urine is recommended until the serum urate level returns to normal limits and tophaceous deposits disappear, i.e., during the period when urinary excretion of uric acid is at high level. (drugcentral.org)
Renal3
N-acetyl S-(1,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-L-cysteine in rabbit renal slices: differential transport and metabolism. (nih.gov)
Renal cortical slices were used to determine the toxicity of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine (N-acetyl-DCVC) as well as to investigate the transport and metabolism of S-(1,2-dichlorovinyl)-L-cysteine (DCVC) and the N-acetyl derivative. (nih.gov)
2-fold to 4-fold elevation has been demonstrated for various penicillins.Probenecid has also been reported to inhibit the renal transport of many other compounds including aminohippuric acid (PAH), aminosalicylic acid (PAS), indomethacin, sodium iodomethamate and related iodinated organic acids, 17-ketosteroids, pantothenic acid, phenolsulfonphthalein (PSP), sulfonamides, and sulfonylureas. (drugcentral.org)
Probenecid3
N-Acetyl-DCVC was shown to be transported via the organic anion system by its ability to inhibit PAH transport by the cells and the ability of probenecid to decrease uptake (80%) and toxicity of N-acetyl-DCVC. (nih.gov)
Both the uptake inhibitor, probenecid, and aminooxyacetic acid (AOAA), a beta-lyase inhibitor, decreased the covalent binding from N-acetyl [35S]DCVC (80 and 50%, respectively), but only AOAA inhibited the covalent binding of DCVC. (nih.gov)
Hypersensitivity to probenecid.Children under years of age.Not recommended in persons with known blood dyscrasias or uric acid kidney stones.Therapy with probenecid should not be started until an acute gouty attack has subsided. (drugcentral.org)
High1
Cyclosporine blood concentrations should be monitored in transplant and rheumatoid arthritis patients taking Cyclosporine Capsules USP MODIFIED to avoid toxicity due to high concentrations. (nih.gov)
Arthritis1
However, if necessary, the daily dosage may be increased by 500 mg increments every weeks within tolerance (and usually not above 2000 mg per day) if symptoms of gouty arthritis are not controlled or the 24 hour uric acid excretion is not above 700 mg. (drugcentral.org)
Structural1
It is a structural analogue of the neurotransmitter γ-aminobutyric acid (GABA). (drugbank.com)
Transport1
These disparate transport mechanisms bear profound ramifications for toxicity. (bvsalud.org)