Pulmonary toxicityReactionsHepatotoxicityHepatic toxicityThreshold for toxicityPredictiveHypersensitivityPredict toxicityBone marrowReactionPredictionPharmacologicalPatientsClinicallyTissueTherapeuticUnpredictableKavaOccursInstancesEfficacyClinicalMechanismDrugsSymptomsAssaysFactorsRisksMedicationsEnvironmentalDoseInjuryPotentialReportsDirectHighlyCasesActivityAnimal
Pulmonary toxicity9
- More than 600 drugs are known to cause pulmonary toxicity, and illicit drugs are well-known to result in pulmonary toxicities. (medscape.com)
- A list of drugs that are reported to cause pulmonary toxicity is available on the continually updated Website PNEUMOTOX online . (medscape.com)
- Drug-induced pulmonary toxicity is a diagnosis of exclusion. (medscape.com)
- The diagnosis of drug-mediated pulmonary toxicity is usually established based on clinical findings. (medscape.com)
- Radiologic patterns observed in drug-induced pulmonary toxicity are highly variable and depend on the type of adverse reaction the patient is experiencing. (medscape.com)
- If the drug-induced pulmonary toxicity causes airway obstruction, then the FEV 1 /FVC ratio and FEV 1 will be reduced. (medscape.com)
- In general, bronchoscopy with transbronchial biopsy is not helpful in establishing the diagnosis of drug-induced pulmonary toxicity. (medscape.com)
- We aimed to assess disease control and pulmonary toxicity in patients who previously received radiotherapy for non-small-cell lung cancer (NSCLC) before receiving pembrolizumab. (scienceopen.com)
- Combination with bleomycin or vinca alkaloids may reinforce pulmonary toxicity. (ikrispharmanetwork.com)
Reactions7
- Adverse drug reactions are classified as type A (intrinsic or pharmacological) or type B (idiosyncratic). (wikipedia.org)
- Both dose-dependent and idiosyncratic reactions have been documented. (wikipedia.org)
- Recent advances in pharmacogenomic research have begun to elucidate the inherited nature of interindividual differences in drug-induced adverse reactions, toxicity, and therapeutic responses. (medscape.com)
- Idiosyncratic drug reactions occur rarely and unpredictably amongst drug users. (helsinki.fi)
- Inflammation and liver damage can sensitize to idiosyncratic drug reactions. (helsinki.fi)
- The latter can develop form a number of different reaction types, namely direct toxicity, idiosyncratic reactions, pharmacological reactions and metabolic reactions. (vin.com)
- Rare, idiosyncratic reactions may deter patients from getting an otherwise useful drug, especially when the population at risk cannot be accurately defined. (veracuity.com)
Hepatotoxicity5
- Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. (wikipedia.org)
- Hepatotoxicity and drug-induced liver injury also account for a substantial number of compound failures, highlighting the need for toxicity prediction models (e.g. (wikipedia.org)
- Drugs or toxins that have a pharmacological (type A) hepatotoxicity are those that have predictable dose-response curves (higher concentrations cause more liver damage) and well characterized mechanisms of toxicity, such as directly damaging liver tissue or blocking a metabolic process. (wikipedia.org)
- Idiosyncratic (type B) injury occurs without warning, when agents cause non-predictable hepatotoxicity in susceptible individuals, which is not related to dose and has a variable latency period. (wikipedia.org)
- Caution should be used if [NT005 trade name] is given to patients with liver disease, since albendazole is metabolised by the liver and has been associated with idiosyncratic hepatotoxicity. (who.int)
Hepatic toxicity1
- Tolvaptan treatment must be initiated and monitored under the supervision of physicians with expertise in managing ADPKD and a full understanding of the risks of tolvaptan therapy including hepatic toxicity and monitoring requirements (see section 4.4). (medicines.org.uk)
Threshold for toxicity2
- As in the case of paracetamol overdose, this type of injury occurs shortly after some threshold for toxicity is reached. (wikipedia.org)
- They don't meet the threshold for toxicity. (btsspark.org)
Predictive1
- He has chaired several international symposia in predictive toxicology, idiosyncratic drug toxicity and DMPK. (selectbiosciences.com)
Hypersensitivity3
- Idiosyncratic drug reaction denotes a non-immunological hypersensitivity to a substance unrelated to drug toxicity. (helsinki.fi)
- Idiosyncratic drug hypersensitivity phenomenon is a recent hypothesis which correlates best with the available facts at this moment. (scienceopen.com)
- Mitomycin should not be used in patients who have an idiosyncratic reaction or demonstrated hypersensitivity. (ikrispharmanetwork.com)
Predict toxicity2
- The application of this knowledge will ultimately help individualize drug dosing and drug therapy selection, predict toxicity or therapeutic failure, and improve clinical outcomes. (medscape.com)
- On this page you will find links to comprehensive gene information for five species and a listing of NCTR publications on understanding the mechanism of mitochondrial toxicity and development of biomarkers to predict toxicity. (fda.gov)
Bone marrow2
- Patients who ingest this mushroom - often mistaking it for another - mostly perish within a few days from complications involving skin tissue, bone marrow, and blood toxicity. (saturdayeveningpost.com)
- Case reports have described direct bone marrow toxicity causing granulomas and aplastic anemia [ 5 - 11 ]. (journalmc.org)
Reaction4
- Type A drug reaction accounts for 80% of all toxicities. (wikipedia.org)
- The exact mechanism is not well known, but it is most likely involves an idiosyncratic drug-induced liver injury or immune-allergic reaction [ 22 ]. (e-jcpp.org)
- There is also a particular idiosyncratic reaction for NSAIDs which has received a great deal of press. (vin.com)
- This particular idiosyncratic reaction is a liver toxicity which is so rare that it did not show up in any of the initial 400 test subjects, nor in the U.K. use of the carprofen and was not recognized until carprofen was used in over a million dogs in the U.S. after its release as the first NSAID. (vin.com)
Prediction2
- Additionally, NCTR scientists have developed MitoChips for human and non-human primates for better prediction of toxicity, in addition to our findings in rodents. (fda.gov)
- For one thing, "drug design" is a catchall phrase that can include everything from basic protein-ligand structure prediction to toxicity prediction, with the latter being at the challenging end of the spectrum. (fieldofscience.com)
Pharmacological1
- Other pharmacological agents producing sedation (sedatives and agents used off-label for sedative side-effects) should be used cautiously for the treatment of insomnia due to the increased risk of next day sleepiness as well as for known toxicities and adverse side effects. (springer.com)
Patients4
- Patients who develop drug toxicity should be advised to avoid the drug in the future. (medscape.com)
- Patients taking mitomycin must be observed for the evidence of renal toxicity. (ikrispharmanetwork.com)
- In the early 2000s, there were reports of cases where patients that experienced liver toxicity had consumed kava, along with other potential supplements. (coralseakava.com)
- Hypnotic medications with low toxicity, addictive potential, minimal next day sleepiness, and an otherwise benign side-effect profile can be utilized safely and effectively to treat and improve function and quality of life for patients suffering from insomnia. (springer.com)
Clinically2
- Warfarin therapy is associated with rare instances of idiosyncratic, clinically apparent liver injury that are usually mild and rapidly reversible on stopping. (nih.gov)
- Clinically meaningful liver toxicity is extremely rare [ 16 ]. (e-jcpp.org)
Tissue1
- Also, due to its long half-life, lipophilicity, and broad tissue distribution, it can cause a wide range of toxicities. (journalmc.org)
Therapeutic1
- With increasing pharmacogenetic evidence, interindividual differences in drug-related toxicity and therapeutic response are no longer idiosyncratic. (medscape.com)
Unpredictable1
- This review will first provide clues for clinicians to suspect idiosyncratic (unpredictable) DILI and succeed in diagnosis. (wjgnet.com)
Kava1
- The herb kava has caused a number of cases of idiosyncratic liver injury, ranging everywhere from asymptomatic to fatal. (wikipedia.org)
Occurs2
- Pharmacogenomics is a powerful tool that can reveal some of these vulnerabilities before toxicity occurs or, if performed after the fact, can explain the cause of an adverse drug event that has already happened. (veracuity.com)
- A higher dose increases the risk of liver function deterioration, and it is known that statin-induced liver toxicity usually occurs in the first year of statin use [ 21 ]. (e-jcpp.org)
Instances1
- Although skin has been the major site of radiation recall toxicity, instances involving other organ have been reported. (scienceopen.com)
Efficacy1
- Individuals with aberrant genes for these enzymes may experience diminished efficacy or increased toxicity in response to certain drugs because of the different levels of activities associated with variant genotypes. (medscape.com)
Clinical2
- Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial. (scienceopen.com)
- As the cost of genomic testing decreases, routine screening for genes responsible for drug toxicity should become a routine part of clinical practice. (veracuity.com)
Mechanism4
- PIs could cause DTMA either by an immune mechanism or dose-dependent/cumulative toxicity. (hindawi.com)
- Here, we report the first case of ixazomib-induced DTMA due to cumulative toxicity rather than immune-mediated mechanism. (hindawi.com)
- Common anticancer chemotherapeutic agents causing drug-induced thrombotic microangiopathy via immune-mediated mechanism or dose-dependent toxicity or both [ 4 , 7 ]. (hindawi.com)
- NCTR has published several papers illustrating the mechanism of mitochondrial toxicity in response to different drugs in the mouse and rat. (fda.gov)
Drugs3
- In addition, physiological dynamics impact the pharmacokinetics and toxicity of drugs due to circadian changes in drug metabolism, affecting our ability to formulate efficient pharmaceutical interventions or properly assess drug toxicity (i.e. (europa.eu)
- Mitochondrial dysfunction has been implicated in the toxicities of certain diseases and many drugs. (fda.gov)
- Drugs that produce chronic toxicity, such as antiretrovirals and antipsychotics, are manageable by regular monitoring drug levels in the blood. (veracuity.com)
Symptoms1
- The appearance of this Japanese mushroom is playful and, perhaps, inviting, but the Podostroma cornu-damae is a highly toxic species that causes brutal and idiosyncratic symptoms. (saturdayeveningpost.com)
Assays1
- DTI), and drug screening assays, such as stem cell-derived hepatocyte-like cells, that are capable of detecting toxicity early in the drug development process. (wikipedia.org)
Factors1
- In this article, we discuss the precipitating factors for cumulative toxicity of ixazomib, resulting in DTMA, diagnostic workup, and management of DTMA. (hindawi.com)
Risks2
- New research reveals full risks of MDMA use - higher strength tablets, idiosyncratic toxicity, different strength within the same batch and varying rates of release. (russellwebster.com)
- These combined risks - higher strength MDMA tablets, idiosyncratic toxicity, within batch strength variance and varying rates of release, need to be considered by those intending to use MDMA and by those providing drug advice. (russellwebster.com)
Medications1
- Therefore, it is necessary to investigate the possible presence of another medical disease, other medications used, and other possible causes of liver toxicity. (e-jcpp.org)
Environmental1
- For example, nickel nanoparticles (NiNPs) are used in electric capacitors, and their consumption is increasing, but there have been few reports of their toxicity and environmental effects. (go.jp)
Dose2
- If toxicity develops before seizures are controlled, the dose is reduced to the pretoxicity dose. (msdmanuals.com)
- Add these to MDMA's idiosyncratic toxicity (people react differently to the same dose of MDMA) and a trend of higher dose ecstasy tablets, and it really can be a game of Russian roulette for both experienced and new users. (russellwebster.com)
Injury1
- This NCTR MitoChip webpage is created to provide comprehensive knowledge and resources on mitochondrial function, mitochondrial injury, and mitchondrial toxicity, while also reporting progress on NCTR's contributions to mitochondrial research. (fda.gov)
Potential2
- As for the liver cell-damaging toxicity potential of xylitol in cats, since this appears to be an idiosyncratic or patient-specific factor effect in dogs, it's still possible that it could also be a patient-specific factor effect in cats. (preventivevet.com)
- This approach avoids potential drug side effects and toxicities and has shown long-term persistence in treating chronic insomnia that can be superior to results obtained using drug therapies (Morin 2005 ). (springer.com)
Reports1
- With all the awareness, the tools to treat, and the possibility that the toxic effects are not as profound, that must be why more reports are not being made about cats and xylitol toxicity. (preventivevet.com)
Direct1
- Phenytoin-initiated micronucleus formation was increased about 4-fold in both +/ j (P = .006) and j/j (P = .009) UGT-deficient cells vs. +/+ UGT-normal cells, providing the first evidence that the bioactivation and oxidative toxicity of phenytoin itself may be avoided by direct N -glucuronidation, which was confirmed by tandem mass spectrometry. (aspetjournals.org)
Highly1
- Work is highly idiosyncratic between two people, let alone groups. (btsspark.org)
Cases1
- Since they have not received or reported any cases of a cat experiencing any serious problems, only sensitivities (but no published data), following ingestion of xylitol, it is assumed that xylitol is not a toxicity threat to cats. (preventivevet.com)
Activity1
- Warfarin (war' far in) was discovered after identification of the hemorrhagic activity that caused toxicity and bleeding in cattle after eating spoiled, sweet clover silage. (nih.gov)