Toxicants may lead. Medical search. Frequent questions

It is not an ortho-phthalate, carcinogen, mutagen or reproductive toxicant. (plasticsnews.com)

Dioxins are potent toxicants with the potential to produce a broad spectrum of adverse effects in humans. (delphiforums.com)
Likewise, you can also find potent toxicants in your workplace. (personalabs.com)

Environmental toxicants and fetal development is the impact of different toxic substances from the environment on the development of the fetus. (wikipedia.org)
[24] Exposure to phthalates, especially DBP and DEHP, can reduce fetal testosterone production, and these anti-androgenic effects may alter fetal cell differentiation and function, leading to altered male genital development. (safecosmetics.org)
Reproductive risk of toxicant exposure includes fetal effects, especially congenital anomalies. (medscape.com)

Humans are exposed occupationally and environmentally to metal aerosols including lead (Pb2+) and cadmium (Cd2+). (cdc.gov)
The aim of this study was to quantify toxic metals lead, cadmium and trace elements zinc, copper, aluminium (Al) and Iron (Fe) levels in pregnant women, cord blood and meconium of new-born infants from industrial zones of Karachi, Pakistan. (who.int)

Dioxins can alter the fundamental growth and development of cells in ways that have the potential to lead to many kinds of impacts. (delphiforums.com)
Ecotoxicological tests were designed with traditional toxic contaminants in mind, such as heavy metals and dioxins, which have historically been the major apparent threat against aquatic organisms in surface waters," lead author Jonatan Klaminder explained in a press release . (alternet.org)

This article deals with potential adverse effects of environmental toxicants on the prenatal development of both the embryo or fetus, as well as pregnancy complications. (wikipedia.org)
Youths with secondhand smoke exposure had blood lead levels suggestive of the potential for adverse cognitive outcomes. (cdc.gov)
While scientists have long understood that certain chemicals like lead and mercury have adverse effects on the body, the precise molecular mechanism by which many of these substances cause harm remain uncertain, the researchers said. (eponline.com)
Two determinations must be made when a physician responds to a patient's concerns about a specific exposure: (1) whether any quantity of the toxicant has known adverse effects on reproduction in humans and (2) whether the substance is present in sufficient quantity to affect the patient or population exposed. (medscape.com)
Research on active smoking and secondhand smoke exposure has led to policy changes to protect individuals from the adverse health impacts of tobacco smoke. (springer.com)
Given these similarities in toxicant exposure, it is not surprising that a growing literature indicates that waterpipe smoking is associated with the same extensive laundry list of adverse health effects as cigarette smoking. (bmj.com)

Substances which have been found to be particularly harmful are lead (which is stored in the mother's bones), cigarette smoke, alcohol, mercury (a neurological toxicant consumed through fish), carbon dioxide, and ionizing radiation. (wikipedia.org)
Neurological and Behavioral Consequences of Childhood Lead Exposure. (cdc.gov)
Another two hundred chemicals are known to act as neurological poisons in human adults and are likely toxic to the developing brains of infants and children as well - animal studies strongly suggest that any neurotoxic chemical is likely also a neurodevelopmental toxicant - but scientific confirmation awaits. (orionmagazine.org)
The editors express how "very concerning" and "startling" the evidence is against fluoridation, and how the neurological damage is "on par with lead. (fluoridealert.org)
Researchers can use ENCODE data-- are associated with epigenetic changes that may lead to which has been combined with other data, such as cancer, cardiovascular diseases, autoimmune diseases, environmental information--to better understand diseases and neurological disorders. (medlineplus.gov)

Exposures to environmental toxins such as lead, tobacco smoke, and DDT have been linked with an increased risk for spontaneous abortion, low birth weight, or preterm birth. (wikipedia.org)
Chemical contaminants in food include natural toxicants, such as mycotoxins and marine toxins, environmental contaminants, such as mercury and lead, and naturally occurring substances in plants. (who.int)
Dr. Reja said that 9/11 first responders were exposed to "many common toxins that are consistently in occupational and environmental toxicant literature. (medscape.com)

Tobacco smoke is a source of exposure to thousands of toxic chemicals including lead, a chemical of longstanding public health concern. (cdc.gov)
The European Chemicals Agency classifies DEHP [19] and DBP [20] as reproductive toxicants. (safecosmetics.org)
This research, which is the first to identify a common molecular trigger for the effects of toxicant exposure, may give scientists new insights into damage caused by toxicant exposure and new methods of evaluating the safety of chemicals, researchers said. (eponline.com)
TK includes processes of uptake, elimination, internal distribution, and biotransformation of chemicals, whereas TD studies the processes leading to toxic effects. (sense.nl)
Understanding how these factors interact with each other and how they affect the uptake of chemicals in organisms allows making predictions not only for bioaccumulation of chemicals but also for the effects that a certain toxicant may have on soil-dwelling organisms. (sense.nl)
Early signs of heart damage can be detected in children exposed to high levels of toxic chemicals in their environment, such as lead and arsenic, a study conducted in Syracuse shows. (upstate.edu)
High levels of toxic chemicals in children who are exposed to lead and arsenic leads to early cardiovascular disease, according to research conducted in Syracuse. (upstate.edu)
When I first arrived at Oswego, they were doing work on PCBs (polychlorinated biphenyls, a group of chemicals banned since 1979), and so we looked at their cohort, the Oswego cohort, and looked at lead levels and saw some differences in the way the kids were reacting to stress. (upstate.edu)

Eating fish is the main source of mercury exposure in humans and some fish may contain enough mercury to harm the developing nervous system of an embryo or fetus, sometimes leading to learning disabilities. (wikipedia.org)
Noble and his colleagues exposed a specific population of brain cells to low levels of lead, mercury and paraquat, one of the most widely used herbicides in the world. (eponline.com)
Even a tiny intake of poisonous substances such as lead, mercury, arsenic, and others could cause complications. (personalabs.com)
Over the years, PEHSU has successfully tackled cases in lead poisoning, fungus, pesticides mercury poisoning, mold, and low-level exposures to air and water pollution. (cdc.gov)

Despite remediation efforts in housing and the environment and declining smoking rates and secondhand smoke exposure in the United States, tobacco smoke continues to be a substantial source of exposure to lead in vulnerable populations and the population in general. (cdc.gov)
Children are more vulnerable to toxicants absorbed through the skin because of their relatively larger surface area:body weight ratio. (cdc.gov)
Children from their earliest stages of development through puberty are vulnerable to environmental toxicants. (cdc.gov)
Children from their earliest stages of development through puberty are vulnerable to environmental toxicants, such as lead, mold, pesticides, air pollution, and many other contaminants. (cdc.gov)
Children are particularly vulnerable, absorbing 4 to 5 times as much ingested lead as adults from a given source. (who.int)

They are agents extrinsic to embryo or fetus which exert deleterious effects leading to increased risk of malformation, carcinogenesis, mutagenesis, altered function, deficient growth or pregnancy wastage. (wikipedia.org)
and the mechanisms by which the toxicants exert their effects. (cdc.gov)

Thus, children's absorption of ingested lead may be five times higher than that of adults [NRC 1993b]. (cdc.gov)
We assessed trends in blood lead levels in youths and adults with cotinine-verified tobacco smoke exposure by using 10 years of data from the National Health and Nutrition Examination Survey. (cdc.gov)
Positive trend tests indicate that a linear relationship exists between smoke exposure and blood lead levels in youths and adults and that secondhand smoke exposure contributes to blood lead levels above the level caused by smoking. (cdc.gov)
Decreased brain volume in adults with childhood lead exposure. (aahd.us)
[2] The amount of lead that can be absorbed by children is also higher than that of adults. (wikipedia.org)
Exposure at work is a common cause of lead poisoning in adults with certain occupations at particular risk. (wikipedia.org)
Exposure to secondhand smoke can lead to lung cancer, acute and chronic coronary heart disease (CHD), and eye and nasal irritation in adults. (tobaccoatlas.org)
The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. (bio5.org)
So, we haven't actually done this kind of work with adults or specifically with toxicants. (upstate.edu)

These toxicants are activating a normal cellular regulatory pathway, they are just activating it inappropriately," Noble said. (eponline.com)
Environmental toxicants impair cellular functions. (gordonmedical.com)
It is a biologically active respirable submicron aerosol that induces cellular responses leading to chronic obstructive pulmonary disease and arterial disease. (bmj.com)

Geometric mean levels of blood lead are presented for increasing levels of tobacco smoke exposure. (cdc.gov)
Secondhand tobacco smoke: a source of lead exposure in US children and adolescents. (cdc.gov)
Exposure to secondhand tobacco smoke (SHS) was one of the leading risk factors for deaths globally in 2019, accounting for approximately 1.3 million deaths and contributing to 37 million Disability-Adjusted life years (DALYs), with 11.2% of the burden in children under the age of 5 years. (tobaccoatlas.org)
From this 'tar', 82 toxicants have been quantified in waterpipe tobacco smoke to date, including polyaromatic hydrocarbons, tobacco-specific nitrosamines, carbonyl compounds and volatile organic compounds. (bmj.com)

Environmental toxicants can be described separately by what effects they have, such as structural abnormalities, altered growth, functional deficiencies, congenital neoplasia, or even death for the fetus. (wikipedia.org)
How toxicants enter the body - the routes of exposure - will be considered in the context of some health effects in newborns, infants, and toddlers. (cdc.gov)
Classically, "lead poisoning" or "lead intoxication" has been defined as exposure to high levels of lead typically associated with severe health effects. (wikipedia.org)
[18] However, professionals often use "lead poisoning" and "lead toxicity" interchangeably, and official sources do not always restrict the use of "lead poisoning" to refer only to symptomatic effects of lead. (wikipedia.org)
Establishing the general principles underlying the effects of toxicant exposure on the body is one of the central challenges of toxicology research," said University of Rochester biomedical geneticist Mark Noble, Ph.D., senior author of the study. (eponline.com)
We are interested in the effects of early life exposures to environmental toxicants on lung growth and development. (bio5.org)
When we study the effects environmental toxicants can have on marine life, the researchers argue, this kind of thing is going unnoticed. (alternet.org)
In a speech given at the symposium, Dr Syed Jaffar Hussain, WHO Representative and Head of Mission to the Islamic Republic of Iran, underscored the harmful effects of lead, especially on children and on women of childbearing age. (who.int)
The effects of this study are comparable to the effects of lead, and if these findings are true there should be as much concern about prenatal fluoride exposure," Christakis told The Daily Beast . (fluoridealert.org)
Airborne toxicants can injure the respiratory tract (local effects) and can also cause systemic injury. (msdmanuals.com)
High-intensity exposures can lead to clinical effects within seconds, minutes, or hours, depending on the actual dose of exposure. (msdmanuals.com)

[19] Lead poisoning may be acute (from intense exposure of short duration) or chronic (from repeat low-level exposure over a prolonged period), but the latter is much more common. (wikipedia.org)
It is estimated that lead exposure was responsible for 30% of the global burden of idiopathic intellectual disability, 4.6% of the global burden of cardiovascular disease and 3% of the global burden of chronic kidney diseases in 2019. (who.int)

Two decades of research suggest that phthalates disrupt hormones, which can lead to harm during critical periods of development. (safecosmetics.org)
We have discovered a previously unrecognized regulatory pathway on which chemically diverse toxicants converge and disrupt normal cell function. (eponline.com)

Anaheim, Calif. - Eastman Chemical Co. conducted a clinical trial to evaluate a non-phthalate plasticizer for medical applications and the results indicate it could become a "lead alternative" to using DEHP to soften PVC blood bags. (plasticsnews.com)
In the clinical trial, overall, the DEHT bags showed comparable performance to the DEHP bags, which "suggests it should be considered a lead alternative plasticizer for PVC blood bags," the study concluded. (plasticsnews.com)
Most of our patients who present with long standing Lyme disease have evidence of a high environmental toxicant load through clinical history and laboratory results. (gordonmedical.com)
Individual studies have reported different estimates for inhaled toxicants from cigarettes or hookahs, which made it hard to know exactly what to report to policy makers or in educational materials," said co-author and expert in meta-analysis Smita Nayak, M.D., research scientist at the Swedish Center for Clinical Research and Innovation . (upmc.com)

More than 70 of these compounds are carcinogens, which has led the US Environmental Protection Agency and the International Agency for Research on Cancer to classify SHS as a group A and group 1 carcinogen, respectively, indicating the most hazardous cancer-causing compounds. (tobaccoatlas.org)

Vulnerability to some toxicants such as nitrates decreases. (cdc.gov)
METHODS AND FINDINGS: Volumetric analyses of whole brain MRI data revealed significant decreases in brain volume associated with childhood blood lead concentrations. (aahd.us)

You are concerned about the risks associated with growing vegetables in soil with naturally high lead and arsenic concentrations. (cdc.gov)
OBJECTIVE: We examined the association between blood lead concentrations assessed throughout early childhood and children's IQ at 6 years of age. (aahd.us)
METHODS: Children were followed from 6 months to 6 years of age, with determination of blood lead concentrations at 6, 12, 18, and 24 months, and 3, 4, 5, and 6 years of age. (aahd.us)
CONCLUSIONS: Evidence from this cohort indicates that children's intellectual functioning at 6 years of age is impaired by blood lead concentrations well below 10 microg/dL, the Centers for Disease Control and Prevention definition of an elevated blood lead level. (aahd.us)
adding blood lead concentrations as a variable to the model attenuated this correlation. (aahd.us)

[2] Lead poisoning poses a significantly increased risk to children as they are far more likely to ingest lead indirectly by chewing on toys or other objects that are coated in lead paint . (wikipedia.org)
Our results show that hookah tobacco smoking poses real health concerns and that it should be monitored more closely than it is currently," said lead author Brian A. Primack, M.D., Ph.D. , assistant vice chancellor for health and society in Pitt's Schools of the Health Sciences. (upmc.com)

And then, the arsenic was an offshoot of a bigger study that we did in Syracuse more recently, where we were looking again at lead and how children react to stress. (upstate.edu)

The amount of lead in the blood and tissues, as well as the time course of exposure, determine toxicity. (wikipedia.org)

2016. Prevention of Childhood Lead Toxicity. (cdc.gov)
Depending on the toxicity level, these substances can lead to mild or severe poisoning. (personalabs.com)

Water contaminants such as lead (and nitrates) are concentrated when water is boiled. (cdc.gov)

If lead exposure occurs, the lead will compete with the calcium for transport at this high rate. (cdc.gov)
A high gastric pH leads to excess bacterial colonization, which increases nitrate-to-nitrite conversion. (cdc.gov)
Three wipe samples taken from work surfaces in the Specialty Unit (PEHSU) investigated two cases of childhood cathode ray tubes area indicated high levels of lead. (cdc.gov)

In this study, we examined the relationship between childhood lead exposure and adult brain volume using magnetic resonance imaging (MRI). (aahd.us)
CONCLUSIONS: Childhood lead exposure is associated with region-specific reductions in adult gray matter volume. (aahd.us)
We determine if the early life exposures leads to adult disease. (bio5.org)

ACCLPP] Advisory Committee on Childhood Lead Poisoning Prevention of the Centers for Disease Control and Prevention. (cdc.gov)
23 October 2023, Tehran, Islamic Republic of Iran - To combat childhood lead poisoning, the WHO Country Office in the Islamic Republic of Iran has teamed up with Shahid Beheshti University of Medical Sciences to mark International Lead Poisoning Prevention Week, from 22 to 28 October 2023. (who.int)
Health Department's Childhood Lead Poisoning Prevention and water before testing. (cdc.gov)

On the other hand, smoking is harmful to a smoker's health as it exposes them to toxicants including ammonia, lead, carbon monoxide, diacetyl, hydrogen cyanide, and benzene. (differencebetween.net)

WHO data reveal a sobering statistic: more than 2 million deaths worldwide in 2019 were attributed to chemical exposure, with lead exposure accounting for nearly half of these fatalities. (who.int)

describe the toxicant exposure routes most likely in early childhood. (cdc.gov)
[5] According to a study, half of the US population has been exposed to substantially detrimental lead levels in early childhood - mainly from car exhaust whose lead pollution peaked in the 1970s and caused widespread loss in cognitive ability. (wikipedia.org)

Alfa Aesar MSDS] See "Lead" and linked occupational diseases. (haz-map.com)

The term toxicant is used when talking about toxic substances that are produced by or are a by-product of human-made activities. (cdc.gov)

Some researchers have recently suggested that any hypothesized toxicant should be compatible with current existing models of development and should include cumulative risk. (medscape.com)
In a previous study , the researchers showed how this leads them to eat more quickly - which could be causing their increased longevity. (alternet.org)

Very Low Lead Exposures and Children's Neurodevelopment. (cdc.gov)
Height stickers featuring informative messages about the impact of lead exposure on children's health were produced and handed out at the symposium to pediatricians, to give to their patients. (who.int)
The children's primary care physician referred them to the of lead. (cdc.gov)

A common potential household exposure involves mixing household ammonia with cleansers containing bleach, leading to the release of the irritant gas chloramine. (msdmanuals.com)

Mutations in genes concerned with production of enzymes for metabolism of tobacco products may lead to increased risk of carcinogenesis with respect to oral mucosa. (bvsalud.org)

Lead poisoning is preventable. (wikipedia.org)
Fortunately, lead exposure is preventable. (who.int)

BACKGROUND: Although environmental lead exposure is associated with significant deficits in cognition, executive functions, social behaviors, and motor abilities, the neuroanatomical basis for these impairments remains poorly understood. (aahd.us)

One area is parturition, in which basic research on the events leading to labor and delivery, which is fundamental to understanding preterm birth, is conducted. (nationalacademies.org)
I'm curious if you know of any research related to MMJ-related treatments for lead poisoning. (realneo.us)
The research team reviewed 542 scientific articles potentially relevant to cigarette and hookah smoking and ultimately narrowed them down to 17 studies that included sufficient data to extract reliable estimates on toxicants inhaled when smoking cigarettes or hookahs. (upmc.com)
Brooks Gump, PhD , who led the study, explains the research and its findings, including that the damage might be reversible, plus plans for further study. (upstate.edu)

These neuroanatomical findings were more pronounced for males, suggesting that lead-related atrophic changes have a disparate impact across sexes. (aahd.us)
After we have more fine-grained data about usage frequencies and patterns, we will be able to combine those data with these findings and get a better sense of relative overall toxicant load. (upmc.com)
Findings seeks to understand how were done using mouse models, environmental exposures which will be used to inform lead to epigenetic changes-- human studies. (medlineplus.gov)

Lead levels were evaluated for smokers and nonsmokers on the basis of age of residence and occupation. (cdc.gov)
A new meta-analysis led by the University of Pittsburgh School of Medicine shows that hookah smokers are inhaling a large load of toxicants. (upmc.com)
But what they do suggest is that hookah smokers are exposed to a lot more toxicants than they probably realize. (upmc.com)

0.001), approximately 1.2% of the total gray matter was significantly and inversely associated with mean childhood blood lead concentration. (aahd.us)
This year's campaign is "End childhood lead poisoning", with the partners focusing in this case on efforts in the Islamic Republic of Iran. (who.int)
NIOSH was unaware with elevated BLLs were exposed through a source other than of the childhood lead poisonings, as was the employer. (cdc.gov)

Victor Katch explores how toxicant exposure over time can lead to illness, disease, and immune disorders. (umich.edu)

If you're pregnant, you might transfer lead poisoning to the fetus, which affects the central nervous system development of the baby. (personalabs.com)

2001]. Maternal toxicokinetics - that is, the solubility and binding properties of a toxicant and the characteristics of breast milk - determine the milk-maternal plasma (M/P) ratio. (cdc.gov)
The observational study, entitled Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada, was led by a team at York University in Ontario, Canada and looked at 512 mother-child pairs from six major Canadian cities. (fluoridealert.org)

Globally, in 2019, lead exposure further resulted in 21.7 million years lost to disability (disability-adjusted life years, or DALYs). (who.int)

Pediatricians should ask about parents' occupations and break room (e.g., floor, tables, and refrigerator handle), and the hobbies that might involve lead when evaluating elevated BLLs water fountain near the restrooms. (cdc.gov)
This aged 2 years were identified by routine screening to have test kit identifies lead on surface wipe samples through a color elevated BLLs of 18 µ g/dL and 14 µ g/dL, respectively. (cdc.gov)

[2] Lead is believed to result in 0.6% of the world's disease burden . (wikipedia.org)
As the world's third leading cereal crop corn and its products are used as food, feed, oil, grits, meal, syrup and starch among others. (cbd.int)

[11] The major treatments are removal of the source of lead and the use of medications that bind lead so it can be eliminated from the body , known as chelation therapy . (wikipedia.org)
The crop is not known to be a source of toxicants and allergens. (cbd.int)
Although deteriorating dent described in this report, NIOSH conducted a health haz- lead paint in pre-1979 housing is the most common source of ard evaluation at facility A, as part of an initiative to learn more lead exposure in children, data indicate that 30% of children about exposures in e-scrap recycling. (cdc.gov)

Program completed a lead risk assessment at the family's home. (cdc.gov)

Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. (aahd.us)
1995. Treatment guidelines for lead exposure in children. (cdc.gov)
2005. Lead Exposure in Children: Prevention, Detection, and Management. (cdc.gov)
Low Level Lead Exposure Harms Children: A Renewed Call for Primary Prevention. (cdc.gov)
Pre-and Postnatal Lead Exposure and Behavior Problems in School-Aged Children. (cdc.gov)
It was designed to be half African American, half Anglo-American (white) children, in Syracuse city, so we selected ZIP codes that had elevated levels of lead. (upstate.edu)
This campaign builds on the successful ban on the use of lead in petrol as well as progress made by many countries to enact laws to limit lead use in paint, especially in places where children are exposed, such as homes, schools and playgrounds. (who.int)
Lower surface lead con- recycling facility where the father of the two children with lead centrations were found outside the production area, including poisoning worked. (cdc.gov)
Wipe samples were taken in children, in routine lead screening questionnaires, and in from the hands of 12 employees from the cathode ray tubes evaluating children with signs or symptoms of lead exposure. (cdc.gov)

1993. Lead poisoning: from screening to primary prevention. (cdc.gov)

Get tested for lead contamination through a lead blood test . (personalabs.com)

Nonlinear modeling of the peak blood lead concentration revealed an inverse association (p = 0.003) between peak blood lead levels and Full-Scale IQ down to 2.1 microg/dL, the lowest observed peak blood lead concentration in our study. (aahd.us)
[5] Concerns for low levels of exposure began in the 1970s with there being no safe threshold for lead exposure. (wikipedia.org)
Results indicated that mothers residing in steel towns were found to have the highest levels of lead. (who.int)

My guest today is Brooks Gump, a professor from SU who led the study. (upstate.edu)
Another NIH-funded study, Utilizing In Vitro Functional lead to poor health. (medlineplus.gov)

We used general linear and semiparametic models to estimate and test the association between blood lead concentration and IQ. (aahd.us)

Lead poisoning , also known as plumbism and saturnism , is a type of metal poisoning caused by lead in the body. (wikipedia.org)
This can lead to short-term illnesses leading to brain damage, coma, or death if not removed from the body. (personalabs.com)

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