Ingestion of toxic alcohols (methanol, ethylene glycol, or other glycols) might result in some signs and symptoms similar to those of ethanol inebriation (vomiting, lethargy, or coma). (cdc.gov)
Renal failure is common after ethylene glycol and diethylene glycol toxicity, whereas optic neuritis and visual impairment are seen with methanol toxicity (1-5). (cdc.gov)
Barceloux DG, Krenzelok EP, Olson K, Watson W. American Academy of Clinical Toxicology practice guidelines on the treatment of ethylene glycolpoisoning. (cdc.gov)
Fomepizole for the treatment of ethylene glycol poisoning: methylpyrazole for toxic alcohols study group. (cdc.gov)
Ethylene glycol is by far the largest volume of the glycol products in a variety of applications. (wikipedia.org)
Availability of DEG will depend on demand for derivatives of the primary product, ethylene glycol, rather than on DEG market requirements. (wikipedia.org)
The LD50 for small mammals has been tested at between 2 and 25 g/kg, less toxic than its relative ethylene glycol, but still capable of causing toxicity in humans (in high concentration only). (wikipedia.org)
At first, scientists thought that DEG metabolized into ethylene glycol, which is poisonous due to the metabolic production of glycolic acid, glyoxylic acid, and ultimately oxalic acid. (wikipedia.org)
The major cause of ethylene glycol toxicity is the accumulation of glycolic acid in the body, but the accumulation of calcium oxalate crystals in the kidneys can also lead to acute kidney failure. (wikipedia.org)
In the case of DEG, observations demonstrated there were no calcium oxalate crystal deposits in the kidneys, implying ethylene glycol is not on the DEG metabolic pathway. (wikipedia.org)
The objective of this study is to summarize existing evidence on short- and long-term outcomes of patients following toxic alcohol poisonings, including methanol, ethylene glycol, isopropanol, propylene glycol, and diethylene glycol. (biomedcentral.com)
The toxicity of methanol and ethylene glycol arises from their respective metabolites while the parent compound is relatively innocuous [ 4 ]. (biomedcentral.com)
Toxicity2
Diethylene glycol has "moderate to low" acute toxicity in animal experiments. (wikipedia.org)
It appears diethylene glycol may be more hazardous to humans than implied by oral toxicity data in laboratory animals. (wikipedia.org)
Toxic alcohols have been implicated in accidental ingestions and intentional exposures. (biomedcentral.com)
However, treatment consensus related to other toxic alcohols is limited. (biomedcentral.com)
To our knowledge, no prior systematic review of clinical outcomes of toxic alcohols exists. (biomedcentral.com)
These alcohols have been implicated in accidental ingestions as well as intentional exposures in suicides and homicides [ 1 ]. (biomedcentral.com)
Methanol2
A case in which glycols or methanol and/or their metabolites in whole blood and/or urine is detected, as determined by hospital or commercial laboratory tests. (cdc.gov)
Detection of glycols or methanol in environmental samples. (cdc.gov)
Renal2
Hanif M, Mobarak MR, Ronan A, Ralman D, Donovan JJ Jr, Bennish ML. Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic. (cdc.gov)
Pre-specified subgroup analyses will be performed according to the type of toxic alcohol intoxication, mode of renal replacement therapy, and medical interventions received. (biomedcentral.com)
Compounds1
4 polyethylene glycol These compounds are all hydrophilic, more so than most diols, by virtue of the ether functionality. (wikipedia.org)
Alcohol9
Ingestion of large amounts of a toxic alcohol typically results in a large osmol gap followed by a high anion gap metabolic acidosis. (cdc.gov)
Therefore, a "normal" osmol gap should never be used to exclude a toxic alcohol poisoning. (cdc.gov)
A clinically compatible case in which a high index of suspicion (credible threat or patient history regarding location and time) exists for toxic alcohol exposure, or an epidemiologic link exists between this case and a laboratory-confirmed case. (cdc.gov)
As a consequence, variations exist in the interventions utilized for management of all toxic alcohol poisonings. (biomedcentral.com)
A meta-analysis will be performed if three or more studies with similar populations, type of toxic alcohol poisoning, and outcome measures, as well as adequate quality, are identified. (biomedcentral.com)
This systematic review aims to synthesize current evidence in the short- and long-term outcomes of post-toxic alcohol poisoning. (biomedcentral.com)
The results will enhance the understanding of patient morbidity and mortality after toxic alcohol poisoning, help inform uniform concrete management guideline development, identify gaps in the current state of knowledge, and provide evidence to help implement post-treatment follow-up. (biomedcentral.com)
Recognition of toxic alcohol poisoning is challenging due to non-specific clinical presentation and that patients are often unable to provide a history of exposure at presentation [ 1 , 2 ]. (biomedcentral.com)
Amounts1
Depending on the conditions, varying amounts of DEG and related glycols are produced. (wikipedia.org)
Clinical1
Clinical manifestations may evolve with the formation of toxic metabolites and are further compounded by co-ingestions [ 1 ]. (biomedcentral.com)