Toxic cardiac glycoside glycosides. Medical search. Frequent questions

Toxicity from herbal cardiac glycosides was well recognized by 1785, when William Withering published his classic work describing therapeutic uses and toxicity of foxglove, D purpurea . (medscape.com)
Therapeutic use of herbal cardiac glycosides continues to be a source of toxicity today. (medscape.com)
Cardiac glycosides have been also found in Asian herbal products and have been a source of human toxicity. (medscape.com)
Toxicity may occur after consuming teas brewed from plant parts or after consuming leaves, flowers, or seeds from plants containing cardiac glycosides. (medscape.com)
Any dysrhythmia characterized by both increased automaticity and depressed conduction is suggestive of cardiac glycoside toxicity. (medscape.com)
Dysrhythmias characterized by increased automaticity and conduction blockade, when combined, are highly suggestive of cardiac toxicity. (medscape.com)
Although acute and chronic plant cardiac glycoside toxicity are treated in similar manners, their noncardiac clinical manifestations differ. (medscape.com)
The early signs of toxicity from the cardiac glycosides can mimic the heart problem it is meant to treat, making diagnosis difficult. (wagwalking.com)
Kanji S, Maclean RD. Cardiac glycoside toxicity: More than 200 years and counting. (cdc.gov)

Digitalis lanata is cultivated for medicine because it makes a cardiac glycoside called digoxin. (futurity.org)
Cardiac glycosides, usually in the form of digoxin, are often used in the treatment of congestive heart failure. (wagwalking.com)

plant contains cardiac glycosides. (poultryhelp.com)

In addition, the venom gland of cane toad ( Bufo marinus ) contains large quantities of a purported aphrodisiac substance that has resulted in cardiac glycoside poisoning. (medscape.com)
Eddleston M, Ariaratnam CA, Sjostrom L, Jayalath S, Rajakanthan K, Rajapakse S. Acute yellow oleander (Thevetia peruviana) poisoning: cardiac arrhythmias, electrolyte disturbances, and serum cardiac glycoside concentrations on presentation to hospital. (medscape.com)
Antidotes for acute cardenolide (cardiac glycoside) poisoning. (medscape.com)
What is Cardiac Glycosides Poisoning? (wagwalking.com)
Vomiting is generally not induced in cases of cardiac glycoside poisoning due to the rapid absorption of the compound. (wagwalking.com)

Milkweeds contain various levels of cardiac glycoside compounds which render the plants toxic to most insects and animals. (usda.gov)
What the birds do not know is that northern monarchs feeding on common milkweed accumulate relatively little of the toxic compounds and probably would be edible. (usda.gov)
The more southern butterflies accumulate large amounts of the compounds from other milkweed species and are in fact toxic. (usda.gov)
The first paper, published online in January in the Journal of Chromatography A , describes methods for assessing the exact mass and structure of cardiac glycosides, and compares compounds found in Digitalis purpurea and Digitalis lanata . (buffalo.edu)
Cardiac glycosides are naturally occurring compounds formed in several plants. (wagwalking.com)
Cardiac glycosides are compounds that can disrupt the natural rhythm of the heart. (wagwalking.com)
Cardiac glycosides are organic compounds that can disrupt regular heart rhythm by acting on the force of the cardiac muscle itself. (wagwalking.com)

At therapeutic doses, cardiac glycosides also may increase inotropy. (medscape.com)
Therapeutic and toxic effects of digitalis: William Withering, 1785. (medscape.com)
Therapeutic index is calculated by dividing the toxic dose for 50% of the population by the minimum effective dose for 50% of the population. (lecturio.com)
The margin between toxic and therapeutic doses is small. (lecturio.com)

More than 200 naturally occurring cardiac glycosides have been identified. (medscape.com)
There are several types of plants that contain naturally occurring cardiac glycosides. (wagwalking.com)
Milkweeds contain cardiac glycosides, naturally occurring drugs that increase the force of heart contraction and have been used to treat heart conditions. (ku.edu)

In work related to our KU Native Medicinal Plant Research program, we have discovered that a cardiac glycoside present in Asclepias , or milkweeds-a widely distributed yet poorly investigated genus of the U.S. Midwest-was found to have strong cytotoxicity against breast cancer cell lines. (ku.edu)

But plants belonging to this genus, Digitalis , also harbor a less visible asset: Chemicals called cardiac glycosides, which have been recorded to treat heart failure since the 1780s, says University at Buffalo biologist Zhen Wang. (buffalo.edu)
Cardiac glycosides are found in a diverse group of plants including Digitalis purpurea and Digitalis lanata (foxgloves), Nerium oleander (common oleander), Thevetia peruviana (yellow oleander), Convallaria majalis (lily of the valley), Urginea maritima and Urginea indica (squill), Strophanthus gratus (ouabain), Apocynum cannabinum (dogbane), and Cheiranthus cheiri (wallflower). (medscape.com)
If you catch your pet consuming the either digitalis-based heart medication or cardiac glycoside laden plant, identification may be all that is required to determine the cause of your pet's reactions. (wagwalking.com)

The milkweeds' cardiac glycosides are potentially poisonous to livestock and humans. (ku.edu)

For some insects, the cardiac glycosides become a defense. (usda.gov)
Overdose can occur from medication, from chewing or eating the plants themselves, or eating insects that dine on the toxic plants, such as monarch caterpillars and monarch butterflies. (wagwalking.com)

Cardiac glycosides primarily affect cardiovascular, neurologic, and gastrointestinal systems. (medscape.com)
cardiovascular system affected by cardiac glycosides. (poultryhelp.com)

As a result of this excessive intracellular calcium, enhanced cardiac contractions, which are delayed after depolarizations, occur. (medscape.com)
Minimum toxic concentration is the minimum drug level in the blood at which toxic side effects occur. (lecturio.com)

The second study, published online in March in the journal Data in Brief , expands on the first, providing additional data on characteristics of cardiac glycosides in both species. (buffalo.edu)

This compound is toxic in large quantities, but it's prescribed sparingly, in small doses, to treat heart failure and certain heart rhythm abnormalities. (futurity.org)
This compound has been used for centuries both as a healing agent for those who already suffer from cardiac disorders as well as a poison. (wagwalking.com)

plant contains toxic resins. (poultryhelp.com)
plant may absorb toxic levels of selenium. (poultryhelp.com)
Serum concentrations might be detectable after an exposure to plant-derived cardiac glycosides, some of which can cross-react with the various hospital laboratory assays used. (cdc.gov)

There are blood tests available to detect the cardiac glycosides, as well as to monitor the levels of glycosides in the system, however the cost of these methods generally limits their accessibility for veterinary diagnosis. (wagwalking.com)

The many beautiful Milkweed varieties have been used over the ages for everything from salves and infusions to treat swelling, rashes, coughs, fevers, asthma, female problems and even seasoning added to dishes for flavor or to thicken soups but since there are some toxic issues with regards to the cardiac glycoside content, I recommend leaving it to the experts and butterflies. (currantc.com)

Of these, effects on the cardiac system are most significant. (medscape.com)

Sadly, even the green leaves are toxic as part of the bouquet! (litter-robot.com)
As the monarch larva consumes the milkweed leaves, it also retains the cardiac glycosides making the monarch toxic to predators. (currantc.com)

When we looked at the cardiac glycosides in each of them, we found drastic differences," Wang says. (buffalo.edu)

In the industrial strain that's grown for medicine, you see much higher amounts of cardiac glycosides, with much more diversity. (buffalo.edu)

Cardiac glycosides also have vagotonic effects, resulting in bradycardia and heart block. (medscape.com)

They can store them in their tissue which renders them inedible or toxic to other animals. (usda.gov)

But plants belonging to this genus, Digitalis , also harbor a less visible asset: Chemicals called cardiac glycosides, which have been recorded to treat heart failure since the 1780s, says University at Buffalo biologist Zhen Wang. (buffalo.edu)
The first paper, published online in January in the Journal of Chromatography A , describes methods for assessing the exact mass and structure of cardiac glycosides, and compares compounds found in Digitalis purpurea and Digitalis lanata . (buffalo.edu)
The toxic principles in the kalanchoe plant are cardenolides and bufadienolides, which are both cardiac glycoside toxins that are similar to digitalis. (github.io)

At therapeutic doses, cardiac glycosides also may increase inotropy. (medscape.com)
They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. (bvsalud.org)

Ancient Egyptians and Romans first used plants containing cardiac glycosides medicinally as emetics and for heart ailments. (medscape.com)
The cardiac glycoside contents of various Australian plants were studied using immunoassay techniques. (nih.gov)
Results obtained indicated that the Digibind antibody cross-reacted with a wide range of glycosides contained in Australian plants and therefore could be of use in the treatment of life-threatening plant poisoning. (nih.gov)
Immunological detection of cardiac glycosides in plants. (nih.gov)
Specifically, her lab is investigating the chemical processes the plants use to create cardiac glycosides: what steps are taken, what genes are turned on, and what enzymes are deployed. (buffalo.edu)
Fast Five Quiz: Toxic Plants - Medscape - Nov 23, 2021. (medscape.com)
Toxic plants of North America. (illinois.edu)
All flowering plants that belong to this group are toxic. (bunnyasapet.com)
The plants contain toxic substances called bufadienolides, which include. (github.io)
The following section discusses specific toxic plants, categorized by the system most severely affected. (medscape.com)

There are many cardiac and noncardiac causes, but patients usually have underlying structural heart disease. (lecturio.com)

As a result of this excessive intracellular calcium, enhanced cardiac contractions, which are delayed after depolarizations, occur. (medscape.com)
fibrillation of heart muscles resulting in interference with rhythmic contractions of the ventricles and possibly leading to cardiac arrest. (wordinn.com)

The most violently toxic plant that grows in North America. (bunnyasapet.com)

In the industrial strain that's grown for medicine, you see much higher amounts of cardiac glycosides, with much more diversity. (buffalo.edu)

Cardiac glycosides primarily affect cardiovascular, neurologic, and gastrointestinal systems. (medscape.com)

Although the entire plant is poisonous, the seeds contain the largest concentration of the toxic principle. (illinois.edu)

Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as myocardial infarction. (lecturio.com)

Case reports and studies have documented that herbal products may contain ingredients, sometimes toxic, not listed on the label. (medscape.com)

In addition, the venom gland of cane toad ( Bufo marinus ) contains large quantities of a purported aphrodisiac substance that has resulted in cardiac glycoside poisoning. (medscape.com)
It's a toxic substance that's present in every part of the plant. (bunnyasapet.com)
This toxic substance is also used in some Asian countries as dart poison . (bunnyasapet.com)
Every part of this plant contains a toxic substance called lycorine . (bunnyasapet.com)

In addition, the quantities of ingredients listed on the label can vary greatly, hindering definition of toxic ingredients and unsafe products for public consumption. (medscape.com)

It is toxic to pet animals such as cats and dogs. (github.io)

Toronto The use of herbal remedies by heart patients is a worrisome trend for cardiologists and cardiac surgeons alike. (medscape.com)

The entire plant is toxic, including its tiny yellow fruits. (bunnyasapet.com)

These unidentified ingredients may be unintentionally included in the product (eg, misidentification of a toxic plant as a desired nontoxic plant or contamination with pesticide residues or heavy metals) or adulterants introduced for increased effect (eg, addition of a pharmaceutical agent to an herbal preparation). (medscape.com)

Anatomy7

Organisms8

Diseases3

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes4

Information Science1

Toxicity9

Digoxin2

Contains cardiac1

Poisoning5

Compounds7

Therapeutic4

Naturally3

Asclepias1

Digitalis3

Milkweeds1

Insects2

Cardiovascular2

Occur2

Species1

Compound2

Plant3

Levels1

Treat1

System1

Leaves2

Found1

Medicine1

Effects1

Store1

Digitalis3

Doses2

Plants10

Noncardiac1

Contractions2

North America1

Amounts1

Gastrointestinal1

Seeds1

Sudden1

Herbal products1

Substance4

Definition1

Animals1

Patients1

Yellow1

Addition1