• Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. (wikipedia.org)
  • However, only about 500 human microRNAs represent bona fide miRNA in the manually curated miRNA gene database MirGeneDB. (wikipedia.org)
  • MicroRNAs (miRNAs or miRs) are involved in the post-transcriptional regulation of gene expression via complete or partial base pairing with the 3′untranslated region of target genes ( 3 ). (spandidos-publications.com)
  • The methyltransferase-related gene S-adenosylmethionine synthase (SAMS) and the flavonoid biosynthesis-related gene (ANS and F3'5'H) were down-regulated in somatic embryogenesis. (bvsalud.org)
  • miRNAs expressed in a wide variety of human cancers can regulate posttranscriptional gene expression by binding to the 3′ untranslated region of the target mRNAs and act as oncogenes or tumor suppressors to regulate cell signaling pathways, affecting tumorigenesis and tumor progression [ 17 ]. (hindawi.com)
  • MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides in length, which play important roles in regulating gene expression post-transcriptionally. (geneticsmr.org)
  • The other approach is to screen CRISPR-Cas9-based guide RNA (gRNA) libraries that target either the whole genome using cancer cell and immune cell co-culture systems 9 , 10 , or focused gene sets using immunocompetent murine tumors 11 , 12 . (nature.com)
  • MicroRNAs (miRNAs) are small non-coding RNAs that bind complementary messenger RNAs (mRNAs) to repress gene expression and regulate essentially all cellular processes 19 . (nature.com)
  • MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)
  • Mature microRNAs (miRNAs) are a class of small, well-conserved, non-coding RNA molecules that silence gene expression usually by interfering with mRNA stability or protein translation ( 6 , 7 ). (spandidos-publications.com)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
  • Also, viral infection has proved to have a great impact on cellular small RNA expression and gene expression [ 9 - 11 ]. (hindawi.com)
  • Small RNAs include microRNA (miRNA), siRNA, tRFs, piRNA, and rasiRNAs, which regulate gene expression in a wide range of processes such as viral replication and host immune response. (hindawi.com)
  • miRNAs regulate gene expression in a wide range of physiological and pathological processes such as in immune response and viral replication [ 18 ]. (hindawi.com)
  • Much work has focused on the role that FGFs play in regulating gene expression within the mesoderm. (york.ac.uk)
  • However, the principles that determine if a gene is regulated by miRNAs are poorly understood. (frontiersin.org)
  • These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. (biomedcentral.com)
  • We examined each of these small RNA classes with respect to the newly assembled tammar wallaby genome for gene and repeat features, salient features that define their canonical sequences, and the constitution of both highly conserved and species-specific members. (biomedcentral.com)
  • The characterization of new miRNA target genes and a unique profile for crasiRNAs has allowed for insight into multiple RNA mediated processes in the tammar, including gene regulation, species incompatibilities, centromere and chromosome function. (biomedcentral.com)
  • Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)
  • The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
  • He, L. & Hannon, G. J. MicroRNAs: small RNAs with a big role in gene regulation. (nature.com)
  • Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 . (nature.com)
  • MicroRNAs (miRNAs) are 21-24 nt long non-coding RNAs that regulate gene expression at the post-transcriptional level. (researchsquare.com)
  • microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. (shengsci.com)
  • Up- or down-regulation of miR-199a-3p and/or the AK4 gene was done to detect their roles in OS multi-drug resistance using drug resistance profiling assays. (biomedcentral.com)
  • MiRNAs (miRNAs) are small non-coding RNAs which are recognized as vital and evolutionarily ancient components of gene regulation [ 1 ]. (biomedcentral.com)
  • For the mRNA analysis, RNA (1 mg) was reverse-transcribed by using the PrimeScript RT reagent Kit with gDNA Eraser (Tiangen), the mRNA level of the AK4 gene was quantified using duplex-qRT-PCR analysis where the Taqman probes with different fluorescence for β-actin were used in the FTC-3000P. (biomedcentral.com)
  • MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression and that are frequently dysregulated in tumorigenesis. (biomedcentral.com)
  • Gene mutations and aberrant signaling pathways play key roles in GBC tumorigenesis. (biomedcentral.com)
  • Non-coding RNAs (ncRNAs), mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), can function as important regulators in gene expression. (biomedcentral.com)
  • Many ncRNAs have critical roles in tumorigenesis, and some ncRNAs function as competing endogenous RNAs (ceRNAs) to perturb gene expression. (biomedcentral.com)
  • The effects of PTX-induced exosomal circBACH1 on BC cell function were assessed using RNA Binding Protein Immunoprecipitation (RIP), dual luciferase reporter gene, tube formation, CCK-8, and Western Blot assays. (biomedcentral.com)
  • Recent studies identified a fast growing list of long noncoding RNAs (lncRNAs) that harbor greater than 200 nucleotides with no open reading frames but play key roles in regulating gene expression thus govern neural stem cell maintenance, neurogenesis, neuronal network assembly, and synaptic plasticity. (grantome.com)
  • MicroRNAs (miRNAs) are a class of short, endogenous primed non-coding RNAs (18-25 nucleotides) that regulate gene expression through pairing with 3′-untranslated region (3′-UTR) bases to mediate translation inhibition or degradation of homologous mRNAs [ 7 ]. (biomedcentral.com)
  • A total of 3185 differentially expressed genes were screened by comparative transcriptomic analysis of embryogenic callus (EC), SE, and non-embryogenic callus (NEC). (bvsalud.org)
  • Compared to NEC, the auxin synthesis-related genes GH3.6 and PCO2 were up-regulated, whereas cytokinin dehydrogenase (CKX6) and CYP450 family genes were down-regulated in somatic embryogenesis. (bvsalud.org)
  • A total of 5645 target genes of hsa-miR-375 were identified from five prediction programs, and among them, 2440 target genes were shared by at least 2 of these 5 programs. (geneticsmr.org)
  • To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
  • Identification of miRNA-regulated targeting genes is important for understanding their specific biological functions [ 11 ]. (degruyter.com)
  • Up to 30% of human protein-coding genes may be regulated by miRNAs ( 8 , 9 ). (spandidos-publications.com)
  • Micro-RNAs (miRNAs) are small RNA molecules that regulate the downstream genes [ 4 ]. (biomedres.info)
  • Potential host target genes were predicated and validated by qRT-PCR to study the impact of microRNAs on the host genes. (hindawi.com)
  • In a set of preliminary experiments we have identified a group of about 100 genes, including 30 novel sequences, which are either significantly down regulated or up regulated in response to inhibiting FGF signalling in early gastrula stage Xenopus embryos. (york.ac.uk)
  • These analyses will allow us to classify the FGF targets into synexpression groups of co-regulated genes, reference to co-regulated genes with known function will be a powerful tool in establishing possible functions for novel genes. (york.ac.uk)
  • In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. (frontiersin.org)
  • We conclude that duplicated paralogous genes that often changed their function, also diverse in their tendency to be miRNA regulated. (frontiersin.org)
  • MicroRNAs (miRNAs) post-transcriptionally regulate genes across all animals and plants. (frontiersin.org)
  • Using a combination of miRNA hairpin predictions and co-mapping with miRBase entries, we identified a highly conserved cluster of miRNA genes on the X chromosome in the tammar and a total of 94 other predicted miRNA producing genes. (biomedcentral.com)
  • An additional nine genes were identified in tammar that do not have an orthologous miRNA target in human and likely represent novel miRNA-regulated genes in the tammar. (biomedcentral.com)
  • Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. (nature.com)
  • We identified seven putative target genes ( MTDH , EPN3 , TPD52 , CYP27B1 , LMAN1 , STAT1 and TXNDC12 ) that were coordinately regulated by miR-145-5p and miR-145-3p in lung SCC. (oncotarget.com)
  • RNA extracted from mock-infected and WNV-infected cells was assessed for differential expression of genes using Affymetrix microarray. (molvis.org)
  • A total of 86 DE-miRNAs and 460 target genes were identified. (biomedcentral.com)
  • Herein, to provide better understanding of the molecular events in GBC pathogenesis, we developed GBCdb ( http://tmliang.cn/gbc/ ), a user-friendly interface for the query and browsing of GBC-associated genes and RNA interaction networks using published multi-omics data, which also included experimentally supported data from different molecular levels. (biomedcentral.com)
  • A total of 13 target genes were predicted to be the target genes of miRNA target genes. (biomedcentral.com)
  • ApoVs are rich in proteins, RNA (microRNAs, mRNAs, ncRNAs, etc.) and lipids, and are a key intercellular communication mediator that can exert different regulatory effects on recipient cells. (biomedcentral.com)
  • The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
  • A total of 124 mRNAs were identified in both strains. (fiocruz.br)
  • MicroRNAs (miRNAs) are small noncoding endogenous RNA molecules that repress target mRNAs through complementary binding in the message 3'-UTR. (ukri.org)
  • MiRNAs silence target mRNAs via the RNA-induced silencing complex (RISC), of which Argonaute proteins (Ago) are the major subunit. (ukri.org)
  • MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. (wikipedia.org)
  • Currently, an increasing number of studies have indicated that miRNAs and small noncoding RNA molecules have great potential for the cancer treatment. (hindawi.com)
  • Half of these fragments aligned to the reverse strand of the transcript, suggesting the occurrence of microRNA (miRNA)-like molecules in fungal EVs. (fiocruz.br)
  • Taking the results together, our study provided information about the RNA molecules present in H. capsulatum EVs and about the differences in composition between the strains. (fiocruz.br)
  • The RNA molecules in EVs have been implicated in a variety of processes. (fiocruz.br)
  • Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. (biomedcentral.com)
  • Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
  • isolated the lin-4 miRNA, they found that instead of producing an mRNA encoding a protein, it produced short non-coding RNAs, one of which was a ~22-nucleotide RNA that contained sequences partially complementary to multiple sequences in the 3' UTR of the lin-14 mRNA. (wikipedia.org)
  • The present study aimed to screen and explore the key circRNA/microRNA (miRNA or miR)/mRNA interactions in head and neck squamous cell carcinoma (HNSCC) using bioinformatics. (spandidos-publications.com)
  • Circular RNAs (circRNAs) are closed, long, non-coding RNAs that are formed via direct reverse splicing of precursor mRNA that function by regulating RNA transcription and protein production, as well as sponging miRNAs ( 4 ). (spandidos-publications.com)
  • MicroRNAs (miRNAs) are a kind of small noncoding RNAs that regulate the expression of protein through targeting the 3′UTR of messenger RNA (mRNA), resulting in mRNA degradation or suppression of translation [ 5 ]. (degruyter.com)
  • The mature miRNA is then loaded onto an Argonaute protein (Ago2 in humans) where it then interacts with and regulates the mRNA target. (biomedcentral.com)
  • An intermediate between DNA and protein is called messenger RNA (mRNA), and neurons can transport mRNA to the parts of the neuron close to synapses and locally control the synthesis of a particular protein that is important for those synapses at a particular time. (ukri.org)
  • Another type of molecule, called micro RNA (miRNA) can bind to mRNA and stop the translation of mRNA into protein. (ukri.org)
  • While most membranous and disease related proteins are regulated by miRNAs, the G-protein coupled receptor (GPCR) family is an exception, being mostly unregulated by miRNAs. (frontiersin.org)
  • Many have been assigned roles in modulating the local translation of proteins that are essential to dendritic spine morphogenesis, synaptic function and memory formation. (ukri.org)
  • RNA-seq results showed that transcription factors and macrophage inflammatory proteins were significantly downregulated in the DNMT3A mutant clones. (frontiersin.org)
  • Here, we attempted to verify the endocrine role of EV production and their contents, such as RNAs and bioactive proteins, from the regulation of biogenesis, secretion, and action mechanisms while discussing the current technical limitations. (molcells.org)
  • Exosomes are extracellular micro-vesicles containing various proteins and nucleic acids, which play roles in transporting information and substance among cells [ 16 , 17 ]. (biomedcentral.com)
  • miRNAs are a class of short (∼22 nucleotide) noncoding RNAs (ncRNAs). (frontiersin.org)
  • Non-coding RNAs (ncRNAs) are enriched in exosomes, which participated in generation, progression, and resistance of BC. (biomedcentral.com)
  • MiRNAs account for about half of the total RNAs of extracellular vesicles, and play important roles in biological processes such as cell proliferation and differentiation, whereas the functions of macrophage-derived apoVs remain largely unknown. (biomedcentral.com)
  • The activity of NEK6 plays important roles in mitotic spindle kinetochore fiber formation, metaphase-anaphase transition, cytokinesis, and checkpoint regulation [ 3 , 4 ]. (hindawi.com)
  • Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
  • Importante information: Extracellular vesicles (EVs) play important roles in cellular communication and pathogenesis. (fiocruz.br)
  • The oncogenic roles of miR-126 have been well validated in bladder cancer, which could promote tumor growth and progression both in vitro and in vivo experiments [ 6 , 7 ]. (biomedres.info)
  • the micrornas (mirnas or mirs), a type of small non-coding rna , have emerged as molecular regulators that can have key roles as tumor suppressors or oncogenes in pathogenesis and progression of different malignancies, including breast cancer. (icbcongress.com)
  • It has been demonstrated that non-coding RNAs, more specifically, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play essential roles in tumor progression [ 9 , 10 ]. (aging-us.com)
  • Previous studies have shown that aberrant microRNA expression can affect MDS-MSCs, which can then affect MDS progression. (techscience.com)
  • It has been suggested that abnormal expression of microRNAs (miRNAs) is associated with carcinogenesis. (spandidos-publications.com)
  • The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
  • These highly upregulated microRNAs may have crucial roles in Adv pathogenesis and are potential biomarkers for adenovirus-infected pneumonia. (hindawi.com)
  • Successful completion of the proposed studies will greatly advance our current knowledge regarding how noncoding RNA-mediated epigenetic regulation governs normal human neuron development and their contribution to the complex etiology of various cognitive and neurological diseases, which is a critical prerequisite for developing novel diagnosis biomarkers and/or therapeutic strategies against brain illnesses. (grantome.com)
  • These findings indicate that miR-323a-3p regulates the proliferation, migration, invasion, and apoptosis of COAD cells by targeting NEK6. (hindawi.com)
  • Small RNAs are important regulators that modulate development, proliferation, differentiation, and apoptosis of organisms [ 15 , 16 ]. (hindawi.com)
  • Besides, miR155 regulated osteogenesis and adipogenesis of MSCs cultured with macrophage-derived apoVs via the SMAD2 signaling pathway. (biomedcentral.com)
  • In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
  • We also compared the transcriptome profiles of H. capsulatum with the RNA composition of EVs, and no correlation was observed. (fiocruz.br)
  • A year later, the lin-4 and let-7 RNAs were found to be part of a large class of small RNAs present in C. elegans, Drosophila and human cells. (wikipedia.org)
  • In COAD cells, NEK6 was highly expressed, whereas miR-323a-3p was expressed at low levels and negatively regulated NEK6. (hindawi.com)
  • We find that the core microRNA (miRNA) biogenesis and targeting machinery maintains the sensitivity of cancer cells to PD-1-independent T cell-mediated cytotoxicity. (nature.com)
  • EMT is an embryologically conserved genetic program by which epithelial cells down regulate intercellular tight junctions, loose polarity, express mesenchymal markers, and manifest a migratory phenotype [ 1 ]. (intechopen.com)
  • Although miRNAs have been examined in Adv type 3-infected human laryngeal epithelial cells and Adv type 2-infected human lung fibroblast cells [ 19 , 20 ], there is no research about small RNA profiling in whole blood of Adv-infected pneumonia children. (hindawi.com)
  • Using these cells we will be able to understand more about the mechanisms that regulate the local control of protein synthesis in neurons in response to synaptic activity, and hence further our knowledge of the mechanisms that underlie long-term memory. (ukri.org)
  • Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis. (shengsci.com)
  • Total RNA from cells was extracted in TRIzol Reagent. (biomedcentral.com)
  • Tanshinone II A is an effective component extracted from Salvia miltiorrhiza and the roles of Tanshinone IIA in regulating the stemness of tumor cells remain unclear. (biomedcentral.com)
  • In neurons derived from human induced- pluripotent stem cells (hiPSCs), Gomafu regulates alternative splicing (AS) of primary transcripts essential for neuronal development and synaptic function. (grantome.com)
  • The binding sites of miR-128-3p and TGFBR2 were predicted by Targetscan online software and confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. (degruyter.com)
  • Here, we determine the embryonic ontogeny of the two main striatal pathways (striatonigral and striatopallidal) and identify novel (non)cell-autonomous roles for the axon guidance receptor Frizzled3 in uncharacterized aspects of striatal pathway formation (i.e., anterior-posterior axon guidance in the striatum and axon entry into the globus pallidus). (jneurosci.org)
  • Based on this concept, we have identified microRNA- (miRNA) mediated oncogenic pathways in lung SCC. (oncotarget.com)
  • miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. (wikipedia.org)
  • At the time, the lin-4 small RNA was thought to be a nematode idiosyncrasy. (wikipedia.org)
  • In 2000, a second small RNA was characterized: let-7 RNA, which represses lin-41 to promote a later developmental transition in C. elegans. (wikipedia.org)
  • The let-7 RNA was found to be conserved in many species, leading to the suggestion that let-7 RNA and additional "small temporal RNAs" might regulate the timing of development in diverse animals, including humans. (wikipedia.org)
  • At this point, researchers started using the term "microRNA" to refer to this class of small regulatory RNAs. (wikipedia.org)
  • In our study, total RNA extracted from whole blood of adenovirus-infected pneumonia children and healthy controls were analyzed by small RNA deep sequencing. (hindawi.com)
  • miRNAs are the most well-studied small RNAs during the latest decades. (hindawi.com)
  • With the maturation of deep sequencing methodologies for small RNA identification, the number of reported mature miRNAs has drastically increased. (frontiersin.org)
  • As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short interacting RNAs (crasiRNAs). (biomedcentral.com)
  • Using next generation sequencing, we have characterized the major classes of small RNAs, micro (mi) RNAs, piwi interacting (pi) RNAs, and the centromere repeat associated short interacting (crasi) RNAs in the tammar. (biomedcentral.com)
  • A survey of the tammar gonadal piRNAs shows that these small RNAs are enriched in retroelements and carry members from both marsupial and tammar-specific repeat classes. (biomedcentral.com)
  • These small RNAs are derived largely from centromere-enriched retroelements, including a novel SINE. (biomedcentral.com)
  • This study encompasses the first analyses of the major classes of small RNAs for the newly completed tammar genome, validates preliminary annotations using deep sequencing and computational approaches, and provides a foundation for future work on tammar-specific as well as conserved, but previously unknown small RNA progenitors and targets identified herein. (biomedcentral.com)
  • Each class of small RNAs is synthesized by a distinct mechanism and each has discrete biological functions. (biomedcentral.com)
  • Another class of important small RNAs is the piRNAs. (biomedcentral.com)
  • miR-34a was found to be up-regulated in small airway fibroblasts in COPD patients compared to non-smokers, and miR-34a could promote cellular senescence in small airway fibroblasts in COPD patients [ 15 ]. (researchsquare.com)
  • The Ct values of the target miRs were normalized to the Ct values of U6 RNA before quantification using the 2 −ΔΔ Ct method. (biomedcentral.com)
  • MicroRNAs (miRNAs) are involved in the prognosis of nasopharyngeal carcinoma (NPC). (biomedcentral.com)
  • Macrophages could regulate the differentiation of MSCs via different molecular mechanisms, including extracellular vesicles. (biomedcentral.com)
  • Furthermore, we performed microRNA loss- and gain-of-function experiments and western blot to determine the molecular mechanism. (biomedcentral.com)
  • Circular RNAs (circRNAs) are molecular sponges that are involved in regulation of multiple types of cancer. (spandidos-publications.com)
  • Altogether, our findings elucidate conserved cellular and molecular mechanisms through which miR-34/449 regulate motile ciliogenesis. (nature.com)
  • Remarkably, the molecular programs regulating striatal pathway development remain poorly characterized. (jneurosci.org)
  • However, molecular mechanisms that regulate human Gomafu expression remain unexplored. (grantome.com)
  • miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (cancerindex.org)
  • In this set of RNA classes, 93 transcripts were enriched in EVs from the G217B strain, whereas 31 were enriched in EVs produced by the G186AR strain. (fiocruz.br)
  • In addition, we found no correlation between the most highly expressed transcripts in the cell and their presence in the EVs, reinforcing the idea that the RNAs were directed to the EVs by a regulated mechanism. (fiocruz.br)
  • Du, T. & Zamore, P. D. microPrimer: the biogenesis and function of microRNA. (nature.com)
  • Circular RNAs (circRNAs) are a new RNA type, deriving from back-splicing. (mdpi.com)
  • These lipid bilayered compartments play essential roles in cellular communication and pathogenesis. (fiocruz.br)
  • miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. (shengsci.com)
  • These discoveries together suggest that Gomafu plays essential roles in governing normal brain function. (grantome.com)
  • However, there are few reports on the microRNA (miRNA/miR) regulation of NEK6. (hindawi.com)
  • Post-transcriptional regulation in multicellular organisms is mediated by microRNAs. (frontiersin.org)
  • The lncRNA TMPO-AS1 promotes cell proliferation, migration, invasion and epithelial-to-mesenchymal transition by regulating the miR-1179/E2F2 axis [ 13 ]. (biomedcentral.com)
  • miRNAs play key roles in a broad range of cellular processes and the response to changes in the environment ( Leung and Sharp, 2010 ). (frontiersin.org)
  • We identified 160 differentially expressed miRNAs using RNA-Seq data from the GEO database. (biomedcentral.com)
  • Our results showed that miR-486-5p was significantly up-regulated in the COPD and smoker groups compared to the control group based on bioinformatics analysis and qPCR validation of alveolar macrophages and peripheral monocytes. (researchsquare.com)
  • Results: Analysis of the ONCOMINE and GEPIA databases showed that VGLL3 was significantly up-regulated in GC tissues (P = 0.003), and associated with the tumor TNM stage (P = 0.0163). (researchgate.net)
  • It relieved the inhibitory effect of DNMT3A mutation, promoted the phenotypic recovery of the co-cultured macrophages, eliminated resistance, and regulated the immune microenvironment. (frontiersin.org)
  • This work aims to explore the roles and underlying mechanisms of Tanshinone IIA in breast cancer stemness. (biomedcentral.com)
  • More specifically, they can act as microRNA sponges, protein sponges or scaffolds, and encode for peptides. (mdpi.com)
  • In mechanism, apoVs were enriched for microRNA155 (miR155), and apoVs regulated osteogenesis and adipogenesis of MSCs by delivering miR155. (biomedcentral.com)
  • We aim to test this hypothesis by analysing the precise mechanism for how PICK1 regulates the function of Argonaute2. (ukri.org)
  • However, the underlying roles and mechanism of Tanshinone IIA in modulating breast cancer stemness are still confusing. (biomedcentral.com)
  • Macrophage-derived apoVs could regulate the osteogenesis and adipogenesis of MSCs through delivering miR155, which provided novel insights for MSC-mediated tissue engineering. (biomedcentral.com)
  • A total of six pairs of cancerous and adjacent healthy tissue were obtained from patients with HNSCC and genome‑wide transcriptional sequencing was performed. (spandidos-publications.com)
  • microRNA (miRNA) expression level alterations between endometrial tissue and endometriotic lesions indicate their involvement in endometriosis pathogenesis. (mdpi.com)