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  • MTOR KINASE
  • That of FKBP12-rapamycin remained mysterious until genetic and molecular studies in yeast established FKBP12 as the target of rapamycin, and implicated TOR1 and TOR2 as the targets of FKBP12-rapamycin in 1991 and 1993, followed by studies in 1994 when several groups, working independently, discovered the mTOR kinase as its direct target in mammalian tissues. (wikipedia.org)
  • The role of mTORC2 in skeletal muscle has taken time to uncover, but genetic loss of mTORC2/Rictor in skeletal muscle results in decreased insulin-stimulated glucose uptake, and resistance to the effects of an mTOR kinase inhibitor on insulin resistance, highlighting a critical role for mTOR in the regulation of glucose homeostasis in this tissue. (wikipedia.org)
  • inhibitor
  • As alterations in fibroblast growth factor receptor (FGFR) activity have been implicated in breast cancer, we examined in breast cancer models with autocrine FGFR activity the impact of targeting FGFRs in vivo with a selective kinase inhibitor in combination with an inhibitor of PI3K/mTOR or with a pan-ErbB inhibitor. (nih.gov)
  • domain
  • From the N-terminus to the C-terminus, these domains are named FRAP-ATM-TRAAP (FAT), the kinase domain (KD), the PIKK-regulatory domain (PRD), and the FAT-C-terminal (FATC). (wikipedia.org)
  • mTORC1 kinase
  • The small GTPase Rheb, in its GTP-bound state, is a necessary and potent stimulator of mTORC1 kinase activity, which is negatively regulated by its GAP, the tuberous sclerosis heterodimer TSC1/2. (agscientific.com)
  • subunit
  • This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. (nih.gov)
  • calcium
  • In response to in- creases in intracellular calcium, the serine/threonine phospha-tase calcineurin becomes activated, dephosphorylating NFAT The hair follicle (HF) is an excellent model for studying stem cell proteins and allowing their nuclear translocation. (gotomydoctor.com)
  • family
  • The human being Aurora kinase family members contains three subtypes: A, B, and C. Aurora kinase A (AURKA) and B are overexpressed in lots of human tumor cell-derived cell lines and tumor tissues, and so are linked to carcinogenesis (4). (acancerjourney.info)
  • activation
  • Moreover, KIBRA expres-sion is induced by androgen signaling and KIBRA is partially required for androgen recep-tor (AR) signaling activation in prostate cancer cells. (unmc.edu)
  • mediator
  • A report of lifespan extension in rapamycin-treated mice suggested that the TOR pathway, a conserved mediator of DR in invertebrates, may also be critical to DR effects in mammals. (isharonline.org)