Topoisomerase I InhibitorsDNA Topoisomerases, Type ICamptothecinTopoisomerase II InhibitorsTopotecanDNA Topoisomerases, Type IITopoisomerase InhibitorsAntineoplastic Agents, PhytogenicIndenesTeniposideEnzyme InhibitorsAntineoplastic AgentsDrug Screening Assays, AntitumorDNA CleavageDNA, SuperhelicalIntercalating AgentsDNA DamageEtoposideTumor Cells, CulturedDNA Topoisomerase IVAmsacrineIsoquinolinesDNABenzodioxolesCarbazolesNaphthyridinesCell Line, TumorDrug Administration ScheduleDose-Response Relationship, DrugHT29 CellsDrug Resistance, NeoplasmDrug SynergismApoptosisCell SurvivalCarboxylesteraseNeoplasmsPoly(ADP-ribose) PolymerasesRotenoneColonic NeoplasmsCell CycleInfusions, IntravenousDNA TopoisomerasesInhibitory Concentration 50Mice, NudeDNA ReplicationDNA FragmentationStructure-Activity RelationshipNovobiocinDNA, NeoplasmDNA RepairCarcinoma, Small CellMolecular Sequence DataBase SequenceXenograft Model Antitumor AssaysMolecular StructureEllipticinesTransplantation, HeterologousModels, MolecularAntineoplastic Combined Chemotherapy ProtocolsNeutropeniaCell DivisionHistonesCell LineAntigens, NeoplasmDNA-Binding ProteinsNucleic Acid ConformationTumor Suppressor Protein p53DNA, CatenatedRazoxaneLung NeoplasmsPlasmidsElectron Transport Complex IMutationPodophyllotoxinEscherichia coliKineticsNeoplasm ProteinsDNA GyraseCatalysisBinding SitesDrug ResistanceOvarian NeoplasmsSubstrate Specificity