Administration, OralDrug Administration ScheduleInjections, IntravenousUnited States Food and Drug AdministrationDose-Response Relationship, DrugDrug Administration RoutesTime FactorsRats, Sprague-DawleyRats, WistarAdministration, IntranasalDisease Models, AnimalInjections, IntraperitonealStereoisomerismTropaeolaceaeLiverMice, Inbred C57BLPlant ExtractsInjections, SubcutaneousAdministration, RectalAntibodies, MonoclonalBiological AvailabilityMice, Inbred BALB CInjections, IntramuscularAdministration, TopicalMagnetic Resonance SpectroscopyInfusions, IntravenousHalf-LifeAdministration, IntravenousDrug InteractionsArea Under CurveInjections, IntraventricularMolecular StructureTreatment OutcomeRats, Inbred StrainsAdministration, CutaneousTissue DistributionNucleic Acid ConformationChromatography, High Pressure LiquidRabbitsDogsImmunoglobulin GRecombinant ProteinsDouble-Blind MethodMolecular ConformationAntibodiesModels, MolecularPhytotherapyGuanineCross-Over StudiesRNA, MessengerBlood PressureAdministration, SublingualEnzyme-Linked Immunosorbent AssayMice, Inbred StrainsBrainAdministration, InhalationKidneyInfusions, ParenteralDNABody WeightRandom AllocationDeoxyguanosineAntineoplastic AgentsBehavior, AnimalPregnancyImmunohistochemistryDrug ToleranceMorphineKineticsSpleenCells, CulturedHydrogen BondingInjectionsAnalysis of VarianceAnti-Inflammatory AgentsInjections, SpinalOrgan SizeMetabolic Clearance RateHeterocyclic Compounds, Bridged-RingMice, Inbred ICRLungBase PairingPachyrhizusRats, Inbred F344Plants, MedicinalAnalgesics, OpioidSelf AdministrationEthanolHeart RateGuanosineEstradiolTumor Necrosis Factor-alphaMotor ActivityDeoxycytosine NucleotidesAdenineMolecular Sequence DataDrug CombinationsMice, KnockoutHemodynamicsBlotting, Western