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  • naive
  • The first population is CD25 − /FOXP3 − and does not proliferate, whereas the second CD25 + /FOXP3 + population proliferates and inhibits the effector function of peptide stimulated naive T cells ( 10 , 11 ). (aacrjournals.org)
  • Of 17 B and T cell subsets analyzed, PHIV and PHEU differed only in the number of CD4+ T cells and frequency of naive B cells, which were higher in PHEU than in PHIV. (frontiersin.org)
  • immune response
  • The clonotypic idiotype of malignant B cells was the first tumor-specific antigen identified as capable of eliciting a T cell-mediated immune response ( 1 , 2 ). (aacrjournals.org)
  • Despite the existence of this tumor-antigen and the well-documented expression of MHC class I and class II molecules ( 3 ), as well as costimulatory molecules by a majority of human B-cell malignancies, no spontaneous clinically significant immune response in these diseases has been documented ( 4 ). (aacrjournals.org)
  • regulatory
  • Regulatory T cells (Treg) play a central role in the induction of tolerance to tumor antigens, yet the precise mechanisms regulating its induction in vivo remain to be elucidated. (aacrjournals.org)
  • Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. (nih.gov)
  • Conclusions Stimulation with pegylated-G-CSF or G-CSF results in different expression of key regulatory genes and different functional properties of mobilized hematopoietic stem cells as well as their progeny, a finding that might be relevant for the application of these cells in blood stem cell transplantation. (haematologica.org)
  • genes
  • We have reported that ablation of the three genes in vascular endothelial cells prevents atherosclerosis in Low-density lipoprotein receptor knockout mice. (nbdiabetes.org)
  • The CD34 + cells mobilized by pegylated G-CSF had higher expression levels of genes indicative of early hematopoiesis, including HOXA9 , MEIS1 and GATA3 . (haematologica.org)
  • experimental
  • Thirdly, the choice of cell dose, route and frequency of administration (both in in experimental models and clinical trials) adds another layer of complexity. (frontiersin.org)
  • efficacy
  • 1 Currently, granulocyte colony-stimulating factor (G-CSF) is the most favored cytokine administered for peripheral blood stem cell mobilization because of its great efficacy and lack of serious toxicity. (haematologica.org)
  • peripheral blood
  • 2017. Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjogren's Syndrome. (uib.no)
  • 2016. An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells. (uib.no)
  • 2015. TLR-7 and -9 Stimulation of Peripheral Blood B Cells Indicate Altered TLR Signalling in Primary Sjögren's Syndrome Patients by Increased Secretion of Cytokines. (uib.no)
  • Peripheral blood stem and progenitor cells are widely utilized for autologous and allogeneic grafts as they provide rapid and sustained hematologic reconstitution following high dose chemotherapy. (haematologica.org)
  • In order to obtain a sufficient harvest, stem cells can be mobilized into the peripheral blood using cytokines, cytotoxic chemotherapy or a combination of both. (haematologica.org)
  • progenitor cells
  • We have shown that, surprisingly, somatic ablation of Foxo1 in Neurog3 + enteroendocrine progenitor cells gives rise to gut insulin-positive cells (Ins + ) that express markers of mature-cells, and secrete bioactive insulin as well as C-peptide in response to glucose and sulfonylureas. (nbdiabetes.org)
  • Background Pegylated granulocyte colony-stimulating factor (G-CSF) has recently been introduced as a new compound for mobilization of CD34 + hematopoietic stem and progenitor cells. (haematologica.org)
  • stromal cells
  • This application discloses a micro-encapsulation system for immobilizing mesenchymal stromal cells (MSCs) while sustaining the molecular communication. (patents.com)
  • The present disclosure relates to composition comprising pooled and expanded allogeneic mesenchymal Stromal cells (MSCs) and a method for management of. (patents.com)
  • protein
  • Kosiewicz MM, Alard P, Streilein JW: Alterations in cytokine production following intraocular injection of soluble protein antigen: impairment in IFN-gamma and induction of TGF-beta and IL-4 production. (springer.com)
  • hematopoietic
  • Flow cytometry and fluorescence activated cell sorting was conducted to assess the CD34 + subset composition and to obtain Lin − , CD34 + , CD38 − hematopoietic stem cells. (haematologica.org)
  • Results Pegylated G-CSF and unconjugated G-CSF mobilized CD34 + and hematopoietic stem cells with different molecular phenotypes and functional properties. (haematologica.org)
  • Consistently, greater numbers of hematopoietic stem cells and common myeloid progenitors and fewer megakaryocyte-erthrocyte progenitors were found in the pegylated-G-CSF-mobilized CD34 + cells. (haematologica.org)
  • Additionally, sorted pegylated-G-CSF-mobilized hematopoietic stem cells displayed higher expression of HOXA9 in comparison to G-CSF-mobilized hematopoietic stem cells. (haematologica.org)
  • In line with the gene expression data, CD34 + cells mobilized by pegylated G-CSF, as well as sorted hematopoietic stem cells, showed a significantly greater cell cycle activity. (haematologica.org)
  • inflammation
  • The preventive effect of FoxO ablation on atherosclerosis likely ensues from its ability to increase cell survival and nitric oxide availability, and dampen inflammation, chemotaxis, and superoxide generation. (nbdiabetes.org)