• NEW HAVEN, Conn., March 09, 2023 (GLOBE NEWSWIRE) -- BioXcel Therapeutics, Inc. (Nasdaq: BTAI), a biopharmaceutical company utilizing artificial intelligence approaches to develop transformative medicines in neuroscience and immuno-oncology, today announced its financial results for the fourth quarter and full year ended Dec. 31, 2022 and provided an update on key strategic initiatives. (globenewswire.com)
  • BRIDGEWATER, NJ, USA I November 17, 2022 I VYNE Therapeutics Inc. (Nasdaq: VYNE) ("VYNE" or the "Company"), a biopharmaceutical company developing proprietary, innovative, and differentiated therapies for the treatment of immuno-inflammatory conditions, today announced that the first subjects have been dosed in a Phase 1a/b clinical trial evaluating VYN201 for the treatment of vitiligo. (pipelinereview.com)
  • Geneva, Switzerland, August 15, 2022 - Addex Therapeutics (SIX and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development, today announced that its collaboration agreement with Indivior PLC (LON: INDV) for discovering and developing novel oral gamma-aminobutyric acid subtype B (GABAB) positive allosteric modulator (PAM) drug candidates has been extended until March 31, 2023. (addexpharma.com)
  • Royalties for the third quarter of 2023 were $23.9 million, compared with $19.3 million for the same period in 2022, with the increase primarily attributable to Amgen's (Nasdaq: AMGN) Kyprolis, Jazz Pharmaceuticals' (Nasdaq: JAZZ) RYLAZE, Merck and Co.'s (NYSE: MRK) Vaxneuvance and Travere Therapeutics' (Nasdaq: TVTX) FILSPARI. (ligand.com)
  • The decrease in net income from the prior year period is due primarily to the decrease in COVID-19 related Captisol sales and the non-cash unrealized loss from short-term investments associated with Viking Therapeutics (Nasdaq: VKTX) stock of $11.5 million. (ligand.com)
  • United Therapeutics Corporation (Nasdaq: UTHR), a public benefit corporation, today announced the publication of additional clinical and long-term safety data from the BREEZE study evaluating Tyvaso DPI™ (treprostinil) in patients with pulmonary arterial hypertension ( PAH ) in the journal Pulmonary Circulation . (industryintel.com)
  • We're pleased to report another quarter of strong financial results and we are now actively executing on our investment strategy as evidenced by the recent Tolerance, Ovid, Novan and Primrose transactions, in which we collectively invested over $75 million in Q3 and early Q4 2023," said Todd Davis, CEO of Ligand. (ligand.com)
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  • Addex Therapeutics is a clinical-stage pharmaceutical company focused on the development and commercialization of an emerging class of novel orally available, small molecule drugs known as allosteric modulators for neurological disorders. (addexpharma.com)
  • In this review, we will focus on three main areas of active research in immune tolerance. (frontiersin.org)
  • First, tolerogenic vaccines aiming at robust, lasting autoantigen-specific immune tolerance. (frontiersin.org)
  • Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
  • Immune tolerance co-evolved as a safety system that maintains a state of immune unresponsiveness to autoantigens and self-tissues ( 2 , 3 ). (frontiersin.org)
  • Evidence suggest that a patient's genetic predisposition together with environmental factors, such as exposure to pathogens that exhibit molecular mimicry, disturb immune tolerance ( 4 ). (frontiersin.org)
  • Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
  • Thus, therapeutics that induce, restore, and maintain immune tolerance toward these autoantigens represent the "Holy Grail" of treatments for autoimmune diseases. (frontiersin.org)
  • The issue of immune tolerance is, of course, central to transplantation research. (nih.gov)
  • Use of these cells in adoptive therapy is designed to restore immune tolerance and eliminate disease. (biospace.com)
  • Here, we demonstrated the impact of iPSC-derived human MSCs on the development of immune tolerance and long-term graft survival in mouse orthotopic airway allografts. (biomedcentral.com)
  • Collectively, these data confirmed that iPSC-derived MSC-mediated immunosuppression has potential to establish immune tolerance and rescue allograft from sustained hypoxic/ischemic phase, and subsequently limits long-term airway epithelial injury and collagen progression, which therapeutically warrant a study of Cymerus iPSC-derived MSCs as a potential management option for immunosuppression in transplant recipients. (biomedcentral.com)
  • Nora's lead compound, NT100, is a novel biologic agent similar to a naturally occurring protein in the female reproductive tract and may better enable embryo implantation and pregnancy maintenance by optimizing maternal-fetal immune tolerance. (prnewswire.com)
  • Our antigen-agnostic immune tolerance restoration approach centered on developing Tim (T-cell immunoglobulin and mucin domain) agonists, along with our in-depth knowledge of immunology and immune tolerance are the keys to unlocking transformative therapies for patients with additional consideration for their quality of life. (bigcountryhomepage.com)
  • LAPIX Therapeutics Inc. is a Boston, MA-based company in the biopharma sector, focused on developing novel, orally bioavailable immune system restoration therapies, including immune tolerance restoration therapy for autoimmune diseases, immune tolerance induction therapies for gene therapy, and immune function restoration therapies for oncology. (bigcountryhomepage.com)
  • Sanofi has its UK R&D base on the Babraham Research Campus, south of Cambridge, which is focused on the discovery of novel therapeutics for the treatment of chronic inflammatory and autoimmune diseases, and also brings expertise around antibody discovery and antibody engineering. (bioindustry.org)
  • Over the past four years, MIP has provided seed funding to a diverse portfolio of projects in the artificial intelligence and digital health spaces, as well as to the development of novel therapeutics and medical devices. (massgeneral.org)
  • PALO ALTO, Calif. , April 17, 2014 /PRNewswire/ -- Nora Therapeutics, a biotechnology company focused on developing therapeutics to address unmet needs in reproductive medicine, today announced the closing of an $18 million Series B financing. (prnewswire.com)
  • Nora Therapeutics is a privately-held biotechnology company focused on developing therapeutics to address IVF failure and recurrent pregnancy loss, two reproductive conditions with significant unmet need. (prnewswire.com)
  • BOSTON--( BUSINESS WIRE )-- JURA Bio , a biotechnology company developing immune-based therapeutics using machine learning and synthetic biology, announced today a research collaboration with Syena, a cell therapy product company and subsidiary of Replay, a genome writing company, to develop T cell receptor (TCR) based therapies. (businesswire.com)
  • Behavioral tolerance occurs with the use of certain psychoactive drugs, where tolerance to a behavioral effect of a drug, such as increased motor activity by methamphetamine, occurs with repeated use. (wikipedia.org)
  • Dr. Tisdale has an active research program in trying to characterize tolerance and create conditions in which patients will more easily tolerate donor cells and tissues without the need for destroying the immune system or perpetual use of immunosuppressant drugs. (nih.gov)
  • A common cause of pharmacodynamic tolerance is high concentrations of a substance constantly binding with the receptor, desensitizing it through constant interaction. (wikipedia.org)
  • Pharmacodynamic tolerance to a receptor antagonist involves the reverse, i.e., increased receptor firing rate, an increase in receptor density, or other mechanisms. (wikipedia.org)
  • Thus, chronic administration of opioids modifies neuronal MOR function through a variety of mechanisms including receptor phosphorylation, signaling, multimerization, and trafficking, which may underlie tolerance to morphine. (hindawi.com)
  • Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice. (neurotree.org)
  • Furthermore, PAMs only act when the natural ligand (GABA) activates the receptor, hence respecting the physiological cycle of activation, which is believed to explain why PAMs lead to less tolerance than direct agonists. (addexpharma.com)
  • The next wave of truly transformative therapeutics should aspire to provide a cure by selectively suppressing pathogenic autoantigen-specific immune responses while leaving the rest of the immune system intact to control infectious diseases and malignancies. (frontiersin.org)
  • Morphine has unfavorable side effects including analgesic tolerance. (hindawi.com)
  • However, chronic opioid use can result in analgesic tolerance, hyperalgesia, and other side effects, which seriously affect the safety and comfort of patients [ 2 ]. (hindawi.com)
  • Morphine tolerance is an adaptive process induced by chronic morphine that has been shown to result from complex alterations at the molecular level with μ opioid receptors (MORs), as well as at the synaptic, cellular, and circuit levels. (hindawi.com)
  • Therapeutic strategies that can bolster opioid analgesia while mitigating tolerance are urgently needed to improve patients' safety. (hindawi.com)
  • Morphine tolerance is an adaptive process that has been proposed to result from complex alterations at the molecular level with μ opioid receptors (MORs), as well as at the synaptic, cellular, and circuit levels, in both the peripheral and central nervous systems. (hindawi.com)
  • Molecular pathways and mechanisms tied to neuroinflammation appear to play similar, yet distinct roles in the development of both opioid tolerance and opioid-induced hyperalgesia. (taylorfrancis.com)
  • This suggests that mediating neuroinflammation would prove beneficial in treating opioid tolerance and opioid-induced hyperalgesia. (taylorfrancis.com)
  • In addition, Dr. Sullivan would like to disclose that he is consulting with Chrono Therapeutics concerning development and testing of an opioid taper device. (cdc.gov)
  • CAMBRIDGE, Mass.--( BUSINESS WIRE )--Casebia Therapeutics, a leading genetic engineering company, and Seattle Children's Research Institute today announced an exclusive license agreement and research collaboration to explore new methods to treat and prevent autoimmune disease using CRISPR/Cas9 gene-edited regulatory T cells (Tregs)-a type of white blood cell that controls and modulates the body's immune response. (biospace.com)
  • Chris Schiering (Director of Translational Biology, Immune Regulation & Tolerance Cluster, I&I Research) and Mark Peakman (Head of Immune Regulation & Tolerance Cluster, I&I Research) will represent Sanofi on the Milner Innovation Board. (bioindustry.org)
  • Now in its 9th year, the Amsterdam Immunogenicity & Tolerance Seminar has become a much-anticipated forum for sharing research and ideas in the fields of immunogenicity and tolerance. (epivax.com)
  • In addition, traditional protein therapeutics research (still somewhat new as well), has expanded complexity to include Bispecific and Multispecifc antibodies, fusion proteins, and peptide therapeutics. (epivax.com)
  • During his research, he investigated therapeutics for glioblastoma multiforme and novel interactions for human PrimPol - a DNA damage tolerance pathway, working with a leading expert in the field of Genome Damage & Stability. (hansonwade.com)
  • Los efectos del cannabidiol lo convierten en una alternativa, of the title and research adicional a la terapéutica convencional, para el control de síntomas en trastornos neurológicos, disminuyendo de forma objectives, exhaustive sostenida el número total de episodios con un perfil de seguridad aceptable. (bvsalud.org)
  • The mechanisms underlying morphine tolerance remain disputed, which has prevented the development of therapies to maximize and sustain analgesic efficacy. (hindawi.com)
  • Pharmacodynamic tolerance begins when the cellular response to a substance is reduced with repeated use. (wikipedia.org)
  • While most occurrences of pharmacodynamic tolerance occur after sustained exposure to a drug, instances of acute or instant tolerance (tachyphylaxis) can occur. (wikipedia.org)
  • Mechanisms of peripheral tolerance include inactivation of autoantigen-recognizing T and B cells by the induction of apoptosis, anergy or conversion into immunosuppressive regulatory cells. (frontiersin.org)
  • Enzyme induction is partly responsible for the phenomenon of tolerance, in which repeated use of a drug leads to a reduction of the drug's effect. (wikipedia.org)
  • Within this group, epilepsy is refractory in up to 40 % of patients, who have shown para el control de síntomas refractarios en a decrease in the frequency of seizures with the concomitant use of cannabidiol and conventional antiepileptics, with mild síndromes convulsivos side effects such as diarrhea and drowsiness. (bvsalud.org)
  • However, it is only one of several mechanisms leading to tolerance. (wikipedia.org)
  • Downregulation of MORs and neuroadaptation may be the main mechanisms of morphine tolerance [ 11 , 12 ]. (hindawi.com)
  • However, its wider use is limited due to a variety of side effects, rapid clearance and the development of tolerance. (addexpharma.com)
  • The Cellular and Molecular Therapeutics Laboratory, led by Dr. John F. Tisdale, is working on multiple strategies both in the laboratory and in the clinic to cure sickle cell disease by repairing or replacing the precursor bone marrow cells that give rise to sickled red blood cells. (nih.gov)
  • are known to withstand disinfection and sterilization procedures as they display a moderate to high-tolerance to stress such as UV-C radiation, antibiotics, and high heavy-metal concentrations. (jcvi.org)
  • We're thrilled that this manuscript builds on earlier data presented at the European Respiratory Society's 2021 International Congress, with additional long-term follow-up data that continues to show a strong safety profile for patients transitioning from nebulized Tyvaso to Tyvaso DPI," said Peter Smith, PharmD , Vice President, Product Development, at United Therapeutics. (industryintel.com)
  • Morphine tolerance counteracts analgesic efficacy and drives dose escalation. (hindawi.com)
  • Broadly, the idea is to advance methods to understand drug tolerance in bacterial, fungal and cancer cells in order to inform techniques for altering cell states as a therapeutic approach for disease. (udel.edu)
  • The significant level of both new and existing investor interest in our Series B financing is further validation of both the approach and the potential of our lead compound, NT100, to address two indications with high unmet need: recurrent pregnancy loss and infertility," said Jeffrey K. Tong , Ph.D., President and CEO of Nora Therapeutics. (prnewswire.com)
  • Peripheral tolerance evolved to counteract autoantigen-recognizing T or B cells that escape central tolerance. (frontiersin.org)
  • Peripheral tolerance occurs in the secondary lymphoid organs (e.g. spleen, lymph nodes, and mucosal/gut associated lymphoid tissues) and peripheral tissues. (frontiersin.org)
  • A medical intervention that has an objective to increase tolerance (e.g., allergen immunotherapy, in which one is exposed to larger and larger amounts of allergen to decrease one's allergic reactions) is called drug desensitization. (wikipedia.org)
  • For example, heavy drinkers initially develop tolerance to alcohol (requiring them to drink larger amounts to achieve a similar effect) but excessive drinking can cause liver damage, which then puts them at risk of intoxication when drinking even very small amounts of alcohol. (wikipedia.org)
  • Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)
  • Pharmacokinetic tolerance (dispositional tolerance) occurs because of a decreased quantity of the substance reaching the site it affects. (wikipedia.org)
  • the former mechanism of behavioral tolerance occurs when one learns how to actively overcome drug-induced impairment through practice. (wikipedia.org)
  • If we know the timing of this switch, maybe clinicians one day will be able to prevent this tolerance by scheduling therapy earlier or later or pulsing medications during optimal time periods to prevent tumor cells from becoming tolerant or resistant. (udel.edu)
  • Drug tolerance should not be confused with drug tolerability, which refers to the degree to which overt adverse effects of a drug can be tolerated by a patient. (wikipedia.org)
  • Morphine tolerance refers to the gradual decrease in the potency of a drug following its long-term administration at a fixed dose and usually requires higher and higher doses to maintain the initial level of analgesia [ 2 ]. (hindawi.com)
  • The combined effects of LPX-TI641's pharmacology is to allow the adaptive immune system to re-establish self-tolerance (T-reg/Th17 balance and B-regs) without affecting the innate immune system. (bigcountryhomepage.com)
  • A new treatment option is now available for patients suffering from agitation associated with schizophrenia or bipolar I or II disorder," said Vimal Mehta, Ph.D., CEO of BioXcel Therapeutics. (globenewswire.com)
  • These upcoming milestones, along with our strong financial foundation and late-stage programs, position BioXcel Therapeutics to deliver significant value to our shareholders while helping treat millions of patients. (globenewswire.com)
  • Casebia was founded as a joint venture between Bayer and CRISPR Therapeutics to harness the potential of CRISPR/Cas9 gene-editing technology and develop new medicines for people with genetic and inherited diseases. (biospace.com)
  • Casebia Therapeutics is a novel joint venture between Bayer and CRISPR Therapeutics, focused on discovering, developing and commercializing CRISPR/Cas9 gene-editing therapeutics to treat the genetic causes of bleeding disorders, autoimmune disease, blindness, hearing loss and heart disease. (biospace.com)
  • Immunogenicity is reduced by removing the major histocompatibility complex molecules from the stem cells with gene editing, and tolerance induced via "immune editing. (medscape.com)
  • The treatment is daily capsules of peanut powder that gently facilitate youngsters to build up a tolerance. (dailybayonet.com)
  • The outside panel of advisors to the Food and Drug Administration voted irresistibly in favor of the treatment from Aimmune Therapeutics. (dailybayonet.com)
  • One may also develop drug tolerance to side effects, in which case tolerance is a desirable characteristic. (wikipedia.org)
  • Morphine tolerance is the primary cause of diminished pain control and dose escalation, which makes the related side effects more serious and widespread [ 1 ]. (hindawi.com)