Tolerance induction in clinical transplantation transplantation tolerance. Medical search. Frequent questions

Induction of immunologic tolerance has been achieved and studied in numerous laboratory animal models, but it remains an elusive goal in clinical organ transplantation and in the management of autoimmune disease in humans. (medscape.com)
Hinrich Bitter-Suermann (born March 10, 1940) is a German-Canadian pathologist and professor of surgery specialized in organ transplantation. (wikipedia.org)
Although MIC treatment has been successful in several animal models for autoimmunity and in clinical studies of solid organ transplantation, the mechanism of immunosuppression is not fully elucidated. (asn-online.org)
Cyclosporine A (CsA), Tacrolimus and Rapamycin are natural, immunophilin-binding products with potent immunosuppressive properties that have revolutionized organ transplantation. (rotrf.org)
We expect to gain novel insights into the mechanism of action of SFA and into its potential clinical use as a novel immunosuppressive agent for tolerance induction in solid organ transplantation. (rotrf.org)
The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches. (tts.org)
She has trained and worked in 3 continents (Asia, Europe and North America), and is passionate about improving outcomes after organ transplantation for both children and adult transplant recipients, globally. (tts.org)
This has implications for immune function in the aging population, and in clinical procedures such as bone marrow and solid organ transplantation, where thymic function is required for T cell reconstitution and/or tolerance induction. (ed.ac.uk)
Successful solid organ transplantation currently requires the life-long use of medications to suppress the immune system in order to prevent transplant rejection. (northwestern.edu)
2015/2021 Repair of tissue and organ damage in refractory chronic graft versus host disease after hematopoietic stem cell transplantation by the infusion of purified allogeneic donor regulatory T lymphocytes. (ulisboa.pt)
REGiMMUNE Corporation announced that the American Journal of Transplantation (AJT) has published its paper that describes a novel approach to long-term tolerance in organ transplantation without continuous administration of immune suppressants. (regimmune.com)
REGiMMUNE chief executive officer Haru Morita commented, "We hope that by using our regimen described in the AJT paper, transplant tolerance without continuous administration of immune suppressants might be achieved for solid organ transplantation. (regimmune.com)
This combination therapy of aGC liposome with CD40/40L blockades offers great promise and another approach to induce solid organ transplant tolerance that may be long lasting. (regimmune.com)
The Division of Transplantation has earned acclaim from the international medical community for such breakthroughs as the Belzer-UW solution for organ preservation, research and clinical trials into the immunosuppressive drug Mycophenolate Mofetil, and improved surgical techniques for pancreas transplantation. (wisc.edu)
Current laboratory research includes programs in organ preservation, the development of new immunosuppressants, gene therapy for diabetes as an alternative to pancreas transplantation, xenotransplantation, normothermic machine perfusion, and induction of immunological tolerance to organ transplantation as an alternative to lifelong immunosuppression. (wisc.edu)
Mamode N, Bestard O, Claas F, Furian L, Griffin S, Legendre C, Pengel L, Naesens M. European Guideline for the Management of Kidney Transplant Patients With HLA Antibodies: By the European Society for Organ Transplantation Working Group. (transplantevidence.com)
Redefining Risk Stratification and Endpoints for Clinical Trials in Kidney Transplantation: Rationale and Methodology of Proposals Submitted to the European Medicines Agency by the European Society for Organ Transplantation. (transplantevidence.com)
Research into the role that MSCs play in the induction of tolerance in bone marrow and organ transplantation holds great for future therapeutic strategies. (tmu.edu.tw)
Dr. Demistris serves as the Co-chairman, Banff Conference on Allograft Pathology and the Chairman of the Liver Working Group, a member of the Editorial Boards of Current Opinion in Organ Transplantation and Digestive and Liver Disease , an Abstract Review Board Member of the United States and Canadian Academy of Pathology, Inc., and the Director of the Liver and Kidney Tissue Core of the Immune Tolerance Network. (mirm-pitt.net)
1. To provide an overview of and introduction to transplantation sciences in the context of solid organ and cell transplants. (ncl.ac.uk)
He studied Biochemistry in Oxford, followed by a Ph.D. in Cambridge, which led to the first demonstrations of tolerance induction to proteins and then organ grafts using CD4 monoclonal antibodies in adult rodents. (ox.ac.uk)
Current clinical strategies to control the alloimmune response after transplantation do not fully prevent induction of the immunological processes which lead to acute and chronic immune-mediated graft rejection, and as such the survival of a solid organ allograft is limited. (scienceexhibitions.org)
2011). This concept is usually now being supported by mounting experimental evidence from basic and clinical studies, which indicate that the next stage in optimizing translation of Tregs to solid organ transplantation will be through the refinement and delivery of donor alloantigen-specific Treg therapy. (scienceexhibitions.org)
This review article discusses the relevance of antigen-specific regulation of alloreactivity by Tregs and explores the concept and goal of defining an optimal Treg for the prevention of transplant rejection and induction of organ transplant tolerance. (scienceexhibitions.org)
Physique 1 (A) Alloantigen presentation via the direct, semi-direct and indirect pathways following organ transplantation, and (W) the relative intensity of each antigen-presentation pathway during the post-transplantation (post-Tx) period. (scienceexhibitions.org)
After stepping down as President of the Royal College of Surgeons, Sir Peter established the Centre for Evidence in Transplantation (CET), with the aim of evaluating and improving the quality of evidence in solid organ transplantation. (transplantevidence.com)
When compared to other solid-organ transplants, liver allografts are considered as immunologically privileged, and, accordingly, constitute a favorable setting to develop experimental as well as clinical strategies for minimization of immunosuppression and even induction of operational tolerance. (unamur.be)
Required for Treg generation in vivo in response to a model antigen introduced into the anterior chamber of the eye [3], F4/80 expression is also essential for organ transplantation [4] and engraftment of Lewis lung cancer cells. (ox.ac.uk)
Existing immunosuppressive drugs for organ transplantation may achieve sufficient immunosuppression to prevent organ rejection or limit autoreactivity, but they are typically not successful in achieving long-term survival of the graft or preventing progression of fibrosis and chronic rejection [ 3 ]. (biomedcentral.com)
A 1 ml (for small children), 5.2 ml 4 12 (2 + 4) 3- = a (log p1 b log(/4p + i snidation states are awaiting organ transplantation. (stonecottagegardens.com)
The motivation for using animal sources for organ or tissue transplantation is driven by supply and demand. (medscape.com)
According to the most current report from the United Network for Organ Sharing (UNOS), more than 107,241 Americans were waiting for organ transplantation as of May 2010. (medscape.com)
Additionally, organs from animal sources could be transplanted into patients currently excluded from the human organ transplantation list. (medscape.com)
Alexis Carrel is known as the founding father of experimental organ transplantation because of his pioneering work with vascular techniques. (medscape.com)
The initial clinical evaluation includes ascertainment/documentation of comorbidity, performance status, organ functions, and heredity. (cancercentrum.se)
In contrast to transmission by blood transfusion, which has been well documented, transmission associated with solid organ transplantation has not been reported. (cdc.gov)
Kidney transplantation is the most common type of solid organ transplantation. (msdmanuals.com)
BACKGROUND: In 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2-6 weeks after transplantation from a common organ donor. (cdc.gov)
Recent infection with yellow fever virus was confirmed in all four organ recipients by identification of yellow fever virus RNA consistent with the 17D vaccine strain in brain tissue from one recipient and seroconversion after transplantation in three recipients. (cdc.gov)

At the Queen Elizabeth II Health Sciences Centre and I.W.K. Hospital for Children he engaged himself for 24 years in kidney, liver and pancreas transplantation. (wikipedia.org)
She has previously been Professor, Pediatrics and Surgery, and Medical Director of the Pediatric Kidney Transplant Program at Stanford University where she developed the first complete steroid avoidance program for renal transplantation in infants and children. (tts.org)
In this review we describe the clinical outcomes and science behind a CD8 + /TCR − facilitating cell-based hematopoietic stem cell transplant approach (termed FCRx) to induce tolerance to mismatched renal allografts while minimizing the risk of graft-versus-host GVHD and achieving avoidance of long-term immunosuppressant drugs in living donor kidney transplant recipients. (northwestern.edu)
CKDs often lead to end stage renal diseases, which require replacement therapy, such as kidney transplantation. (igtp.cat)
The 'OCATT' (Catalan Transplantation Organization) 2019 report revealed up to 882 kidney transplants were performed in Catalonia, a transplant rate of 115.0 per million population (pmp). (igtp.cat)
The REMAR group (from Catalan, REcerca en Malalties d'Afectació Renal, or Kidney Related Diseases Research Group) is a multidisciplinary group including more than 25 professionals from the Germans Trias University Hospital (HUGTP) & Research Institute - including doctors, biologists, veterinarians, biochemists and biotechnologists. (igtp.cat)
The researchers aim to foster basic, clinical and translational research in the field of kidney diseases and disorders associated with kidney failure. (igtp.cat)
Pre-emptive living donor kidney transplantation: A public health justification to change the default. (transplantevidence.com)
Trends in systematic reviews of kidney transplantation: A 10-year analysis of the evidence base. (transplantevidence.com)
Is Preemptive Kidney Transplantation Associated With Improved Outcomes when Compared to Non-preemptive Kidney Transplantation in Children? (transplantevidence.com)
He recently suffered end stage renal failure and received a reciprocal paired donation kidney transplant with CAMPATH induction - perhaps the ultimate in clinical translation of his work? (ox.ac.uk)
Critical Appraisal of International Clinical Practice Guidelines in Kidney Transplantation Using the Appraisal of Guidelines for Research and Education (AGREE) II Tool: A Systematic Review. (transplantevidence.com)
Systematic review of clinical practice guidelines in kidney transplantation. (transplantevidence.com)
Perform islet isolation, assessment of quality and function in vitro, and transplantation under the kidney capsule, intraportal, or gonadal fat pad. (postdocjobs.com)
Experience with the transplantation of solid organs, heart or kidney is highly desirable. (postdocjobs.com)
It is pointed out that protocols based on the using BM cells, permit to work out the tolerance state and now they are estimate at clinical kidney transplantation, during multicentre investigations. (genescells.ru)
Tolerance in kidney transplantation. (genescells.ru)
They developed the buttonhole technique for anastomosis of donor and recipient vessels in kidney transplantation to prevent thrombus formation. (medscape.com)

From 1977 through 1982 he was staff of the Department of Pathology, Georgetown University, Washington, D.C. Supported by the National Institutes of Health he studied the mechanisms of spleen graft induced transplantation tolerance in guinea pigs, and islet transplantation in rats. (wikipedia.org)
A minimum of 3 years of experience in performing microsurgery in rodents with a focus on islet transplantation. (postdocjobs.com)
Promising preliminary results are also emanating from an ongoing open randomized clinical study conducted in collaboration with Prof Katarina LeBlanc, KI, Stockholm, in which the efficacy of islet transplantation with or without the support of autologous MSC is investigated. (uu.se)

Transplant tolerance is defined as a state of donor-specific unresponsiveness without a need for ongoing pharmacologic immunosuppression. (medscape.com)
However, during the study of achieving immune tolerance, ways in which to induce states of "partial tolerance" have been discovered, in which lower-than-conventional amounts of ongoing pharmacologic immunosuppression are needed. (medscape.com)
1. Transplantation immunology: allo-Ag presentation/recognition, cellular and molecular factors involved in alloreactive immune responses, antibody mediated rejection, immunotolerance induction and immunosuppression. (ncl.ac.uk)
HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression. (genescells.ru)
In contrast to research in rodents claiming the development of donor-specific tolerance in case of graft survivals of over 100 days without immunosuppression, it is impractical to confirm tolerance induction in this way in humans. (unamur.be)
Collectively, these data confirmed that iPSC-derived MSC-mediated immunosuppression has potential to establish immune tolerance and rescue allograft from sustained hypoxic/ischemic phase, and subsequently limits long-term airway epithelial injury and collagen progression, which therapeutically warrant a study of Cymerus iPSC-derived MSCs as a potential management option for immunosuppression in transplant recipients. (biomedcentral.com)

Трансплантація підшлункової залози Pancreas transplantation is a form of pancreatic beta-cell replacement that can restore normoglycemia in diabetic patients. (msdmanuals.com)

The department's principal investigators conduct fundamental research on topics including the role of CEACAM1 in T cell activation, TH17 cells and their role in controlling inflammation, graft-versus-host disease in allogeneic hematopoietic cell transplantation (HCT), and the role of T lymphocytes in type 1 diabetes. (cityofhope.org)
However, our current understanding of the alloimmune response suggests that regulation of donor-reactive immunity primed by specific pathways of alloantigen-presentation following transplantation may be central to achieving long-term or indefinite graft survival (Nepom et al. (scienceexhibitions.org)
We identify the main features of the immune response which Tregs need to control by firstly reviewing evidence for the induction and temporal pattern of the alloimmune response, in terms of alloantigen presentation GW791343 HCl and allopriming following transplantation, and the resulting effector mechanisms of graft rejection. (scienceexhibitions.org)
Here, we demonstrated the impact of iPSC-derived human MSCs on the development of immune tolerance and long-term graft survival in mouse orthotopic airway allografts. (biomedcentral.com)
We demonstrated that iPSC-derived MSC treatment leads to significant increases in hTSG-6 protein, followed by an upregulation of mouse Tregs and IL-5, IL-10, and IL-15 cytokines, which augments graft microvascular blood flow and oxygenation, and thereby maintained a healthy airway epithelium and prevented the subepithelial deposition of collagen at d90 post transplantation. (biomedcentral.com)
Background and Aim: Chronic graft-versus-host disease (cGVHD) is a major cause of nonrelapse morbidity and mortality following hematopoietic stem cell transplantation (HSCT). (elsevierpure.com)

My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. (uchicago.edu)
Dr. Yolcu is an accomplished research scientist and medical professional concentrating in molecular biology, transplantation immunology, autoimmunity, and cancer immunology and immunotherapy with over 20 years of professional experience. (itolerance.com)

Below is a list of previous publications from the Centre for Evidence in Transplantation. (transplantevidence.com)
Sir Peter stepped down as director of the CET in July 2016, but the work of the centre continues and it has now been renamed to the Peter Morris Centre for Evidence in Transplantation in recognition of his vision and contribution. (transplantevidence.com)

He is also a member of numerous professional and scientific societies, including but not limited to, the American Society of Clinical Pathologists, the American Association for Advancement of Science, the Transplantation Society, and the International Liver Transplantation Society. (mirm-pitt.net)
In 2012, Dr. Demetris received the International Liver Transplantation Society Distinguished Service Award. (mirm-pitt.net)

Dendritic cells (DCs) are professional antigen presenting cells that initiate adaptive immunity by the activation of naïve lymphocytes and induce central and peripheral tolerance by mechanisms that include deletion, anergy and induction of regulatory T lymphocytes. (rotrf.org)
It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical tolerance trials. (tts.org)
We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. (uchicago.edu)
He has published more than 250 articles and patents on the therapeutic applications of monoclonal antibodies and the mechanisms of transplantation tolerance. (ox.ac.uk)
It was given supposition that at using BM cells the forming of steady transplant tolerance state is a result of successive entering of central (thymical induction of temporary mixed chimer-ism) and peripheral tolerance mechanisms. (genescells.ru)
Treg and DCreg induce mechanisms only peripheral tolerance. (genescells.ru)
Such cell-based therapy is likely to simultaneously target several different immunological pathways, thereby utilizing numerous physiological mechanisms for re-establishing immune tolerance and induction of cellular repair mechanisms. (uu.se)
The detailed analysis of circulating lymphocytes and their antigen-specific cellular responses will be instrumental in the understanding of the mechanisms behind the autoimmune progression towards TID and to monitor the effect of the transplanted MSC in clinical trials. (uu.se)

His research interests focused on induction of transplantation tolerance by spleen transplants in rats and the preservation of pig liver transplants. (wikipedia.org)
A randomized trial of normothermic preservation in liver transplantation. (transplantevidence.com)
The aim of this work is to review the current knowledge in the field of immunological monitoring of allogenic responsiveness in clinical liver transplantation. (unamur.be)
A conceptual framework for the development of tolerance assays in clinical liver transplantation is also proposed. (unamur.be)
Liver Transplantation , 12 (3), 373-383. (unamur.be)
Who expert committee to identify induction or inhibition dence also suggests the need for liver diseases can be used in the powder cup until sufcient airow has been previously analyzed and polymorphism rev. (continued) fig. Gerrity tr (1989) pathophysiological and disease prevention and drug i)ispositirrri. (stonecottagegardens.com)

Diverse concurrent workshops on Saturday will consider important clinical and immunological issues ranging from current concepts of chronic rejection to innate immunity. (tts.org)
A major breakthrough in our understanding of its immunological function derived from studies using F4/80 knockout mice, which revealed this molecule to be dispensible for macrophage development, but responsible for peripheral tolerance. (ox.ac.uk)
Immunotolerance is a major immunological phase, which facilitates reparative microenvironment during transplantation, and plays a vital role to suppress alloimmune responses. (biomedcentral.com)

Establishment of durable hematopoietic chimerism through hematopoietic stem cell transplantation (HSCT) has been shown in preclinical models and patients to lead to donor specific tolerance. (northwestern.edu)
Robust, lifelong, donor-specific tolerance can be reliably achieved by induction of mixed chimerism in various animal models of bone transplantation. (regimmune.com)
With mixed chimerism established, mice were able to successful accept cardiac transplants with long-term and durable tolerance. (regimmune.com)
Combined application of BM cells and Treg permits to increase the terms for maintaining of donor chimerism into all cell lines (incuding Tcells) and transplant tolerance in recipient organism. (genescells.ru)
Sachs D.H., Kawai T., Sykes M. Induction of tolerance through mixed chimerism. (genescells.ru)

In addition, a brief overview and update on cell-based tolerogenic clinical trials is provided. (tts.org)
The Transplant Clinical Trials Office can be contacted at (608) 263-2565. (wisc.edu)
This includes engineered radiolabeled antibodies for immunoPET imaging and radioimmunotherapy, in preclinical models as well as translation into pilot and phase I clinical trials. (cityofhope.org)
Clinical trials are underway to assess the safety, feasibility and efficacy of MSC transplantation in a variety of human diseases. (tmu.edu.tw)
In a attempt to produce JAK2 selective compounds for the treatment of MPDs, TG 101348 and XL 019 have now been recently identified and are now in clinical trials for MPDs. (igfprotein.com)
This trial is registered in the Brazilian registry of clinical Trials - number RBR-7354r6. (bvsalud.org)
Eventually, most trials were based on short-term endpoints, while the clinician would need information concerning responses and tolerance in the long term especially since many sarcoidosis patients are young. (medscape.com)

3. Transplant therapeutic effect: haematopoietic stem cell transplant for leukaemia, lymphoma, and primary immunodeficiency, islet transplant and beta-cell replacement for type1 diabetes, corneal/limbal stem cell transplant for damaged tissue repair and identification of biomarkers of tolerance and rejection. (ncl.ac.uk)
5. Techniques and approaches being developed to improve transplant outcome and increase the supply of donor organs, such as manipulation of haematopoietic stem cell grafts for clinical use and reconditioning donor organs for transplantation. (ncl.ac.uk)
such as haematopoietic stem cell transplantation, are clearly warranted. (reninsignaling.com)

[ 3 ] Seemingly impossible without genetic identity, the field of transplantation was left silent for another 20 years. (medscape.com)
Minnie Sarwal is a pediatric and adult transplant nephrologist who has worked in the field of transplantation since 1997. (tts.org)

GW791343 HCl After reviewing these findings we then discuss the mechanistic bases of tolerance induction by antigen-specific Tregs, and the requirements of an optimized Treg to improve the success of this approach for the induction and maintenance phases of achieving donor-specific tolerance. (scienceexhibitions.org)

The main research focus of our laboratory is the study of immune reconstitution after hematopoietic stem cell transplantation (HSCT) in humans and the development of strategies that modulate immune responses and tolerance post-transplant. (ulisboa.pt)

His research focuses on the modulation of immune system for the treatment of immune-based diseases with particular focus on type 1 diabetes, transplantation (cell, tissue, and solid organs), and cancer immunoprevention and immunotherapy. (lidsen.com)
Xenotransplantation involves the transplantation of nonhuman tissues or organs into human recipients. (medscape.com)
In light of the lack of supply of human organs for transplantation, several alternatives have been investigated and debated. (medscape.com)
Finally, most patients perceive xenotransplantation as an acceptable bridge to transplantation of human organs in life-threatening situations. (medscape.com)

Jeffrey Wong, M.D., is renowned for his efforts in targeted therapy using image-guided/intensity modulated radiotherapy, recently applying this approach to bone marrow transplantation. (cityofhope.org)
This review presents analysis of the modern state of transplant tolerance forming problem in recipient organism by using stem/ progenitory cells of bone marrow (BM) and differentiated immunoregulatory (tolerogenic) subsets of blood cells-regulatory B- and T-lymphocytes (Treg), and regulatory dendritic cells (DCreg). (genescells.ru)

In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess broad immunoregulatory properties that are being investigated for potential clinical application in treating immune-based disorders. (pdffox.com)
Mesenchymal stromal cells in renal transplantation: opportunities and challenges. (genescells.ru)

2021/2024 Generation and in-depth characterization of antigen-specific regulatory T cells to be applied in allogeneic hematopoietic stem transplantation. (ulisboa.pt)

The state-of-the-art sessions will give a comprehensive overview of contemporary transplantation medicine covering a wide range of topics from clinical issues such as intestinal or composite tissue transplantation to basic science topics like innate immunity or the role of microRNAs. (tts.org)
Simpson E, 2015, Medawar's legacy to cellular immunology and clinical transplantation: a commentary on Billingham, Brent and Medawar (1956) 'Quantitative studies on tissue transplantation immunity. (imperial.ac.uk)
The current clinical standard in tissue preservation, static hypothermic preservation (HP) in ice-cold preservation solution (+4°C), is insufficient to preserve tissue viability for more than a few hours, creating a technological bottleneck to realizing tolerance protocols in VCA transplantation. (cetrulolaboratory.com)
These technologies provide our group unique readiness to extend "revolutionize ex vivo VCA tissue preservation strategies to extend the timeline between procurement and transplantation", as well as test its utility to enable tolerance induction in a clinically relevant large animal model. (cetrulolaboratory.com)
Our objective is to extend tissue preservation for 3 days, and that this the extended preservation time will enable utilization of tolerance induction protocols with a schedule that would be realistic for clinical implementation. (cetrulolaboratory.com)

Dr. Camillo Ricordi is ranked among the top ten world experts in transplantation of insulin-producing cells for the treatment of diabetes, and is acknowledged as one of the world's leading scientists in diabetes cure-focused research, cell transplantation and regenerative medicine. (itolerance.com)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)

Mesenchymal stem cells (MSCs) can be readily isolated from a number of adult and fetal tissues, and have the capacity of expansion in vitro on a clinical scale. (tmu.edu.tw)
An informed view of the scope of this clinical potential will require a clear understanding of the dynamic interplay between MSCs and the innate and adaptive immune systems. (pdffox.com)
Finally, we discuss progress toward clinical application of MSCs, focusing on GvHD as a case study. (pdffox.com)
1999). Historically, a challenge that has faced the field has been the lack of uniform criteria to define MSCs, which has hindered efforts to compare results obtained from different experimental and clinical studies. (pdffox.com)

Marques M.B., Schwartz J. Update on extracorporeal photopheresis in heart and lung transplantation. (genescells.ru)
Lung transplantation is a life-saving surgical replacement of diseased lungs in patients with end-stage respiratory malfunctions. (biomedcentral.com)
Lung transplantation is a life-saving surgical procedure for patients with end-stage lung diseases. (biomedcentral.com)

Transplantation tolerance could eliminate many of the adverse events associated with immunosuppressive agents. (medscape.com)

Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy. (uchicago.edu)
We then review evidence for the association of Tregs and Treg-mediated donor-specific immune regulation in clinical transplantation with particular focus on data emerging from the study of operationally tolerant transplant recipients. (scienceexhibitions.org)
These include, but are not limited to, (1) preventing hyperacute rejection, (2) preventing acute vascular rejection, (3) facilitating immune accommodation, (4) inducing immune tolerance, (5) preventing the transmission of viruses from xenografts into humans, and (6) addressing the ethical issues surrounding animal sources for xenografts and the appropriate selection of recipients (given that xenotransplantation remains experimental). (medscape.com)
with careful selection of donors and recipients and with pretransplant treatment (plasma exchange and/or IV immune globulins [IVIG]), outcomes can be comparable to those of ABO-compatible transplantation. (msdmanuals.com)

2. To provide sound understanding of the scientific basis underlying the therapeutic benefits and adverse effects of clinical transplantation. (ncl.ac.uk)
Our understanding of factors such as the temporal activity and intensity of alloantigen presentation pathway activity, and resulting alloimmune priming following transplantation is usually integral to identifying the specificity of the Treg required and the time or frequency at which it needs to be administered to deliver an optimized and targeted therapeutic. (scienceexhibitions.org)
Although the natural privileged status of ES cell-derived tissues is, therefore, insufficient to overcome even mH barriers, our findings suggest it may be harnessed effectively for the induction of dominant tolerance with minimal therapeutic intervention. (ox.ac.uk)
There are a few other goals of therapeutic interest to produce effective IS that in conjunction with other drugs are highly desirable for immune tolerance induction. (igfprotein.com)

Non-myeloablative autologous hemopoietic stem-cell transplantation (HSCT) shows some promise in treating scleroderma. (mountsinai.org)
The patients will receive autologous MSC, although substantially expanded in vitro prior to transplantation, thereby avoiding potential risk of HLA immunization, transfer of viral infections and other diseases. (uu.se)

The company's proprietary platform technology, reVax, induces immune tolerance in an antigen-specific manner through pharmacological induction of regulatory T (Treg) cells. (regimmune.com)

The data suggest a new insight - that the immune direction of iNKT cells is controlled through a type of APC presenting a-GalCer and costimulation signals, and that it is possible to enhance the innate ability of immune tolerance by appropriate activation of iNKT cells. (regimmune.com)

Fernando S, Varma S, Dengu F, Menon V, Malik S, O'Callaghan J. Bariatric surgery improves access to renal transplantation and is safe in renal failure as well as after transplantation: A systematic review and meta-analysis.Transplantation Reviews, Volume 37, Issue 3. (transplantevidence.com)
Macklin PS, Morris PJ, Knight SR. A systematic review of the use of rituximab as induction therapy in renal transplantation. (transplantevidence.com)

Her vision for TTS is to improve outreach, alliances and advances in technology and diagnostics globally and to developing countries to improve outcomes and equity in transplantation. (tts.org)

To highlight the "Progress and Challenges in Transplantation Surgery," selected pioneers will present their insights on Thursday, July 19th. (tts.org)

Participate in the generation and use of humanized mouse models to assess the efficacy of lead immunomodulatory protocols to prevent rejection of human islets or stem-cell-derived beta cells in humanized mice as a prelude to clinical translation. (postdocjobs.com)
Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. (imperial.ac.uk)

The alloimmune response Induction of the adaptive immune response to an allograft begins with recognition of alloantigen by recipient T cells which is usually now well characterized and known to occur through three main processes known as the direct, the indirect, and the semi-direct pathways of antigen presentation. (scienceexhibitions.org)

the most common are by pathophysiology, depending on where pathway intermediates accumulate (hepatic vs erythropoietic) or by clinical manifestation (acute vs cutaneous). (medscape.com)

One of the first clinically relevant observations pertaining to transplantation was made by Dr. Earl Padgett in the 1920s, when skin grafts were noted to survive longer when skin from close relatives was used. (medscape.com)

Tregs in GW791343 HCl experimental and clinical studies of tolerance and explore the concept of delivering an optimal Treg for the induction and maintenance phases of achieving transplantation tolerance. (scienceexhibitions.org)
Areas related to clinical and experimental transplantation are also of interest. (lidsen.com)
They also performed heterotopic experimental transplantation. (medscape.com)

Stem cell-based immunotherapy has been recognized as a crucial immunoregulatory regimen in various preclinical and clinical studies. (biomedcentral.com)

We continue to develop several lines of research in the field of genetic susceptibility for viral and fungal infections after hematopoietic stem cell transplantation. (ulisboa.pt)
Although human embryonic stem (ES) cells may one day provide a renewable source of tissues for cell replacement therapy (CRT), histoincompatibility remains a significant barrier to their clinical application. (ox.ac.uk)
Non - low risk-patients are evaluated for stem cell transplantation in first remission. (medscape.com)

Colvin is an internationally-recognized renal pathologist renowned for his contributions to our understanding of immune disease and transplantation, including approaches for tolerance induction. (infoplanners.com)

Anatomy25

Organisms18

Diseases34

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment77

Phenomena and Processes44

Disciplines and Occupations1

Information Science3

Named Groups2

Health Care16

Organ39

Kidney18

Islet transplantation3

Immunosuppression6

Pancreas transplantation1

Graft6

Autoimmunity2

Centre for Evidence in Transplantation2

International Liver Transplantation Society2

Mechanisms8

Liver6

Immunological3

Chimerism5

Trials7

Haematopoietic stem3

Field of transplantation2

Donor specific tolerance1

Immune reconstitution1

Organs4

Bone2

Stromal cells2

Allogeneic hematopoietic1

Tissue5

Regenerative2

MSCs4

Lung3

Immunosuppressive1

Recipients4

Therapeutic4

Autologous2

Antigen-specific1

INKT cells1

Systematic Review2

Outcomes1

Surgery1

Rejection2

Allograft1

Hepatic1

Grafts1

Experimental3

Immunotherapy1

Stem3

Approaches1