OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
TobramycinGentamicinsAminoglycosidesAnti-Bacterial AgentsAmikacinKanamycinPseudomonas aeruginosaNetilmicinPseudomonas InfectionsAzlocillinTicarcillinCarbenicillinMicrobial Sensitivity TestsCystic FibrosisSisomicinPiperacillinColistinMoxalactamCeftazidimeDrug Resistance, MicrobialAdministration, InhalationFosfomycinDrug IncompatibilityAztreonamConjunctivitis, BacterialPenicillinsDrug SynergismCefamandoleEnterobacteriaceaeProvidenciaEncyclopedias as TopicHearing Loss
GentamicinContains tobramycin sulfate equivalentInjectionDexamethasonePseudomonasGranules with TobramycinTobiInhalation SolutionParenteralTobraDexAminoglycoside antibioticsOphthalmic SuspensionSulfateCysticTobrexAntibiotic treatmentCaused by bacteriaVancomycinAminoglycosidesAzithromycinIntravenous antibioticNephrotoxic effectsBacterial protein synthesisIntravenouslyBacteriaRecurrentBone void fillerDrugsSymptomsInfectionSerumMedicationTenebrariusMoxifloxacinDropsBotulinumAntimicrobialDiscomfortConcentrationsEfficacyEffectivenessDosageExacerbation TreatmentIsolatesSystemicSolutionPreparationsRetrospectiveCombinationPlacebo
Gentamicin3
  • Gentamicin- and tobramycin-containing ophthalmic drops have been widely used off-label for the treatment of otologic infections. (medscape.com)
  • A fixed ratio combination of tobramycin and dexamethasone (TobraDex) has been especially popular in the United States, while gentamicin-containing drops have been more popular in Canada and Europe. (medscape.com)
  • A single case report describes development of a rash following inhaled tobramycin, in a patient who had developed a similar rash following a course of intravenous gentamicin and piperacillin-tazobactam [ 5 ]. (biomedcentral.com)
Contains tobramycin sulfate equivalent1
Injection16
  • Patients treated with Tobramycin Injection, USP and other aminoglycosides should be under close clinical observation, because these drugs have an inherent potential for causing ototoxicity and nephrotoxicity. (nih.gov)
  • Tobramycin Injection, USP is a clear and colorless sterile aqueous solution for parenteral administration. (nih.gov)
  • Your doctor may not want you to receive tobramycin injection or will monitor you carefully for side effects. (medlineplus.gov)
  • If you become pregnant while using tobramycin injection, call your doctor immediately. (medlineplus.gov)
  • Tobramycin injection is used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract. (medlineplus.gov)
  • Tobramycin injection is in a class of medications called aminoglycoside antibiotics. (medlineplus.gov)
  • Antibiotics such as tobramycin injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • Tobramycin injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). (medlineplus.gov)
  • You may receive tobramycin injection in a hospital or you may administer the medication at home. (medlineplus.gov)
  • If you will be receiving tobramycin injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
  • You should begin to feel better during the first few days of treatment with tobramycin injection. (medlineplus.gov)
  • Use tobramycin injection until you finish the prescription, even if you feel better. (medlineplus.gov)
  • If you stop using tobramycin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • Sterile tobramycin sulfate is supplied as a sterile dry powder and is intended for reconstitution with 30 mL of Sterile Water for Injection, USP. (nih.gov)
  • Like all aminoglycosides, tobramycin does not pass the gastro-intestinal tract, so for systemic use it can only be given intravenously or by injection into a muscle. (wikipedia.org)
  • Zoledronic acid is an injection that only requires administration every year for the treatment of osteoporosis, and every two years for the prevention of osteoporosis. (drugs.com)
Dexamethasone2
  • Ciprofloxacin and hydrocortisone combinations have a pH of 4.5-5.0, as do tobramycin and dexamethasone combinations. (medscape.com)
  • Eye drops and ointments (tobramycin only, Tobrex, or combined with dexamethasone, sold as Tobradex) and nebulised formulations both have low systemic absorption. (wikipedia.org)
Pseudomonas9
Granules with Tobramycin3
  • In June 2021, Elute, Inc. received authorization from the US FDA to use its EP Granules with Tobramycin in clinical trial. (globenewswire.com)
  • Elute's lead product is EP Granules with Tobramycin, a bone void filler that has been shown to provide clinically relevant 8-week delivery of antibiotics and grow new bone in voids that result from bone infections, especially surrounding total hip and knee replacement joints or, periprosthetic joint infections (PJIs). (gust.com)
  • Upon final approval, we believe that EP Granules with Tobramycin will be a new standard of care in the surgical treatment of bone infections. (gust.com)
Tobi3
  • The hybrid tobramycin solution is a nebulized medication with the same active substance as TOBI Nebuliser solution, but with a different strength (170 mg) and using a different nebulizer device that enables the user to inhale it over a shorter period. (medscape.com)
  • The goal of the Active Comparator Study was to look at 2 approved medications, CAYSTON and TOBI, by tracking changes in FEV 1 people with CF and PA taking CAYSTON or TOBI over 3 treatment courses. (cayston.com)
  • Tobramycin administered by the TOBI Podhaler for persons with cystic fibrosis: a review. (medicalletter.org)
Inhalation Solution1
  • Watch this video and see how Kitabis ® Pak Tobramycin Inhalation Solution can help minimize Mo! (pari.com)
Parenteral2
  • For these reasons parenteral tobramycin needs to be carefully dosed by body weight, and its serum concentration monitored. (wikipedia.org)
  • Furthermore, a patient with end-stage renal disease who was treated for sepsis with parenteral tobramycin and vancomycin developed persistent fever, eosinophilia and rash. (biomedcentral.com)
TobraDex1
  • In certain countries, it is available over the counter, It is also available in Egypt as Tobrin eye drops produced by EIPICo, Tobrex, Tobradex and Tobrin are indicated in the treatment of superficial infections of the eye, such as bacterial conjunctivitis. (wikipedia.org)
Aminoglycoside antibiotics2
  • Tobramycin is contraindicated in people with hypersensitivity against aminoglycoside antibiotics. (wikipedia.org)
  • Tobramycin and fluorometholone are aminoglycoside antibiotic, which means it belongs to a group of medications known as aminoglycoside antibiotics. (eyerisvisioncare.com)
Ophthalmic Suspension2
Sulfate1
  • To compare ofloxacin solution with a combination of fortified antibiotic cefazolin sodium and tobramycin sulfate solutions in the treatment of bacterial keratitis. (jamanetwork.com)
Cystic14
  • Controlled trial of ceftazidime vs. ticarcillin and tobramycin in the treatment of acute respiratory exacerbations in patients with cystic fibrosis. (nih.gov)
  • Tobramycin PARI represents an alternative treatment option for cystic fibrosis patients with chronic P. aeruginosa lung infections," according to the EMA news release. (medscape.com)
  • Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. (nih.gov)
  • In a 24-week study of patients with cystic fibrosis, intermittent administration of inhaled tobramycin was well tolerated and improved pulmonary function, decreased the density of P. aeruginosa in sputum, and decreased the risk of hospitalization. (nih.gov)
  • 1. Polymicrobial infections and antibiotic treatment patterns for cystic fibrosis pulmonary exacerbations. (nih.gov)
  • 5. Antibiotic Regimen Changes during Cystic Fibrosis Pediatric Pulmonary Exacerbation Treatment. (nih.gov)
  • 9. Effect of Concomitant Azithromycin and Tobramycin Use on Cystic Fibrosis Pulmonary Exacerbation Treatment. (nih.gov)
  • 11. Changes in airway bacterial communities occur soon after initiation of antibiotic treatment of pulmonary exacerbations in cystic fibrosis. (nih.gov)
  • An institution's tobramycin pharmacokinetics (PK) database was reviewed to evaluate the efficacy and safety of empiric tobramycin dosing and monitoring strategies used in pediatric patients with cystic fibrosis (CF). The relationship between patient age and tobramycin dosing needed to achieve the area under the curve (AUC) goal was investigated. (allenpress.com)
  • Vancomycin 200 mg/Tobramycin 125 mg/Betamethasone 0.5 mg Capsules are used to treat a variety of respiratory diseases, including Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Bronchiectasis, Asthma, and Allergic Rhinitis. (bayviewrx.com)
  • Oral Azithromycin Use and the Recovery of Lung Function from Pulmonary Exacerbations Treated with Intravenous Tobramycin or Colistimethate in Adults with Cystic Fibrosis. (nih.gov)
  • Rationale: The potential of azithromycin to alter the antimicrobial and clinical benefits of inhaled tobramycin in patients with cystic fibrosis (CF) has been previously reported. (nih.gov)
  • Tobramycin inhalation powder for P. aeruginosa infection in cystic fibrosis: The EVOLVE trial. (medicalletter.org)
  • Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: The EAGER trial. (medicalletter.org)
Tobrex3
  • Tobrex eye drops are a 0.3% tobramycin sterile ophthalmic solution produced by Alcon Pharmaceuticals. (wikipedia.org)
  • Tobrex, Tobramycin Ophth, more. (medscape.com)
  • Tobramycin ( Tobrex ) is an aminoglycoside antibiotic eye drop used to treat external infections of the eye caused by bacteria. (medicinenet.com)
Antibiotic treatment6
  • Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. (medlineplus.gov)
  • 13. Antibiotic treatment of signs and symptoms of pulmonary exacerbations: a comparison by care site. (nih.gov)
  • 17. Study design considerations for the Standardized Treatment of Pulmonary Exacerbations 2 (STOP2): A trial to compare intravenous antibiotic treatment durations in CF. (nih.gov)
  • 8) A randomised controlled trial comparing at least 14 days of antibiotic treatment for exacerbations with shorter-course treatments is required. (ersjournals.com)
  • We tested the hypothesis that antibiotic treatment of preterm infants with aminoglycosides is associated with higher rates of surgical patent ductus arteriosus (PDA) closure. (uni-koeln.de)
  • Conclusion First-line antibiotic treatment of preterm infants with aminoglycosides was associated with higher rates of surgical PDA closure. (uni-koeln.de)
Caused by bacteria2
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of tobramycin and other antibacterial drugs, tobramycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Infections of the eyes caused by bacteria are treated with this combination treatment. (zexuspharma.com)
Vancomycin3
  • Although temporal sequence had suggested vancomycin as the probable cause [ 10 ], the possible contribution of tobramycin could not be totally excluded. (biomedcentral.com)
  • This formulation is a combination of Vancomycin 200 mg, Tobramycin 125 mg, and Betamethasone 0.5 mg capsules, used for nasal irrigation/nebulizer. (bayviewrx.com)
  • Bayview Pharmacy is proud to offer a unique compounded formulation of Vancomycin 200 mg/Tobramycin 125 mg/Betamethasone 0.5 mg Capsules for Nasal Irrigation/Nebulizer. (bayviewrx.com)
Aminoglycosides1
Azithromycin5
  • The patient started treatment with oral azithromycin, oral trimethoprim-sulfamethoxazole (TMP/SMX) and intravenous tobramycin on January 23, 2020. (nature.com)
  • The potential interaction between azithromycin and intravenous antibiotics in the treatment of pulmonary exacerbations is unknown. (nih.gov)
  • Objectives: To determine if chronic azithromycin use as a concomitant therapy is associated with change in lung function after receiving intravenous antibiotic regimens including tobramycin or colistimethate. (nih.gov)
  • Methods: This was a retrospective cohort study evaluating the association of azithromycin with intravenous tobramycin or colistimethate in adult patients with CF treated for a pulmonary exacerbation. (nih.gov)
  • Results: A total of 220 exacerbation events occurred in 121 patients in the tobramycin group (47% using azithromycin), and 207 exacerbation events occurred in 86 patients in the colistimethate group (59% using azithromycin). (nih.gov)
Intravenous antibiotic1
  • Treatment failure may extend the need for oral or intravenous antibiotic therapy and increase the required dosage. (rcjournal.com)
Nephrotoxic effects2
  • Methoxyflurane, when used as an inhalational anesthetic, can aggravate the nephrotoxic effects of injected tobramycin. (wikipedia.org)
  • Inhaled tobramycin was not associated with detectable ototoxic or nephrotoxic effects or with accumulation of the drug in serum. (nih.gov)
Bacterial protein synthesis2
  • Tobramycin in an aminoglycoside antibiotic that causes rapid concentration-dependent bacterial cell death by targeting bacterial protein synthesis. (medscape.com)
  • Tobramycin kills susceptible bacteria by blocking bacterial protein synthesis. (medicinenet.com)
Intravenously2
  • When tobramycin is injected intravenously, it is usually infused (injected slowly) over a period of 20 to 60 minutes as frequently as every 6 hours but may be given less often depending on your age or other factors. (medlineplus.gov)
  • Also, he developed similar signs and symptoms when he was administered tobramycin intravenously on one occasion at 5 1/2 years. (biomedcentral.com)
Bacteria8
  • Tobramycin has a narrow spectrum of activity and is active against Gram-positive Staphylococcus aureus and various Gram-negative bacteria. (wikipedia.org)
  • 1 Bacteria protected within biofilms are up to 1,000 times more resistant to antibiotics than if they were free-floating (planktonic), 2 which severely complicates treatment options. (nih.gov)
  • Healthcare providers treating VIM-GES-CRPA infections should consult with a specialist knowledgeable in the treatment of antibiotic-resistant bacteria to determine the best treatment option. (cdc.gov)
  • Tobramycin is an aminoglycoside antibiotic that works by killing bacteria. (bayviewrx.com)
  • Moxifloxacin 0.5%, Tobramycin 0.3% Eye Drops - Zeximox-T Eye Drops is an antibacterial eye drop that kills and prevents the growth of infection-causing bacteria. (zexuspharma.com)
  • It aids in the treatment of bacteria-related symptoms such as discomfort, redness, itching, and soreness. (zexuspharma.com)
  • Tobramycin is an antibiotic that kills bacteria by preventing the synthesis of essential proteins that bacteria require to perform vital functions. (zexuspharma.com)
  • Do not skip any dosage and make sure to complete the treatment course to ensure the bacteria is completely dead and won't be harming your eye anymore. (zexuspharma.com)
Recurrent4
  • Tobramycin, in its injectable form, is also indicated for various severe or life-threatening infections caused by susceptible strains: sepsis, meningitis, lower respiratory tract infections, intra-abdominal infections, skin infections, bone infections, and skin structure infections, complicated and recurrent urinary tract infections. (wikipedia.org)
  • Failure to respond to treatment, recurrent episodes, and signs of complications should prompt referral to an otolaryngologist. (medscape.com)
  • We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age. (biomedcentral.com)
  • Hypersensitivity reaction should be considered in patients who develop recurrent eosinophilia and deterioration of pulmonary function following the use of tobramycin by inhalation or by intravenous administration. (biomedcentral.com)
Bone void filler1
  • The product is a resorbable bone void filler that delivers a broad-spectrum antibiotic in a local and targeted manner in the surgical treatment of bone infections following hip or knee replacements. (globenewswire.com)
Drugs2
  • Pharmacotherapeutics Pharmacotherapeutics is the medical science concerned with the use of drugs in the treatment of disease. (slideshare.net)
  • What drugs might interact with Tobramycin? (zexuspharma.com)
Symptoms6
  • The use of INCSs plus antibiotics is reserved for patients who fail to respond to INCSs after 72 hours and for initial treatment of patients with severe symptoms. (medscape.com)
  • This has led to a huge impact on the treatment protocols which were previously focused on managing the sequelae and symptoms of dry eyes rather than targeting directly on the underlying cause, the MGD. (researchgate.net)
  • Temporal sequence of his signs and symptoms after each administration of tobramycin (similar to re-challenge testing), and his improvement after discontinuation of the drug strongly suggest an adverse drug reaction. (biomedcentral.com)
  • Many new treatments are being introduced for easing the symptoms of CF and increasing the life expectancy of a person with the disease, which are discussed below. (newworldencyclopedia.org)
  • To stay healthy and control symptoms, people of all ages with CF can manage their disease by following a regular treatment routine that includes airway clearance, oral and inhaled medications, a fitness plan, and nutritional therapies. (pari.com)
  • In CAYSTON], I had found a treatment that I could fit into my busy day-to-day life and could improve my breathing symptoms and help with my lung function, as measured by FEV 1 . (cayston.com)
Infection8
  • Your doctor will decide how often you should receive tobramycin, The length of your treatment depends on the type of infection you have. (medlineplus.gov)
  • The aerosol administration allows high concentrations of tobramycin to be delivered to the site of infection with limited systemic absorption. (biomedcentral.com)
  • A study was undertaken to see if there was a difference in treatment requirements between CF patients with chronic infection with their own unique P aeruginosa strains (group 1) and those who harbour a highly transmissible strain (group 2). (bmj.com)
  • Data on treatment requirements for the year 2000 were collected from the case records of CF patients with chronic P aeruginosa infection who had received inpatient treatment. (bmj.com)
  • 8 We have studied the treatment requirements of two groups of CF patients with chronic P aeruginosa infection-those who harbour their own unique strains and those who harbour a highly transmissible strain. (bmj.com)
  • Patients with chronic P aeruginosa infection who attend the Manchester Adult CF Centre were included in the study if they had received inpatient treatment with intravenous antibiotics during the year 2000. (bmj.com)
  • The length of your treatment depends on your general health, how you tolerate the medication, and the type of infection you have. (epnet.com)
  • Antibiotic medication Moxifloxacin & Tobramycin Eye Drops works by preventing the infection-causing germs from growing. (zexuspharma.com)
Serum2
  • Tobramycin should be used with caution in premature and neonatal infants because of their renal immaturity and the resulting prolongation of serum half-life of the drug. (nih.gov)
  • The treatment of lobar pneumonia with refined specific antibacterial serum. (jameslindlibrary.org)
Medication1
  • 11 Aerosolized medication has been successfully implemented in the treatment of obstructive lung disease. (rcjournal.com)
Tenebrarius1
  • Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius that is used to treat various types of bacterial infections, particularly Gram-negative infections. (wikipedia.org)
Moxifloxacin9
Drops1
  • Side effects associated with the use of tobramycin eye drops are mostly limited to the area(s) of application. (medicinenet.com)
Botulinum2
  • Treatment involves supportive care, intubation and mechanical ventilation when necessary, and administration of botulinum antitoxin. (cdc.gov)
  • The timeliness of diagnosis is crucial to successful treatment because botulinum antitoxin, the only specific therapy for botulism, must be administered to patients as quickly as possible. (cdc.gov)
Antimicrobial2
  • Multidrug-resistant M. chelonae infections present a challenge for treatment, and prolonged antimicrobial courses lead to significant toxicities and further antimicrobial resistance. (nature.com)
  • The patient's course of antimicrobial treatment has been characterized by a series of severe toxicities resulting in modification of treatment (Fig. 2 ). (nature.com)
Discomfort1
  • Side effects of Ocuflox that are different from Tobramycin include eye discomfort, redness, dryness, feeling as if something is in your eye, and sensitivity to light . (medicinenet.com)
Concentrations1
  • Other diuretics can also increase the risk for side effects because they raise tobramycin concentrations in the body fluids. (wikipedia.org)
Efficacy6
  • A prospective, randomized study was undertaken to compare the efficacy and safety of ceftazidime with those of a combination of ticarcillin and tobramycin in the treatment of 40 nonneutropenic patients with pneumonia or bacteremia. (nih.gov)
  • A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndrome. (cdc.gov)
  • The efficacy of ofloxacin solution in treating bacterial keratitis is equivalent to that of the fortified cefazolin and tobramycin solutions. (jamanetwork.com)
  • To evaluate the long-term clinical efficacy of ultrasound cyclo-plasty (UCP) in the treatment of moderate glaucoma and molecular effects in animal experiments. (frontiersin.org)
  • The purpose of the present study was to examine the molecular effects and clinical efficacy of UCP for the treatment of moderate glaucoma ( 11 ). (frontiersin.org)
  • Drug A substance which is intended for use in the diagnosis, cure, mitigation, treatment, or prevention of diseases and has efficacy to affect the structure or any function of the body. (slideshare.net)
Effectiveness1
  • The effectiveness of surgical procedures, such as thyroidectomy and nutraceutical treatments, are accompanied by several difficulties and still require further research. (bvsalud.org)
Dosage2
  • Your doctor will determine the dosage and duration of treatment based on your condition. (zexuspharma.com)
  • The recommended oral dosage in the treatment of antibiotic induced pseudomembranous enterocolitis is 125 to 500 mg every 6 hours for 7 to 10 days. (healthjade.com)
Exacerbation Treatment1
  • The primary outcome was relative lung function recovery (forced expiratory volume in 1 s [FEV1]) after exacerbation treatment. (nih.gov)
Isolates1
  • The proportion of patients with P. aeruginosa isolates for which the minimal inhibitory concentration of tobramycin was 8 microg per milliliter or higher increased from 25 percent at week 0 to 32 percent at week 24 in the tobramycin group, as compared with a decrease from 20 percent at week 0 to 17 percent at week 24 in the placebo group. (nih.gov)
Systemic5
  • These goals are achieved through the provision of adequate drainage and appropriate systemic treatment of the likely bacterial pathogens. (medscape.com)
  • In rare patients, systemic absorption of inhaled tobramycin may be significant enough to produce toxic effects, such as renal and vestibular toxicities. (biomedcentral.com)
  • The portion of inhaled tobramycin available for systemic absorption includes approximately 10% of the total dose that is delivered to the lungs, and some that gets to the oropharynx and eventually swallowed [ 1 ]. (biomedcentral.com)
  • There is poor systemic absorption of aerosolized tobramycin into the lungs among patients with CF, and its absorption from alveolar space into the pulmonary circulation is rate-limited [ 2 ]. (biomedcentral.com)
  • 12 , 13 Treatment with inhaled β 2 agonists and steroids has rapid and effective onset and decreases the frequency and severity of adverse systemic effects. (rcjournal.com)
Solution2
  • After reconstitution, the solution will contain 40 mg of tobramycin per mL. (nih.gov)
  • Patients under care at any one of 28 participating clinical centers who had an eye with suspected bacterial keratitis were randomly allocated in a double-masked manner to treatment with 0.3% ofloxacin solution or a combination of the fortified antibiotics (1.5% tobramycin and 10.0% cefazolin solutions). (jamanetwork.com)
Preparations1
  • Development of acute bronchospasm has been associated with use of intravenous preparations of tobramycin for aerosol administration. (biomedcentral.com)
Retrospective2
  • Retrospective chart review was performed for patients who received tobramycin during a CF exacerbation from 2009 to 2019 who received PK monitoring by pediatric pharmacists. (allenpress.com)
  • A new treatment algorithm for acute exacerbation of IPF: a retrospective cohort study. (ers-education.org)
Combination2
  • Eosinophilia has been reported to be associated with intravenous administration of tobramycin, including a patient treated for Gram-negative bacteremia [ 8 ], and among nine of 88 patients who received tobramycin in combination with cefamandole for peritonitis [ 9 ]. (biomedcentral.com)
  • The combination of 2-AIT with antibiotics could serve as a parallel treatment for antibiotic-resistant infections. (nih.gov)
Placebo4
  • A total of 520 patients (mean age, 21 years) were randomly assigned to receive either 300 mg of inhaled tobramycin or placebo twice daily for four weeks, followed by four weeks with no study drug. (nih.gov)
  • Patients received treatment or placebo in three on-off cycles for a total of 24 weeks. (nih.gov)
  • The patients in the tobramycin group were 26 percent (95 percent confidence interval, 2 to 43 percent) less likely to be hospitalized than those in the placebo group. (nih.gov)
  • A statistical review of controlled trials of imipramine and placebo in the treatment of depressive illnesses. (jameslindlibrary.org)