Similarly, a potentiating effect of chlorpromazine on kanamycin, gentamicin and neomycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides. (springer.com)
A synergistic effect of this extract on gentamicin and kanamycin was demonstrated. (springer.com)
Amikacin and gentamicin are the most commonly used in veterinary medicine. (wedgewoodpharmacy.com)
Amikacin has a broader spectrum of activity than some of the other members of this group and is often used for bacterial infections resistant to gentamicin. (wedgewoodpharmacy.com)
Amikacin is generally preferred over gentamicin for systemic use in neonatal foals. (wedgewoodpharmacy.com)
Gentamicin and tobramycin have similar antimicrobial spectra against gram-negative bacilli, but tobramycin is more active against P. aeruginosa , and gentamicin is more active against Serratia marcescens . (msdmanuals.com)
Amikacin is frequently active against gentamicin - and tobramycin -resistant pathogens. (msdmanuals.com)
Plazomycin is an aminoglycoside antibiotic similar to gentamicin and amikacin. (drlact.com)
There are some gram-positive Staphyloccus that are sensitive to amikacin although generally the aminoglycosides are combined with other antibiotics when both gram-negative and gram-positive bacteria are present. (wedgewoodpharmacy.com)
Pharmacokinetics - Tobramycin, like the other aminoglycosides is not appreciably ab-sorbed after oral or intrauterine administration, but it is absorbed from topical administra-tion (not skin or urinary bladder) when used in irrigations during surgical procedures. (elephantcare.org)
Newborn infants apparently absorb small amounts of other aminoglycosides, but serum levels with typical three times daily dosages are far below those attained when treating newborn infections and systemic effects of amikacin are unlikely. (drlact.com)
Inhalation7
Amikacin liposome inhalation suspension is the first drug approved under the US limited population pathway for antibacterial and antifungal drugs (LPAD pathway). (wikipedia.org)
The US Food and Drug Administration (FDA) granted the application for amikacin liposome inhalation suspension fast track, breakthrough therapy, priority review, and qualified infectious disease product (QIDP) designations. (wikipedia.org)
The FDA granted approval of Arikayce to Insmed, Inc. The safety and efficacy of amikacin liposome inhalation suspension, an inhaled treatment taken through a nebulizer, was demonstrated in a randomized, controlled clinical trial where patients were assigned to one of two treatment groups. (wikipedia.org)
One group of patients received amikacin liposome inhalation suspension plus a background multi-drug antibacterial regimen, while the other treatment group received a background multi-drug antibacterial regimen alone. (wikipedia.org)
By the sixth month of treatment, 29 percent of patients treated with amikacin liposome inhalation suspension had no growth of mycobacteria in their sputum cultures for three consecutive months compared to 9 percent of patients who were not treated with amikacin liposome inhalation suspension. (wikipedia.org)
Tobramycin is also available as a capsule and as a solution for inhalation. (rxwiki.com)
Common side effects of tobramycin for inhalation include voice changes and ringing in the ears. (rxwiki.com)
Antibiotics6
Amikacin may be combined with other antibiotics to provide coverage for gram positive bacteria. (wedgewoodpharmacy.com)
Systemic use of amikacin and other aminoglycoside antibiotics are usually reserved for serious illnesses because of the risk of nephrotoxicity and ototoxicity. (wedgewoodpharmacy.com)
When using amikacin or other aminoglycoside antibiotics, monitoring of renal function and peak trough drug concentrations can be very useful to decrease the risks of nephrotoxicity. (wedgewoodpharmacy.com)
Tobramycin belongs to a group of drugs called aminoglycoside antibiotics. (rxwiki.com)
Pharmacology - Tobramycin, like the other aminoglycoside antibiotics, act on susceptible bacteria presumably by irreversibly binding to the 30S ribosomal subunit thereby inhibit-ing protein synthesis. (elephantcare.org)
Susceptibility to the different antibiotics varied but none of the isolates from chicken was resistant to amikacin. (who.int)
Amikacin can also be used to treat non-tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection. (wikipedia.org)
The following drugs or solutions are reportedly incompatible or only compatible in spe-cific situations with tobramycin: cefamandole naftate, furosemide and heparin sodium. (elephantcare.org)
Common side effects of tobramycin include upset stomach, pain at the injection site, fever, and headache. (rxwiki.com)
Precautions1
See the "Tobramycin Precautions" section. (rxwiki.com)
Streptomyces2
Chemistry - An aminoglycoside derived from Streptomyces tenebrarius , tobramycin oc-curs as a white to off-white, hygroscopic powder that is freely soluble in water and very slightly soluble in alcohol. (elephantcare.org)
KANAMYCIN MONOSULFATE, From Streptomyces kanamycetikus Crystalline, Activity: Approx. (alna-bioscience.com)
Topical2
Amikacin is also used in topical preparations for the skin, ears and eyes. (wedgewoodpharmacy.com)
Proper cleaning of the ear will increase the effectiveness of topical treatments with amikacin. (wedgewoodpharmacy.com)
Breast milk2
While it is known to cross the placenta, amikacin is only partially secreted in breast milk. (wikipedia.org)
Tobramycin is a prescription medication used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract. (rxwiki.com)
Tobramycin can also be used to treat eye infections. (rxwiki.com)
Tobramycin is a prescription medication used to treat infections of the eyes that care caused by bacteria. (rxwiki.com)
Uses/Indications - While there are no approved veterinary tobramycin products in the U.S., tobramycin may be useful clinically to treat serious gram negative infections in most species. (elephantcare.org)
Deafness1
A pregnant woman taking amikacin with another aminoglycoside has a possibility of causing congenital deafness in her child. (wikipedia.org)
Does Amikacin has any long term or short term side effects on infants? (drlact.com)
Older infants would be expected to absorb even less amikacin. (drlact.com)
Irreversible1
The mechanism of action for amikacin is through disruption of the bacterial cell wall, irreversible binding of the 30S ribosomal subunit, and inhibition of bacterial protein synthesis. (wedgewoodpharmacy.com)
Dependent1
The bactericidal properties of amikacin are concentration dependent and there is significant bactericidal activity even after drug concentrations are below the minimum inhibitory concentration (MIC). (wedgewoodpharmacy.com)
Include1
Common side effects of tobramycin for the eyes include tearing or swelling of the eye and irritation of the eye. (rxwiki.com)
Anesthesia Central , anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109063/7/kanamycin. (unboundmedicine.com)
Kidney2
Amikacin should be used in smaller doses in the elderly, who often have age-related decreases in kidney function, and children, whose kidneys are not fully developed yet. (wikipedia.org)
Tobramycin can cause kidney damage and hearing loss. (rxwiki.com)