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  • proteins
  • Furthermore, it offers a versatile technology for the complexation of targeting ligands with therapeutic recombinant proteins and by this a novel way to enhance their specificity and activity. (uu.nl)
  • Nineteen proteins have been identified as part of the TNF family on the basis of sequence, functional, and structural similarities. (wikipedia.org)
  • All members of the TNF family, with the exception of the secreted lymphotoxin and a proliferation-inducing ligand (APRIL), are type II transmembrane proteins that protrude from immune cells. (wikipedia.org)
  • induction
  • Its role in induction of apoptosis remains to be studied. (aacrjournals.org)
  • The assembled complexes killed tumor cells (Jurkat T cells) via apoptosis induction. (uu.nl)
  • HDAC inhibitors are able to mediate the induction of both apoptosis and autophagy, which are related to anticancer activity in a variety of cancer cell lines. (hindawi.com)
  • Although further investigation is required to fully elucidate the consequences of both autophagy and apoptosis induction by treatment with HDAC inhibitors, the pharmacological inhibition of HDAC provides a new therapeutic basis for targeting cell death processes. (hindawi.com)
  • Apoptosis induction is monitored by cell surface phosphatidylserine (PS) detection. (hindawi.com)
  • When tested on the human monocytic cell line THP-1, blueberry Pcys are less effective for PS externalisation and DNA fragmentation is absent, highlighting a specificity of apoptosis induction in gut cells. (hindawi.com)
  • We highlight here that berries Pcys, especially lowbush blueberry Pcys, are of putative interest for nutritional chemoprevention of colorectal cancer in view of their apoptosis induction in a human colorectal cancer cell lines. (hindawi.com)
  • Ag-stimulated T cells express Fas ligand (FasL), 3 and induction of Fas-mediated cell death represents also a major strategy exploited by CTLs to erase targets expressing immunogenic peptide-MHC class I complexes ( 8 , 9 ). (jimmunol.org)
  • 1992). "The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle. (wikipedia.org)
  • pathway
  • The aim of this work is to identify which proapoptotic pathway is induced in human colon cancer cell lines, in contact with proanthocyanidins extracted from various berries. (hindawi.com)
  • NDV triggers apoptosis in a wide range of cancer cell types via the mitochondrial/intrinsic pathway, through loss of membrane potential and thereby inducing release of cytochrome c in the tumor cell. (wikipedia.org)
  • proapoptotic
  • Proanthocyanidins (Pcys) extracted from 11 berry species are monitored for proapoptotic activities on two related human colon cancer cell lines: SW480-TRAIL-sensitive and SW620-TRAIL-resistant. (hindawi.com)
  • cells
  • TNF-related apoptosis-inducing ligand (TRAIL) holds promise for treatment of cancer credited to its ability to selectively kill cancer cells while sparing regular cells. (researchreportone.com)
  • FACS Evaluation of Apoptosis with Annexin Sixth is v/Propidium Iodide Labels MCF10A cells had been treated with 30 systems/ml Trek for 2 l. (researchreportone.com)
  • The consequences of NF-B and JNK on Path signalling are questionable, with some reviews displaying that their activation protects cells from Path induced apoptosis among others suggesting the contrary effect . (bostonscienceandengineeringlectures.com)
  • Although Path induced JNK and NF-B activation was abolished in the lack of TAK1, just NF-B seems to play an integral role in permitting survival of Path treated cells. (bostonscienceandengineeringlectures.com)
  • Strategies consisting in preventing and even treating cancer with natural dietary compounds able to induce apoptosis of cancerous cells are currently largely admitted and studied [ 16 - 21 ]. (hindawi.com)
  • A new mAb to these CD99 epitopes, Ad20, induces programmed cell death of transformed T cells as determined by morphological changes, phosphatidylserine exposure on the cell surface, and uptake of propidium iodide. (jimmunol.org)
  • In contrast to the effect on transformed T cell lines, Ad20-induced death responses were not observed with normal peripheral T cells. (jimmunol.org)
  • Of these, the Fas-CD95-Apo-1 Ag has a critical function in the control of mature peripheral T cells by activation-induced apoptosis ( 2 , 3 , 4 , 5 , 6 , 7 ). (jimmunol.org)
  • The role of TRAIL in control of normal T cells and immune responses is not clear, but it has been reported that a subset of IL-2-stimulated mature T cells apparently acquires sensitivity to TRAIL-induced cell death ( 31 ). (jimmunol.org)
  • miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1. (cancerindex.org)
  • It induces the proliferation of co-stimulated T cells and enhances the generation of cytolytic T cells. (wikipedia.org)
  • Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells. (wikipedia.org)
  • In 1960, Klein and colleagues found that in mice, primary methylcholanthrene-induced sarcomas exhibited an antitumor immune response mediated by lymph node cells to cancer cells derived from the primary tumor. (wikipedia.org)
  • 2002) Perforin deficient mice were also shown to have a reduced ability to ward off MCA induced cancers, suggesting an important role of CD8+ T cells. (wikipedia.org)
  • The researchers suggested in cells that resist the normal inducement of apoptosis when infected will give NDV more time to incubate in cell and spread. (wikipedia.org)
  • Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. (wikipedia.org)
  • The recruited tumour-infiltrating NK cells and macrophages produce interleukin 12 and interferon gamma, which kill tumour cells by cytotoxic mechanisms such as perforin, TNF-related apoptosis-inducing ligands (TRAILs), and reactive oxygen species. (wikipedia.org)
  • This again promotes more tumor killing by these cells via apoptosis and the production of reactive oxygen and nitrogen intermediates. (wikipedia.org)
  • vivo
  • It has been shown that this induces greater cell migration in vivo and in vitro, possibly by promoting degradation of the ECM. (wikipedia.org)
  • Angiogenesis
  • Hypoxia also causes the upregulation of hypoxia-inducible factor 1 alpha (HIF1-α), which induces angiogenesis and is associated with poorer prognosis and the activation of genes associated with metastasis, leading, for instance, to increased cell migration and also ECM remodeling. (wikipedia.org)
  • vitro
  • New drugs, such as fosbretabulin (a type of combretastatin), bortezomib and TNF-Related Apoptosis Induced Ligand (TRAIL), are however being under investigation in vitro and in human clinical studies. (wikipedia.org)
  • The analogs are believed to inhibit the production of TNF-α, where the analogs are up to 50.000 times more potent in vitro than the parent drug thalidomide. (wikipedia.org)