Therapeutic intervention aims to reverse tumor-induced NK cell suppression and sustain NK cells' tumorlytic capacities. (frontiersin.org)
The CD56 bright population produces immunoregulatory cytokines, including interferon-γ (IFN-γ), tumor necrosis factor-beta (TNF-B), tumor necrosis factor-α (TNF-α), granulocyte macrophage-colony stimulating factor (GMCSF), IL-10, and IL-13 ( 4 ). (frontiersin.org)
At that time, the application of tumor treatment with the spontaneous viruses or wild type viruses which quite often being scavenged by immune system, merely induces a subtle inhibition to tumor progression in patients. (biomedcentral.com)
Receptors5
Apoptosis can be triggered by the engagement of cell surface receptors by their ligands. (ox.ac.uk)
A growing number of receptors belonging to the TNF receptor family have been identified that contain a conserved cytoplasmic death domain. (ox.ac.uk)
The latter two are receptors for the cytotoxic ligand TNF-related apoptosis-inducing ligand (TRAIL), and one of the paradoxes raised by the cloning of these molecules was why do most cells not die upon contact with the widely expressed TRAIL molecule? (ox.ac.uk)
In the 1990's, the Human Genome Project inspired my team to discover several novel members of the TNF cytokine superfamily, most notably, Apo2L/TRAIL and its "death" and "decoy" receptors. (gene.com)
A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)
Cytotoxic1
IFNg or TNF), or cytotoxic granules (i.e., perforin/granzyme B) expressed by effector cells are some ways in which target cell death can be induced. (jove.com)
LIT is expressed predominantly on PBL, where it can competitively inhibit TRAIL-induced apoptosis through DR4/TRICK2, and may function to modulate lymphocyte sensitivity to TRAIL. (ox.ac.uk)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
In this Commentary, we discuss the implications of these findings for the regulation of apoptosis by Bcl-2 family proteins. (biologists.com)
Inhibit1
These therapies inhibit the proinflammatory action of TNF-α in common autoimmune diseases such as rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease. (frontiersin.org)
However, in certain cell types, the extrinsic pathway also induces mitochondrial damage by cleaving the pro-apoptotic Bcl-2 family protein Bid to its activated truncated form (tBid), which leads to Bak and Bax activation. (biologists.com)
Cells3
Mechanisms of peripheral tolerance include inactivation of autoantigen-recognizing T and B cells by the induction of apoptosis, anergy or conversion into immunosuppressive regulatory cells. (frontiersin.org)
RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
We have discovered that the key UPR enzyme IRE1 is hijacked by certain cancer cells to avert apoptosis and resist proteotoxic stress. (gene.com)
Undergo1
All patients will undergo PET imaging with the high affinity TSPO ligand [18F]GE-180, FET-PET and MRI prior to the neurosurgical intervention. (uni-regensburg.de)
Immune3
Thus, therapeutics that induce, restore, and maintain immune tolerance toward these autoantigens represent the "Holy Grail" of treatments for autoimmune diseases. (frontiersin.org)
Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
The primary objectives of this study are: - To determine the proportion of children with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) related death, rehospitalization or major complications after infection with SARS-CoV-2 and/or Multisystem Inflammatory Syndrome in Children (MIS-C), and - To determine immunologic mechanisms and immune signatures associated with disease spectrum and subsequent clinical course during the year of follow-up. (stanford.edu)
Mechanisms3
Area B will provide information on the structure and function of the TSPO molecule in response to TSPO ligands and within its multimeric complex by biophysical methods in order to unravel further molecular mechanisms of TSPO signaling and to give further input for TSPO ligand drug development. (uni-regensburg.de)
Our contributions to elucidating the mechanisms of apoptosis led to clinical investigation of a novel class of molecules called Pro-Apoptotic Receptor Agonists, and aided in the advancement of apoptosis-promoting cancer medicines such as venclexta. (gene.com)
Therapeutic2
However, anti-TNF-α therapies have limitations, including known adverse safety risk, loss of therapeutic efficacy due to drug resistance, and lack of efficacy in numerous autoimmune diseases, including multiple sclerosis. (frontiersin.org)
Therefore, the planned research group aims to characterize the role of TSPO as a diagnostic and therapeutic target from structural biology over neurology to psychiatry and to delineate the potential of TSPO ligands as a novel therapeutic approach within the nervous system. (uni-regensburg.de)
Taking alpha-lipoic acid by mouth daily for up to 6 months does not improve liver function or reduce liver damage in people with alcohol-related liver disease. (medlineplus.gov)
Cell1
This led us to investigate a cell-suicide process called Apoptosis-which has important roles in normal physiology as well as in disease. (gene.com)
Cancer1
Globally, HCC is the sixth most prevalent cancer and the third-most prevalent reason for neoplastic disease-related deaths. (wjgnet.com)
In addition, the role of TSPO for behavior such as anxiety, fear and stress in relation to the modulating effects of TSPO ligands will be studied in respective animal models including PET labeling in relation to neurosteroidogenesis and spine plasticity. (uni-regensburg.de)
Receptor3
A growing number of receptors belonging to the TNF receptor family have been identified that contain a conserved cytoplasmic death domain. (ox.ac.uk)
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. (nih.gov)
Proteases2
Engagement of the DRs with cognate ligands including FasL induces recruitment and activation of the apoptosis-initiating proteases, such as caspase-8 and caspase-10, and then induces apoptosis through various molecules. (frontiersin.org)
The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. (nih.gov)
Pathways1
Extrinsic and intrinsic pathways are the major DR-mediated pathways of apoptosis. (frontiersin.org)
Activation3
In this review, we discuss markers identified in different anatomical sites of the body including periphery, brain, and gut, as well as markers related to DNA that may serve as reliable predictors of accelerated aging in HIV infected individuals as it relates to inflammatory state and immune activation. (frontiersin.org)
This mechanism, known as activation-induced cell death (AICD), deletes overactivated or autoreactive T cells in the periphery ( 12 ). (frontiersin.org)
Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. (nih.gov)
Mice2
Fas-mediated apoptosis of peripheral T cells, which represents a key mechanism that maintains immunological tolerance, is impaired in MRL- lpr/lpr mice. (frontiersin.org)
Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. (nih.gov)
Processes2
Fas-mediated apoptosis contributes to physiological and pathological cellular processes, such as differentiation and survival. (frontiersin.org)
The interaction of Fas with its ligand FasL (FasL/CD95L) regulates numerous physiological and pathological processes that are mediated through programmed cell death ( 3 ). (frontiersin.org)
Engagement1
Apoptosis can be triggered by the engagement of cell surface receptors by their ligands. (ox.ac.uk)
Gene1
Three alternatively spliced variants of mTid-1 were isolated, two of which correspond to the recently identified hTid-1(L) and hTid-1(S) forms of the human TID1 gene that exhibit opposing effects on apoptosis. (embl.de)
Exhibit1
Even HIV-infected individuals receiving cART are likely to exhibit mild forms of neurological impairment related to HAND ( 11 ). (frontiersin.org)
Nuclear1
By contrast, the binding of some cognate ligands to DR triggers transcriptional events leading to nuclear factor-kappa β (NF-κB)- or activator protein-1 (AP-1)-dependent pro-inflammatory cytokine expression (Figure 1 ). (frontiersin.org)
Activity1
Ligands associated with a target, listed in ChEMBL, with activity over a cutoff relative to the targetclass. (nih.gov)
Conditions1
Chronic HIV infection in the setting of anti-retroviral therapy (ART) is commonly associated with inflammaging, low-grade inflammation, a primary contributor to age-related conditions such as increased vulnerability to infections, and development of age associated co-morbid conditions including cancers, cardiovascular diseases (CVD), and neurodegenerative diseases ( 2 , 3 ). (frontiersin.org)