• Tumor necrosis factor-alpha (TNF-alpha) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors. (ox.ac.uk)
  • Tumor necrosis factor-alpha (TNF-alpha) is a bifunctional regulator of hematopoiesis, and its cellular responses are mediated by two distinct cell surface receptors. (ox.ac.uk)
  • TNF signaling occurs through two receptors: TNFR1 and TNFR2. (wikipedia.org)
  • Also, due to the high clearance rate of TNF-α from circulation, analyzing the circulating levels of soluble TNF-α receptors 1 and 2 (STNFR1 and STNFR2) may provide a better indication of inflammatory events. (iucc.ac.il)
  • However, anti-TNF therapies targeting TNF and its receptors failed in clinical trials. (usda.gov)
  • There is growing evidence that TNF-alpha and its two receptors play an important role in hormonal regulation, metabolism, inflammation and cancer. (aaem.pl)
  • The biological effects of TNF-alpha are mediated by two receptors, p55 and p75. (aaem.pl)
  • Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects. (aaem.pl)
  • Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. (aaem.pl)
  • Onsrud M, Shabana A, Austgulen R, Nustad K. Comparison between soluble tumor necrosis factor receptors and CA125 in peritoneal fluids as a marker for epithelial ovarian cancer. (aaem.pl)
  • Opala T, Rzymski P, Wilczak M, Woźniak J. Evaluation of soluble tumour necrosis factor alpha receptors p55 and p75 in ovarian cancer patients. (aaem.pl)
  • Tumor necrosis factor (TNF)-alpha and TNF receptors in viral pathogenesis. (koreamed.org)
  • TNF-alpha generally inhibits the growth of primitive murine hematopoietic progenitor cells (Lin-Scal+) in response to multiple cytokine combinations, and the p75 TNF receptor is essential in signaling such inhibition. (ox.ac.uk)
  • In the present study we show the reverse phenomenon in that TNF-alpha on the same progenitor cell population in combination with stem cell factor (SCF) and interleukin-7 (IL-7) through the p55 TNF receptor can recruit additional progenitors to proliferate. (ox.ac.uk)
  • The binding of TNF to its receptor and its displacement by LT confirmed the functional homology between the two factors. (wikipedia.org)
  • Expression of the TNFα receptor subytpe-1 was detected in the human NCI-H716 and murine GLUTag L-cell models and in mouse ileal sections. (nih.gov)
  • Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
  • Olsson I, Gatanaga T, Gullberg U, Lantz M, Granger GA. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. (aaem.pl)
  • Engelmann H, Holtmann H, Brakebusch C, Avni YS, Sarov I, Nophar Y, Hadas E, Leitner O, Wallach D. Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity. (aaem.pl)
  • Chegini N. An inverse relation between the expression of tumor necrosis factor alpha (TNF-alpha) and TNF-alpha receptor in human endometrium. (aaem.pl)
  • Does not cross-react with TNF-beta, lymphotoxin and receptor bound TNF-alpha. (lsbio.com)
  • Younes F, Quartey EL, Kiguwa S, Partridge M. Expression of TNF and the 55-kDa TNF receptor in epidermis, oral mucosa, lichen planus and squamous cell carcinoma. (medscape.com)
  • Wistar male rats were divided into six groups a control-group (treated with 0.1 mL/kg of saline) and five groups treated with anti-TNF-α infliximab (INF) at 1, 3, 5, 7, and 10 mg/kg immediately before OTU production . (bvsalud.org)
  • Such reports exist for each of the three currently licensed anti-TNF therapies: infliximab (INF), etanercept (ETA) and adalimumab (ADA). (bmj.com)
  • Other TNF blockers include Remicade (infliximab), Enbrel (etanercept), Cimzia (certolizumab pegol) and Simponi (golimumab). (drugwatch.com)
  • In 1985, Bruce A. Beutler and Anthony Cerami discovered that cachectin (a hormone which induces cachexia) was actually TNF. (wikipedia.org)
  • These products work by blocking TNF-α, an inflammatory cytokine, and are approved for treating rheumatoid arthritis and other selected autoimmune diseases. (cdc.gov)
  • formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and a cytokine. (wikipedia.org)
  • As a cytokine, TNF is used by the immune system for cell signaling. (wikipedia.org)
  • From this membrane-integrated form the soluble homotrimeric cytokine (sTNF) is released via proteolytic cleavage by the metalloprotease TNF alpha converting enzyme (TACE, also called ADAM17). (wikipedia.org)
  • Oral lichen planus lesions contain increased levels of the cytokine tumor necrosis factor (TNF)-alpha. (medscape.com)
  • Hyperglycemia and hyperinsulinemia were reduced in HFD mice treated with the anti-TNFα biological, etanercept, for 2 weeks. (nih.gov)
  • This may suggest that natural inhibitors of TNF-α decline as early as middle age. (iucc.ac.il)
  • Tumour necrosis factor-alpha inhibitors. (nih.gov)
  • Rarely, kidney inflammation (nephritis) can develop with drug-induced lupus caused by TNF inhibitors or with ANCA vasculitis due to hydralazine or levamisole. (medlineplus.gov)
  • cyclosporine , plasmapheresis or IV immune globulin, early corticosteroid therapy, and tumor necrosis factor-alpha inhibitors have been used. (msdmanuals.com)
  • The ulcers were clinically measured, and the mucosa samples were histologically (scores 0-4), histochemically ( collagen assay (pircrosirius)), histomorphometrically ( cell counting), and immunohistochemically (TNF-α, α-smooth- muscle - actin (α-SMA), monocyte -chemoattractive- protein -1 (MCP-1), interleukin-8 ( IL-8 ), and fibroblast - growth -factor (FGF)) analyzed. (bvsalud.org)
  • TNF is primarily produced as a 233-amino acid-long type II transmembrane protein arranged in stable homotrimers. (wikipedia.org)
  • [ 3 ] This includes eosinophils (as suggested by the presence of eosinophilia), eosinophil cationic protein (ECP), and eosinophil cationic factor (ECF) found in biopsy specimens from select patients with DPU, particularly those with bullous DPU. (medscape.com)
  • Mechanistically, HD-13 activated mitogen-activated protein kinase (MAPK) and nuclear factor kB (NF- κ B) signals. (hindawi.com)
  • It has been reported that various hosts recognize lipopolysaccharides in the cell membrane structure through TLR9 and activate downstream mitogen-activated protein kinase (MAPK) and nuclear transcription factor- κ B (NF- κ B) pathways mediated by MyD88 to promote the MAPK protein phosphorylation, and NF- κ B enters the nucleus, further releasing cellular inflammatory factors [ 12 ]. (hindawi.com)
  • Activation of the transcription factor nuclear factor KB (NF-KB) requires the NEMO protein. (medscape.com)
  • Tristetraprolin (TTP), an anti-inflammatory protein, binds to the AREs of clinically important mRNAs such as TNF mRNA and promotes the destruction of those transcripts. (usda.gov)
  • TNF is a protein produced naturally by the body's immune system. (drugwatch.com)
  • The synergistic effects of TNF-alpha were seen at the single cell level, suggesting that its effects are directly mediated. (ox.ac.uk)
  • Western Blot: TNF-alpha Antibody [NBP1-19532] - Recombinant human TNF alpha (10 ng) was separated on a 12% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane and blocked in 5% non-fat milk in TBST. (novusbio.com)
  • Western Blot: TNF-alpha Antibody [NBP1-19532] - Scutellarin attenuates hypertension-induced brain expression of NF-kappaB, TNF-alpha, IL-1beta, and IL-18. (novusbio.com)
  • Immunohistochemistry-Paraffin: TNF-alpha Antibody [NBP1-19532] - Analysis of a FFPE tissue section of mouse intestine using TNF-alpha antibody (NBP1-19532) at 1:300 dilution. (novusbio.com)
  • TNF Alpha antibody LS-B2123 is an unconjugated mouse monoclonal antibody to TNF Alpha from human. (lsbio.com)
  • Anti-TNF Alpha antibody IHC of human lung. (lsbio.com)
  • Certolizumab pegol is a recombinant, humanized antibody Fab' fragment against tumour necrosis factor alpha (TNFα), conjugated to polyethylene glycol (PEG) and in accordance with the CHMP guideline on the environmental risk assessment (EMEA/CHMP/SWP/4447/00) is exempted from testing because of its chemical structure. (janusinfo.se)
  • 7 Following the introduction of anti-tumour necrosis factor (anti-TNF) therapies for patients with RA, there have been a number of case reports and case series documenting either a rapid progression of pre-existing RA-ILD or the development of new-onset interstitial disease. (bmj.com)
  • Kevin J. Tracey and Cerami discovered the key mediator role of TNF in lethal septic shock, and identified the therapeutic effects of monoclonal anti-TNF antibodies. (wikipedia.org)
  • Horse Tumor necrosis factor α, TNF-α ELISA Kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
  • TNF-α exists as a transmembrane form (mTNF-α) and as a soluble form (sTNF-α). (wikipedia.org)
  • Reacts with soluble (17kD) and membrane (26kD) human TNF-alpha. (lsbio.com)
  • TNF is a member of the TNF superfamily, which consists of various transmembrane proteins with a homologous TNF domain. (wikipedia.org)
  • Mice given a high-fat diet (HFD) for 12 weeks developed impaired glucose tolerance, hyperinsulinemia, and increased TNFα mRNA expression in fat and ileal tissue. (nih.gov)
  • [ 8 ] T cells in oral lichen planus contain mRNA for TNF and secrete TNF in vitro. (medscape.com)
  • abstract = "Background Tumor necrosis factor-alpha (TNF-α) has been shown to be implicated in both muscle regeneration and muscle wasting. (iucc.ac.il)
  • Recognizes human native and recombinant TNF-alpha. (lsbio.com)
  • Furthermore, both NCI-H716 and GLUTag cells pretreated with TNFα for 24 hours no longer responded to known GLP-1 secretagogues, an effect that was reversed by coincubation with the Nuclear Factor Kappa B inhibitor, 5-aminosalicylic acid, in the NCI-H716 cells. (nih.gov)
  • To investigate the association between tobacco smoking and disease activity, treatment adherence and treatment responses in patients with AS treated with their first tumour necrosis factor-alpha inhibitor (TNFi) therapy in routine care. (nih.gov)
  • Therefore, we set up a study using nationwide Swedish high-coverage administrative register data with the objective to identify patient groups with distinct persistence of subcutaneous tumor necrosis factor inhibitor (SC-TNFi) treatment in IA, using recursive partitioning, a statistical learning algorithm. (lu.se)
  • The human TNF gene was cloned in 1985. (wikipedia.org)
  • Detection of allele A and /or G at the 308 position in the promoter region of the TNF-α gene was carried out using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) technique. (bmj.com)
  • There was no statistically significant difference in the distribution of the low (G) or high (A) producer alleles at position 308 of the TNF-α gene between patients with cervical cancer and healthy women. (bmj.com)
  • Similar to AS, people with the gene HLA-B27 have a higher risk factor of developing enteropathic arthritis. (medicalnewstoday.com)
  • In 2000, the International Incontinentia Pigmenti Consortium reported that incontinentia pigmenti is caused by a genomic rearrangement of the gene for NEMO, or nuclear factor kappa B essential modulator (IKBKG-IKK gamma). (medscape.com)
  • [ 2 ] The defect in the X chromosome is proximal to the gene for factor VIII at Xq28. (medscape.com)
  • Tumour necrosis factor-alpha gene polymorphisms in asbestos-induced diseases. (cdc.gov)
  • [ 9 ] Serum and salivary TNF levels are elevated in oral lichen planus patients. (medscape.com)
  • The last exon shares similarity with lymphotoxin alpha (LTA, once named as TNF-β). (wikipedia.org)
  • Drugs that counter the action of TNF are used in the treatment of various inflammatory diseases, for instance rheumatoid arthritis. (wikipedia.org)
  • Background Anti-tumour necrosis factor (anti-TNF) therapy has been associated with reports of rapid severe progression of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). (bmj.com)
  • Durable blockade of tumour necrosis factor-alpha (TNF-α) in patients with rheumatoid arthritis (RA) suppresses disease activity and its progression. (bmj.com)
  • Blood pressure and heart rate, markers of active smoking and secondhand smoke exposure (exhaled CO and saliva cotinine levels), and selected inflammatory cytokines in blood (ineterleukin (IL)-1b, IL-6, IL-8, interferon gamma (IFN-gamma), tumour necrosis factor (TNF-alpha)) were assessed in workers immediately prior to and immediately after their work shift. (who.int)
  • In 2003, the state of California Department of Health Services asked local jurisdictions to report TB cases associated with TNF-α antagonists since January 2002. (cdc.gov)
  • We further provided evidence that IL-37 inhibited effectively tumor metastasis in vitro and in vivo . (nature.com)
  • The drug suppresses the immune system by blocking the activity of TNF. (drugwatch.com)
  • The aim of this study was to examine changes in circulating concentrations of TNF-α, STNFR1, and STNFR2 following acute eccentric exercise in young (YA) and middle-aged (MA) men. (iucc.ac.il)
  • Plasma concentrations of TNF-α were unchanged following MDP. (iucc.ac.il)
  • Short-term effects of anti-TNF on plasma lipid concentrations seemed beneficial and anti-atherogenic. (bmj.com)
  • 1 Among the traditional cardiovascular risk factors, the lipid profile in RA has often been described as "pro-atherogenic", 2 based on decreased HDL-cholesterol (HDL-C) and increased LDL:HDL-C ratio and lipoprotein (a) plasma concentrations in both active and treated RA. (bmj.com)
  • Three patients underwent a medical history for TB risk factors before beginning therapy with a TNF-α antagonist. (cdc.gov)
  • 05). In conclusion, chronic exposure to TNFα directly impairs GLP-1 secretion at the level of the intestinal L-cell, an effect that is reversed by anti-TNFα therapy in association with improved glucose tolerance. (nih.gov)
  • Evaluate patients for tuberculosis risk factors and test for latent tuberculosis infection prior to initiating CIMZIA and during therapy. (theodora.com)
  • However, reports also exist of favourable responses to anti-TNF therapy in patients with ILD. (bmj.com)
  • The aim of this study was to examine the influence of anti-TNF therapy on mortality in patients with pre-existing RA-ILD. (bmj.com)
  • Conclusion The mortality in patients with RA-ILD is not increased following treatment with anti-TNF therapy compared with traditional DMARDs. (bmj.com)
  • The proportion of deaths attributable to RA-ILD is higher in patients treated with anti-TNF therapy, although reporting bias may exist. (bmj.com)
  • In the present study, we investigated the effects of 1-year therapy with anti-TNF on the lipid profile of RA patients. (bmj.com)
  • To assess the safety of anti-tumor necrosis factor (TNF)-alpha therapy in patients with rheumatic disease and chronic Hepatitis B virus (HBV) infection. (koreamed.org)
  • One of the cases treated with lamivudine before anti-TNF-alpha therapy for chronic hepatitis B treatment. (koreamed.org)
  • His hepatitis status was maintained stable after he initiated anti-TNF-alpha therapy. (koreamed.org)
  • Five of the cases started anti-TNF-alpha therapy without lamivudine. (koreamed.org)
  • Two of these five cases were received lamivudine during anti-TNF-alpha therapy due to elevation of HBV DNA titer without liver function test abnormality and then HBV DNA was normalized. (koreamed.org)
  • HBV viral load and ALT level during anti-TNF- α therapy in patient 3. (koreamed.org)
  • Infections and anti-tumor necrosis factor alpha therapy. (koreamed.org)
  • Anti-tuberculosis treatment of patients with latent tuberculosis infection reduces the risk of reactivation in patients receiving treatment with TNF blockers such as CIMZIA. (theodora.com)
  • CIMZIA is a medicine called a Tumor Necrosis Factor (TNF) blocker. (theodora.com)
  • Endometrial cancer invasion depends on cancer-derived tumor necrosis factor-alpha and stromal derived hepatocyte growth factor. (aaem.pl)
  • Research in the laboratory led by Mark Mattson has shown that TNF can prevent the death/apoptosis of neurons by a mechanism involving activation of the transcription factor NF-κB which induces the expression of antioxidant enzymes and Bcl-2. (wikipedia.org)
  • [ 6 ] NF-KB protects cells from apoptosis in response to tumor necrosis factor-alpha (TNF-alpha). (medscape.com)
  • More specifically, Humira is a tumor necrosis factor-α blocker, or TNF blocker. (drugwatch.com)
  • Humira is designed to stop tumor necrosis factor-α, or TNF, from attacking healthy cells. (drugwatch.com)
  • Humira binds to TNF molecules and blocks the molecules from attaching to healthy cells and attacking them. (drugwatch.com)
  • Finally, whereas SCF plus IL-7 promoted primarily granulopoiesis, the addition of TNF-alpha switched the differentiation toward the production of almost exclusively macrophages. (ox.ac.uk)
  • If macrophages (certain white blood cells) detect an infection, they release TNF to alert other immune system cells as part of an inflammatory response. (wikipedia.org)
  • Subsequently, in 1975 Lloyd J. Old from Memorial Sloan Kettering Cancer Center, New York, reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF). (wikipedia.org)
  • Lack of tumor necrosis factor alpha induces impaired proliferation of hepatitis B virus-specific cytotoxic T lymphocytes. (koreamed.org)
  • They then identified TNF as a mediator of lethal endotoxin poisoning. (wikipedia.org)
  • Eleven of the patients had at least one risk factor for LTBI (e.g., born in countries where TB is prevalent or contact with a person with TB disease). (cdc.gov)
  • In this study, clinical data from 84 patients showed that loss or reduced expression of IL-37 in lung adenocarcinoma tissues was significantly associated with tumor metastasis. (nature.com)
  • Results 70/299 patients (23%) in the anti-TNF cohort died after a median follow-up of 3.8 years compared with 14/68 (21%) in the DMARD cohort after a median follow-up of 2.1 years. (bmj.com)
  • RA-ILD was the underlying cause of death in 15/70 (21%) and 1/14 (7%) patients in the anti-TNF and DMARD cohorts, respectively. (bmj.com)
  • 6 However, the increased incidence of cardiovascular events in RA patients cannot be entirely explained by these traditional risk factors. (bmj.com)
  • This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
  • La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)
  • The diagnosis of ORN can be made based on clinical signs and symptoms of ulceration or necrosis on the mucosa, with exposure of necrotic bone for more than 3 months in irradiated patients. (bvsalud.org)
  • Some people with certain autoimmune diseases produce too much TNF. (drugwatch.com)
  • People with certain autoimmune conditions have elevated levels of TNF. (drugwatch.com)
  • Tumor necrosis factor alpha (TNF-α) blockage reduces acute inflammation and delayed wound healing in oral ulcer of rats. (bvsalud.org)
  • Our aim was to evaluate the role of TNF-α in the healing process of OTU in rats . (bvsalud.org)
  • Oral traumatic ulcers (OTU) are common in dental routine, and the control of proinflammatory cytokines , such as the tumor necrosis factor-alpha (TNF-α), may interfere with OTU repair. (bvsalud.org)
  • Cytokines secreted by adipocytes, such as tumor necrosis factor-α, transforming growth factor-β, and interleukin-6, are implicated in NAFLD. (wjgnet.com)
  • Cytokines including tumor necrosis factor alpha (TNF) are important in the development and progression of these diseases. (usda.gov)
  • TTP-deficient mice develop a profound inflammatory syndrome with cachexia, dermatitis, erosive arthritis, autoimmunity and myeloid hyperplasia, due to excessive production of TNF and other cytokines. (usda.gov)
  • Obese body mass may be an important risk factor for inflammatory response to mTBI and long-term clinical outcomes. (bmj.com)
  • As an adipokine, TNF promotes insulin resistance, and is associated with obesity-induced type 2 diabetes. (wikipedia.org)
  • Evidence suggests that obesity and insulin resistance are the major factors that contribute to the development of NAFLD. (wjgnet.com)
  • TTP expression is induced by various factors including insulin and extracts from cinnamon and green tea. (usda.gov)
  • Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. (springer.com)
  • The mortality was 68 deaths/1000 person years (pyrs) (95% CI 53 to 86) in the anti-TNF cohort and 92/1000 pyrs (95% CI 50 to 155) in the DMARD cohort, generating an age- and sex-adjusted mortality rate ratio (aMRR) of 1.26 (95% CI 0.69 to 2.31). (bmj.com)
  • Corrigendum to 'No association between the promoter variants of tumor necrosis factor alpha (TNF-α) and schizophrenia in Chinese Han population' [Neurosci. (elsevierpure.com)
  • The purpose of the study was to investigate the hypothesis that the genetically programmed ability to produce low, medium, or high levels of tumor necrosis factor-alpha (TNF-α), as determined by TNF-α promoter polymorphism at position 308, influenced the development of cancer of the uterine cervix. (bmj.com)
  • INF treatment reduced TNF-α immunostaining and delayed MPC-1, FGF, and α-SMA expression, with little/none influence in IL-8 immunostaining. (bvsalud.org)
  • Under the name tasonermin, TNF is used as an immunostimulant drug in the treatment of certain cancers. (wikipedia.org)
  • Hence, there are both clinical and economic incentives for the identification of factors associated with treatment persistence. (lu.se)
  • Until now, studies have mainly leveraged traditional regression analysis, but it has been suggested that novel approaches, such as statistical learning techniques, may improve our understanding of factors related to treatment persistence. (lu.se)
  • The recursive partitioning algorithm identified sex and treatment as factors associated with SC-TNFi treatment persistence in PsA and AS/uSpA. (lu.se)
  • The factors associated with treatment persistence in RA were less distinct but may comprise disease activity and concurrent conventional systemic disease-modifying anti-rheumatic drug (DMARD) treatment. (lu.se)
  • Though controversial, some studies have linked depression and IBD to increased levels of TNF. (wikipedia.org)
  • Obesity is associated with systemic inflammation and elevated levels of TNFα, leading to impaired glucose tolerance. (nih.gov)
  • These data suggest that the genetically acquired ability to produce higher levels of TNF-α is present in a minority of women with or without cervical cancer in the Zimbabwean population. (bmj.com)
  • White adipose tissue is associated with elevated levels of TNF [tumor necrosis factor]-alpha. (medpagetoday.com)
  • Haider S, Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. (aaem.pl)
  • Given the crucial roles of Rac1 in tumor angiogenesis and metastasis, intracellular mature IL-37 might serve as a potential strategy for the control of Rac1 activity and tumor progression. (nature.com)
  • TNF-α blockage by INF reduced acute inflammation in OTU but delayed cell migration and wound healing . (bvsalud.org)
  • TNF, as an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, and inflammation, inhibit tumorigenesis and viral replication, and respond to sepsis via IL-1 and IL-6-producing cells. (wikipedia.org)
  • TNF parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated. (wikipedia.org)
  • These concepts were extended to systemic disease in 1981, when Ian A. Clark, from the Australian National University, in collaboration with Elizabeth Carswell in Old's group, working with pre-sequencing era data, reasoned that excessive production of TNF causes malaria disease and endotoxin poisoning. (wikipedia.org)
  • The consumption of nuts is frequently associated with reduction in risk factors for chronic diseases. (mdpi.com)
  • Unhealthy lifestyles and chronic diseases are commonly seen and treatable factors in older adults and are both associated with dementia. (frontiersin.org)
  • In response to the urgent need to clarify the relationship among multidomain lifestyles, chronic diseases, and dementia, this study investigated the independent associations of multidomain lifestyles and chronic diseases with dementia and examined whether these factors interact with each other creating greater risks of dementia in older adults. (frontiersin.org)
  • Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression, psoriasis and inflammatory bowel disease (IBD). (wikipedia.org)
  • Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
  • Although TNF-α has well-established effects on lipid metabolism, the long-term effects of TNF-α blockade on lipid pattern are still unclear. (bmj.com)
  • The primary role of TNF is in the regulation of immune cells. (wikipedia.org)
  • Both factors were described based on their ability to kill mouse fibrosarcoma L-929 cells. (wikipedia.org)
  • Intracellular mature form of IL-37, but not its extracellular form, markedly inhibited migration of multiple kinds of tumor cells through inhibiting Rac1 activation. (nature.com)
  • We hypothesized that TNFα plays a direct role in the impairment of GLP-1 secretion from the enteroendocrine L-cell and that blocking TNFα can restore both GLP-1 secretion and glucose homeostasis. (nih.gov)
  • PMA and TNF-α, with increased concentration, increased MMP-9 secretion, while IL-1ß and LPS did not significantly modify MMP-9 activity. (drrathresearch.org)
  • Accumulating evidences indicate that it is also involved in tumor progression. (nature.com)