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Antibodies, Antineutrophil CytoplasmicImmunoassayVasculitisWegener GranulomatosisAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisMyeloblastinAntibodiesAntibody SpecificityPeroxidaseAntibodies, ViralAntibodies, MonoclonalAntibodies, BacterialChurg-Strauss SyndromeFluorescent Antibody Technique, IndirectMicroscopic PolyangiitisPropylthiouracilAutoantibodiesEnzyme-Linked Immunosorbent AssayImmunoenzyme TechniquesAntibody FormationFluorescent Antibody TechniqueVasculitis, Leukocytoclastic, CutaneousGlomerulonephritisAntithyroid AgentsImmunoglobulin GAntibodies, NeutralizingNeutrophilsSerine EndopeptidasesAntibodies, AntinuclearAntibody AffinityPolyarteritis NodosaCross ReactionsSensitivity and SpecificityAntibodies, Anti-IdiotypicAntibodies, FungalFluorescence Polarization ImmunoassayHIV AntibodiesBinding Sites, AntibodyEnzyme Multiplied Immunoassay TechniqueImmunoglobulin MEpitopesImmune SeraAntibodies, ProtozoanBiological MarkersColitis, UlcerativeImmunosuppressive AgentsAutoantigensAntibodies, NeoplasmEndocarditis, Subacute BacterialAutoimmune DiseasesNeutralization TestsPurpura, Schoenlein-HenochAntibodies, Monoclonal, Murine-DerivedReagent Kits, DiagnosticGraves DiseaseRadioimmunoassayLysosomal-Associated Membrane Protein 2Neutrophil ActivationPrednisoloneFixativesMethimazoleCyclophosphamideMolecular Sequence DataAntigen-Antibody ReactionsNose DiseasesMice, Inbred BALB CRespiratory BurstAntibodies, HeterophileCathepsin GEosinophilia-Myalgia SyndromeAntigen-Antibody ComplexLung DiseasesPlasma ExchangeRabbitsAmino Acid SequenceFocal InfectionDrug ContaminationAntigens, BacterialScleritisRecurrenceTime FactorsMethylprednisoloneHemoptysisProctocolectomy, RestorativeAntigens, ViralImmunoglobulin Fab FragmentsPancreatic ElastaseFluoroimmunoassayAntibodies, BispecificImmunizationHemagglutination TestsHemagglutination Inhibition TestsEvaluation Studies as TopicLupus Erythematosus, SystemicComplement Fixation TestsBiopsyAntibodies, BlockingSingle-Chain AntibodiesImmunoglobulin ASerologic Tests
ANCAAssaysAnti-dsDNA antibodiesAntinuclear AntibodiesImmunofluorescenceAutoantibodiesAntigenCANCAPatternsGlycoproteinsBindsSystemicPerinuclearAutoimmuneAntigensELISAMolecularAdditionDevelopmentDiseaseResultsBloodFoundPatientsAnti-nuclear antibodies and anti-neAntinuclear antibodiesImmunofluorescenceEnzymeHepatitisCutaneousClinicalInfectionDetectSpecificityImmunePatternTestsPrimaryCells
ANCA9
  • Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases, inflammatory bowel disease, as well as other autoimmune diseases. (mmchs.org)
  • The ANCA assay (INOVA) detects the presence of IgG antibodies that bind to human neutrophil antigens using direct immunofluorescence.¹,² Screening all samples with ethanol fixed slides allows ANCA reactivity to be separated into two diagnostically useful categories. (nemours.org)
  • Simple episcleritis is observed in association with seronegative spondyloarthritides, inflammatory bowel disease, and certain forms of vasculitis, particularly those associated with antineutrophil cytoplasmic antibodies (ANCA). (medilib.ir)
  • Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies against cytoplasmic constituents of neutrophils and monocytes (2). (calbiotech.com)
  • Staining by indirect immunofluorescence (IFA) shows two main staining patterns: cytoplasmic (c-ANCA) and perinuclear (p-ANCA) (3,4). (calbiotech.com)
  • Anti-MPO antibodies usually generate a p-ANCA pattern but not all p-ANCA patterns are caused by anti-MPO antibodies. (calbiotech.com)
  • Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies against various lysosomal enzymes (2). (calbiotech.com)
  • ANA, anti-mitochondrial antibody (AMA)/anti-liver-kidney microsomal antibody (LKM), anti-smooth muscle antibody (ASMA), antineutrophil cytoplasmic antibody (ANCA) assays were performed by indirect immunofluorescence method (IIF) (Euroimmune AG, Luebeck, Germany). (unboundmedicine.com)
  • Warm?CALM: Café aulait macules?cANCA: Cytoplasmic pattern of ANCA?CAP: Community-acquired pneumonia?cap. (kuwaitpharmacy.com)
Assays4
  • Indirect immunofluorescence tests (IIFT) are diagnostic assays used to detect antibodies in a patient sample. (rdworldonline.com)
  • In addition to an extensive portfolio of diagnostic test systems, EUROIMMUN offers a large range of flexible laboratory automation solutions for IIFT, as well as enzyme-linked immunosorbent assays, chemiluminescence immunoassays, immunoblots and molecular assays fulfilling the demands of diagnostic laboratories of any size. (rdworldonline.com)
  • Calbiotech specializes in immunoassay development and manufacturing, with a comprehensive range of ELISA and CLIA assays for human and animal research, including specific assays for hormone, autoimmune disorders, cancer, infectious diseases and much more. (calbiotech.com)
  • Methods: Anti-DFS70 antibodies were measured using enzyme-linked immunosorbent assays in 377 biopsy-proven LN patients, 268 non-LN SLE patients, 232 chronic kidney disease (CKD) patients, and 78 healthy individuals (HI). (bvsalud.org)
Anti-dsDNA antibodies2
Antinuclear Antibodies2
  • 1. American College of Rheumatology Position Statement, 'Methodology of Testing for Antinuclear Antibodies,' Approved by the Committee on Rheumatologic Care: January 2009, Approved by the Board of Directors: February 2009. (nemours.org)
  • Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. (wikipedia.org)
Immunofluorescence3
  • The immunofluorescence ANA assay (Antibodies, Inc) utilizes the method considered the gold standard for ANA testing by the American College of Rheumatology: detecting circulating autoantibodies reactive with nuclear antigens of HEp-2 cells. (nemours.org)
  • The combined system of hardware and software allows for ultrafast automated immunofluorescence image acquisition, pattern recognition and titer estimation as well as modern diagnostics at the screen. (rdworldonline.com)
  • In addition, it was aimed to compare the results of indirect immunofluorescence (IIF) antinuclear antibody (ANA) patterns and extractable nuclear antigen (ENA) antibodies. (unboundmedicine.com)
Autoantibodies1
Antigen8
  • Many of these factors stem from the location of the epitope that can affect accessibility of the antibody to the epitope at a cellular or molecular level, direct inhibition of target antigen activity, conservation of function despite escape mutations, and even non-competitive inhibition sites. (preprints.org)
  • Through the incorporation of novel computational methods for predicting antigen changes to model-informed drug discovery and development, superior vaccines and antibody-based therapeutics or diagnostics can now be more easily designed to mitigate failures. (preprints.org)
  • The antibody recognizes a unique molecule of the pathogen, called an antigen . (wikipedia.org)
  • [2] [3] Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. (wikipedia.org)
  • To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. (wikipedia.org)
  • The class hence determines the function triggered by an antibody after binding to an antigen, in addition to some structural features. (wikipedia.org)
  • After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
  • Structurally an antibody is also partitioned into two antigen-binding fragments (Fab), containing one V L , V H , C L , and C H 1 domain each, as well as the crystallisable fragment (Fc), forming the trunk of the Y shape. (wikipedia.org)
CANCA1
  • A granular cytoplasmic pattern (cANCA) is a serologic marker in up to 96% of patients with granulomatosis with polyangiitis. (nemours.org)
Patterns1
  • In addition to the positive/negative classification for a variety of different substrates, the patterns of anti-nuclear antibodies (in conformity with the International Consensus on Antinuclear Antibody Patterns ) and anti-neutrophil cytoplasmic antibodies can also be recognized by leveraging deep learning algorithms. (rdworldonline.com)
Glycoproteins2
Binds1
  • Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. (wikipedia.org)
Systemic3
  • The pattern and semiquantitative titer provide useful information for both the diagnosis and the monitoring of therapy for patients with systemic lupus erythematosus (SLE) and other connective tissue diseases such as rheumatoid arthritis (RA), scleroderma, and Sjogren's disease. (nemours.org)
  • Objective: The significance of anti-dense fine speckles 70 (DFS70) antibodies in systemic lupus erythematosus (SLE) is still unclear, especially in lupus nephritis (LN) patients. (bvsalud.org)
  • In this cross-sectional study, 25-hydroxy (OH) vitamin D3 levels were measured in adult patients with systemic small and medium vessel vasculitis including antineutrophil cytoplasmic antibody-associated vasculitis (AAV), cryoglobulinaemic vasculitis (CryV), IgA vasculitis (IgAV) and polyarteritis nodosa (PAN), and age- and sex-matched healthy subjects (HS) and patients with rheumatoid arthritis (RA) as control groups. (reumatologiaclinica.org)
Perinuclear1
  • A classic perinuclear pattern (pANCA) is primarily due to antibodies to myeloperoxidase (MPO) but may also be caused by others including elastase and lactoferrin. (nemours.org)
Autoimmune4
  • Sometimes, however, this process malfunctions and antibodies are produced against human antigens, which may lead to autoimmune disease. (wikipedia.org)
  • Extractable nuclear antigens (ENA) are a group of autoantigens that were originally identified as antibody targets in people with autoimmune disorders. (wikipedia.org)
  • Anti-Ro and anti-La antibodies, also known as SS-A and SS-B, respectively, are commonly found in primary Sjögren's syndrome, an autoimmune disorder that affects the exocrine glands. (wikipedia.org)
  • Anti-Ro antibodies are also found less frequently in other disorders including autoimmune liver diseases, coeliac disease, autoimmune rheumatic diseases, cardiac neonatal lupus erythematosus and polymyositis. (wikipedia.org)
Antigens3
ELISA1
  • 2018) Valoración de un nuevo ensayo quimioluminiscente en comparación con ELISA en la detección de IgG contra el virus de la hepatitis E. Revista de la Sociedad Andaluza de Microbiología y Parasitología Clínica. (vircell.com)
Molecular1
  • The performance of the nanoribbon biosensor upon the use of two different types of molecular probes - the antibodies and the aptamers against HCVcoreAg - has been tested. (preprints.org)
Addition2
  • In addition, MPO antibody titer may correlate with disease activity (3). (calbiotech.com)
  • In addition, anti-DFS70 antibodies were more prevalent in proliferative LN (22.0%, 68/309) compared to membrane LN patients (10.2%, 6/59, P=0.0376). (bvsalud.org)
Development1
  • The target of an antibody plays a significant role in the success of antibody-based therapeutics and diagnostics, and to an extent, that of vaccine development. (preprints.org)
Disease1
  • The ENAs consist of ribonucleoproteins and non-histone proteins, named by either the name of the donor who provided the prototype serum (Sm, Ro, La, Jo), or the name of the disease setting in which the antibodies were found (SS-A, SS-B, Scl-70). (wikipedia.org)
Results1
  • Results: The prevalence of anti-DFS70 antibodies in LN (19.6%) was comparable to non-LN SLE patients (19.8%, P=0.9630), but was significantly higher than CKD patients (13.4%, P=0.0468) and HI (9.0%, P=0.0252). (bvsalud.org)
Blood1
  • [4] Soluble antibodies are released into the blood and tissue fluids , as well as many secretions . (wikipedia.org)
Found1
  • The presence of both antibodies is found in 30-60% of Sjögren's syndrome, anti-Ro antibodies alone are found in 50-70% of Sjögren's syndrome and 30% of SLE with cutaneous involvement, and anti-La antibodies are rarely found in isolation. (wikipedia.org)
Patients4
  • We investigated the prevalence, clinical and pathological relevance of anti-DFS70 antibodies in LN patients. (bvsalud.org)
  • Demographic, clinical, and pathological parameters were compared between LN patients with and without anti-DFS70 antibodies. (bvsalud.org)
  • Using multivariable logistic regression analysis, the titer of anti-double-stranded DNA (dsDNA) antibodies (adjusted odds ratio=1.002, 95% confidence interval 1.001-1.003, P=0.004) was associated with positive anti-DFS70 antibodies in LN patients. (bvsalud.org)
  • Furthermore, LN patients with positive anti-DFS70 antibodies had significantly higher activity index (AI) compared to patients who were negative (8.0 vs 6.0, P=0.0131). (bvsalud.org)
Anti-nuclear antibodies and anti-ne1
  • In addition to the positive/negative classification for a variety of different substrates the patterns of anti-nuclear antibodies and anti-neutrophil cytoplasmic antibodies can also be recognized by leveraging deep learning algorithms. (scienceadvantage.net)
Antinuclear antibodies8
  • 3. Detection of serum antinuclear antibodies in lymphoma patients. (nih.gov)
  • 4. Clinical significance of elevated antinuclear antibodies in patients with diffuse large B-cell lymphoma: A single center study. (nih.gov)
  • 5. Epidemiological survey of antinuclear antibodies in healthy population and analysis of clinical characteristics of positive population. (nih.gov)
  • 7. [Investigation of antinuclear antibodies in chronic hepatitis B patients]. (nih.gov)
  • 13. Detection of antinuclear antibodies: comparative evaluation of enzyme immunoassay and indirect immunofluorescence methods. (nih.gov)
  • 15. Antinuclear Antibodies predict a higher number of Pregnancy Loss in Unexplained Recurrent Pregnancy Loss. (nih.gov)
  • 16. Oral lichenoid lesions and serum antinuclear antibodies in Thai patients. (nih.gov)
  • Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. (wikipedia.org)
Immunofluorescence5
  • The combined system of hardware and software allows for ultrafast automated immunofluorescence image acquisition, pattern recognition and titer estimation as well as modern diagnostics at the screen. (scienceadvantage.net)
  • Georgian Technical University Indirect immunofluorescence tests (IIFT) are diagnostic assays used to detect antibodies in a patient sample. (scienceadvantage.net)
  • 11. Correlation of antinuclear antibody immunofluorescence patterns with immune profile using line immunoassay in the Indian scenario. (nih.gov)
  • 12. Association of Immunofluorescence pattern of Antinuclear Antibody with Specific Autoantibodies in the Bangladeshi Population. (nih.gov)
  • In the laboratory of today the most appropriate way to detect the presence of vasculitis-associated ANCA is by using both indirect immunofluorescence and direct enzyme immuno-assay for antibodies to proteinase 3 and myeloperoxidase. (go.jp)
Enzyme1
  • Georgian Technical University addition to an extensive portfolio of diagnostic test systems Georgian Technical University offers a large range of flexible laboratory automation solutions for Georgian Technical University as well as enzyme-linked immunosorbent assays chemiluminescence immunoassays, immunoblots and molecular assays fulfilling the demands of diagnostic laboratories of any size. (scienceadvantage.net)
Hepatitis2
  • 8. Expression and clinical significance of antinuclear antibody in hepatitis C virus infection. (nih.gov)
  • 20. Antineutrophil cytoplasmic antibody in patients with antinuclear antibody-positive chronic hepatitis C. (nih.gov)
Cutaneous2
  • 17. Antinuclear antibody seropositivity in patients with cutaneous T-cell lymphoma. (nih.gov)
  • The presence of both antibodies is found in 30-60% of Sjögren's syndrome, anti-Ro antibodies alone are found in 50-70% of Sjögren's syndrome and 30% of SLE with cutaneous involvement, and anti-La antibodies are rarely found in isolation. (wikipedia.org)
Clinical3
  • 2. [Study of clinical characteristics in patients with gp210 antibody-positive primary biliary cholangitis]. (nih.gov)
  • 10. Clinical features of antinuclear antibody-positive patients with atopic dermatitis. (nih.gov)
  • A mitochondrial antibody test is used to determine the presence of mitochondrial antibodies which can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of primary biliary cirrhosis (PBC). (walkinlab.com)
Infection1
  • They are found in many disorders including autoimmunity, cancer and infection, with different prevalences of antibodies depending on the condition. (wikipedia.org)
Detect2
  • Now, our mitochondrial ab (antibody) blood test is available that can help your healthcare professional to detect the presence of specific antibodies that attack the mitochondria of your cells. (walkinlab.com)
  • To detect anti-mitochondrial antibodies that can contribute to the body attacking its own cellular mitochondria. (walkinlab.com)
Specificity1
  • These antibodies can be subdivided according to their specificity, and each subset has different propensities for specific disorders. (wikipedia.org)
Immune1
Pattern1
  • The detection of Ro52 and Ro60 according to the presence of SS-B/La, and ANA pattern and titer. (nih.gov)
Tests1
  • Anti-neutrophil Cytoplasmic Antibodies Tests: Which Tests Should be Used in Practice? (go.jp)
Primary1
  • Our mitochondrial ab (antibody) blood test is often used by women who are between the ages of 35 and 60 - an age and gender group that is highly susceptible to hepatic issues like primary biliary cirrhosis (PBC). (walkinlab.com)
Cells1
  • The ACR/EULAR classification requires an antinuclear antibody (ANA) titer of at least 1:80 on HEp-2 cells or an equivalent positive test at least once. (medscape.com)