• Colorectal cancer (CRC) is the third most common form of malignant tumor and is characterized by high rates of proliferation and metastases. (hindawi.com)
  • While knockout circIFT80 in HT29 cell or SW480 cells, the proliferation, and migration of the cells were inhibited, the cell cycle was arrested in G2/M phase, and the cell apoptosis was increased. (hindawi.com)
  • Colorectal cancer (CRC) is characterized by high rates of proliferation and metastasis and represents the third most common form of malignant tumor and the fourth leading cause of mortality in the world, thus creating a serious threat to health [ 1 ]. (hindawi.com)
  • For example, circRNA_000166 can function as an oncogene by promoting the proliferation of CRC cells and by limiting apoptosis. (hindawi.com)
  • β -Catenin is a transcription factor that plays an important role in cell proliferation, cellular differentiation, apoptosis, and metastasis [ 10 ]. (hindawi.com)
  • Hypoxia and genetic defects that chronically drive proliferation leave such tumors dependent on a steady supply of nutrients, especially glucose. (springer.com)
  • Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
  • Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent apoptosis. (spandidos-publications.com)
  • Increasing evidence has shown that KSHV infection can alter central carbon metabolic pathways to produce biomass for viral replication, as well as the survival and proliferation of infected cells. (frontiersin.org)
  • Cancer cells often rewire metabolic pathways to balance ATP production for supporting rapidly tumor proliferation. (frontiersin.org)
  • For producing energy sufficient to maintain cancer cell proliferation, glutaminolysis is also often elevated in most of cancer cells. (frontiersin.org)
  • Thus, the metabolic plasticity of cancer cells is essential to generate energy required for cell proliferation. (frontiersin.org)
  • Importantly, the regulatory functions of 4 DEmiRNAs and 3 verified target genes on cell proliferation and migration were explored in TNBC cell lines. (nature.com)
  • IM combined with IR can synergistically inhibit the proliferation, apoptosis, clonogenesis, invasion, migration and cell cycle of GIST cells. (researchsquare.com)
  • Furthermore, the proliferation of Th17 cells and Th17‑associated cytokines, including interleukin (IL)17, IL23 and RAR‑related orphan receptor γt, was analyzed by reverse transcription‑quantitative polymerase chain reaction. (spandidos-publications.com)
  • MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
  • Curcumin (diferuloylmethane), the yellow pigment in turmeric (Curcuma longa), is known to inhibit proliferation of cancer cells by arresting them at various phases of the cell cycle and to induce apoptosis in tumor cells. (iiarjournals.org)
  • Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. (oncotarget.com)
  • MAGEH1 reduced HCC cell proliferation, migration and invasion ability. (nih.gov)
  • Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. (thermofisher.com)
  • Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation. (thermofisher.com)
  • Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
  • Transwell migration, cell cycle analysis, MTT and colony formation assays were performed to determine the effect of DRAM2 overexpression and knockdown on NSCLC-cell migration and proliferation. (cancerindex.org)
  • Additionally, DRAM2 overexpression promoted cell metastasis and proliferation in vitro, while knockdown of DRAM2 expression yielded opposite result. (cancerindex.org)
  • New antitumor strategies using drugs targeted to intracellular signaling involved in cell proliferation and survival, angiogenesis, and metastasis have become promising in recent years. (researchgate.net)
  • Subendothelial proliferation, edema, and medial thickening may progressively deplete the blood supply to the irradiated tissue. (medscape.com)
  • Study IV showed that tamoxifen inhibited the proliferation, disrupted the cell cycle progression, and inhibited the ECM adhesion capacity of healthy breast epithelial cells. (lu.se)
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
  • or physiological or as a description of key events and processes starting toxic effects that affect cell proliferation. (cdc.gov)
  • Here, we used circRNA microarray sequencing technology to analyze the different circRNAs between CRC tissues and normal tissues and explore the role of circIFT80 in progression of colorectal cancer. (hindawi.com)
  • Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. (springer.com)
  • Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. (nature.com)
  • Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
  • Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
  • While some patients experience spontaneous regression or differentiation of the tumor, others are affected by rapid and fatal tumor progression despite increasingly intensive treatment strategies [ 9 ]. (biomedcentral.com)
  • These ANN ment, cell-cycle progression, drug treat- with different dyes. (lu.se)
  • Accumulating studies have suggested that miRNAs are frequently dysregulated in tumors compared with normal tissues, resulting in aberrant expression of target genes or proteins and cancer progression 13 . (nature.com)
  • A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression. (aacrjournals.org)
  • T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
  • Abstract The multiple roles of the tumor necrosis factor (TNF)-α-inducible protein 8 (TNFAIP8), also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis. (techscience.com)
  • For example, while TIPE is primarily associated with tumor progression and antitumor drug resistance, TIPE1 suppresses tumor progression in most instances. (techscience.com)
  • These bone metastases produce osteoblastic lesions that are associated with high morbidity and high mortality [ 8 ] and attempts at delaying this tumor progression with chemotherapeutic agents have only prolonged survival a few months. (oncotarget.com)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • Notably, the studied models presented adaptation at different cell cycle nodes to facilitate progression through the cell cycle and responded differently to CDK inhibitors. (lu.se)
  • circITGA7 serves as a tumor suppressor in CRC by inhibiting growth and metastasis by suppressing the Ras signaling pathway [ 8 ]. (hindawi.com)
  • Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
  • No evidence of tumor was identified in adnexa, uterus or omentum in microscopy, but only GCT metastasis was detected in Douglas space peritoneal nodules. (researchsquare.com)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • The tumor staging of the patients was performed in accordance with the American Joint Committee on Cancer tumor-node metastasis (TNM) classification ( 12 ). (spandidos-publications.com)
  • Cancer (medical term: malignant neoplasm) is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via lymph or blood). (medicalxpress.com)
  • TAK-285 was examined in a model of breast cancer brain metastasis using direct intracranial injection of BT-474-derived luciferase-expressing cells and showed greater inhibition of brain tumor growth compared to animals treated with lapatinib. (jcancer.org)
  • DRAM2 was preferentially upregulated in NSCLC tissues and higher expression of DRAM2 in NSCLC correlated with tumor node metastases stage and lymph node metastasis. (cancerindex.org)
  • Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)
  • We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
  • These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
  • Only one month of disease-free after four cycles of postoperative chemotherapy was remained when metastatic tumor developed in liver. (researchsquare.com)
  • The patient remained only one month of disease free when metastatic tumor developed in liver. (researchsquare.com)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
  • A tumor that starts in another part of the body and spreads to the brain is called a metastatic brain tumor. (kaiserpermanente.org)
  • These are called metastatic brain tumors (or brain metastases). (kaiserpermanente.org)
  • Metastatic brain tumors are more common than primary brain tumors. (kaiserpermanente.org)
  • Up to half of metastatic brain tumors are from lung cancer. (kaiserpermanente.org)
  • Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)
  • Randomized, Open Label Phase 3 study of SAR408701 versus Docetaxel in Previously Treated metastatic non-squamous Non-Small Cell Lung Cancer patients with CEACAM5 positive tumors. (who.int)
  • These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, and do not invade or metastasize. (medicalxpress.com)
  • Benign brain and spinal cord tumors grow and press on nearby areas of the brain. (kaiserpermanente.org)
  • Both benign and malignant brain tumors cause signs and symptoms and need treatment. (kaiserpermanente.org)
  • Excessive growth hormone is almost always caused by a noncancerous (benign) pituitary tumor. (msdmanuals.com)
  • This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. (who.int)
  • Only 3 benign breast tumour tissues (12.5%) and none of the healthy breast tissue specimens were HPV-DNA-positive. (who.int)
  • Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
  • Most tumors (65%) are benign, with hemangiomas being the most common, followed by pleomorphic adenomas. (medscape.com)
  • Interestingly, the 1p36 region is frequently deleted not only in NB, but also in other human cancer types, including those of neural, epithelial and hematopoietic origin, indicating that the same tumor suppressor genes might be involved in a broad range of human cancers [ 11 ]. (biomedcentral.com)
  • 1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
  • Classical polarization is usually associated with a proinflammatory response, including the increased production of tumor necrosis factor (TNF)-α, IL-1, and IL-6. (haematologica.org)
  • 1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
  • Because APE1/Ref-1 is expressed and elevated in prostate cancer, we sought to characterize APE1/Ref-1 expression and activity in human prostate cancer cell lines and determine the effect of selective reduction-oxidation (redox) function inhibition on prostate cancer cells in vitro and in vivo . (oncotarget.com)
  • Due to the role of oncogenic transcriptional activators NFĸB and STAT3 in survivin protein expression, and APE1/Ref-1 redox activity regulating their transcriptional activity, we assessed selective inhibition of APE1/Ref-1's redox function as a novel method to halt prostate cancer cell growth and survival. (oncotarget.com)
  • The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. (nih.gov)
  • Inhibition of pro-inflammatory myeloid cell responses by short-termS 100A9 blockade improves cardiac function after myocardial infarction. (lu.se)
  • If a cell has an error in its DNA that cannot be repaired, it may undergo self-destruction ( apoptosis ). (medlineplus.gov)
  • Apoptosis is a common process throughout life that helps the body get rid of cells that no longer work or that it doesn't need. (medlineplus.gov)
  • Apoptosis protects the body by removing genetically damaged cells that could lead to cancer, and it plays an important role in the development of the embryo and the maintenance of adult tissues. (medlineplus.gov)
  • Curcumin-induced apoptosis mainly involves the activation of caspase-3 and mitochondria-mediated pathway in various cancer cells of different tissue origin. (iiarjournals.org)
  • In the present study, the induction of apoptosis and cytotoxicity by curcumin in colon cancer colo 205 cells was investigated by using flow cytometry. (iiarjournals.org)
  • Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits. (nih.gov)
  • Re-expression of ASC/TMS1 in silenced RCC cell lines inhibited cell viability, colony formation, arrested cell cycle, induced apoptosis, suppressed cell invasion and repressed tumorigenicity in SCID mice. (oncotarget.com)
  • Knockdown of ASC/TMS1 reduced DNA damaging agents-induced p53 activation and cell apoptosis. (oncotarget.com)
  • with non-MCC high-grade neuroendocrine carcinomas (5 and Pierre Coursaget small-cell lung carcinomas and 3 well-differentiated in- testinal carcinomas) and an FFPE tissue specimen from a We investigated whether Merkel cell carcinoma (MCC) patient with high-grade neuroendocrine carcinoma of the patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. (cdc.gov)
  • Researchers identified that an abundance of fungi in the gut, particularly strains of Candida albicans yeast, could trigger an increase in immune cells, which could worsen lung damage. (medicaldaily.com)
  • DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53. (cancerindex.org)
  • Here, we show that DRAM2 may act as an oncogenic regulator in non-small cell lung cancer (NSCLC). (cancerindex.org)
  • Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors. (jax.org)
  • In chemically induced mouse lung tumors, the p16INK4a gene is a target of inactivation, and Rb is reduced at the mRNA level (Northern blot) although similar at the protein level (Western blot) when compared to normal lung tissues. (jax.org)
  • The expression of cyclin D1, cdk4, p16INK4a, and Rb protein was examined by immunohistochemistry in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mouse lung tumors. (jax.org)
  • Immunohistochemical staining revealed exclusive nuclear staining of both cyclin D1 and cdk4 that was light to moderate in normal mouse lung tissues, but intense in lung adenomas and adenocarcinomas. (jax.org)
  • Western blot analysis confirmed the increased expression of cyclin D1 and cdk4 in lung tumors compared to normal lung. (jax.org)
  • Immunohistochemical analyses of lung tumors showed focal areas which lacked p16INK4a staining. (jax.org)
  • Expression of p16INK4a, as determined by RT-PCR, was variable in lung tumors. (jax.org)
  • however, in the lung tumors the staining intensity was reduced and the distribution was altered. (jax.org)
  • Expression of Rb was detected in normal lung tissues but was barely detectable by Northern blot hybridization in lung tumors. (jax.org)
  • Western blot analysis indicated the presence of both hypophosphorylated and hyperphosphorylated Rb protein in lung tumors and in normal lung tissues. (jax.org)
  • Furthermore, they demonstrate the importance of immunohistochemical studies to examine expression in tissues that contain multiple cell types, such as the lung, and in tumors that by nature are heterogeneous. (jax.org)
  • Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
  • Based on the consistent expression patterns associated with patient survival outcomes and in tumors vs. normal lung tissues, 10 miRNAs were considered to be putatively tumor suppressive and 4 miRNAs were deemed as oncogenic in lung cancer. (cdc.gov)
  • This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
  • Background/aim: Insulin-like growth factor-1 receptor (IGF-1R) is a pivotal receptor tyrosine kinase involved in the cell cycle and malignant tumor transformation. (tubitak.gov.tr)
  • Cluster of differentiation (CD) 4 + T cells are essential organizers of cell-mediated immunity, participating in each stage of the immune response. (spandidos-publications.com)
  • Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
  • miR-203 drives breast cancer cell differentiation. (medscape.com)
  • Cardiovascular MRI offers excellent soft tissue differentiation, 4D data acquisition with high spatial and temporal resolution. (lu.se)
  • In addition, proteome analysis of NBPF1-overexpressing DLD1 cells identified 32 differentially expressed proteins, of which several are implicated in carcinogenesis. (biomedcentral.com)
  • We demonstrated that NBPF1 exerts different tumor suppressive effects, depending on the cell line analyzed, and provide new clues into the molecular mechanism of the enigmatic NBPF proteins. (biomedcentral.com)
  • Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)
  • DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
  • These results suggest that alterations in the cell cycle proteins, cyclin D1, cdk4, p16INK4a, and Rb, may play a role in the acquisition of autonomous growth by adenomas. (jax.org)
  • To understand fascin further, the team created a series of cancer cell lines with and without functional fascin, as well as a suite of fascin 'nanobodies' labelled with fluorescent markers, to alter its location in cells and explore its interactions with other proteins in the nucleus. (elifesciences.org)
  • Fascin also interacted with another group of important proteins in the cell nucleus, called histones. (elifesciences.org)
  • The primary barriers for invading respiratory pathogens are the respiratory tract epithelial cells and antimicrobial proteins generated by these cells. (cdc.gov)
  • All tissue samples were collected for cinomas specimens, had MCPyV. (cdc.gov)
  • A new virus, Merkel frozen specimens, tissue was directly treated with protei- cell polyomavirus (MCPyV), recently was discovered in nase K and processed as above. (cdc.gov)
  • 2 ). PCR was performed with 31 in most MCC specimens ( 2 ), and clonal integration of the cycles for each primer set. (cdc.gov)
  • The 86 specimens contained the cellular tumor and adjacent non-malignant tissue from the surgical margin. (ucsf.edu)
  • The researchers were able to combine two techniques to achieve a map of paracrine signals - single-nucleus RNA-sequencing of frozen tissue specimens and spatial transcriptomics profiling of formalin-fixed specimens. (ucsf.edu)
  • Additionally, about 56% of the Hodgkin lymphoma, 80% of the rhabdomyosarcoma, and 70% of the Wilms tumor specimens showed positivity for IGF-R1 expression. (tubitak.gov.tr)
  • Tumor specimens from 259 NSCLC patients were collected and analyzed. (cancerindex.org)
  • We investigated by real-time quantitative RT-PCR the expression profile of a panel of genes important in cell cycle regulation. (biomedcentral.com)
  • How do genes control the growth and division of cells? (medlineplus.gov)
  • A variety of genes are involved in the control of cell growth and division. (medlineplus.gov)
  • The cell cycle has checkpoints (also called restriction points), which allow certain genes to check for problems and halt the cycle for repairs if something goes wrong. (medlineplus.gov)
  • Scientists from the divisions of Professor Dr. G nther Sch tz and Professor Dr. Peter Lichter at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have recently shown in mouse brains that brain stem cells in the subventricular zone are characterized by a specific molecule: Protein Tlx, a transcription factor, which stimulates the activity of various genes. (dkfz.de)
  • The results revealed that the prevalence of Th17 cells in patients with LSCC was elevated in their primary tumors, as well as in peripheral blood, compared with that in healthy controls. (spandidos-publications.com)
  • The present study revealed that patients with LSCC have elevated levels of Th17 cells in their primary tumors and peripheral blood compared with those in healthy controls. (spandidos-publications.com)
  • Breast cancer is one of the most common primary tumors to develop associated brain metastases ( 1 , 2 ), and while recent progress in cancer therapy has improved control of primary breast tumors, methods to effectively treat brain metastases from breast cancer remain inadequate. (jcancer.org)
  • In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • The vascular endothelial growth factor (VEGF) is a well characterized angiogenic factor known to stimulate angiogenesis within a tumor ( 1 ). (spandidos-publications.com)
  • Kaposi's sarcoma-associated herpesvirus (KSHV), a human oncogenic herpesvirus, is tightly associated with several human malignancies by infecting B-lymphocyte or endothelial cells. (frontiersin.org)
  • KSHV is tightly associated with Kaposi's sarcoma (KS) and two B-cell lymphomas including primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD) by infecting B-lymphocyte and endothelial cells, respectively. (frontiersin.org)
  • In oncology, immune cell types can be quickly identified alongside stromal and endothelial cells within the tumor. (techscience.com)
  • Modulation of tight junction structure in blood-brain barrier endothelial cells. (worthington-biochem.com)
  • ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. (jci.org)
  • The exact biological mechanism(s) by which the BBB limits drug exposure is not clear, but in addition to epithelial tight junctions, enhanced efflux of chemotherapeutic agents out of the CNS space by endothelial cell membrane transporters in brain blood vessels plays a primary role ( 2 ). (jcancer.org)
  • Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. (lu.se)
  • Insulin-like growth factor-1 receptor expression in pediatric tumors: " by RESUL KARAKUŞ, ESRA KARAKUŞ et al. (tubitak.gov.tr)
  • We aimed to determine the expression of IGF- 1R in di erent pediatric tumors and to shed light on possible new indications of anti-IGF-1R treatment approaches. (tubitak.gov.tr)
  • This gene encodes a histone H1 binding protein that is involved in transporting histones into the nucleus of dividing cells. (wikipedia.org)
  • In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. (wikipedia.org)
  • We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)
  • In the adult brain, the Tlx protein is responsible for generating new neurons from tissue stem cells. (dkfz.de)
  • Functioning of the stem cells thus appears to depend on the presence of this protein. (dkfz.de)
  • 1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
  • 2) Therefore, the proper control of protein levels is crucial for the cell cycle. (ukessays.com)
  • These paracrine (cell extrinsic) signals stimulated the activator protein (AP1) pathway, leading to mesenchymal transition, therapy resistance and tumor recurrence. (ucsf.edu)
  • The dCK activity of our cell lines varied considerably and differed up to three fold from 5 to 15 pmol/h/mg protein between the tested cell lines. (biomedcentral.com)
  • Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. (thermofisher.com)
  • Researchers have shown that a protein called fascin is transported into the nucleus of cancer cells where it plays an important role in cell motility and growth. (elifesciences.org)
  • Researchers have shown that a protein called fascin acts in the control centre of cancer cells and influences their ability to repair themselves, grow and move, according to a study published today in eLife. (elifesciences.org)
  • Fascin is known to control the structures that allow cells to move - specifically the assembly of bundles of a protein called actin, which create the tiny 'legs' that cancer cells use to migrate to distant sites within the body. (elifesciences.org)
  • They found DNA repair was impaired in cells lacking fascin, indicating that the protein might be required for cancer cells to trigger their response to DNA damage caused by chemo- or radiotherapy. (elifesciences.org)
  • On a portion of thyroid cell facing the blood stream there is a protein called sodium iodine symporter that transports iodine into the thyroid cell. (cdc.gov)
  • These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors. (ukessays.com)
  • The first miRNA was discovered in 1993 by Lee, Freinbaum and Ambros ( 6 , 7 ), and since then an increasing load of literature data have pointed that they can act as both tumor suppressors and oncogenes ( 1 - 3 ). (frontiersin.org)
  • A total of 70 tumors and 70 adjacent control tissues (pathologically confirmed normal mucosa) were obtained from patients with LSCC undergoing surgery. (spandidos-publications.com)
  • MAGEH1 expression was downregulated in HCC tumor tissues compared with adjacent normal liver tissues and in samples from patients with tumor recurrence. (nih.gov)
  • A significant downregulation was also detected in sixty-seven paired renal tumors compared with adjacent non-cancerous tissues. (oncotarget.com)
  • Moreover, ASC/TMS1 hypermethylation was further detected in 41.1% (83/202) of RCC tumors, but only 12% in adjacent non-cancerous tissues. (oncotarget.com)
  • In study III, we showed that FGFR1 expression was upregulated in almost 60% of tumor tissues versus tumor-adjacent tissues from the same patients. (lu.se)
  • The authors used artificial neural croarrays is to study changes in gene ex- .nature organ the tumor arose from, how big it networks (ANNs) to identify gene-ex- pression that accompany changes in is, and what it looks like after it has pression signatures associated with spe- cell physiology, such as during develop- been imbedded in wax and colored cific subtypes of tumors. (lu.se)
  • Bioinformatic analysis of differential biology within the population of cells studied relies on inferences and grouping of cells due to the spotty nature of data within individual cell scRNA-seq gene counts. (techscience.com)
  • One biologically relevant variable is readily inferred from scRNA-seq gene count tables regardless of individual gene representation within single cells: aneuploidy. (techscience.com)
  • From each tumor biopsy, they performed single-nucleus RNA-seq which measures transcriptome-wide gene expression in individual cells, for thousands of cells at a time. (ucsf.edu)
  • Cloning and subcellular localization of apr-1--a new gene of tumor specific antigen family]. (nih.gov)
  • This study investigated the epigenetic alteration and biological function of the pro-apoptotic gene ASC/TMS1 in renal cell carcinoma. (oncotarget.com)
  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)
  • Indeed, it has been shown that miRNAs play an important role in gene expression, mainly when associated with the monitoring of several cell and metabolic pathways, being also an essential component of the gene silencing machinery in most eukaryotic organisms ( 4 , 8 ). (frontiersin.org)
  • Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
  • Therefore, our results suggest that PFPE-CH is safe and effective in reducing breast tumor incidence and toxicity of chemotherapeutic drugs during cancer treatment in mammary tumor rats. (bvsalud.org)
  • One of the treatments applied in cancer is radiotherapy (RT), a therapeutic modality that uses ionizing radiation to induce damage in unwanted cells. (frontiersin.org)
  • The tumor is ablated using small high-voltage pulses that induce slow cell death over time. (hfma.org)
  • Furthermore, the clear heterogeneity of CRC tumors indicates a clear need for new biological markers and therapeutic targets for CRC. (hindawi.com)
  • they can also serve as potential biomarkers and therapeutic targets for tumors, as demonstrated in multiple studies [ 7 ]. (hindawi.com)
  • We review the possible roles for calorie restriction (CR) and very low carbohydrate ketogenic diets (KDs) in modulating the five R's of radiotherapy to improve the therapeutic window between tumor control and normal tissue complication probability. (springer.com)
  • In this review, we summarize recent studies exploring how KSHV manipulates host cell metabolism to promote viral pathogenesis, which provides the potential therapeutic targets and strategies for KSHV-associated cancers. (frontiersin.org)
  • The present study investigated the expression of T helper (Th)17 cytokines in patients with laryngeal squamous cell carcinoma (LSCC) and their clinical significance in providing new therapeutic insights. (spandidos-publications.com)
  • In conclusion, Th17 cells have a substantial impact on the carcinogenesis of LSCCs, and could serve as a potential therapeutic target to modulate the anti‑tumor response in these carcinomas. (spandidos-publications.com)
  • This was the first time that researchers were able to comprehensively map intra-cellular signaling in the tumor-anatomical niches of recurrent GBM and identify novel cell-extrinsic therapeutic targets. (ucsf.edu)
  • ASC/TMS1 tumor specific methylation may be a useful biomarker for designing improved diagnostic and therapeutic strategies for RCC. (oncotarget.com)
  • Given fascin is at very high levels in many solid tumours, but not in normal tissues, this molecule is an interesting therapeutic target. (elifesciences.org)
  • The same treatment, however, does not affect normal tissue, suggesting this approach for the development of an efficient and safe therapeutic strategy for several cancer types. (intechopen.com)
  • Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. (thermofisher.com)
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
  • The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the image below. (medscape.com)
  • Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
  • Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)
  • They found that cells in this surgical margin acted as niches of recurrence where non-malignant glia were broadcasting pro-growth signals that influenced the tumor cells to regrow. (ucsf.edu)
  • [ 2 ] Sources providing higher energies produce better tissue penetration, resulting in smaller doses to surrounding normal tissues. (medscape.com)
  • The use of more beams allows a lower dose per beam, thus reducing the maximum dose to normal structures beyond the target tissues. (medscape.com)
  • 5) increasing the intrinsic radioresistance of normal cells through ketone bodies but decreasing that of tumor cells by targeting glycolysis. (springer.com)
  • Disruption of normal regulation of the cell cycle can lead to diseases such as cancer. (medlineplus.gov)
  • The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
  • Serum sex hormone and other tumor markers including AFP, CA199, CEA, β-HCG and inhibin were within normal range. (researchsquare.com)
  • In normal cells, glucose is converted into pyruvate through glycolysis, and pyruvate is oxidized in mitochondria to produce ATP ( Figure 1 ). (frontiersin.org)
  • But for the most part, normal tissues and 9 cell lines). (lu.se)
  • Approximately 40% of those affected with leukemia will have Acute Myeloid Leukemia (AML), a cancer of the BM and blood wherein blood cells are unable to develop or function normally, are overproduced at an immature stage of development and overtake any normal elements remaining in the BM and blood. (aiche.org)
  • Somatic mutations are now recognized to contribute to clonal heterogeneity within otherwise normal, aged tissue. (techscience.com)
  • Aneuploidy, the loss or gain of chromosome arms, appears less prevalent in normal tissue in these clonal mutant next-generation sequencing analyses. (techscience.com)
  • The main goal of RT consists in delivering a precise dose of radiation in a target volume, such as tumor, promoting the tumor cells eradication with as minimal damage as possible in surrounding normal tissues ( 13 ). (frontiersin.org)
  • Fascin-depleted cells also had changes to their chromatin structure - the way the DNA is packaged in the cell - compared to cells with normal fascin levels. (elifesciences.org)
  • We found that normal human proliferating cells express a family of noncoding mitochondrial RNAs (ncmtRNAs), comprised of sense (SncmtRNA) and antisense (ASncmtRNA). (intechopen.com)
  • I did not have any major issues, and my monthly menstrual cycle was normal. (cdc.gov)
  • In the normal U.S. diet, iodine intake is about 250 micrograms or ¼ milligram (mg) of iodine per day, which goes into the thyroid cells and is incorporated into amino acids called tyrosine (in a large thyroglobulin molecule). (cdc.gov)
  • In conclusion, ASC/TMS1 is a novel functional tumor suppressor in renal carcinogenesis. (oncotarget.com)
  • Decreased expression of NBPF1 in neuroblastoma cell lines with loss of 1p36 heterozygosity and the marked decrease of anchorage-independent clonal growth of DLD1 colorectal carcinoma cells with induced NBPF1 expression further suggest that NBPF1 functions as tumor suppressor. (biomedcentral.com)
  • Additionally, forced expression of NBPF1 in two p53-mutant neuroblastoma cell lines also resulted in a G1 cell cycle arrest and CDKN1A upregulation. (biomedcentral.com)
  • Tumors of the pelvic organs (ie, prostate, bladder, colon, rectum) are common in men, constituting 41% of expected new cancer diagnoses for 2021. (medscape.com)
  • In this present study, we found that circIFT80 was abnormally overexpression in colorectal cancer tissues and tumor cells. (hindawi.com)
  • Quantification of cell-cycle state at a single-cell level is essential to understand fundamental three-dimensional (3D) biological processes such as tissue development and cancer. (nature.com)
  • We applied our workflow to quantify cell-cycle effects of three antimitotic cancer drugs over 8 d in HT-1080 fibrosarcoma xenografts in living mice using a data set of 38,000 cells and compared the induced phenotypes. (nature.com)
  • Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
  • In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
  • Considering this genetic defect and the frequent genomic alterations of the NBPF1 locus in several cancer types, we hypothesized that NBPF1 is a tumor suppressor. (biomedcentral.com)
  • LC-MS/MS analysis was used to investigate the proteome of DLD1 colon cancer cells with induced NBPF1 expression. (biomedcentral.com)
  • NB tumors are derived from the sympathetic nervous system and account for approximately 15% of cancer deaths in children [ 8 ]. (biomedcentral.com)
  • Cancer cell energy metabolism is mainly dominated by three pathways of central carbon metabolism, including aerobic glycolysis, glutaminolysis, and fatty acid synthesis. (frontiersin.org)
  • Interleukin (IL)17-producing Th17 cells, which are different from Th1 and Th2 cells, have been described as serving critical roles in inflammation and autoimmune diseases, as well as in cancer development ( 8 - 11 ). (spandidos-publications.com)
  • Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown for the first time that malignant brain tumors arise directly from brain stem cells. (dkfz.de)
  • If the cancer stem cell model is correct and if such cells retain the hallmarks of some tissue stem cells in being rare and entering the cell cycle infrequently, they could constitute a population that is intrinsically resistant to current therapies designed to kill cycling cells. (aacrjournals.org)
  • The participants critically discussed the need for a precise definition of cancer stem cells, the requirement for new markers and more rapid and tractable in vitro and in vivo assays, and the need to develop drug screening strategies to selectively target cancer stem cells to generate therapeutics for this subpopulation of cells that could be resistant to classic treatments while possessing potent tumor-forming capacity. (aacrjournals.org)
  • In the cancer stem cell model of tumors, there is a small subset of cancer cells, the cancer stem cells, which constitute a reservoir of self-sustaining cells with the exclusive ability to self-renew and maintain the tumor. (aacrjournals.org)
  • These cancer stem cells have the capacity to both divide and expand the cancer stem cell pool and to differentiate into the heterogeneous nontumorigenic cancer cell types that in most cases appear to constitute the bulk of the cancer cells within the tumor. (aacrjournals.org)
  • If cancer stem cells are relatively refractory to therapies that have been developed to eradicate the rapidly dividing cells within the tumor that constitute the majority of the nonstem cell component of tumors, then they are unlikely to be curative and relapses would be expected. (aacrjournals.org)
  • Pediatric Brain Tumor Cancer Stem Cells: Cell Cycle Dynamics, DNA Repair, and Etoposide Extrusion. (worthington-biochem.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Biomedical engineers at Duke University have significantly enhanced the capabilities of a computational model that simulates the movement of individual cancer cells across long distances within the entire human body. (medicalxpress.com)
  • Other cancer-promoting genetic abnormalities may be randomly acquired through errors in DNA replication, or are inherited, and thus present in all cells from birth. (medicalxpress.com)
  • In studies of tumor cells, the "Ki-67 labeling index" refers to the number of Ki-67 positive cells within the population and this is used to predict outcome of particular cancer types. (thermofisher.com)
  • What's the link between stem cell divisions and cancer? (custom-writing.org)
  • The advantages of this type of ablation are it is very tissue selective, only destroying the cancer cells and preserving the vital structures that surround the tumor, and it is also very quick. (hfma.org)
  • Fascin is also known to be at much higher levels in most solid tumours, where it helps cancer cells migrate and invade into other tissues. (elifesciences.org)
  • Given the interaction of fascin with histones, the team looked at whether fascin was also involved in DNA repair processes in cancer cells, which helps them to survive. (elifesciences.org)
  • Although nuclear fascin plays an important role in nuclear actin assembly, DNA structure and repair, it is also important in the cell cytoplasm, where it helps cancer cells build tiny appendages called filopodia, which promote invasion. (elifesciences.org)
  • Collectively, these results indicate that, rather than trying to find ways to block fascin, forcing it all into the nucleus of cancer cells could prevent their growth and movement. (elifesciences.org)
  • We propose that promoting fascin accumulation in the nucleus of cancer cells, rather than only focusing on targeting it in the cell cytoplasm, could be an alternative approach that would prevent both tumour growth and spread. (elifesciences.org)
  • However, tumor cells express only sense transcripts, suggesting that ASncmtRNA downregulation as a cancer new hallmark. (intechopen.com)
  • Preclinical assays show that systemic administration of ASO delayed tumor growth in melanoma and renal cancer models and, caused total remission in subcutaneous renal cancer tumors. (intechopen.com)
  • A low piperine fractional Piper nigrum extract (PFPE) was prepared by mixing cold-pressed coconut oil and honey in distilled water, namely, PFPE-CH. In this study, PFPE-CH was orally administered as a dietary supplement to decrease the risk of tumor formation and reduce the side effects of chemotherapeutic drugs during breast cancer treatment. (bvsalud.org)
  • In a cancer prevention study, treatment with PFPE-CH at 100 mg/kg BW for 101 days induced oxidative stress and increased the immune response by altering the levels of cancer-associated cytokines (IL-4, IL-6, and IFN-g), leading to a reduction in the tumor incidence of up to 71.4% without any adverse effects. (bvsalud.org)
  • These results suggest a strong link between ovulatory menstrual cycles and the risk of developing breast cancer, with progesterone playing an important role. (medscape.com)
  • SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models. (medscape.com)
  • Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. (medscape.com)
  • Stage 1B1 cervical cancer indicates that the tumor appears clinically to be confined to the tissues of the cervix, and is less than 4 cm in diameter. (cdc.gov)
  • In the breast cancer group, cocktail HPV genotypes were detected in 60 (46.5%) archived tissue blocks. (who.int)
  • L'étude menée en Iraq a utilisé la méthode d'hybridation in situ pour déterminer la fréquence du papillomavirus humain et pour son génotypage dans les échantillons de tissus prélevés auprès de 129 patientes ayant reçu un diagnostic de cancer du sein malin, de 24 patientes porteuses d'une tumeur du sein bénigne et de 20 femmes témoins en bonne santé. (who.int)
  • Many tumor microenvironments, including lymphoma and carcinoma, are enriched in immune suppressive cells that contribute to immune exhaustion by means expression of inhibitory ligands, suppressive cytokines, and tumor-promoting factors. (researchgate.net)
  • Antitumor therapies targeted to reduce the induction, recruitment, or suppressive activities of the immune cells have been investigated. (researchgate.net)
  • Radiation may also directly cause rapid cell death from mitotic arrest, point mutations in deoxyribonucleic acid (DNA), and cell membrane damage. (medscape.com)
  • Forced expression of NBPF1 in HEK293T cells resulted in a G1 cell cycle arrest that was accompanied by upregulation of the cyclin-dependent kinase inhibitor p21 CIP1/WAF1 in a p53-dependent manner. (biomedcentral.com)
  • The few ASncmtRNAs copies in tumor cells seem essential to tumor cell viability: knockdown of these transcripts with antisense oligonucleotides (ASO) causes massive apoptotic death of tumor cells, preceded by cell cycle arrest. (intechopen.com)
  • As main findings, 23 miRNAs were already identified as being involved in genetic regulation of PCa cell response to RT. (frontiersin.org)
  • The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. (frontiersin.org)
  • With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)
  • Single-cell sequencing data has transformed the understanding of biological heterogeneity. (techscience.com)
  • It combines image analysis and machine learning methods for automated 3D segmentation and cell-cycle state identification of individual cell-nuclei with widely varying morphologies embedded in complex tumor environments. (nature.com)
  • All seeding densities should be based on cell counts gained by established methods. (abcam.com)
  • Four cycles of postoperative intravenous-chemotherapy with paclitaxel and cisplatin was carried out. (researchsquare.com)
  • a) Having progressive disease during or after platinum-based chemotherapy (at least 2 cycles). (who.int)
  • In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)
  • In conclusion, we provide evidence that proinflammatory polarization of macrophages does not lead to enhanced procoagulatory function, whereas alternative polarization of macrophages leads to an increased expression of TF and increased production of TF bearing extracellular vesicles by these cells suggesting a procoagulatory phenotype of alternatively polarized macrophages. (haematologica.org)
  • Red not have the tumor-specific ex- with these dangerous drugs, rhab- represents relatively high expression level, whereas green pression pattern. (lu.se)
  • They compared the expression of signal receptors to that of their known ligands, between the different cell populations sequenced. (ucsf.edu)
  • Analysis was performed on tissue sections by immunohistochemically staining for IGF-1R expression. (tubitak.gov.tr)
  • Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. (thermofisher.com)
  • We further showed that FGFR1 expression was associated with less favorable tumor characteristics. (lu.se)
  • Radiation interacts with intracellular water and produces free radicals that interfere with DNA synthesis, resulting in cell death. (medscape.com)
  • 5 Functionally, proinflammatory polarization leads to potent effector cells that kill intracellular micro-organisms and tumor cells. (haematologica.org)
  • Other partners of the intracellular metabolism of gemcitabine in relation to the cell cycle effects and DNA repair could be more responsible for the radiosensitising effect than dCK activity. (biomedcentral.com)
  • The Warburg phenotype provides tumors an enhanced resistance against cytotoxic insults. (springer.com)
  • CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging. (nature.com)
  • Alternative polarization with interleukin-4 and IL-13 led to a macrophage phenotype characterized by increased tissue factor (TF) production and release and by an increase in extracellular vesicle production. (haematologica.org)
  • They found that some cells shift to a mesenchymal, radiation-resistant phenotype (state) as a stress response following standard therapy. (ucsf.edu)
  • Proinflammatory polarization is associated with increased tissue degradation and propagation of inflammation whereas alternative polarization within a Th2 cytokine environment is associated with wound healing and angiogenesis. (haematologica.org)
  • Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment. (nih.gov)
  • Importantly, cells that had forced nuclear fascin had significantly reduced growth rates and viability because they assembled large stable actin bundles in the nucleus which prevented them from going through the cell cycle. (elifesciences.org)
  • Our study provides insights into a new role for fascin in controlling nuclear actin bundling to support tumour cell viability," concludes senior author Maddy Parsons, Professor of Cell Biology at the Randall Centre for Cell and Molecular Biophysics, King's College London. (elifesciences.org)
  • Flow cytometry was used to investigate the percentage of Th17 and Th1 cells in peripheral blood mononuclear cells. (spandidos-publications.com)
  • The thyroid secretes thyroxine (T4), & triiodothyronine (T3) that exert effects on peripheral tissues exerting the actions of thyroid hormone. (cdc.gov)
  • The pituitary gland produces thyroid stimulating hormone (TSH) that goes into the blood stream to activate thyroid cells, which then secrete T3 and T4 into the peripheral tissues. (cdc.gov)
  • ASC/TMS1 methylation was significantly correlated with higher tumor nuclear grade. (oncotarget.com)
  • Indeed, cells without fascin were unable to build nuclear actin bundles to the same extent. (elifesciences.org)
  • As they anticipated, in cells with enhanced nuclear fascin, the number of filopodia was significantly reduced because there was no fascin in the cytoplasm to support assembly of these structures. (elifesciences.org)
  • However, incidental irradiation of nearby tissues is unavoidable, either because of the invasion of surrounding organs by tumors or because of the proximity of cancers to neighboring pelvic structures. (medscape.com)
  • 63cm small intestine with mesentery and the mass was resected merely in toto , and primary ileal mesenchymal tumor with whole intestinal layer invasion was suggested by the intraoperative frozen section. (researchsquare.com)
  • explains the growth of cancerous tumors. (medlineplus.gov)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • Ki-67 is used as a marker for determining the growth fraction of a given population of cells. (thermofisher.com)
  • The tumors are formed by the abnormal growth of cells and may begin in different parts of the brain or spinal cord. (kaiserpermanente.org)
  • We have previously shown that fascin resides in the control centre of the cell - the nucleus - at certain times in the cell's growth cycle," explains lead author Campbell Lawson, Research Associate at the Randall Centre for Cell and Molecular Biophysics, King's College London, UK. (elifesciences.org)
  • Excessive growth hormone, therefore, leads to abnormally robust growth of all of these tissues. (msdmanuals.com)
  • Certain rare tumors of the pancreas and lungs also can produce hormones that stimulate the pituitary to produce excessive amounts of growth hormone, with similar consequences. (msdmanuals.com)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
  • 4 μm slides from FFPE tumor tissue are required. (who.int)
  • Peak sensitivity to radiation is at the M and G2 phases of the cell reproductive cycle. (medscape.com)
  • Ki-67 is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0). (thermofisher.com)
  • Comparison of pre- and post-treatment paired tumor biopsies from patients treated with fulvestrant revealed an upregulation of cyclin E2 upon development of resistance. (lu.se)
  • It regulates the serum cholesterol level by influencing the level of cholesterol uptake into cells. (cdc.gov)
  • Contrast enhancement in an experimental tumor model reveals heterogeneous uptake of tracer throughout the tumor. (lu.se)
  • The mass was diagnosed for ovarian tumor initially, followed by laparotomy. (researchsquare.com)
  • The determination of testosterone in women is helpful in the diagnosis of androgenic syndrome (AGS), polycystic ovaries (Stein-Leventhal syndrome) and when an ovarian tumor, adrenal tumor, adrenal hyperplasia or ovarian insufficiency is suspected. (cdc.gov)
  • In HIV-infected individuals, systemic NHL is the most common and can be further divided into subtypes such as diffuse large B-cell lymphoma (DLBCL), Burkitt's lymphoma, T-cell lymphoma, and plasmablastic lymphoma (PBL), to name a few [ 2 ]. (hindawi.com)
  • Overproduction of Tlx in mice stimulates the development of malignant brain tumors from brain stem cells. (dkfz.de)
  • This is where neural or brain stem cells reside, which are responsible for generating new neurons if needed. (dkfz.de)
  • In the adult animal, Tlx is expressed exclusively in brain stem cells. (dkfz.de)
  • When the scientists switched off Tlx, there were no more detectable stem cells in the brain and the formation of new neurons ceased. (dkfz.de)
  • Using a molecular-biological trick, the investigators induced an overproduction of Tlx by the brain stem cells of mice. (dkfz.de)
  • Moreover, the scientists discovered that stem cells with increased Tlx production stimulate the formation of new vessels. (dkfz.de)
  • The meeting participants were charged with evaluating data suggesting that cancers develop from a small subset of cells with self-renewal properties analogous to organ stem cells. (aacrjournals.org)
  • Indeed, one critical question contemplated at the Workshop was whether tumors derive from organ stem cells that retain self-renewal properties but acquire epigenetic and genetic changes required for tumorigenicity or whether tumor stem cells are proliferative progenitors that acquire self-renewal capacity. (aacrjournals.org)
  • This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)
  • Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
  • In mouse and rat xenograft tumor models, TAK-285 showed antitumor activity against cancers that expressed HER2 or EGFR. (jcancer.org)
  • Antitumor immunotherapy using monoclonal antibodies is considered selective and efficient in the treatment of different types of tumors, but its cost and toxic effects limit its application. (researchgate.net)