Tissues neurodegenerative disease susceptibility. Medical search. Frequent questions

Neural recording and stimulation have been widely used to mitigate traumatic injuries, neurodegenerative diseases or mental disorders. (biorxiv.org)
Therefore, this novel endovascular neural interface will broaden the range of applications from neurological diseases and mental disorders to bioelectronics medicine. (biorxiv.org)
Neural recording and stimulation opened the doors to a deeper understanding of the brain and, at the same time, led to the development of treatments for heavily-impairing conditions following traumatic injuries, neurodegenerative diseases or mental disorders. (biorxiv.org)
In turn, each separate regional motor neuron pool displays differential susceptibility to neurodegenerative disorders, e.g. (wisc.edu)
Disruption of this balance can lead to many human diseases including degenerative disorders and cancer. (birmingham.ac.uk)
SNCA as a principal component of Lewy bodies can be associated with neurodegenerative disorders such as Parkinson's disease [ 5 , 6 ]. (biomedcentral.com)
Iron, brain ageing and neurodegenerative disorders. (springer.com)
This decline is influenced by both genetic and environmental factors, and can lead to a reduced ability to repair cellular damage, decreased immune function, and increased susceptibility to diseases such as cancer, heart disease, and neurodegenerative disorders. (khaledlotfy.com)
Our research aims to pinpoint how specific classes of transposable elements have contributed to the evolution of human neuronal gene expression networks and understand how these changes may relate to human's increased susceptibility to neurodevelopmental disorders such as Autism and Schizophrenia and human neurodegenerative diseases such as Alzheimer's and Parkinson's disease. (uva.nl)
Lysosomal storage diseases describe a heterogeneous group of dozens of rare inherited disorders characterized by the accumulation of undigested or partially digested macromolecules, which ultimately results in cellular dysfunction and clinical abnormalities. (medscape.com)
Lysosomal storage diseases are generally classified by the accumulated substrate and include the sphingolipidoses, oligosaccharidoses, mucolipidoses, mucopolysaccharidoses (MPSs), lipoprotein storage disorders, lysosomal transport defects, neuronal ceroid lipofuscinoses and others. (medscape.com)
Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases (such as Krabbe disease), including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses as well as peroxisome disorders such as X-linked adrenoleukodystrophy. (medscape.com)
In general, transplantation yields the best results when performed early in the course of the disease (ie, in an asymptomatic affected sibling of a child with a lysosomal storage disorder), in centers with experience in performing transplantations to treat inherited metabolic disorders, and in patients healthy enough to tolerate the conditioning and transplantation regimen. (medscape.com)

Transmissible spongiform encephalopathies (TSEs or prion diseases) are a heterogeneous group of fatal neurodegenerative diseases that affect animals and humans. (cdc.gov)

Cell lines were exposed to the infectious agents of sporadic and variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy (BSE). (cdc.gov)
TSEs include scrapie in sheep and goats, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease in cervid ruminants, and mink encephalopathy. (cdc.gov)
these diseases include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, and variant Creutzfeldt-Jakob disease (vCJD) in humans. (blogspot.com)

Although UCH-L1 protein expression is specific to neurons and testis/ovary tissue, it has been found to be expressed in certain lung-tumor cell lines. (wikipedia.org)
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc) and the development of alpha-synuclein-containing aggregates called Lewy-bodies and Lewy-neurites 1 . (nature.com)
Laser-captured microdissected (LCM) DAergic neurons from postmortem tissue of patients with Lewy-pathology revealed a deficiency in expression for nuclear-encoded genes involved in mitochondrial respiration and function 12 . (nature.com)
Our preliminary data suggest that the over-expression of Wt1 in neurons may be associated with an increase in susceptibility to death. (fundacionareces.es)
Olfactory neurons relay the information to interneurons that interpret the information to command other neurons and peripheral tissues," Mutlu said. (neurosciencenews.com)
Synucleins are a family of three proteins highly expressed in neurons involved in Parkinson's and certain other neurodegenerative diseases. (asbmb.org)
The authors also showed that the presence of β-synuclein increased resistance to subchronic administration of the Parkinson's disease-inducing prodrug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, or MPTP, in dopaminergic neurons of the substantia nigra pars compacta when one or both of the other synucleins are absent. (asbmb.org)
Motor neurons (MNs) die in amyotrophic lateral sclerosis (ALS), a clinically heterogeneous neurodegenerative disease of unknown etiology. (frontiersin.org)
Spine loss without dendritic changes was present in striatal neurons from disease onset. (frontiersin.org)
Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease. (lu.se)

Also, the different motor neuron subtypes express specific molecular markers and show differential susceptibility towards neurodegenerative diseases. (rwth-aachen.de)

In conclusion, our comprehensive investigation employing both rat and hiPSC models uncovers plausible molecular pathways connecting SCI to neurodegenerative diseases, providing insights into the enduring consequences of these injuries on affected patients. (purdue.edu)
Although the causal relationship between these mutations and disease development is widely accepted, the exact molecular mechanisms underlying disease pathogenesis remain enigmatic. (nih.gov)
Several molecular mechanisms have been identified by means of which mutated Huntington (mHtt) is able to produce neuronal toxicity in advanced stages of the disease. (fundacionareces.es)
The objective of this project is to explore molecular mechanisms of aggregated a-syn propagation in PD in order to seek for novel therapies to delay the onset and slow down the disease progression. (neurodegenerationresearch.eu)
This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
A deep understanding of molecular mechanisms relevant to gene-environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. (frontiersin.org)
Indeed, "functional and mechanistic work on the molecular etiology of disease remains one of the major challenges in modern biology" ( 5 ). (frontiersin.org)
Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
Our research is to investigate the molecular control of cell death and how dying cells communicate with their neighbours to maintain tissue homeostasis. (birmingham.ac.uk)
Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease. (sagepub.com)
The researchers showed that both tissues had more chondroitin sulfate moieties of higher molecular weight than other tissues, concurrent with chondroitin polymerization proteins being upregulated in most cancer types. (asbmb.org)
The molecular basis of human diseases, including but not limited to the most common single-gene cause of intellectual disability and autism, Fragile X Syndrome, and the development of therapeutics. (rochester.edu)

Traumatic injuries are the leading cause of disability, and moreover are associated with elevated risk of developing cognitive impairments and neurodegenerative diseases (ND) such as Alzheimer's Disease (AD) and Parkinson's Disease (PD). (purdue.edu)
The gene is also associated with Alzheimer's disease, and required for normal synaptic and cognitive function. (wikipedia.org)
For example, we know that patients with Alzheimer's disease tend to have metabolic problems, Mutlu said. (neurosciencenews.com)
The same is also true of the most common neurodegenerative disease, Alzheimer's Disease (AD). (ukessays.com)
Epigenetic regulation in the pathophysiology of Alzheimer's disease. (nature.com)
Alzheimer's disease. (nature.com)
Sanchez-Mut, J. V. & Gräff, J. Epigenetic alterations in Alzheimer's disease. (nature.com)
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. (nature.com)
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. (nature.com)
DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. (nature.com)
Luchsinger JA, Mayeux R. Dietary factors and Alzheimer's disease. (springer.com)
Damage to mitochondria can lead to diseases, such as Alzheimer's disease, diabetes, and obesity. (fda.gov)
The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. (iospress.com)
The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. (iospress.com)
The aggregation and deposition of amyloid-β (Aβ) in the brain is thought to be an early event in the pathology of Alzheimer's disease (AD). (iospress.com)

Parkinson's Disease is the second most common neurodegenerative disease, after Alzheimer's. (ukessays.com)
Parkinson's disease (PD) is a common neurodegenerative disorder that exhibits motor and non-motor symptoms, as well as pathological hallmarks, including dopaminergic (DA) neuron death and formation of alpha-synuclein (alpha-Syn) Lewy bodies. (sdbonline.org)
New neuroimaging methods not only facilitate diagnosis of the most common neurodegenerative conditions (particularly AD) after symptom onset but also show diagnostic promise even at very early or presymptomatic phases of the disease. (medscape.com)

A recent study published online in PLOS Pathogens provides new insight on why some animals and humans might be more susceptible than others to prion diseases. (blogspot.com)
Although cross-species transmission of prion diseases seems to be limited by an apparent species barrier, the epidemic of BSE in the United Kingdom, which began in 1986, and its transmission to humans indicated that animal prion diseases could pose a significant public health risk. (medscape.com)
Human prion diseases can be divided etiologically into inherited, sporadic, and acquired forms. (medscape.com)
Prion diseases are associated with an accumulation of a disease-related isoform of host-encoded PrP through a posttranslational process involving conformational change and aggregation. (medscape.com)
[ 16 ] A common coding polymorphism at codon 129 of the PrP gene ( PRNP ), where either methionine (M) or valine (V) may be encoded, is a strong susceptibility factor for human prion diseases. (medscape.com)

Amyotrophic Lateral Sclerosis or Spinal Muscular Atrophy, and as a template for engineering implantable tissues. (wisc.edu)
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a rapidly progressive, fatal neurological disease that affects nerve cells in the brain and spinal cord, causing nerves in the muscle to die, thereby affecting voluntary muscle movement. (cdc.gov)

A point mutation (I93M) in the gene encoding this protein is implicated as the cause of Parkinson's disease in one German family, although this finding is controversial, as no other Parkinson's disease patients with this mutation have been found. (wikipedia.org)
Fifty patients (83%) reported persisting hypersomnolence, but only 33 (55%) had no other disease that could also explain the patient's excessive daytime sleepiness and/or prolonged sleep. (bvsalud.org)
In two patients (3%), the diagnosis in the meantime had changed to narcolepsy type 2, and 15 patients (25%) had developed a disease or diseases potentially causing hypersomnolence since the initial diagnosis. (bvsalud.org)
On average, ocular blood flow (OBF) is reduced in glaucoma patients in various tissues of the eye. (molvis.org)
[ 2 ] Also, endovascular neural interfaces do not involve craniotomies, reducing the risks associated with the surgical procedure (e.g., susceptibility to seizures) and, therefore, increasing the possibility of patients undergoing these innovative treatments. (biorxiv.org)
Recently an increase in its expression has been described in a mouse HD model and in patients with this disease. (fundacionareces.es)
TRIB3 promoter 33 bp VNTR is associated with the risk of cerebrovascular disease in type 2 diabetic patients. (cdc.gov)
affects seizure susceptibility in ischemic stroke patients. (cdc.gov)
Blood vessels change in the mesencephalon of patients with Parkinson's disease. (springer.com)
Age of onset and clinical manifestations may vary widely among patients with a given lysosomal storage disease, and significant phenotypic heterogeneity between family members carrying identical mutations has been reported. (medscape.com)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), Pompe disease, and recently Batten disease (neuronal ceroid lipofuscinoses, CLN2). (medscape.com)
Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients. (lu.se)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), and Pompe disease. (medscape.com)
A variety of imaging modalities, including structural and functional magnetic resonance imaging (MRI) and positron emission tomography (PET) studies of cerebral metabolism, have shown characteristic changes in the brain of patients with Alzheimer disease in prodromal and even presymptomatic states. (medscape.com)
Patients with PID have increased susceptibility to recurrent and persistent infections, but other symptoms are also common. (lu.se)

Multiple sclerosis and T1D have distinct target organs, genetic risk factors, onset ages, and female to male ratios, but target organ-specific T cells as initiators unite these diseases. (frontiersin.org)
Deciphering these mechanisms will make substantial contributions to our understanding of the cellular strategies and genetic pathways used to maintain tissue homeostasis in response to apoptosis. (birmingham.ac.uk)
Genetic mechanisms of susceptibility to congenital and infectious lung diseases, focusing on developmental antecedents and the influence of environmental factors. (rochester.edu)
AD is a genetic and sporadic neurodegenerative disease that is a common cause of cognitive impairment acquired in midlife and in late life, but its clinical impact is modified by other neurodegenerative and cerebrovascular conditions. (medscape.com)

During the past 10 years new functions of WT1 have been identified in different tissues and organs, although its role in the brain has yet to be studied. (fundacionareces.es)
Alpha-synuclein (SNCA) as the presynaptic protein is expressed in different tissues and prevents insulin-resistance (IR) through increasing glucose-uptake by adipocytes and muscles. (biomedcentral.com)

Furthermore, a polymorphism (S18Y) in this gene has been found to be associated with a reduced risk for Parkinson's disease. (wikipedia.org)
Individuals with a neurodegenerative disease called spinocerebellar ataxia 11 (SCA11) have mutations in a gene called TTBK2. (hum-molgen.org)
Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
Research into the gene mutations discovered in such hereditary cases has also contributed to the understanding of the aetiology of the spontaneous, late onset form of the disease. (ukessays.com)
Animal models of the disease, created using neurotoxins such as rotenone or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), or transgenic mice that overexpress human SYN gene (for ï ¡-synuclein) mutations, do not faithfully replicate the structure and antigenicity of the Lewy bodies found in PD (Dickson 2001). (ukessays.com)
The microtubule-associated protein tau (MAPT) is a susceptibility gene for idiopathic PD. (edu.au)
Furthermore, more literatures suggest gene-environment interaction as a potential contributor to disease mechanism. (cdc.gov)
Cyclin-G-associated kinase (GAK) , a PD susceptibility gene identified through genome-wide association studies (GWAS), is a ubiquitous serine/threonine kinase involved in clathrin uncoating (see Drosophila Clathrin heavy chain ), though its PD-related function remains elusive. (sdbonline.org)
Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)

Background: Parkinson's disease (PD) is a neurodegenerative disorder for which environmental factors influence disease risk and may act via an epigenetic mechanism. (edu.au)
Alzheimer disease is a progressive neurodegenerative disorder characterized by gradual onset of dementia . (medscape.com)

TSEs are characterized by the accumulation in the central nervous system and, less often, in lymphoid tissues of TSE-associated prion protein (PrP TSE ), a conformational variant of a normal host cellular prion protein (PrP C ). PrP C is a nonessential protein but, at least in mice and cows, must be expressed by animals susceptible to TSE infection. (cdc.gov)
According to the authors, after animals or humans are orally infected with prions, these misfolded proteins accumulate and replicate within the gut-associated lymphoid tissues (GALT), including the Peyer's patches of the small intestine, before the disease spreads to the brain. (blogspot.com)

Altered intestinal microbiota composition in later life is associated with inflammaging , declining tissue function, and increased susceptibility to age-associated chronic diseases, including neurodegenerative dementias . (fightaging.org)
We used a previously validated multiplexed 10-min, targeted proteomic assay to assess 54 candidate cerebrospinal fluid (CSF) biomarkers in two independent cohorts comprising individuals with neurodegenerative dementias and healthy controls. (lu.se)

White matter hyperintensity distribution differences in aging and neurodegenerative disease cohorts. (cdc.gov)

UCH-L1 has also been shown to interact with α-synuclein, another protein implicated in the pathology of Parkinson disease. (wikipedia.org)
Dopaminergic neuronal death and alpha-synuclein (a-syn) aggregate formation (Lewy pathology) are the neuropathological hallmarks in Parkinson?s disease (PD). (neurodegenerationresearch.eu)
Recent our and other studies have shown that Lewy pathology can be spread from peripheral tissues (e.g. intestine) to the brain, and from one brain region to another. (neurodegenerationresearch.eu)
Although these studies have provided insights into individual components of the neuro-motor network at specific time points in disease pathogenesis, there remains a need to define the onset and progression of neuronal pathology at successive stages of disease in ALS in key subcortical structures receiving cortical outputs: the striatum, hippocampus ( Spalloni and Longone, 2015 ), brainstem, and spinal cord. (frontiersin.org)
Organomegaly, connective-tissue and ocular pathology, and central nervous system dysfunction may result. (medscape.com)
Early white matter pathology in the fornix of the limbic system in Huntington disease. (lu.se)

Brain Iron Deposits (IDs) are associated with neurodegenerative diseases and impaired cognitive function in later life, but their cause is unknown. (springer.com)

and assessed immediate and persistent changes in transcriptomic and epigenetic markers via next generation sequencing (NGS) at primary lesion site and distal spinal cord tissue. (purdue.edu)
Discovery of this innate emergent behavior raises the possibility that human CNS morphogenesis can be engineered ex vivo to generate diverse brain and spinal cord tissues with biomimetic structure, cellular composition, cytoarchitecture- micro-to-millimeter scale spatial organization of cell phenotypes-, and even function via biomimetic neuronal circuits. (wisc.edu)

Here, we review the current knowledge on the functional impact of specific mutations, possible Pol III-related disease-causing mechanisms, and animal models that may help to better understand the links between Pol III mutations and disease. (nih.gov)
A deeper understanding of the mechanisms underlying DAergic neuron susceptibility is needed to generate disease-modifying therapies for PD. (nature.com)
A deep understanding of disease mechanisms will be needed to deliver etiology-based strategies to reverse this vexing trend. (frontiersin.org)
We drew mainly on MS and T1D research because intensive investigation has generated detailed insights into vitamin D mechanisms in these diseases and provided valuable guidance for research on other autoimmune diseases. (frontiersin.org)
A recent chapter ( 6 ) and a review ( 7 ) have summarized vitamin D mechanisms in autoimmune diseases more generally. (frontiersin.org)
We have discovered that apoptosis can induce cell proliferation through distinct mechanisms in a context-dependent manner, e.g. in proliferating versus differentiating tissues ( Fan and Bergmann, Dev Cell 14: 339 ). (birmingham.ac.uk)

The image shows fat storage tissue - yellow pixels show high fat levels - with the olfactory AWC neuron pseudo-colored in blue. (neurosciencenews.com)

Loss of Uchl1 increases the susceptibility of pancreatic beta-cells to programmed cell death, indicating that this protein plays a protective role in neuroendocrine cells and illustrating a link between diabetes and neurodegenerative diseases. (wikipedia.org)
In a recent article in the Journal of Biological Chemistry , Morten Dall, Anna Hassing and a team at the University of Copenhagen describe how they determined that removing hepatic nicotinamide phosphoribosyltransferase, or NAMPT, the enzyme responsible for NAD+ formation, increases susceptibility to liver injury in diet-induced metabolic stress. (asbmb.org)
Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. (who.int)

Parkinson's Disease (PD) is characterized clinically by tremors at rest, bradykinesia (slowness of voluntary movement), muscle rigidity, decrease in postural reflex and facial expression and an altered gait (Kumar et al. (ukessays.com)

Finally, unanswered questions and potentially informative future research directions are highlighted to speed delivery of etiology-based strategies to reduce autoimmune disease. (frontiersin.org)

Kuru is among the fatal neurodegenerative prion protein (PrP) diseases in humans. (medscape.com)
Others include Creutzfeldt-Jakob disease (CJD), Gerstmann-Straüssler-Scheinker (GSS) disease, fatal familial insomnia (FFI), and variant CJD (vCJD). (medscape.com)

Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)

The conclusion that PrP TSE is central to the pathogenesis of TSE is based on the temporal and anatomic correlations between accumulation of PrP TSE and the development of pathologic changes in tissues of the central nervous system ( 1 ). (cdc.gov)
Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)

Quantitative susceptibility mapping (QSM) is one of the newest magnetic resonance imaging (MRI)-based methods for assessing iron accumulation in target areas. (springeropen.com)
His research focus is on quantitative brain MRI and includes mapping tissue susceptibility, myelin mapping, and studying the effects of anisotropic tissue orientation on MRI. (philips.no)

Autoimmune diseases represent a failure of self-identification leading to an immune-mediated assault on host tissues. (frontiersin.org)
Independent studies suggest orally administered prions may similarly be transported by M cells into host tissues and that this transport may be important to establish host infection," the authors said. (blogspot.com)

Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. (sagepub.com)

The dopamine transporter (DaTScan) is used to distinguish Lewy body dementia from Alzheimer disease. (medscape.com)

By using the Drosophila eye as a model, we have revealed striking dynamics in the apoptotic susceptibilities of different cell types in a developing organ ( Fan and Bergmann, Dev Cell 30: 48 ). (birmingham.ac.uk)

Brain pathological changes during neurodegenerative diseases and their identification methods: How does QSM perform in detecting this process? (springeropen.com)
Identify the mechanism of the most significant pathological changes in the brain during neurodegenerative diseases. (springeropen.com)
This observational-descriptive article explains the main pathological factors in neurodegenerative diseases and how they work and move step by step to diagnostic imaging methods for these pathological factors and their advantages/disadvantages by summarizing the results of different articles. (springeropen.com)
The pathological and clinical characteristics of kuru that distinguish it from other PrP diseases in humans are also discussed. (medscape.com)

A promising strategy designed to overcome these risks involves exploiting the cerebrovascular system as an access route to the neural tissue. (biorxiv.org)
Endovascular neural interfaces interact with the surrounding neural tissue from within blood vessels. (biorxiv.org)
To gain insight into this diversity and produce potential cellular therapeutics that display regionally matched phenotypes, and thereby could facilitate enhanced regeneration of tissue function, we are developing scalable and clinically translatable protocols to derive region-specific neural stem cells and derivatives from hPSCs. (wisc.edu)
In this research thrust, we are engineering biomaterials at the micro-to-nanoscale that can serve as precisely defined culture substrates that can be 'programmed' to control hPSCs and their derivative neural tissues in a spatiotemporal manner. (wisc.edu)
Such substrates will be critical to control in vitro morphogenesis of hPSC-derived neural tissues. (wisc.edu)
In pursuit of this goal, we meld neurodevelopmental and hPSC biology with engineered biomaterial platforms to create novel methodologies for instructing ex vivo, 3D morphogenesis of human neural tissues. (wisc.edu)
PrP Sc is a conformational isoform of PrP C , but this orientation tends to accumulate in compact, protease -resistant aggregates within neural tissue. (wikidoc.org)

The neurodegenerative process is believed to occur sub-clinically before the disease is typically diagnosed in the third decade of life. (frontiersin.org)

Evidence linking sunlight, vitamin D, and the risk of multiple sclerosis and type 1 diabetes is summarized to develop the thesis that vitamin D is the environmental factor that most strongly influences autoimmune disease development. (frontiersin.org)
The global burden has risen with the near tripling in the last half-century of multiple sclerosis (MS) ( 2 , 3 ), type 1 diabetes (T1D) ( 4 ), and other autoimmune diseases. (frontiersin.org)
Insulin resistance (IR) as the main hyperglycemic process in non-insulin dependent diabetes mellitus (NIDDM) is observed in many tissues such as adipose and skeletal muscle [ 2 ]. (biomedcentral.com)

The brain tissue we need and value can be vulnerable to the free radicals that exist everywhere - they surround us perpetually. (trustedhealthproducts.com)
Alpha-synuclein (SNCA, α-Syn) as one of the members of synuclein protein family is mainly expressed in brain tissue. (biomedcentral.com)

antitrypsin deficiency associated with lower blood pressure and reduced risk of ischemic heart disease: a cohort study of 91,540 individuals and a meta-analysis. (cdc.gov)

In addition, the Biorepository collaborates with the Temple University ALS Postmortem Core to support and expand ALS research in the areas of biomarkers, genetics, and disease progression. (cdc.gov)
Role of cancer stem cell interactions with their microenvironment in disease progression. (rochester.edu)
Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases, including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses. (medscape.com)
Routine structural neuroimaging evaluation has long been based on nonspecific features such as atrophy, which is a late feature in the progression of the disease. (medscape.com)

The burden of foodborne and waterborne disease is not uniformly distributed globally: because of the inequitable distribution of the world's resources some countries carry a disproportionately heavy burden of infectious disease, and what is considered a re-emergent pathogen in one location may be endemic in another. (who.int)
They are now the most commonly reported bacterial cause of infectious intestinal diseases in the United Kingdom and most other industrialized countries [4]. (who.int)

Comorbidities and clinical outcomes in adult- and juvenile-onset Huntington's disease: a study of linked Swedish National Registries (2002-2019). (lu.se)
[ 12 ] Local verbal history, recorded when the disease was first studied by Western medicine in the 1950s, dated the onset of the first case of kuru to the 1920s. (medscape.com)

every tissue and/or organ investigated, including the liver and heart [3,4]. (researchgate.net)
Diet supplements and fatty liver disease. (asbmb.org)
Nonalcoholic fatty liver disease, or NAFLD, is a set of diseases involving fat accumulation and inflammation of the liver that affect almost a quarter of the U.S. population. (asbmb.org)

Upon culturing of these cells in specialized medium and subjecting them to multiple developmental signals, these cells can be directed into highly organized cortical tissues. (uva.nl)
We call these tissues 'cortical organoids' or 'minibrains' and showed that they recapitulate key aspects of human brain development as observed during early stages of embryonic development. (uva.nl)
The opportunity to generate cortical tissues that mimic early developmental stages of brain development, allows us to investigate the functionality of genomic novelties in the context of the development and evolution of the primate and human neocortex. (uva.nl)

Joan Domingo-Espín J, Lindahl M, Nilsson-Wolanin O, Cushman S W, Stenkula K G, Lagerstedt J O. Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal. (lu.se)

In these diseases, abnormal, misfolded proteins-known as prions-accumulate in the tissues of infected individuals. (blogspot.com)

Today's open access paper reports on an effort to measure the effects of microbial rejuvenation on tissue function in mice. (fightaging.org)
The researchers conducted a study using mice to investigate the role of M cells in the development of prion disease. (blogspot.com)
In mice that lacked M cells, prion accumulation within Peyer's patches and the subsequent spread of prion disease to the brain were blocked, emphasizing that M cells play an important role in transferring prions across the gut epithelium to establish infection. (blogspot.com)
In contrast, however, the researchers found that mice that had more M cells in their gut were about ten times more susceptible to developing prion disease and had shortened disease duration and survival time. (blogspot.com)
In present study we assessed the probable effect of insulin resistance on SNCA expression in muscle C2C12 cells and also skeletal muscle tissues of type 2 diabetic mice. (biomedcentral.com)
The obtained results have showed a significant ~ 27% decrease in SNCA expression level in muscle tissue of diabetic mice (P = 0.022). (biomedcentral.com)

The immune system - one of the most important systems within the body - regulates the overall susceptibility to threats and diseases. (trustedhealthproducts.com)

Recently, 3-D aggregates of neurally differentiating hPSCs were observed to spontaneously morph in vitro into organotypic masses, a.k.a. cerebral organoids, containing diverse brain tissues. (wisc.edu)

IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model. (lu.se)

Pathologic hallmarks of the disease include beta-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs), and reactive gliosis. (medscape.com)

In addition, an ever-increasing number of distinct mutations in the POLR3A, POLR3B, POLR1C and POLR3K subunits cause a spectrum of neurodegenerative diseases, which includes most notably hypomyelinating leukodystrophy. (nih.gov)
Targeted copy number variant identification across the neurodegenerative disease spectrum. (cdc.gov)

In addition, the findings are relevant to the observations that have been made between olfaction, fat metabolism and neurodegenerative diseases. (neurosciencenews.com)
In addition to the role of SNCA in cell susceptibility to insulin and glucose uptake, the SNCA expression can also be affected by insulin metabolism. (biomedcentral.com)

Thus, these results suggest that the SD proteins in human kidney undergo the same endocytosis and recycling pathway to maintain the filtration structure, and mutations in any genes in this pathway could lead to abnormal SD and renal diseases. (sdbonline.org)
Up-regulation of HSP90, a steroid receptor chaperone, in the AD CP may indicate abnormal hormone receptor expression in this secretory tissue. (iospress.com)

Thankfully, royal jelly can help to strengthen the receptors and tissues in the brain that often fail in the beginning stages of neurodegenerative diseases. (trustedhealthproducts.com)

For example, in animals, some cancers and neurodegenerative diseases are associated to a defective SUMOylation. (sciencedaily.com)

More recently, the concept of lysosomal storage disease has been expanded to include deficiencies or defects in proteins necessary for the normal post-translational modification of lysosomal enzymes (which themselves are often glycoproteins), activator proteins, or proteins important for proper intracellular trafficking between the lysosome and other intracellular compartments. (medscape.com)

Primary immunodeficiency diseases (PIDs) are intrinsic defects of the immune system. (lu.se)

Additionally, therapeutic applications remain limited by a lack of methodologies for in vitro tissue formation, which entails generating cell aggregates containing discrete spatial domains of diverse cellular phenotypes in biomimetic orientations. (wisc.edu)
My research aims to overcome this limitation by elucidating how factors of the cellular microenvironment work synergistically to regulate hPSC fate and utilizing this information to rationally engineer materials and methods for generating higher-order tissue structures in vitro that accurately recapitulate human anatomy and physiology. (wisc.edu)
Although we are broadly interested in generating numerous tissues within the human body, our research is presently focused on in vitro engineering of tissues representative of the human central nervous system and vasculature. (wisc.edu)
Results from this research could yield humanized tissue platforms that could serve as invaluable in vitro models for drug discovery and investigating neurodegenerative diseases, e.g. (wisc.edu)

Accumulation of DNA damage over time can lead to mutations and genomic instability, which can have detrimental effects on cellular function and increase the risk of age-related diseases. (khaledlotfy.com)

Surprisingly, it was discovered in the last decade that various inherited mutations in genes encoding nine distinct subunits of Pol III cause tissue-specific diseases rather than a general failure of all vital functions. (nih.gov)
Furthermore, other rare diseases are also associated with mutations in genes encoding subunits of Pol III (POLR3H, POLR3GL) and the BRF1 component of the TFIIIB transcription initiation factor. (nih.gov)
While ERRγ deletion did not fully recapitulate the transcriptional alterations observed in postmortem tissue, it caused reductions in genes involved in synaptic and mitochondrial function and autophagy. (nature.com)

Anatomy26

Organisms12

Diseases59

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology9

Phenomena and Processes64

Disciplines and Occupations3

Information Science3

Named Groups2

Health Care8

Geographicals2

Disorders13

Group of fatal neurodegenerative1

Bovine spongiform enc3

Neurons10

Differential susceptibility1

Molecular12

Alzheimer's Disease15

Common neurodegenerative3

Prion diseases5

Amyotrophic Lateral S2

Patients15

Genetic4

Different tissues2

Gene9

Disorder2

Lymphoid tissues2

Dementias2

Cohorts1

Pathology6

Cognitive function1

Spinal cord2

Mechanisms6

Neuron1

Increases3

Parkinson's Disease1

Etiology1

Fatal2

Changes in Huntington's disease1

Pathogenesis2

Quantitative2

Host tissues2

Schizophrenia1

Lewy1

Drosophila1

Pathological4

Neural7

Clinically1

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