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  • cardiac
  • In order to further test the hypothesis that the positive inotropic effect of theophylline (T) in mammalian cardiac muscle is due mainly to an increase in Ca inward current. (naver.com)
  • ber den Mechanismus der positiv inotropen Wirkung von Theophyllin am Warmbl�terherzenOn the mechanism of the positive inotropic action of theophylline in mammalian cardiac. (naver.com)
  • These subcellular changes manifest as heart defects and cause severely compromised cardiac function and embryonic death around embryonic day 11.5. (rupress.org)
  • neurons
  • To determine the requirement for target in neuropeptide regulation, embryonic DRG neurons were isolated at times before central and peripheral connections had formed, placed in culture, and immunocytochemically assayed for CGRP and substance P. Cultured neurons expressed neuropeptides with a time course and in proportions similar to those in vivo . (jneurosci.org)
  • Thus, some neurons in the embryonic DRG seem to be intrinsically specified to later express CGRP and substance P. The percentage of CGRP-immunoreactive neurons was not changed by cell density, non-neuronal cells, neurotrophins in addition to nerve growth factor (NGF), or antibody inactivation of neurotrophin-3 in the presence of NGF. (jneurosci.org)
  • To test the role of extrinsic cues on CGRP expression, DRG neurons were co-cultured with potential target tissues. (jneurosci.org)
  • Thus, multiple appropriate sensory neuron phenotypes arise in a regulated fashion in cultured neurons isolated before target connections have formed, and some candidate target tissues can modulate that intrinsic expression pattern. (jneurosci.org)
  • human
  • Likewise, the adult human transcript is present and differs in size and tissue distribution from cytosolic C1-THF synthase. (utexas.edu)
  • pancreatic
  • Indian hedgehog ( Ihh ), another hedgehog family member, and Patched 1 ( Ptc1 ), a receptor and negative regulator of hedgehog activity, are expressed in pancreatic tissue. (sdbonline.org)
  • Targeted inactivation of Ihh in mice allows ectopic branching of ventral pancreatic tissue resulting in an annulus that encircles the duodenum, a phenotype frequently observed in humans suffering from a rare disorder known as annular pancreas. (sdbonline.org)
  • Comparison of massive parallel sequence (RNA-Seq) databases demonstrates predominant expression of the Ca 2+ -sensitive archetype form in heart and skeletal muscle, but substantial expression of the Ca 2+ -insensitive variants in brain, pancreatic islets and other tissues. (biochemj.org)
  • vitro
  • Barrach HJ, Bauman I, Neubert D (1978) The applicability of in vitro systems for the evaluation of the significance of pharmacokinetic parameters for the induction of an embryonic effect. (springer.com)
  • Plant regeneration can be achieved in vitro from explants of plant tissue cultured in hormone containing medium. (frontiersin.org)
  • Abstract
  • Björklund, Anders 1982-03-01 00:00:00 Abstract: Dopaminergic innervation of the caudate nucleus in adult rats can be partially restored by the grafting of embryonic substantia nigra into the overlying parietal cortex with concomitant compensation of certain behavioral abnormalities. (deepdyve.com)
  • metabolic
  • Measurements of glucose utilization by (14C)deoxyglucose autoradiography indicated equivalent metabolic rates for the grafted tissue and the intact substantia nigra. (deepdyve.com)
  • Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types. (biochemj.org)
  • organ
  • Rosen V and Clark NB: Effects of parathyroid hormone and calcitonin on embryonic chick bone in organ culture. (springer.com)
  • Saito M, Kawashima K and Endo H: The establishment of a new biological assay system for simultaneous measurement of bone resorption and mineralization in organ cultures of chick embryonic femur. (springer.com)
  • The current standard of care for many diseases that result in total tissue and/or organ destruction is transplantation of donor tissues, but the number of available organs is limited. (jrank.org)
  • Mammalian skin is a dynamic organ that provides protection against a variety of environmental insults. (rupress.org)
  • epidermal
  • Skin malignancies, including epidermal squamous cell carcinoma (SCC), alone account for nearly as many cancers as all other tissues combined. (stanford.edu)
  • bone
  • To clarify what kind of process participates in bone resorption, time course of indices of bone resorption was investigated using 13-day-old embryonic chick calvaria. (springer.com)
  • Sakamoto S and Sakamoto M: Biochemical and immunohistochemical studies on collagenase in resorbing bone in tissue culture. (springer.com)
  • The effect of cadmium of bone resorption in tissue culture. (springer.com)
  • Chambers TJ, Darby JA and Fuller K: Mammalian collagenase predisposes bone surfaces to osteoclastic resorption. (springer.com)
  • types
  • Given these observations, we have sought to address the challenge of determining which cellular and biological processes that miRNAs might regulate in different cell types and tissues. (mit.edu)
  • They include tumours of single or mixed tissue types, potentially affecting any part of the body, with a risk of malignant transformation. (britannica.com)
  • Biochemical
  • We have developed approaches for high efficiency gene transfer to EB and LI patient skin tissue that are corrective at biochemical, histologic, clinical and functional levels. (stanford.edu)
  • functional
  • Myocardial infarction, caused by coronary artery occlusion, can lead up to loss of muscle tissue of the heart and functional detriment, even at times where rapid reperfusion strategies like PTCA or thrombolysis are at hand. (innovations-report.com)
  • Studies
  • Detailed proteomic and activity studies comparing OGDH complexes from rat heart and brain confirmed the substantial difference in expression between these tissues. (biochemj.org)
  • turnover
  • Moreover, measurements of DOPA accumulation for a 30‐min period after DOPA decarboxylase inhibition indicated similar fractional dopamine turnover rates in normal and transplantreinnervated tissues. (deepdyve.com)