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Bone MarrowBone Marrow CellsBone Marrow TransplantationBone and BonesBone RemodelingBone Marrow DiseasesBone Marrow ExaminationBone Marrow NeoplasmsHematopoietic Stem CellsBone DensityBone ResorptionBone Marrow PurgingHematopoiesisBone NeoplasmsTransplantation, HomologousBone DevelopmentMice, Inbred C57BLBone DiseasesColony-Forming Units AssayCell DifferentiationCells, CulturedBone RegenerationWhole-Body IrradiationTransplantation, AutologousRadiation ChimeraStromal CellsGraft vs Host DiseaseAnemia, AplasticOsteogenesisFlow CytometryLeukemiaBone MatrixBone TransplantationAntigens, CD34GranulocytesSpleenOsteoblastsOsteoclastsHematopoietic Stem Cell TransplantationTransplantation ChimeraMultiple MyelomaTime FactorsPancytopeniaCell SeparationLeukemia, Myeloid, AcuteBone SubstitutesMice, KnockoutBone Diseases, MetabolicMice, Inbred BALB CMegakaryocytesStem CellsCell LineageMyelodysplastic SyndromesFemurImmunophenotypingT-LymphocytesGranulocyte Colony-Stimulating FactorFractures, BoneMice, TransgenicLeukemia, MyeloidGraft SurvivalBone Morphogenetic ProteinsCyclophosphamideBone Morphogenetic Protein 2Mesenchymal Stromal CellsAntigens, CDBlood CellsCell DivisionCell CountLeukocyte CountErythropoiesisThymus GlandBlood Cell CountPrecursor Cell Lymphoblastic Leukemia-LymphomaPrimary MyelofibrosisLeukemia, Myelogenous, Chronic, BCR-ABL PositiveBusulfanChimeraMacrophagesTibiaAntibodies, MonoclonalTissue DonorsTransplantation ConditioningBone CystsPlasma CellsMice, Inbred StrainsGranulocyte-Macrophage Colony-Stimulating FactorCell ProliferationColony-Stimulating FactorsDisease Models, AnimalHistocompatibility TestingMesenchymal Stem Cell TransplantationTransplantation, IsogeneicChemokine CXCL12Hematologic DiseasesTreatment OutcomeCell MovementRecombinant ProteinsHistocompatibilityPhenotype
TransplantationAdipocytesMSCsSpleenMesenchymalYellow bone mHematopoietic cellsMultiple myelomaAspirationSpongyMacrophagesContributesDifferentiationRegenerative medicineLymphoid TissueSkeletalLiverStromalEndothelial cellsOsteogenicAdult tissuesOrgans and tissuesOrganMicroenvironmentProteinPhenotypePelvisHematopoiesisWhite adiposAngiogenesisInflammationCancersLymphocytesBonesBrown adiposLeukemiaHomogenateNicheVivoConcentrateVitroRegenerationOsteogenesisDonorsCellBloodLymphomaFragilityRecipient
Transplantation6
  • http://www.researchandmarkets.com/research/f7thqr/organ_and_tissue ) has announced the addition of the "Organ and Tissue Transplantation - Global Strategic Business Report" report to their offering. (prnewswire.com)
  • This report analyzes the worldwide markets for Organ and Tissue Transplantation in Number of Procedures. (prnewswire.com)
  • The global and regional markets (except the US) for 'Organ and Tissue Transplantation' in this report are analyzed by the following Product Segments - Organ Tranplantation (Heart, Kidneys, Liver, Pancreas, and Lungs). (prnewswire.com)
  • Additional treatment wanting to combine remission into treatment, consolidation therapy, includes extra chemotherapy or bone tissue marrow stem cell transplantation (SCT). (techblessing.com)
  • Is the Subject Area "Bone marrow transplantation" applicable to this article? (plos.org)
  • Transplantation of Organs and Tissues of Human Origin, adopted by the Council of Europe in 2002. (who.int)
Adipocytes8
  • Bone marrow adipocytes (BMAds) originate from mesenchymal stem cell (MSC) progenitors that also give rise to osteoblasts, among other cell types. (wikipedia.org)
  • In addition to WAT and BAT, adipocytes also exist in the bone marrow, and such marrow adipose tissue (MAT) has been estimated to account for over 10% of total adipose tissue mass in lean, healthy humans ( 3 ). (frontiersin.org)
  • Most adipocytes exist in discrete depots throughout the body, notably in well-defined white and brown adipose tissues. (wustl.edu)
  • However, adipocytes also reside within specialized niches, of which the most abundant is within bone marrow. (wustl.edu)
  • The characteristics of BMAT are also distinct depending on whether marrow adipocytes are contained within yellow or red marrow, as these can be thought of as 'constitutive' and 'regulated', respectively. (wustl.edu)
  • The ability of bone marrow adipocytes to regulate skeletal biology and hematopoiesis, combined with their metabolic activity, endocrine functions, and proximity to tumor cells means that they are ideally placed to impact both tumor growth and bone disease. (ox.ac.uk)
  • It is known that significant percentages of visceral adipocytes are derived from mesenchymal stem cells and high glucose enhances adipogenic differentiation of mouse bone marrow-derived MSCs (BM-MSCs). (hindawi.com)
  • Adipocytes in the accumulated fat tissues, especially around waist area and visceral organs, release several cytokines which reduce the sensitivity of several cell types to insulin leading to insulin resistant and type 2 diabetes [ 4 , 5 ]. (hindawi.com)
MSCs16
  • However, the results indicate that bone marrow -derived MSCs are superior to those from subcutaneous adipose tissue in terms of differentiation into pancreatic islet -like clusters. (bvsalud.org)
  • MSCs are ideal stem cells for tissues regeneration because of their excellent capacities for differentiation and proliferation. (researchassistantresume.com)
  • In this study we compared MSCs derived from three different sources (iliac crest bone marrow (ICBM), adipose tissue (AT), and (RIA)) regarding the morphology, the success rate of isolating MSCs, colony frequency, expansion potential, osteogenic and chondrogenic differentiation capacity. (cellmolbiol.org)
  • A comparison of the colonogenic ability in different tissues by CFU-F assay after 10 days showed that more colonies are formed from RIA-MSCs than from ICBM-MSCs, and AT-MSCs. (cellmolbiol.org)
  • However, bone marrow-derived MSCs and adipose tissue-derived MSCs have not yet been directly compared with each other under human platelet lysate conditions. (biomedcentral.com)
  • The bone marrow- and adipose tissue-derived MSCs were cultured under human platelet lysate conditions and their biological characteristics evaluated for cell therapy (morphology, immunophenotype, colony-forming unit-fibroblast efficiency, proliferation capacity, potential for mesodermal differentiation, secreted proteins, and immunomodulatory effects). (biomedcentral.com)
  • Under human platelet lysate-supplemented culture conditions, bone marrow- and adipose tissue-derived MSCs exhibited similar fibroblast-like morphology and expression patterns of surface markers. (biomedcentral.com)
  • Adipose tissue-derived MSCs had greater proliferative potential than bone marrow-derived MSCs, while no significantly difference in colony efficiency were observed between the two types of cells. (biomedcentral.com)
  • However, bone marrow-derived MSCs possessed higher capacity toward osteogenic and chondrogenic differentiation compared with adipose tissue-derived MSCs, while similar adipogenic differentiation potential wase observed between the two types of cells. (biomedcentral.com)
  • There were some differences between bone marrow- and adipose tissue-derived MSCs for several secreted proteins, such as cytokine (interferon-γ), growth factors (basic fibroblast growth factor, hepatocyte growth factor, and insulin-like growth factor-1), and chemokine (stem cell-derived factor-1). (biomedcentral.com)
  • Adipose tissue-derived MSCs had more potent immunomodulatory effects than bone marrow-derived MSCs. (biomedcentral.com)
  • Over the past decade, MSCs which are isolated from the umbilical cord, umbilical cord blood, bone marrow (BM), adipose tissue (AT) and many other adult tissues have been explored as potential therapeutic strategies for a number of diseases [ 2 ], but AT and BM are the most widely used sources of MSC, especially in autologous cell-based therapies due to ease of harvest and potential autologous application [ 3 ]. (biomedcentral.com)
  • However, the effect of high glucose on adipogenic differentiation of human bone marrow and gestational tissue-derived MSCs is still poorly characterized. (hindawi.com)
  • This study aims to investigate the effects of high glucose on proliferation as well as adipogenic and osteogenic differentiation of human MSCs derived from bone marrow and several gestational tissues including chorion, placenta, and umbilical cord. (hindawi.com)
  • Although the effects of high glucose on the proliferation and differentiation of rat and mouse BM-MSCs have been previously reported, the effects of high glucose on biological properties of human MSCs derived from gestational tissues which, due to their ease of isolation by noninvasive procedure, are considered more suitable sources of MSCs for clinical applications have yet to be determined. (hindawi.com)
  • Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
Spleen5
  • This article focuses on identifying and describing genes with an elevated expression in four lymphohematopoietic tissue types (bone marrow, lymph node, spleen and appendix), based on the Human Protein Atlas-strategy that combines high throughput transcriptomics with affinity-based proteomics. (nih.gov)
  • The cytogenetic effects of benzene on rat bone marrow and spleen cells. (cdc.gov)
  • The genotoxic effects of benzene (71432) on bone marrow and spleen lymphocytes were investigated in rats using micronucleus and sister chromatid exchange assay systems. (cdc.gov)
  • No effect on the nuclear division index of spleen cells was noted at 24 hours nor was there a significant decrease in the replicative index of bone marrow or spleen cells. (cdc.gov)
  • Presence of a mounted immune response, as evidenced by seropositivity, might have contributed to negative culture results in all specimens other than spleen tissue. (cdc.gov)
Mesenchymal4
  • Huang, G.T., Gronthos, S. and Shi, S. (2009) Mesenchymal stem cells derived from dental tissues vs. those from other sources: Their biology and role in regenerative medicine. (scirp.org)
  • Differentiation of mesenchymal stem cells derived from human bone marrow and subcutaneous adipose tissue into pancreatic islet-like clusters in vitro. (bvsalud.org)
  • The results reveal that mesenchymal stem cells (MSC) derived from bone marrow and subcutaneous adipose tissue can differentiate into pancreatic islet -like clusters, as evidenced by their islet-like morphology, positive dithizone staining and expression of genes such as Nestin , PDX1, Isl 1, Ngn 3, Pax 4 and Insulin . (bvsalud.org)
  • Bone tissue marrow-derived mesenchymal stem cells (BMSCs) are widely used in regenerative medicine in light of their ability to differentiate along the chondrogenic and osteogenic lineages. (researchassistantresume.com)
Yellow bone m1
Hematopoietic cells5
  • Hematopoietic cells (also known as blood cells) reside in the bone marrow along with BMAds. (wikipedia.org)
  • These hematopoietic cells are derived from hematopoietic stem cells (HSC) which give rise to diverse cells: cells of the blood, immune system, as well as cells that break down bone (osteoclasts). (wikipedia.org)
  • In this paper we present a strategy of combining next generation RNA-sequencing with in situ affinity-based proteomics in order to identify and describe new gene targets for further research on lymphatic or hematopoietic cells and tissues. (nih.gov)
  • Herein we review the site specificity, age-related development, regulation and metabolic characteristics of BMAT under various metabolic conditions, including the functional interactions with bone and hematopoietic cells. (wustl.edu)
  • The easy accessibility of hematopoietic cells, which are not tightly embedded in tissue, has supported. (karger.com)
Multiple myeloma1
Aspiration1
Spongy3
Macrophages4
  • Steer in Synergism Together with IFNγ Acts in Bone tissue Marrow-Resident Macrophages to boost your Quiescence regarding Hematopoietic Originate Cellular material. (micrornainhibitor.com)
  • Here, we show that persistent DNA damage accumulation in tissue-infiltrating macrophages carrying an ERCC1-XPF DNA repair defect ( Er1 F/− ) triggers Golgi dispersal, dilation of endoplasmic reticulum, autophagy and exosome biogenesis leading to the secretion of extracellular vesicles (EVs) in vivo and ex vivo. (nature.com)
  • Using mice with an engineered ERCC1-XPF defect in tissue-infiltrating macrophages, we provide evidence for a fundamental mechanism by which irreparable DNA damage triggers an exosome-based, metabolic reprogramming that leads to chronic inflammation and tissue pathology in NER progeroid syndromes and likely also during aging. (nature.com)
  • Fig. 1b, c ) or the pancreas and the white adipose tissue (WAT) that are infiltrated with MAC1-possitve macrophages expressing YFP (Fig. 1d ). (nature.com)
Contributes3
  • Bone marrow adipose tissue (MAT) contributes to increased circulating adiponectin, an insulin-sensitizing hormone, during caloric restriction (CR), but whether this occurs in other contexts remains unknown. (frontiersin.org)
  • This review discusses the recent advances in our understanding of how marrow adipose tissue contributes to bone metastasis and cancer-induced bone disease. (ox.ac.uk)
  • Since the implant contributes to the host's blood supply, rather than replacing it altogether, it cannot be used to treat people who have blood cancers, who would still need to have their own bone marrow stem cells wiped out to cure the disease. (newscientist.com)
Differentiation5
  • BMAT is thought to result from preferential MSC differentiation into an adipocyte, rather than osteoblast lineage in osteoporosis based on the inverse relationship between bone and BMAT in bone-fragile osteoporotic states. (wikipedia.org)
  • HSC renewal occurs in the marrow stem cell niche, a microenvironment that contains cells and secreted factors that promote appropriate renewal and differentiation of HSC. (wikipedia.org)
  • Differentiation potential cell therapy stem cells regenerative medicine orthopedic tissue engineering. (cellmolbiol.org)
  • Rebar N. Mohammed Hematopoietic stem cells (HSCs) are a rare population of cells that reside mainly in the bone marrow and are capable of generating and fulfilling the entire hematopoietic system upon differentiation. (karger.com)
  • An increase in adipogenic differentiation levels was accompanied by an upregulation of the expression levels of several adipogenic genes including peroxisome proliferator-activated receptor gamma ( PPAR γ ), adipocyte protein 2 ( AP2 ), adipose tissue-specific secretory factor ( ADSF ), sterol regulatory element-binding protein 1C ( SREBP1C ), lipoprotein lipase ( LPL ), adiponectin ( ADIPOQ ), and glucose transporter type 4 ( GLUT4 ) [ 8 , 9 , 11 ]. (hindawi.com)
Regenerative medicine1
  • Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
Lymphoid Tissue3
  • therefore, MALT is understood to include gut-associated lymphoid tissue (GALT), bronchial/tracheal-associated lymphoid tissue (BALT), nose-associated lymphoid tissue (NALT), and vulvovaginal-associated lymphoid tissue (VALT). (medscape.com)
  • Major accumulations of lymphoid tissue are found in the lamina propria of the intestine. (medscape.com)
  • M cells in the intestinal epithelium overlying Peyer patches allow transport of antigens to the lymphoid tissue beneath it. (medscape.com)
Skeletal3
  • It increases in states of low bone density -osteoporosis, anorexia nervosa/ caloric restriction, skeletal unweighting such as that which occurs in space travel, and anti-diabetes therapies. (wikipedia.org)
  • A prior study within a rabbit calvarial defect model additional revealed that there is seductive spatial and temporal relationship between newly produced blood vessels and further skeletal bone tissue development [12]. (researchassistantresume.com)
  • It's also the main part of the bone that lends firmness and support to your skeletal system. (webmd.com)
Liver2
Stromal1
Endothelial cells1
  • As demonstrated in previous studies many approaches have been applied to stimulate angiogenesis in the process of bone healing including the combination with endothelial cells the application of vascular growth factors vascular redesigning by microsurgery and gene transfection techniques [14-17]. (researchassistantresume.com)
Osteogenic1
  • Interestingly Chinese medicine which could promote the secretion of osteogenic factors such as collagen type 1 (COL1) bone morphogenetic protein 2 (BMP-2) osteocalcin (OCN) and osteopontin (OPN) and the gene manifestation of BMP-4 runt-related transcription element 2 (Runx2) OCN and OPN has been increasingly applied in osteogenic induction study [18-20]. (researchassistantresume.com)
Adult tissues1
Organs and tissues3
  • By signing and carrying cards attesting to the commitment to donate such organs and tissues upon death, those in need will be helped. (wlcj.org)
  • Simulation of radiation dose distribution in human organs and tissues is possible by tissue equivalent materials. (hindawi.com)
  • ICRU report 44 [ 1 ] describes various types of tissue substitutes for human organs and tissues. (hindawi.com)
Organ5
  • Whilst it is clear that BMSSC-mediated osteogenesis has the capacity to integrate with pre-existing bone tissue, substantial progress in this and other approaches needs to be achieved for the accurate reassembly of functional complex organ systems. (sahmri.org.au)
  • Organ and tissue donations as well as bone marrow registration are life-giving acts. (wlcj.org)
  • Those who do not receive organ, tissue and/or bone marrow donations continue to suffer and die primarily from the lack of awareness of donor consent. (wlcj.org)
  • Women's League for Conservative Judaism, in accordance with the Committee on Jewish Law and Standards of the Rabbinical Assembly, affirms the life-giving benefits of organ, tissue and bone marrow donation. (wlcj.org)
  • We encourage enrollment in bone marrow registration and enrollment of eligible organ, tissue and bone marrow donors. (wlcj.org)
Microenvironment1
  • This specialized microenvironment is highly supportive, not only for tumor growth and survival but also for the development of an associated destructive cancer-induced bone disease. (ox.ac.uk)
Protein5
  • The Human Protein Atlas project aims to systematically map the human gene and protein expression landscape in a multitude of normal healthy tissues as well as cancers, enabling the characterization of both housekeeping genes and genes that display a tissue-specific expression pattern. (nih.gov)
  • The results constitute lists of genes with enriched or enhanced expression in the four lymphohematopoietic tissues, exemplified also on protein level with immunohistochemical images. (nih.gov)
  • Finally, rosiglitazone upregulated uncoupling protein 1 in brown adipose tissue (BAT), but this protein was undetectable in tibiae, suggesting that MAT is unlikely to share thermogenic properties of BAT. (frontiersin.org)
  • Tissue total protein is prepared from whole tissue homogenates. (biochain.com)
  • Whereas bone marrow adipose tissue (BMAT) shares many properties in common with white adipose tissue, the distinct functions of BMAT are reflected by its development, regulation, protein secretion, and lipid composition. (wustl.edu)
Phenotype1
  • BMAT, by its "specific marrow location, and its adipocyte origin from at least LepR+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors", and likely indicates a different fat phenotype. (wikipedia.org)
Pelvis1
Hematopoiesis1
  • AML is normally a malignancy arising inside the bone tissue marrow, where leukemia cells proliferate uncontrollably in colaboration with a disruption of regular hematopoiesis or bloodstream cell creation. (techblessing.com)
White adipos3
  • Since BMAT is increased in the setting of obesity and is suppressed by endurance exercise, or vibration, it is likely that BMAT physiology, in the setting of mechanical input/exercise, approximates that of white adipose tissue (WAT). (wikipedia.org)
  • The antidiabetic thiazolidinediones (TZDs) also promote MAT expansion and hyperadiponectinemia, even without increasing adiponectin expression in white adipose tissue (WAT). (frontiersin.org)
  • Adipose tissue is typically classified into two broad subtypes, white adipose tissue (WAT) and brown adipose tissue (BAT). (frontiersin.org)
Angiogenesis4
Inflammation2
  • This, in turn, establishes chronic inflammation and tissue pathology in mice with important ramifications for DNA repair-deficient, progeroid syndromes and aging. (nature.com)
  • It restores collagen and connective tissue and fights inflammation. (constantcontact.com)
Cancers1
Lymphocytes2
Bones9
  • These are strong tissues that connect your bones to one another. (webmd.com)
  • This is a semi-rigid tissue that covers bones where they touch one another. (webmd.com)
  • These make new bone tissue and help repair damage to your bones. (webmd.com)
  • These are mature bone cells that help the bones of newborns mature. (webmd.com)
  • These are bones that contain red bone marrow. (webmd.com)
  • When you're born, your bones mostly contain red bone marrow, but it becomes yellow in your arms and legs as you grow up. (webmd.com)
  • Sometimes, your bones can heal small breaks on their own, but oftentimes, you'll need medical help to fix a broken bone. (webmd.com)
  • You can make marrow soup by boiling a two-three pound organic chicken until the meat falls off the bones. (constantcontact.com)
  • Add one-two tablespoons of apple cider vinegar and a few cups of chopped carrots, celery, squash and beets to help extract the marrow from the bones. (constantcontact.com)
Brown adipos1
  • Visceral abdominal fat (VAT) is a distinct type of WAT that is "proportionally associated with negative metabolic and cardiovascular morbidity", regenerates cortisol, and recently has been tied to decreased bone formation Both types of WAT substantially differ from brown adipose tissue (BAT) as by a group of proteins that help BAT's thermogenic role. (wikipedia.org)
Leukemia1
  • At display, the marrow Rabbit Polyclonal to CFI of an individual with AML is normally occupied with around 1012 leukemia cells. (techblessing.com)
Homogenate1
  • The best solution is to slice the tissues into smaller pieces and make a homogenate solution (using tissue homogenizer or grinding liquid nitrogen frozen samples) in presence of RNAse inhibitors. (labettor.com)
Niche1
  • In addition to its potential role as a local energy reservoir, BMAT also secretes proteins, including adiponectin, RANK ligand, dipeptidyl peptidase-4, and stem cell factor, which contribute to local marrow niche functions and which may also influence global metabolism. (wustl.edu)
Vivo4
  • From the in vivo examination, laminin coating of the scaffolds induced hard tissue in the pores with the cells. (scirp.org)
  • It is concluded that laminin is useful for bone formation, as in an in vitro culture study using bone marrow cells, in hydroxyapatite scaffolds in vivo . (scirp.org)
  • Yoshikawa, M. , Kakigi, H. , Yabuuchi, T. and Hayashi, H. (2014) Effects of laminin on hard tissue formation by bone marrow cells in vivo and in vitro . (scirp.org)
  • Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)
Concentrate2
  • Use of Bone Marrow Aspirate Concentrate (BMAC) Associated with Hyperbaric Oxygenation Therapy in Maxillary Appositional Bone Reconstruction. (mdpi.com)
  • Objectives: The objective of this study was to evaluate bone reconstruction using xenograft alone and associated with bone marrow aspirate concentrate (BMAC) and hyperbaric oxygen therapy. (mdpi.com)
Vitro2
  • For i n vitro examinations, 1 × 10 5 rat bone marrow cells in 2 ml culture medium were then cultured with the addition of dexamethasone and laminin. (scirp.org)
  • In vitro examinations showed the effectiveness of laminin for hard tissue formation from the results of biochemical and immunochemical analysis. (scirp.org)
Regeneration1
Osteogenesis1
Donors1
Cell3
  • It is anticipated that a concerted multidiscipline approach is required to facilitate the reality and great potential benefits of cell-based tissue engineering applications. (sahmri.org.au)
  • Quickly, murine bone tissue marrow cell suspensions had been incubated with an assortment of M5/114 (anti-major histocompatibility complicated [MHC] course II), RA3-6B2 (anti-B220), 53-6.7 (anti-CD8), GK1.5 (anti-CD4), and RB6-8C5 (anti-Ly-6G) monoclonal antibodies (MAbs), and stained cells were eliminated by negative selection using Dynabeads M-450 coated with sheep anti-rat immunoglobulin G (IgG). (buyresearchchemicalss.net)
  • We used the CliniMACS Plus system located in our Cell and Tissue. (karger.com)
Blood8
Lymphoma1
  • Once the medical team has a suspicion of Hodgkin's Lymphoma, if the lymph nodes don't feel normal when examined by a doctor, the doctor may need to extract a small piece of tissue and look at it under the microscope to see if there are any cancer cells. (lymphomainfo.net)
Fragility2
  • BMAT increases in states of bone fragility. (wikipedia.org)
  • Thus, bone fragility, osteoporosis, and osteoporotic fractures are thought to be linked to mechanisms which promote BMAT accumulation. (wikipedia.org)
Recipient1