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  • aortic
  • Comparison of relative telomere length measured in aortic tissue and leukocytes in patients with end stage heart failure. (nel.edu)
  • Therefore, we examined whether LrTL would reflect rTL in aortic tissue (ArTL) and whether it could be used as a marker of biological heart age. (nel.edu)
  • The age of patients with end stage heart failure was not associated with leukocyte or aortic telomere length. (nel.edu)
  • CORMs have been shown to promote vasorelaxant effects on aortic and cardiac tissues of rats [ 17 , 19 - 21 ], and decreased myocardial ischemia/reperfusion damage [ 18 , 22 ]. (ijbs.com)
  • MRNA
  • Ang-1, Ang-2, Tie1 and Tie2 mRNA and protein expression were quantified in synovial tissues and RA synovial tissue fibroblasts with real-time reverse transcription polymerase chain reaction and western blot analysis. (springer.com)
  • Generally Ang-1, Ang-2, Tie1 and Tie2 mRNA levels were higher in RA synovial tissue compared to normal and OA synovial tissues, and RA synovial tissue fibroblasts. (springer.com)
  • In conclusion, the dominance of Ang-1 mRNA and protein expression over Ang-2 is in agreement with an active neovascularization in RA synovial tissue. (springer.com)
  • To determine which of these angiogenic factors may play a role in RA, we investigated both the distribution and the levels of mRNA for Tie1, Tie2, Ang-1 and Ang-2 in synovial tissue obtained from RA patients, compared with that from subjects with osteoarthritis (OA) and normal tissues. (springer.com)
  • infection
  • Leukocytes are professional migratory cells that routinely patrol the body for signs of infection or damage and accurately navigate through virtually any body tissue. (cam.ac.uk)
  • We will use bacterial infection models in zebrafish to establish the physiological relevance of nuclear rupture and repair in the survival of leukocytes in vivo and their ability to clear infection. (cam.ac.uk)
  • After intracranial infection, Theiler's murine encephalomyelitis virus (TMEV) generates T RM that are maintained in the central nervous system (CNS) tissues of B7-H1 WT animals. (frontiersin.org)
  • In contrast, tissue resident memory CD8 + T-cells (T RM ) remain at sites of previous infection and provide tissue-specific protection from secondary exposure ( 3 ). (frontiersin.org)
  • A subset of lung T cells can persist as tissue-resident memory T cells (TRMs) following infection and allergen induction, although the generation and role of TRM in asthma persistence and pathogenesis remain unclear. (jimmunol.org)
  • In mouse models of respiratory virus infection, we previously found that noncirculating tissue-resident memory CD4 + and CD8 + T cells were generated in the lung (designated lung tissue-resident memory T cells [TRMs]), potentially providing optimal protective responses to virus challenge, with minimal morbidity ( 19 - 21 ). (jimmunol.org)
  • It is a response of vascularized tissues to infection and damaged tissues that brings cells and molecules of host defense from the circulation to the sites where they are needed, in order to eliminate the offending agents. (brainscape.com)
  • lung tissue
  • One hundred and fifty minutes after CPB, lung tissue samples from the non-dependent and dependent portions of the left and right lungs were harvested for polymorphonulear leukocyte (PMNs) counts. (nih.gov)
  • molecules
  • Recently, transition metal carbonyls have been identified as CO-releasing molecules (CORMs) with the potential to facilitate the pharmaceutical use of CO by delivering it to tissues and organs [ 16 - 18 ]. (ijbs.com)
  • ligands
  • The integrin CD103 has been shown to promote the retention of T RM in brain tissues ( 7 ) and interactions with ligands expressed in the brain may provide support for their maintenance and retention within the CNS. (frontiersin.org)
  • We have compared the distribution of the receptor tyrosine kinase (Tie) and the Ang ligands in synovial tissues from normal subjects and those with rheumatoid arthritis (RA) and osteoarthritis (OA). (springer.com)
  • Little is known about the role of Tie receptors and the ligands Ang-1 and Ang-2 in RA synovial tissue. (springer.com)
  • Initially one wonders why the 'glue' is so 'unsticky', until you realise that this weak binding is actually an advantage - the degree of stickiness can be regulated by the number of CAMs expressed (or the density of CAM ligands on the target), and CAMs also do not have to grab hold of the target like grim death - they can be used (for example) to slow down a moving leukocyte! (anaesthetist.com)
  • Adult
  • In adult mice, lung-localized, tissue-resident memory T cells (TRMs) mediate optimal protection to respiratory pathogens, and we hypothesized that reduced protection in infancy could be due to impaired establishment of lung TRM. (rupress.org)
  • Differential expression of matrix metalloproteinases and tissue-derived inhibitors of metalloproteinase in fetal and adult skins. (uni-bielefeld.de)
  • homeostasis
  • Upon viral clearance, the CD8 + T-cell population contracts in a regulated process to avoid continuous immune mediated pathology and to restore tissue homeostasis. (frontiersin.org)
  • the skin as an immunological organ and the role of tissue-leukocyte-microbiota crosstalk in mediating immunological and structural homeostasis. (nih.gov)
  • infants
  • The objectives of this study were to identify tissue-specific differentially methylated regions (T-DMR's) in the folate transport genes in placental tissue compared with leukocytes, and from placental tissues obtained from normal infants or with neural tube defects (NTDs). (diva-portal.org)
  • Normal
  • Immunohistochemical analysis was used to determine the expression of Ang-1, Ang-2, Tie1 and Tie2 in synovial tissue of normal subjects and those with RA and OA. (springer.com)
  • The expression pattern of Ang-2 in synovial tissue was similar in RA and OA, whereas the Ang-2 expression was low in normal tissue. (springer.com)
  • cells
  • I am working with living leukocytes, which I use for surface-enhanced Raman spectroscopy (SERS) and it is crucial that the cells are as still as possible in order for me to create a spectral image. (protocol-online.org)
  • If you mean red blood cells, I cannot tell as I receive those leukocytes from another laboratory. (protocol-online.org)
  • There are many different types of white blood cells, and our work has been to define the specific types that migrate into the tissues, and define the role these cells play in causing type II diabetes. (usda.gov)
  • Finally, mucosal organs, which are frequent sites of CMV reactivation, are primarily inhabited by tissue-resident memory T cells, which do not recirculate. (frontiersin.org)
  • Walker 256 cancer cells secrete tissue inhibitor of metalloproteinase-free metalloproteinase-9. (uni-bielefeld.de)
  • expression
  • Expression of matrix metalloproteinases and their endogenous tissue inhibitors in skin lesions from patients with tuberous sclerosis. (uni-bielefeld.de)
  • specific
  • These deformations pose a challenge to the cell nucleus and leukocytes have evolved specific nucleoskeletal architectures to endow minimal rigidity to this compatment. (cam.ac.uk)
  • determine
  • The HLA system is useful in tissue typing, in which tissues from one individual are analyzed to determine whether they can be successfully transplanted to another individual. (britannica.com)
  • main
  • The main goals of this thesis were to analyze whether the genes responsible for the folate transport (FOLR1, PCFT, and RFC1) could be regulated by DNA methylation in placenta, blood leukocytes and colorectal cancer. (diva-portal.org)