AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
AntimetabolitesAdipose TissueGene Expression ProfilingAdipose Tissue, WhiteGene Expression RegulationGene ExpressionSubcutaneous FatOligonucleotide Array Sequence AnalysisAntimetabolites, AntineoplasticRNA, MessengerObesityReverse Transcriptase Polymerase Chain ReactionTetrahydrouridineFloxuridineTrabeculectomyInosine MonophosphatePhosphoribosyl PyrophosphateFluorouracilMitomycinLeptinMethotrexate6-MercaptopurineLeukemia L1210Folic Acid AntagonistsCluster AnalysisCytarabinePurinesAntineoplastic AgentsCell LineDrug SynergismTumor Cells, CulturedGene Expression Regulation, DevelopmentalDrug Screening Assays, AntitumorCell SurvivalDeoxycytidineTranscription, GeneticDrug Evaluation, PreclinicalCell CyclePromoter Regions, GeneticGene Expression Regulation, NeoplasticNeoplasmsCell DivisionTranscription FactorsBase SequenceGene Expression Regulation, EnzymologicGene Expression Regulation, PlantMolecular Sequence DataGene Expression Regulation, BacterialGene Expression Regulation, ViralKineticsDNA-Binding ProteinsSignal TransductionCells, CulturedTranscriptomeGene Expression Regulation, FungalGenes, ReporterMicroarray AnalysisUp-RegulationBlotting, NorthernTransfectionCell DifferentiationRNATranscriptional ActivationMutationDNA PrimersDown-RegulationIn Situ HybridizationCell Line, TumorTrans-ActivatorsNuclear ProteinsGene Regulatory NetworksRepressor ProteinsPolymerase Chain ReactionMice, Inbred C57BLDNA, ComplementaryPhenotypeReal-Time Polymerase Chain Reaction
ApoptosisTumourMethotrexateOncogenesFluorouracilInhibitsPathwaysNeoplastic tissueAdipose tissueAngiogenesisRegulateMutationLymphoid tissueTumor suppPTENProliferationSynthesisRegulationReplicationDifferentiationTumorsMitosisLiverResistanceDatasetEnzymeCytokinesInactivationCharacteristicCellsMembraneImmuneOrganProteinPredictiveNormalRegressionMechanismsMalignantMethodsPulmonaryTargetsTherapyMultipleDevelopmentOccursAnalysisAddition
Apoptosis1
  • The protein products of tumor suppressor genes are normal genes that slow down cell division, repair DNA mistakes, and tells when to undergo apoptosis (programmed cell death). (doctorlib.info)
Tumour3
  • These characteristics are caused by altered gene expression, as a result of genetic mutations that inactivate tumour suppressor genes and / or activate oncogenes. (savedelicious.com)
  • Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease. (medscape.com)
  • LS is caused by germline (likely) pathogenic variants in the DNA mismatch repair (MMR) genes, leading to a characteristic MMR-deficient (dMMR) / microsatellite unstable (MSI) tumour phenotype. (edu.au)
Methotrexate1
Oncogenes2
  • The two main types of genes that are now recognized as playing a role in cancer are oncogenes and tumor suppressor genes. (doctorlib.info)
  • The results not only help the practitioner and patient choose an effective combination of therapies, but also helps them understand which cancer genes (oncogenes) are blocked by which treatments. (dunphynunley.com)
Fluorouracil1
  • The most administered chemotherapeutic regimen in Australia is FOLFOX, whose constituent drugs are the pyrimidine antimetabolite 5-Fluorouracil and the platinum based alkylating agent Oxaliplatin. (edu.au)
Inhibits2
  • it inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha (all involved in early T-cell activation). (medscape.com)
  • It leads to decreased expression of IL-3, IL-4, IL-5, and TNFα, and it inhibits mast cell and neutrophil activation. (medscape.com)
Pathways2
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • On the other hand, non-genomic actions may indirectly affect gene transcription via the regulation of intracellular signaling pathways that target transcription factors ( 3 ). (jcancer.org)
Neoplastic tissue3
  • Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. (lookformedical.com)
  • Cells grown in vitro from neoplastic tissue. (lookformedical.com)
Adipose tissue3
  • The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. (nature.com)
  • The brain integrates metabolic signals from peripheral tissues such as the liver, pancreas, adipose tissue, gut and muscle. (nature.com)
  • Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
Angiogenesis1
  • 2002) FEBS Lett, 519: 147-152) and to regulate a spectrum of genes which suppress angiogenesis (Abdollahi et al. (justia.com)
Regulate3
  • it may down-regulate FCeRI expression on Langerhans cells. (medscape.com)
  • In addition, hydroxytyrosol is able to regulate the expression of other genes involved in the regulation of tumor cell proliferation, such as extracellular signal-regulated and cyclin-dependent kinases. (blogspot.com)
  • It is important to block the activity of multiple genes to successfully regulate cancer expression because single therapies are extremely rare in cancer care, as they often allow the cancer genome to adapt and become more aggressive. (dunphynunley.com)
Mutation2
  • Numerous pathophysiogenetic mechanisms have been suggested such as venous dysplasia of the emissary veins in the intracranial circulation, neural crest alterations leading to alterations of autonomic perivascular nerves, mutation of the GNAO gene in the Sturge-Weber syndrome, PIK3CA mutation in malformative/overgrowth syndromes such as the Klippel-Trenaunay syndrome, and the twin-spotting phenomenon in phakomatosis pigmentovascularis. (hindawi.com)
  • These genes contribute to carcinogenesis when they are inactivated by mutation and can no longer provide a brake on cell division. (pvpharma.com)
Lymphoid tissue6
  • A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
  • Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
  • They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder. (lookformedical.com)
  • Staal SP, Ambinder R, Beschorner WE, Hayward GS, Mann R. A survey of Epstein-Barr virus DNA in lymphoid tissue. (medscape.com)
Tumor supp2
  • Just like the well-known tumor suppressor gene Phosphatase and Tensin Homolog (PTEN) it hydrolyses phosphatidylinositol (3,4,5) triphosphate (PI(3,4,5)P3). (oncotarget.com)
  • P53 is a tumor suppressor gene that codes for a transcription factor that regulates the expression of other genes and arrests the cell cycle. (doctorlib.info)
PTEN2
  • It has been noted that lack of PTEN expression is widespread in CCC of the ovary. (deubiquitinase.com)
  • CCC may be a good candidate for therapy with a mTOR inhibitor, as it is well known that loss of PTEN expression and consequent activation of AKT signaling end in hypersensitivity to mTOR inhibition. (deubiquitinase.com)
Proliferation4
  • The pathogenic alterations in various cancer tissues depend on mutant BTK for cell proliferation and survival, and BTK is also overexpressed in a range of hematopoietic cells. (bvsalud.org)
  • GR signaling controls genes required for differentiation of a subset of proliferative mesenchymal progenitors into matrix fibroblasts, in turn, regulating signals controlling AT2/AT1 progenitor cell proliferation and differentiation and identifying cells and processes by which glucocorticoid signaling regulates fetal lung maturation. (stanford.edu)
  • Finally, we determined that knockdown of LIPT1 gene expression inhibited proliferation and invasion of hepatoma cells. (biomedcentral.com)
  • These genes are deleted or inactivated in cancer cells, allowing unregulated proliferation. (doctorlib.info)
Synthesis2
  • Antimetabolites interfere with the synthesis of nucleic acids. (wikipedia.org)
  • Replication may be categorized into immediate early, delayed early, and late gene expression based on time of synthesis after infection. (medscape.com)
Regulation2
  • The heterodimer binds to vitamin D response element in target genes and leads to gene transcription regulation ( 1 ). (jcancer.org)
  • In addition, calcitriol has rapid effects that are independent of gene transcription regulation, which are defined as non-genomic effects and not mediated directly through steroid receptor-ligand-DNA interaction. (jcancer.org)
Replication2
  • However, this expression depends on a preliminary DNA replication that occurs normally between 21 h and 31 h following activation at 18°C. Thus, the gene for DNA-ligase I is overtly expressed at the 1-cell stage. (silverchair.com)
  • In the same cytoplasmic environment, and following egg activation and DNA replication, the gene for DNA-ligase I introduced by the male pronucleus is unable to direct any production of the corresponding enzyme. (silverchair.com)
Differentiation2
  • GR enhanced differentiation of a newly defined proliferative mesenchymal progenitor cell (PMP) into matrix fibroblasts (MFBs), in part by directly activating extracellular matrix-associated target genes, including Fn1, Col16a4, and Eln and by modulating VEGF, JAK-STAT, and WNT signaling. (stanford.edu)
  • Analysis of single cell transcriptomic profiles reveals that gene expression from all root tissues are identified improving insights into cell-type differentiation. (plantae.org)
Tumors2
  • Desmoid tumors are rare connective tissue tumors that typically arise in the upper and lower extremities, abdominal wall, head and neck area, mesenteric root, and chest wall, or other parts of the body. (gcs-web.com)
  • Tumor promoters are not able to cause tumors to form, but increase the frequency of tumor formation in tissue previously exposed to the tumor initiator. (doctorlib.info)
Mitosis1
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
Liver2
  • Mycophenolate mofetil is an antimetabolite immunosuppressant indicated for the prophylaxis of organ rejection in recipients of allogeneic kidney, heart or liver transplants, and should be used in combination with other immunosuppressants. (nih.gov)
  • It cannot be detected in the unfertilized egg, sperm or differentiated tissues such as liver or muscle. (silverchair.com)
Resistance3
  • Multidrug resistance, generally, results from over expression of ATP-dependent efflux pumps [5]. (savedelicious.com)
  • Lack of sequence information makes harnessing the diversity of disease resistance (R) genes in wild crops highly challenging. (plantae.org)
  • report AgRenSeq, a reference genome-free technique, for rapid cloning of nucleotide binding/Leucine-rich repeat (NLR) resistance genes from wild crops. (plantae.org)
Dataset2
  • Then, the prognostic model and the expression levels of the three genes were validated using the dataset from GEO. (biomedcentral.com)
  • We applied our proprietary RADR® platform to an NCI-60 discovery dataset encompassing LP-184 IC50s and publicly available gene expression data. (biomedcentral.com)
Enzyme1
  • The heavy molecular form of the enzyme, referred to as DNA-ligase I, is generally present in proliferating tissues. (silverchair.com)
Cytokines1
  • They act by inhibiting gene expression of cytokines including Interleukin 1 (IL-1), IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, and TNF-alpha by binding to corticosteroid response elements on DNA. (wikipedia.org)
Inactivation1
  • However, dMMR / MSI is not only caused by LS and can also result from somatic causes of MMR gene inactivation. (edu.au)
Characteristic1
  • Haploid androgenetic axolotl embryos develop devoid of the 8S DNA-ligase characteristic of control embryos ( Fig. 1A,B ). The paternal gene for DNA-ligase I is in a repressed state. (silverchair.com)
Cells5
  • Deletion of the glucocorticoid receptor gene (Nr3c1) from fetal pulmonary mesenchymal cells phenocopied defects caused by global Nr3c1 deletion, while lung epithelial- or endothelial-specific Nr3c1 deletion did not impair lung function at birth. (stanford.edu)
  • During aging, a subset of AT2 cells expressing the canonical Wnt target gene, Axin2, function as stem cells, renewing themselves while generating new AT1 and AT2 cells. (stanford.edu)
  • A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
  • Moreover, SHIP2 is more active in colorectal cancer tissue, suggesting that SHIP2 can induce oncogenesis in colonic epithelial cells. (oncotarget.com)
  • Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of gene expression within and amongst individual cells. (plantae.org)
Membrane1
  • Defective gene expression of the membrane complement inhibitor CD46 in patients with progressive immunoglobulin A nephropathy. (edu.pl)
Immune2
  • The disruption of this balance causes either the systemic invasion of microbes or harmful host immune stimulation damaging intestinal tissue. (nature.com)
  • Two distinct subtypes of LIHC were identified based on cuproptosis-related genes, with different prognosis and immune characteristics. (biomedcentral.com)
Organ2
  • This strategy often results in undesirable side-effects such as hair loss and normal tissue/organ damage. (justia.com)
  • It is widely used in organ and tissue transplantation and skin diseases (eg, psoriasis, atopic dermatitis). (medscape.com)
Protein1
  • 923 Mb) provided the information about 55930 protein-coding genes and 339 microRNA genes present in the genome. (plantae.org)
Predictive1
  • We used multiple feature selection layers followed by the XGBoost regression model and reduced the complexity of 20,000 gene expression values to generate a 16-gene signature leading to the identification of a set of predictive candidate biomarkers which form an LP-184 response gene signature. (biomedcentral.com)
Normal3
  • The interval between cycles should be the shortest one that allows recovery of normal tissues. (msdmanuals.com)
  • We found that SHIP2 and INPPL1 expression is increased in colorectal cancer tissue in comparison to adjacent normal tissue, and this is correlated with decreased patient survival. (oncotarget.com)
  • Proto-oncogene is a normal gene that can become an oncogene due to mutations or increased expression. (pvpharma.com)
Regression2
  • We then extracted the expression of cuproptosis-related genes and established a prognostic model by lasso cox regression analysis. (biomedcentral.com)
  • Using lasso cox regression analysis, we developed a prognostic risk model based on three cuproptosis-related genes (GCSH, LIPT1 and CDKN2A). (biomedcentral.com)
Mechanisms2
  • We integrated genome-wide gene expression profiling, ATAC-seq, and single cell RNA-seq data in mice in which GR was deleted or activated to identify the cellular and molecular mechanisms by which glucocorticoids control prenatal lung maturation. (stanford.edu)
  • Although the mechanisms of action through which hydroxytyrosol exerts its effects have yet to be fully determined, this agent affects the expression of various components of the inflammatory response, possibly through the modulation of the nuclear factor-kappa B (NF-kB) pathway. (blogspot.com)
Malignant1
  • Together, these data indicate that SHIP2 expression contributes to the malignant potential of colorectal cancer, providing a possible target in the fight against this devastating disease. (oncotarget.com)
Methods1
Pulmonary1
  • of the three forms it can take when involving pulmonary tissue, nodular pulmonary amyloidosis is the most uncommon. (bvsalud.org)
Targets1
  • AL102 is designed to inhibit the expression of Notch gene targets by blocking the final cleavage step by the gamma secretase required for Notch activation. (gcs-web.com)
Therapy1
  • Dr. Ho did her PhD work in herpesvirus pathogenesis and postdoctoral research in CNS gene therapy with viral vectors at Stanford University. (stanford.edu)
Multiple1
Development1
  • Open data on the gene expression of the NCI-60 cell lines, provides a unique opportunity to add another dimension to the preclinical development of such drugs by interrogating correlations with gene expression patterns. (biomedcentral.com)
Occurs1
Analysis2
  • The sample can then be used for oncogene analysis, as well as creating an autologous (made from the patient's own tissue) vaccine. (dunphynunley.com)
  • Treating a cancer without oncogenetic (cancer gene) analysis is like trying to tell where a ship is coming from when it is thirty miles from the shore, without a telescope. (dunphynunley.com)
Addition1
  • In addition, hyperbaric oxygen may improve the healing of radiation-induced injuries by improving oxygen delivery to damaged tissue. (blogspot.com)