• Mammary fibroadenoma: A fibrous, benign, epithelial tumor in which cells are derived from glandular tissue. (ratguide.com)
  • They are benign but are precursors to adenocarcinoma. (anatomywarehouse.com)
  • On the basis of histologic similarities and distribution pattern, the histogenesis for most of the benign (adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum) and malignant (adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma) glandular tumors arising in the EAC is in all likelihood the ceruminous glands or their embryologic anlage. (medscape.com)
  • [ 29 , 30 ] Studies suggest that even if the site is restricted to tumors of the external auditory canal (EAC), glandular tumors are much less common (though these studies focused on carcinomas and did not record the presence of benign tumors). (medscape.com)
  • Benign tumors do not spread into, or invade, nearby tissues. (cancer.gov)
  • Ab-3 shows no reaction with a variety of normal tissues .CEA is not found in benign glands, stroma, or malignant prostatic cells. (samatashkhis.com)
  • 2. A benign neoplasm composed of glandular and fibrous tissues, with a relatively large proportion of glands. (wordquests.info)
  • A benign neoplasm composed of glandular and adipose tissues. (wordquests.info)
  • 1. A benign tumor of glandular origin or with a gland-like cell arrangement. (wordquests.info)
  • Study of prostate tumor profiles showed that the profile (PSA+, PSMA-) expression levels decreased between normal prostate, benign prostatic tissue and primary prostate cancer. (biomedcentral.com)
  • 1,8 The detection of CK5 in basal cells is a feature of normal and benign prostatic processes and the absence of CK5 is indicative of prostate adenocarcinoma. (roche.com)
  • Additionally, CK5 is expressed in myoepithelial cells (MECs) in normal breast tissue and benign processes. (roche.com)
  • many of these benign yet floridly proliferative lesions have been mistaken for invasive adenocarcinoma. (fliphtml5.com)
  • 2Introduction The distinction between benign proliferative glandular lesions of the endocervixand well-differentiated invasive cervical adenocarcinoma continues to be problematic, ashighlighted by the number of reports in the literature considering this diagnostic issue.Interestingly, the relatively recent recognition of a number of potential mimics ofinvasive adenocarcinoma of the endocervix underscores the likelihood that in the pastmany of these benign yet floridly proliferative lesions have been mistaken for invasiveadenocarcinoma. (fliphtml5.com)
  • For instance, in one institutional review five cases diagnosed asinvasive adenocarcinoma over a 14-year period were reclassified as benign mimics (1).Although a variety of immunoperoxidase stains have been tried, ultimately therecognition of benign pseudoneoplastic glandular lesions of the cervix rests upon theirdistinctive histologic features. (fliphtml5.com)
  • A number of benign processes may mimic adenocarcinoma in situ, invasiveadenocarcinoma or both. (fliphtml5.com)
  • Benign Mimics of Invasive Adenocarcinoma of the Cervix Tunnel Clusters Microglandular Hyperplasia Mesonephric Hyperplasia Endocervical Glandular Hyperplasias Arias-Stella ReactionTunnel Clusters Fluhmann first introduced the term "tunnel cluster" in his description of thehistology of the endocervix (2;3). (fliphtml5.com)
  • According to the World Health Organization's histopathologic classification, gastric adenomyoma is a benign tumor of the stomach characterized by a smooth muscle stroma in the glandular structures of the cuboidal epithelium or columnar epithelium [ 1 ]. (biomedcentral.com)
  • It has nipple-like structures with fibrovascular cores (papillae) that are long in relation to their width (villus-like), which are covered with a glandular pseudostratified columnar epithelium. (wikipedia.org)
  • During subsequent histological observation of the pancreas, it was discovered that the glandular epithelial cells had lost the pancreatic acinar structure, tubular areas with obvious structure in the pancreas, and the ductal epithelium was substituted by high columnar mucus cells. (bvsalud.org)
  • Of note, differentiated goblet cells retained longer telomeres than columnar lined BE epithelium. (oncotarget.com)
  • In conclusion, our studies suggest that shortened telomeres are functionally important for tumor development in a mouse model of BE and are associated with proliferating columnar epithelium in human BE. (oncotarget.com)
  • Both of the two types of endometrial glands are lined with pseudostratified columnar or cubic-storey epithelium. (fuyanpills.com)
  • Claudin-2 expression was examined by immunohistochemistry on tissue microarrays, containing EAC, high grade dysplasia (HGD), low grade dysplasia (LGD), Barrett's esophagus (BE), columnar cell metaplasia (CM), squamous cell carcinoma (SCC), and squamous epithelium (SE) cases. (biomedcentral.com)
  • Barrett's esophagus (BE) is an acquired condition in which normal squamous epithelium is replaced with metaplastic columnar epithelium as a consequence of gastroesophageal reflux disease. (jcancer.org)
  • Barrett's esophagus (BE), also defined as columnar-lined esophagus, is a metaplastic condition in which the normal non-keratinizing squamous epithelium of the esophagus is replaced by a columnar mucosal epithelium [ 1 , 2 ]. (jcancer.org)
  • The region of columnar esophageal metaplasia is considered the "cancerization field" in which esophageal adenocarcinoma (EAC) develops [ 3 - 5 ]. (jcancer.org)
  • 3Type A tunnel clusters Type A tunnel clusters are characterized by a lobulated proliferation of small,closely packed glands that are lined by columnar mucinous epithelium. (fliphtml5.com)
  • Using tissue microarrays and full tissue sections of normal and 448 neoplastic tissues, HE4 immunoreactivity was found in normal glandular epithelium of the female genital tract and breast, the epididymis and vas deferens, respiratory epithelium, distal renal tubules, colonic mucosa, and salivary glands, consistent with HE4 gene expression. (nature.com)
  • An OCT probe can be passed through the accessory channel of an endoscope and can be kept in contact with the mucosa of interest which allows for a resolution of 7-10 micrometers and an imaging depth of 2-3 mm depending on the wavelength of light used and the type of tissue being imaged [ 6 , 7 ]. (hindawi.com)
  • Compared to EAC, squamous mucosa for healthy controls (SqN) was defined by a strong aldehyde oxidation theme (Fig. 1 a, b and Supplementary Data 3 ), suggesting reduced aldehyde defense in EAC tissue. (nature.com)
  • Introduction/Background Vaginal adenosis occurs when normal squamous cell mucosa is replaced with metaplastic glandular epithelium. (bmj.com)
  • Adenoma is a tumour of glandular tissue originating from the mucosa of uterus, small intestine or colon, in which tumour cells start to grow, these adenomas may be pedunculated or sessile too. (planetayurveda.net)
  • Tumors can arise anywhere that mammary tissue type is present but is most often seen at the pit of the arm, abdomen, and groin of female rats. (ratguide.com)
  • The concentrations of these hormones are found to be higher in hormone dependent tumors, whereas in hormone independent tumors (as seen in latter stages of mammary adenocarcinoma) they tend to be lower. (ratguide.com)
  • Many of these reported middle ear tumors might have been better classified as middle ear adenoma or as neuroendocrine adenoma of the middle ear (NAME), tumor types that are believed to arise from the epithelium of the middle ear rather than from ceruminous glands. (medscape.com)
  • far fewer tumors are derived from glandular elements. (medscape.com)
  • These cells may form tumors, which are lumps of tissue. (cancer.gov)
  • Cancerous tumors spread into, or invade, nearby tissues and can travel to distant places in the body to form new tumors (a process called metastasis ). (cancer.gov)
  • Many cancers form solid tumors, which are masses of tissue. (snehita.in)
  • Cancerous tumors are malignant, which means they can spread into, or invade, nearby tissues. (snehita.in)
  • whereas all other epithelioid soft tissue tumors including clear cell sarcoma, epithelioid sarcoma, epithelioid hemangiosarcoma, PEComa and melanoma were negative. (chemdict.com)
  • Histologically, all cases were characterized by discrete to confluent, polypoid, adenomatous masses of hyperplastic mucosal epithelium that formed papilliferous projections and glandular structures lined by pseudostratified epithelium and hyperplastic goblet cells overlying a fibrous connective tissue stroma. (vin.com)
  • Histologically, the mass comprises a core of connective tissue covered with hyperplastic glandular epithelium of colonic type, with focal nuclear atypia. (anatomywarehouse.com)
  • A significant difference in their expression was see in hyperplastic and neoplastic prostates tissues (16.14 ± 0.17 and 30.72 ± 0.85, respectively) for PSMA and (34.39 ± 0.53 and 17.85 ± 1.21, respectively) for PSA. (biomedcentral.com)
  • Uniformly strong immunoreactivity for both TGF-beta receptor proteins, R-I and R-II, was exclusively localized to the prostatic glandular epithelium of normal prostates. (nih.gov)
  • The transition zone accounts for 10% of the prostatic glandular tissue and 20% of the adenocarcinomas. (medscape.com)
  • The feasibility of OCT for carrying out in vivo real time imaging of Barrett's esophagus, high grade dysplasia and esophageal adenocarcinoma has been well demonstrated (Figures 1 , 2 , and 3 ). (hindawi.com)
  • High grade dysplasia and esophageal adenocarcinoma images exhibited more heterogeneous structures corresponding to irregular, heterogeneous tissue morphology from distorted and cribriform or villiform glandular architecture. (hindawi.com)
  • In addition, pilot studies of human BE-, dysplasia- and EAC tissue samples confirmed that BE epithelial cells with or without dysplasia (LGD) had shorter telomeres compared to gastric cardia tissue. (oncotarget.com)
  • Previous studies have suggested a sequence of events leading to EAC that starts from normal esophageal squamous epithelium to reflux esophagitis, followed by BE, dysplasia, and finally EAC [ 2 ]. (biomedcentral.com)
  • The adenomatous proliferation is distinguished by different degrees of cell dysplasia ( loss of normal epithelium ). (planetayurveda.net)
  • The pathology showed that: severe chronic cervical inflammation, accompanied by low Cervical Intraepithelial Glandular Neoplasia (CIGN), focal area cervical intraepithelial moderate-severe dysplasia, and small focal Cervical Intraepithelial Neoplasia (CIN) I-II grade. (biomedres.info)
  • Using single primary murine pancreatic ductal adenocarcinoma (PDAC) cells embedded in a collagen matrix and adapted media supplementation, we generate organoids that self-organize into highly branched structures displaying a seamless lumen connecting terminal end buds, replicating in vivo PDAC architecture. (tum.de)
  • Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant cancer of the digestive system common among humans. (bvsalud.org)
  • Masson staining showed that there were several fibrous tissue proliferative reactions around the ductal adenocarcinoma and immunohistochemical staining revealed that CK7 and CK19 were positively expressed in the pancreatic tissue. (bvsalud.org)
  • This allows visualization of histologic morphology in real time, especially the epithelial structures such as villi, crypts, and squamous and intestinal epithelium. (hindawi.com)
  • In their study using ultra-high resolution OCT, Chen and colleagues [ 16 ] demonstrated characteristic layered epithelium in a normal esophagus with normal architecture, while images of Barrett's esophagus corresponded to crypt-like glandular structures. (hindawi.com)
  • [ 3 ] The remaining majority of the ear canal contains a thin layer of epithelium lining dense bone and contains no adnexal structures. (medscape.com)
  • 1. A tumor composed of connective tissue containing glandular structures. (wordquests.info)
  • CK5 is a type II CK (high molecular weight, 62 kDa) expressed in the basal and myoepithelial cells of various epithelia and glandular structures including the bronchi, prostate and breast. (roche.com)
  • Sections show fibrous connective tissue with dissecting pools of mucin associated with scanty strips of malignant glandular epithelium in keeping with metastatic mucinous adenocarcinoma. (cancer.org)
  • Invasion through the baseman membrane into the underlying connective tissue ( in the stomach that is into the lamina propria). (imperial.ac.uk)
  • The rectovesical fascia is a connective tissue that is located between the anterior wall of the rectum and posterior aspect of the prostate. (medscape.com)
  • It curves backward and abruptly downward to enter the delicate connective tissue investment of the porta hepatis. (clinicalgate.com)
  • Acute inflammation of a gland and the adjacent connective tissue. (wordquests.info)
  • Together, this suggests the esophagus is exposed to aldehyde stress, and that glandular esophageal cells may be vulnerable to this stress. (nature.com)
  • Barrett's esophagus (BE) is a precursor of the esophageal adenocarcinoma (EAC). (oncotarget.com)
  • Separation or ectopia of glands or glandular tissue from their usual anatomical sites, e.g., pancreatic glands in the wall of the small intestine, gastric glands in the wall of the esophagus. (wordquests.info)
  • Adenocarcinoma occurs in the distal esophagus. (msdmanuals.com)
  • However, up to 40% of lesions larger than 4cm in diameter progress to adenocarcinoma. (anatomywarehouse.com)
  • These lesions were biopsied and the result was consistent with adenocarcinoma (malignant transformation of the vaginal adenosis). (bmj.com)
  • Recently, we found that vitamin D receptor (VDR) enhanced Claudin-2 expression in colon and that bile salt receptors VDR and Takeda G-protein coupled receptor5 (TGR5) were highly expressed in esophageal adenocarcinoma (EAC) and precancerous lesions. (biomedcentral.com)
  • It was significantly more highly-expressed in EAC, SCC and glandular lesions than in SE and more in EAC than in BE and CM. A significant association was found between Claudin-2 expression and VDR and TGR5 expression. (biomedcentral.com)
  • CK5 is expressed in the basal epithelium of the lung and its overexpression is an indicator of malignant squamous differentiation in pulmonary lesions. (roche.com)
  • Volatile aldehydes are enriched in esophageal adenocarcinoma (EAC) patients' breath and could improve early diagnosis, however the mechanisms of their production are unknown. (nature.com)
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
  • Nonsmall-cell lung cancer (NSCLC) is also divided into three categories: (1) superficial tissue cancer, (2) mucosal epithelial gland cancer (glandular epithelium), and (3) large-cell lung cancer. (ccij-online.org)
  • About 40% of lung cancers are "adenocarcinomas," which usually form in the lateral lung tissue. (ccij-online.org)
  • Newcomer Supply E-cadherin Control Slides are for the positive immunohistochemical staining of E-cadherin, expressed in epithelial lineage and glandular epithelium cells as well as adenocarcinoma of the lung, gastrointestinal tract, and ovary. (newcomersupply.com)
  • MUC4 is expressed in the cytoplasm of certain epithelial surfaces, such as colonic, breast, and lung epithelia. (chemdict.com)
  • Lung cancer is a malignant tumor starting point of glandular bronchial epithelium. (about-health-problems.com)
  • Subsequently, she underwent cervical conisation, and her results were consistent with invasive cervical adenocarcinoma with negative margins. (bmj.com)
  • In 1994, it was classified as the pathological type of cervical cancer by WHO in 1994, which is a subtype of cervical adenocarcinoma. (biomedres.info)
  • Adenocarcinoma is a type of cancer that develops in glandular tissue and is typically found in the epithelium and salivary glands. (allenstewart.com)
  • The prostate consists of approximately 70% glandular tissue and 30% fibromuscular stroma. (medscape.com)
  • Cuboidal Adenocarcinoma is considered a precursor to nasal cancer and refers to the abnormal growth of cells in the sinonasal cavity. (allenstewart.com)
  • New abnormal growth of tissue. (lookformedical.com)
  • Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. (lookformedical.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • However, as testosterone is released in the male rat fetus before mammary tissue development occurs the mammary glands are rudimentary, and they do not have nipples. (ratguide.com)
  • Sinonasal Adenenocarcinoma is a form of Adenocarcinoma affecting the nasal cavity glands. (allenstewart.com)
  • Like other apocrine-related glands, including mammary tissue, ceruminous glands are composed of an inner secretory layer of cells and an outer myoepithelial layer of cells. (medscape.com)
  • Absence of glands or abeyance of glandular functions. (wordquests.info)
  • The common admixture of type A and B tunnelclusters, in combination with the predominantly lobulated architecture, absence ofdesmoplasia and lack of deep, widely infiltrative glands helps distinguish it fromadenoma malignum.Type B tunnel clusters Type B tunnel clusters also have a lobular architecture, but are composed ofdilated glands lined by cuboidal or flattened epithelium and filled with inspissated,mucinous secretions. (fliphtml5.com)
  • In this study, we investigated the expression of the two types of TGF-beta1 receptors, R-I and R-II, in a normal human prostate, primary prostate adenocarcinoma and lymph nodes with metastatic deposits. (nih.gov)
  • The prostate arises from a budding collection of tissue in the urogenital sinus. (medscape.com)
  • In our study we found that in normal prostate tissue, PSMA and PSA were equally expressed (3.7 ± 0.18 and 3.07 ± 0.11). (biomedcentral.com)
  • In the other hand, the profile (PSA-, PSMA+) expression levels increased from normal to prostate tumor tissues. (biomedcentral.com)
  • With regard to the duality PSMA-PSA, this implies the significance of their investigation together in normal and pathologic prostate tissues. (biomedcentral.com)
  • Although the PSMA have been noted in a subset of non prostatic tissues (small intestine, proximal renal tubule), the level of expression of PSMA in these tissues is less than in prostate tissue [ 14 ]. (biomedcentral.com)
  • Pap test result showed atypical glandular cells. (bmj.com)
  • AGUS stands for atypical glandular cells of undetermined significance. (com.ng)
  • Villoglandular adenocarcinoma of the cervix is a rare type of cervical cancer that, in relation to other cervical cancers, is typically found in younger women and has a better prognosis. (wikipedia.org)
  • Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). (samatashkhis.com)
  • 4,5 The immunohistochemistry (IHC)-based detection of CK5 with anti-Cytokeratin 5/6 (D5/16B4) antibody can be used to aid in the distinction between pulmonary SCCA and pulmonary adenocarcinoma (ADC). (roche.com)
  • Rarely, adenocarcinomas arise within endometrial polyps. (slideserve.com)
  • Epithelial tissue from both the rat BE model and human BE patients strongly expressed KLF5, CDX2, MUC2, and villin. (jcancer.org)
  • Expression of receptor proteins was examined by immunohistochemical analysis in paraffin-embedded prostatic tissue sections, and mRNA expression was determined by Northern blot and RT-PCR analysis. (nih.gov)
  • Immunohistochemistry (IHC) on paraffin embedded tissues. (samatashkhis.com)
  • Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Anti-Cytokeratin 5/6 (D5/16B4) Mouse Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of cytokeratin 5 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument. (roche.com)
  • MRI demonstrated no residual neoplastic tissue with cystic changes on the proximal and middle third of the vagina. (bmj.com)
  • Cancer is a disease caused when cells divide uncontrollably and spread into surrounding tissues. (cancer.gov)
  • In all types of cancer, some of the body's cells begin to divide without stopping and spread into surrounding tissues. (snehita.in)
  • Immunohistochemical staining showed that CK7 , CA72-4 , CEA , CA125 and P16 expression were positive in tumor tissues, but ER , PR , P53 and Vimentin were negative. (biomedres.info)
  • Intestinal Type Adenocarcinoma is extremely malignant and those diagnosed with this type of nasal cancer often have a poor prognosis. (allenstewart.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Cancer cells are also often able to evade the immune system, a network of organs, tissues, and specialized cells that protects the body from infections and other conditions. (snehita.in)
  • The tissue (biopsy, performed generally by fibroscopy bronchitis) or cancer cells (by sputum analysis) allow confirmation of the diagnosis. (about-health-problems.com)
  • A few notes on each cancer site and its subgroups staining techniques (e.g., glandular and diffuse neoplasms of are included in this chapter. (who.int)
  • Clinically, the most significant histological forms are malignant neoplasms developing from the integumentary squamous epithelium of the external genital organs. (med-blog.com)
  • Axillary PD can arise from underlying axillary accessory breast tissue. (medscape.com)
  • Typically seen as a soft, circumscribed (round), or somewhat flat appearing growth that can be movable on palpation, to a more firm and attached growth (seen more in malignancy) anywhere along the region of mammary tissue. (ratguide.com)
  • however, the expression in normal and malignant adult tissues has not been examined in detail. (nature.com)
  • Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
  • Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
  • The development dynamics and self-organization of glandular branched epithelia is of utmost importance for our understanding of diverse processes ranging from normal tissue growth to the growth of cancerous tissues. (tum.de)
  • The ectopic occurrence or diffuse implantation of adenomatous tissue in muscle (usually smooth muscle). (wordquests.info)