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  • lamellar
  • Thus, the sequential dynamic culture process that was designed according to corneal physiological characteristics could successfully reconstruct an auto-lamellar cornea with favorable morphological characteristics and satisfactory physiological function. (jove.com)
  • With the input of corneal surgeons, eye banks have developed thorough protocols to safely and effectively prepare posterior lamellar tissue for DSAEK surgery. (jove.com)
  • In part because of the ability of the eye banks to provide high quality posterior lamellar corneal in a timely manner, DSAEK has become the standard of care for surgical management of corneal endothelial disease. (jove.com)
  • shortage
  • Reprocessing the tissue has the potential to have a considerable impact on addressing the problems associated with cadaveric donor shortage. (lboro.ac.uk)
  • infiltration
  • The therapeutic procedure and its timing depend on various conditions, such as cause, location, size of perforation, corneal infiltration and melting, and state of internal globe tissues [ 1 , 4 - 7 ]. (hindawi.com)
  • membranes
  • These approaches range from the use of natural membranes, biological polymers and biosynthetic material compositions, to completely synthetic materials as matrices for corneal endothelial cell sheet generation. (mdpi.com)
  • disease
  • Corneal disease can be caused by illnesses such as Aniridia or Steven Johnson Syndrome as well as by external factors such as chemical burns or radiation. (jove.com)
  • The donor tissue is carefully screened to prevent transmission of disease to the recipient. (cornealassociates.com)
  • transplantable
  • This review gives an overview about currently used materials for the generation of transplantable corneal endothelial cell sheets with a special focus on thermo-responsive polymer coatings. (mdpi.com)
  • CECs
  • Delivery of molecules into CECs by carbon nanoparticles activated by femtosecond laser could prove useful for future cell or tissue therapy. (jove.com)
  • immunomodulatory
  • However, all of these manipulations have involved systemic immunomodulatory strategies, leaving open the specific role of tissue-expressed PD-Ls in regulating the alloimmune response. (jimmunol.org)
  • physiological
  • There is a need to design and manufacture new corneal biomaterial devices able to mimic in detail the physiological environment where stem cells reside in the cornea. (jove.com)