Tissues bcl x protein. Medical search. Frequent questions

Apoptosis factor EI24/PIG8 is a novel endoplasmic reticulum-localized Bcl-2-binding protein which is associated with suppression of breast cancer invasiveness.Zhao X., Ayer R.E., Davis S.L., Ames S.J., Florence B., Torchinsky C., Liou J.S., Shen L., Spanjaard R.A.Cancer Res. (joplink.net)
For example, excessive inhibition by which tissue remodeling takes place during normal of apoptosis is an underlying mechanism of cancer, while growth and development and the physiologic mechanism an inappropriate increase is seen in some neurodegenera- by which labile cell populations such as gastrointestinal tive diseases and other conditions. (cdc.gov)
Over the last few decades, it has been studied that the mechanisms of cisplatin-induced kidney damage are complex and involved numerous cellular and molecular processes including inflammation, apoptosis, accumulation of cisplatin in renal tubular cells via renal drug transporters, Ctr1 and OCT2, and involvement of mitogen-activated protein kinases (MAPK) pathways [ 3 ] [ 4 ]. (thieme-connect.com)
The expression of P2Y12 increased in OA cartilage tissue, and P2Y12 inhibited apoptosis. (researchsquare.com)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
Exposure to cerium oxide nanoparticle s is associated with activation of mitogen-activated protein kinases signaling and apoptosis in rat lungs. (cdc.gov)
No investigation has yet been performed to assess whether respiratory tract exposure to cerium oxide (CeO2) nanoparticle s is associated with alterations in protein signaling, inflammation, and apoptosis in rat lungs. (cdc.gov)
Lung tissues were collected and evaluated for the expression of proteins associated with inflammation and cellular apoptosis. (cdc.gov)
Given the critical roles of BCL-2 family proteins in maintaining cellular homeostasis, perturbation of the complexes between pro- and antiapoptotic BCL-2 proteins or their levels of expression could alter the cellular homeostatic balance and lead to overcoming apoptosis. (chemdiv.com)
The present study explored the effect of NAC on LPS‑induced apoptosis of HUVECs and determined the participation of the p38 mitogen‑activated protein kinase (MAPK) pathway in the process of apoptosis. (spandidos-publications.com)
A series of caspases proteins have been shown to be activated by the death induced signal complex [a form of death ligand that binds to the corresponding death receptor on the cell surface ( 13 )], which in turn induces apoptosis. (spandidos-publications.com)
The t(14;18) translocation (characteristic for follicular lymphoma but also common in other types) results in activation of the BCL-2 gene and suppression of apoptosis. (oncolink.org)
Apoptosis (programmed cell death) is essential for development and tissue maintenance in many organisms. (biologists.com)
In mammals and C. elegans , Bcl-2 family proteins facilitate apoptosis by regulating mitochondrial dynamics but do they play a similar role during apoptosis in Drosophila ? (biologists.com)
In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
Reactive oxygen species (ROS) level was determined using 2,7-dichlorodi-hydro fluorescein diacetate (DCFHDA) while Western blotting was used to determine the expression of apoptosis- and RISK signaling pathway-related proteins in kidney tissues. (ajol.info)
Sevoflurane represses the release of inflammatory factors, lowers ROS level and apoptosis of renal cells and improves renal function through activation of RISK signaling pathway in kidney tissues of rats with renal IRI. (ajol.info)
Our study suggests that TFs can decrease cell apoptosis, which may be mediated by altering the expression of miR-21, PTEN/Akt, and Bcl/Bax. (hindawi.com)
Prostate carcinoma cells have increased proliferation indices and lower levels of apoptosis when compared to benign tissue. (canjurol.com)
This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. (nih.gov)
Apoptosis is essential for many fundamental processes, such as embryogenesis and tissue homeostasis. (nature.com)
Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
Additionally, the anti-apoptotic protein Bcl-2 was elevated prompting us to study the effect of LTD4 on survival and apoptosis. (lu.se)

An alternative model proposes the opposite, that HK2 regulates binding of the anti-apoptotic protein Bcl-Xl to VDAC. (wikipedia.org)
The pro-apoptotic function of bcl-XL is realized by binding to anti-apoptotic protein Bcl-XL and inhibiting its anti-apoptotic activity. (researchsquare.com)
As an important anti-apoptotic protein, dissociated Bcl-XL mainly binds to BAK or Bax and inhibits the pore-promoting activity of BAK or Bax [ 10 ] to achieve its anti-apoptotic function. (researchsquare.com)
In addition, the present study indicated that treatment with GP suppressed the I/R-induced increase in the pro-apoptotic protein levels of Bax and cytochrome c and the activity of caspase-3/8, as well as the I/R-induced decrease in the levels of anti-apoptotic protein Bcl‑2. (spandidos-publications.com)

The viral transactivating protein p40Tax activates the genes for interleukin-2 (IL-2) and its receptor's high-affinity alpha chain. (medscape.com)
Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
But in humans, these genes are spliced together in different ways to create various kinds of messenger RNA to produce the many different proteins humans require. (sciencedaily.com)
For one of the genes we study, which is called Bcl-x, we want the short form because it has anti-cancer properties. (sciencedaily.com)
RESULTS: Whole genome sequencing analysis identified 260 genes that showed increased prevalence of single-nucleotide variations in exonic regions with high (>20) combined annotation-dependent depletion scores between persons with high versus low intramuscular adipose tissue levels when cross-referenced with persons who had recurrent PIs. (bvsalud.org)
Gene set enrichment analysis using Hallmark and KEGG (Kyoto Encyclopedia of Genes and Genomes) gene sets of these candidate genes revealed enrichment in genes encoding proteins involved in fatty acid metabolism (P (bvsalud.org)

HK2 gene expression is regulated by a phosphatidylinositol 3-kinaselp70 S6 protein kinase-dependent pathway and can be induced by factors such as insulin, hypoxia, cold temperatures, and exercise. (wikipedia.org)
Activation of P2Y12 receptor first phosphorylates BAD through the PI3K Akt pathway, and the liquid acidified BAD binds to 14-3-3 protein to separate BAD from BAD Bcl-XL complex, thus releasing free Bcl-XL. (researchsquare.com)
To achieve the effects of controlling cell fate, small molecules have been developed to compensate for the imbalance between pro- and antiapoptotic BCL-2 proteins and restore the apoptotic pathway. (chemdiv.com)
We have demonstrated the MicroRNA-873-5p-p53/ Bcl-2 Associated X-protein regulatory pathway in the development of glioma, which provides a theoretical basis for the development of the alternative strategies for the clinical treatment of glioma. (ijpsonline.com)
Akt (PKB) is a serine threonine protein kinase downstream of the phosphoinositide 3-kinase (PI3K) pathway. (biomedcentral.com)

Mutations of the B-cell CLL/lymphoma 6 ( BCL-6 or zinc finger protein 51) gene have been associated with LIP and mucosa-associated lymphoid tissue (MALT) lymphoma. (medscape.com)
Together with B cell lymphoma (Bcl)10 and the paracaspase, mucosa-associated lymphoid tissue lymphoma translocation protein (Malt)1, Card9 links spleen-tyrosine kinase (Syk)-coupled C-type lectin receptors to inflammatory responses. (nih.gov)
Venetoclax (Venclexta) targets the B-cell lymphoma 2 (BCL-2) protein, leading to the death of CLL cells. (cancercare.org)

GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
MCL-1 is widely expressed in human tissues and is primarily located in the mitochondria in cells, in which it inserts into the mitochondrial membrane via a hydrophobic tail. (chemdiv.com)
These mitochondrial dynamics, they report, are dependent on caspases, the Bcl-2 family, the mitochondrial fission and fusion machinery and the autophagic machinery. (biologists.com)
Thus, the researchers conclude, Bcl-2 family proteins do play a major role in controlling both mitochondrial dynamics and cell death in the Drosophila ovary. (biologists.com)
0.01) of cytochrome c, a mitochondrial protein associated with cell death. (uwaterloo.ca)
Outer mitochondrial membrane permeabilization and cytochrome c release are typically achieved by pro-apoptotic Bcl-2 proteins, such as Bax and Bak. (nature.com)

These include members of the Bcl-2 protein family, course, and extent of programmed cell death will aid man- which have both proapoptotic and antiapoptotic activity agement of patients with severe infections. (cdc.gov)
Bcl-2 is antiapoptotic), and other inhibitors (Figure 1). (cdc.gov)
Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins. (chemdiv.com)
The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. (thermofisher.com)

BCL2L11 interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and acts as an apoptotic activator. (neuromics.com)
Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: Biological and clinical implications. (ucy.ac.cy)

Kinase inhibitors block these proteins. (cancercare.org)

The relationship between the expression of p53, Bcl-2 Associated X-protein and MicroRNA-16-5p was studied by dual-luciferase gene assay, Quantitative Reverse transcription- polymerase chain reaction, and Western blotting. (ijpsonline.com)
The results of Quantitative Reverse transcription- polymerase chain reaction and Western blotting showed that the target gene of MicroRNA-16-5p was p53, and the over expression of MicroRNA-16-5p could promote the expression of p53 and Bcl-2 Associated X-protein, which was positively correlated. (ijpsonline.com)

It may be through decreasing the serum IL-6 and TNF-α levels and FasmRNA, FasLmRNA, Bax protein expression and increasing the Bcl-2 mRNA expression of the liver tissues that XCHT significantly relieved the D-galactosamine -induced liver injury. (nih.gov)
Also, cisplatin increased ERK1/2 phosphorylation and NF-κB expression, which subsequently increased mRNA expression of TNF-α, IL-6, KIM-1, NGAL, and Bax/Bcl-2 ratio as well as decreased mRNA expression of IL-10 in kidney tissues. (thieme-connect.com)

One model proposes that HK2 competes with the pro-apoptotic proteins BAX to bind VDAC, and in the absence of HK2, BAX induces cytochrome c release. (wikipedia.org)
Definition of the homologous of bovine subunit VII of ubiquinol-cytochrome C reductaseshould facilitate further analysis of structure/function relationships of silkworm cytochrome bcl complex. (researchgate.net)
Apoptotic proteins (Bcl-2, caspase 3, Bax, cytochrome c), inflammatory cytokine proteins (TNF-α and IL-10) and a transcription factor for pro-inflammatory cytokines (NFκB) were determined in isolated mouse IL by Western blot analysis. (uwaterloo.ca)
3 Pro-apoptotic proteins, such as cytochrome c and second mitochondria-derived activator of caspase (SMAC), are released from mitochondria into the cytosol where they participate in the activation of execution caspases. (nature.com)

Immunohistochemistry (% stained area) was used to assess active caspase‐3, Bax, Bcl‐2 and cell‐cycle proteins ( PCNA ). (mcmaster.ca)
We examined by immunohistochemistry the expression of the bcl-2 protein in sixty-eight cases of operated breast carcinoma patients (stage I, II and III) and correlated the findings with the prognosis. (ucy.ac.cy)
Expression of the hormone-related proteins hsp27, pS2, and also of cathepsin D (CD) and metallothionein (MT) was studied by immunohistochemistry and analyzed against clinical data in breast cancer. (ucy.ac.cy)
The histopathologic change of liver tissue wasevaluated by H&E staining and immunohistochemistry. (cnki.net)
In the present study, BCRP expression was assessed in clinical breast cancer tissue specimens using quantitative reverse em - /em transcriptase polymerase chain reaction (RT em - /em PCR) by use of the Master SYBR-Green I reagent and immunohistochemistry (IHC) by use of the BXP em - /em 21 anti em - /em BCRP monoclonal antibody. (monossabios.com)

It has been previously shown that rbf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy. (sdbonline.org)
We conclude that high levels of pre‐natally administered glucocorticoid reduce foetal testicular development, perhaps via changes in the balance between pro‐ and anti‐apoptotic proteins and cell‐cycle proteins. (mcmaster.ca)
There are also reports that bLf can alter apoptotic proteins in the intestinal epithelium to favour cell death. (uwaterloo.ca)

YAP activity could be also inhibited through the relationships with angiomotin (AMOT) family members proteins, which result in localization and sequestration from the YAP proteins to limited junction 29C31. (colinsbraincancer.com)
Our research isolated several previously reported YAP-binding companions - like the TEAD family members Rabbit Polyclonal to HSF2 protein, 14-3-3 protein, LATS1, the angiomotin protein AMOT/AMOTL2, PATJ, LIN7C and PALS1- and many book or not-well-studied YAP-associated protein, including PTPN14 and MUPP1 (Desk 1 and Desk S1). (colinsbraincancer.com)
In nucleated cells, BAD is an important target gene downstream of Akt [ 9 ] and belongs to the pro-apoptotic Bcl-2 family of proteins. (researchsquare.com)
Buffy often acts opposite to Debcl , the other Drosophila Bcl-2-family protein. (sdbonline.org)
Furthermore, cell death in the ovary is defective in Bcl-2 family mutants. (biologists.com)
Bcl-2-like protein 11 (BCL2L11) is a member of the Bcl-2 family and contains a Bcl-2 homology domain 3 (BH3). (neuromics.com)
Bax, a pro-apoptotic protein from the Bcl-2 family of proteins, has a microsatellite composed of an eight deoxyguanine [(G)8] tract located in exon 3. (canjurol.com)
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
Non-muscle cofilin (n-cofilin) is a member of the ADF/cofilin family of actin depolymerizing proteins. (nature.com)
The multidrug resistance-associated proteins was the next ABC transporter proteins to be discovered (4), accompanied by other MRP family. (monossabios.com)
BCRP is normally a newly discovered person in the ABC proteins family and serves as a power em - /em reliant efflux pump (7,8). (monossabios.com)

The expression levels of caspase‑3, Bax and Bcl‑2 mRNA were determined using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). (spandidos-publications.com)

The protective effects of TFs resulted in higher expression of miR-21 in H/R-induced H9c2 cells than that of controls, which in turn upregulated Akt signaling activity via suppressing the expression of PTEN together with decreasing the ratio of Bax/Bcl-2, caspase3, and cleaved-caspase3 expression in H/R-induced H9c2 cells. (hindawi.com)

This protein kinase is calcium-independent and phospholipid-dependent. (nih.gov)
Kinase proteins send signals to the cell's control center to help tumor cells grow. (cancercare.org)
The protein kinase Akt also known as PKB, regulates multiple cellular functions including proliferation, survival, and growth during embryonic development and adult tissue homeostasis [ 1 - 5 ]. (biomedcentral.com)
It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE. (bvsalud.org)

Although Bcl-XL and Bax do not bind directly in platelets, they may inhibit Bax activation by reducing the translocation of Bax from cytoplasm to mitochondria through some indirect effects. (researchsquare.com)

Source of all serum proteins is from USDA inspected abattoirs located in the United States. (bdbiosciences.com)
The concentration of enzymes incuding T-SOD,MDA,GSH-PX in serum and liver tissue was determined with a commercial kit. (cnki.net)
Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (msdmanuals.com)
Rarely, patients have no M-protein in blood and urine, although the currently used serum free light chain assay now demonstrates monoclonal light chains in many of these formerly so-called nonsecretory patients. (msdmanuals.com)

Lipopolysaccharide (LPS) can regulate the expression of apoptotic factors, including caspase‑3, Bcl‑2 and Bcl‑2‑associated X protein (Bax). (spandidos-publications.com)

Compared with the normal tissues, the expression of MicroRNA-16-5precursor was low in glioma tissues, which was consistent with that in the Uppsala87 and Uppsala251 cell lines. (ijpsonline.com)

BCL-2 inhibitor. (cancercare.org)

EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. (rndsystems.com)
The planarian ortholog Smed-Akt is molecularly conserved providing unique opportunities to analyze the function of Akt during cellular turnover and repair of adult tissues. (biomedcentral.com)
The reduced neoblast numbers largely affected the maintenance of adult tissues including the nervous and excretory systems and ciliated structures in the ventral epithelia, which impaired planarian locomotion. (biomedcentral.com)

Enzyme-linked immunosorbent assay (ELISA) was used to assess malonaldehyde (MDA) content and inflammatory factors in kidney tissues and peripheral blood, respectively. (ajol.info)

Furthermore, an increased protein expression of heme oxygenase-1 in the liver tissues of the I/R mice was attenuated by the administration of GP. (spandidos-publications.com)
The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. (thermofisher.com)
Blocking a key protein involved in the growth of a rare, incurable type of soft-tissue cancer may eliminate the disease, according to a new study involving mice. (ladylively.com)

In particular, HK2 is ubiquitously expressed in tissues, though it is majorly found in muscle and adipose tissue. (wikipedia.org)

Tissue regeneration is a fascinating phenomenon, but the cellular and molecular mechanisms underlying regeneration remain incompletely understood. (biologists.com)
Nonetheless, there is limited understanding of how Akt signaling controls the response of stem cells during cellular turnover and tissue injury in the complexity of the whole organism. (biomedcentral.com)
The neoblasts are the only dividing cells in planarians and constantly proliferate to repair tissues and support systemic cellular turnover [ 21 ]. (biomedcentral.com)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)

also Del-1 and integrin-binding DEL1) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. (rndsystems.com)

The non-receptor proteins tyrosine phosphatase type 14 (PTPN14) is situated in the adheren junctions (AJ) in both endothelial and epithelial cells and is important in rules of cell adhesion and cell development 32C35. (colinsbraincancer.com)
P2Y12 receptor (P2YR) is a G-coupled7-membrane-spanning proteins. (researchsquare.com)
These effects of LTD4 were shown to be mediated through the G-protein coupled receptor, CysLT1 and this strongly indicates that inflammatory mediators such as LTD4 may have large impacts on the state of cell survival regulation. (lu.se)

It has been found, however, re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. (rndsystems.com)
Researchers from UT Southwestern found that inhibiting the action of a protein, known as BRD4, caused cancer cells in malignant peripheral nerve sheath tumors to die. (ladylively.com)
Malignant peripheral nerve sheath tumors are highly aggressive soft-tissue cancers, or sarcomas, that form around nerves. (ladylively.com)
For the study, the researchers examined changes in cells as they evolved into cancerous soft-tissue tumors. (ladylively.com)

The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)

Intracellular iron levels are elaborately balanced by iron efflux, uptake, and storage proteins that are regulated by iron regulatory proteins (IRPs, including IRP1 and IRP2) [ 16 ]. (nature.com)
The breast cancer resistance protein (BCRP) is a recently characterized xenobiotic fifty percent em - /em transporter protein that acts as a power em - /em reliant efflux pump and could be from the multidrug em - /em resistant phenotype. (monossabios.com)
Appearance of plasma membrane ATP em - /em binding cassette (ABC) transporter proteins that become efflux pushes to positively extrude drug substances from the cell is among the predominant systems of MDR (1,2). (monossabios.com)

Periodontal diseases are a group of chronic inflammatory diseases induced by Porphyromonus gingivalis ( P. gingivalis ) that affect the tooth-supporting tissues. (spandidos-publications.com)
Bovine lactoferrin (bLf) is a dietary whey protein with demonstrated ability to promote anti-inflammatory responses by reducing pro-inflammatory or increasing anti-inflammatory cytokine concentrations within the intestine. (uwaterloo.ca)
0.05), both pro-inflammatory proteins. (uwaterloo.ca)

Tissue inflammation was determined by histology (H&E staining) on segments of mouse small and large intestine. (uwaterloo.ca)
Further, the exercise protocol resulted in oxidative stress, as measured by 8-iso prostaglandin F2α levels in plasma, but did not induce intestinal inflammation, evident by the absence of both tissue damage and infiltration of immune cells. (uwaterloo.ca)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
BCL-6 mutations in HIV-associated LIP do not show features of immunoglobulin variable heavy chain (IgV[H]) hypermutations, while HIV-negative LIP BCL-6 mutations do. (medscape.com)

YAP, also called Yes-associated proteins 1, is usually an element of nuclear transcriptional complexes 9. (colinsbraincancer.com)
Caspase recruitment domain-containing protein (Card)9 is a nonredundant adapter protein that functions in the innate immune system in the assembly of multifunctional signaling complexes. (nih.gov)

Exogenous application of EDIL3 has been demonstrated to augment angiogenesis and improve blood flow and tissue function in murine models of hind-limb ischemia, cardiac ischemia and cerebral ischemia. (rndsystems.com)
A peptide corresponding to the C-terminus of murine Stat5a coupled to a protein carrier. (thermofisher.com)

Iron regulatory protein 2 (IRP2) is a key factor in regulating brain iron homeostasis. (nature.com)

The histologic diagnosis is defined as pulmonary tissue containing both granulomatous and lymphocytic interstitial pneumonitis (LIP), follicular bronchiolitis, and/or lymphoid hyperplasia. (medscape.com)

SSCP analysis showed no alteration in the number of bands detected upon comparison of tumor tissue to leukocytes, suggesting no alterations in the microsatellite. (canjurol.com)
The clinical relevance of quantitative assessment of tumor-tissue expression of the bcl-2 protein in operated stage II breast cancer was investigated in this study. (ucy.ac.cy)

microRNAs (miRNAs) are important regulators of target messenger RNA translation by binding mainly to complementary sequences of the 3′ untranslated region of target messenger RNA transcripts thereby leading to RNA degradation and/or inhibition of protein synthesis [ 4 ]. (hindawi.com)
Inhibition of this enzyme reduces cancer risk and it is highly elevated in tumour tissue. (lu.se)

Real-time PCR was performed to assess the expression of FasmRNA, Fas-LmRNA, Bcl-2mRNA of the liver tissues. (nih.gov)
Western blotting was used to detect the Bax protein expression of the liver tissues. (nih.gov)

The protein RBM4, a molecule crucial to the process of gene splicing, is drastically decreased in multiple forms of human cancer, including lung and breast cancers, researchers have discovered. (sciencedaily.com)
The breast cancers resistance proteins (BCRP) is normally a lately characterized xenobiotic fifty percent em - /em transporter proteins that was initially discovered in the MCF-7/AdrVp breast cancers AZD2171 cost cell line, that includes a multidrug em - /em resistant phenotype, notwithstanding the addition AZD2171 cost of a P em - /em gp-blocking agent (verapamil, Vp) (5,6). (monossabios.com)

Here, we report OTUD3 (OTU domain-containing protein 3) functions as a deubiquitylase for IRP2, interacts with IRP2 in the cytoplasm, de-polyubiquitylates, and stabilizes IRP2 protein in an iron-independent manner. (nature.com)

The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. (cancerindex.org)

Phosphorylation of YAP at S381 by Lats1/2 primes the proteins for following phosphorylation at multiple sites, which in turn prospects to polyubiquitination and degradation 27. (colinsbraincancer.com)

Histology of the affected tissue is the key. (oncolink.org)
these changes in tissue histology were not affected by the addition of bLf. (uwaterloo.ca)

Levels of proteins, including Cyt C, Bcl-2/BAX, and Nrf2 /HO-1-associated proteins, were determined by western blotting and immunofluorescence. (sdbonline.org)

BimEL, BimL and BimS are the main isoforms which are ubiquitously expressed with a tissue-specific variation. (neuromics.com)

In 15 to 20% of patients, plasma cells secrete only Bence Jones protein. (msdmanuals.com)

Proteins were transferred to a nitrocellulose membrane and blocked with 5 % skim milk for 1 hour at room temperature. (thermofisher.com)

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
This antibody recognizes the STAT5a protein from a variety of species including human, mouse, and rat and it reacts specifically with the STAT5a protein and does not exhibit any cross-reactivity with the highly related STAT5b protein. (thermofisher.com)
This antibody detects endogenous protein at a molecular weight of 90 kDa. (thermofisher.com)

Thus, Akt signaling regulates neoblast biology and mediates in the distribution of injury-mediated cell death during tissue repair in planarians. (biomedcentral.com)

Results Id of PTPN14 being a YAP-interacting proteins In order to elucidate the system mixed up in legislation of YAP, we performed immunoprecipitation (IP) and mass spectrometry evaluation to recognize the protein that type a complicated with YAP. (colinsbraincancer.com)
She is associated with the Swedish National Infrastructure for Biological Mass Spectrometry, and a member of the Working group on Protein Misfolding and Aggregation Diseases in B/D HPP. (lu.se)

Taken all together this demonstrates a role for Buffy, a Bcl-2 pro-cell survival gene, in neuroprotection. (sdbonline.org)
EDIL3 promotes adherence and migration of endothelial cells, and acts as an endothelial cell survival agent through upregulation of Bcl-2 expression. (rndsystems.com)

Through the analysis of the The Cancer Genome Atlas database and clinical tissue samples, the expression of MicroRNA-16-5p in glioma was detected. (ijpsonline.com)

Anatomy28

Organisms13

Diseases23

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes76

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Genes6

Pathway5

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Inhibitors1

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MRNA expression2

Cytochrome4

Immunohistochemistry5

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