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  • antibody
  • SAN DIEGO--( BUSINESS WIRE )--Fortis Therapeutics, Inc., an immuno-oncology biotech developing a novel antibody-drug conjugate (ADC) against CD46, today announced the U.S. Food and Drug Administration (FDA) has cleared two investigational new drug (IND) applications for the company's lead candidate, FOR46, for the treatment of metastatic castration-resistant prostate cancer and late-stage multiple myeloma. (businesswire.com)
  • The FOR46 program originated at the University of California, San Francisco, in the laboratory of Bin Liu, Ph.D. It was identified through an antibody selection process that uses living tumor cells residing in their tissue microenvironment, thereby preserving the natural range of surface antigens present on the cells. (businesswire.com)
  • Weyand NJ, Lee SW, Higashi DL, Cawley D, Yoshihara P, So M: Monoclonal antibody detection of CD46 clustering beneath Neisseria gonorrhoeae microcolonies. (sysmex-flowcytometry.com)
  • C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection. (hindawi.com)
  • 1. A fusion protein comprising: (i) an antibody, an antigen-binding antibody fragment or a cytokine conjugated to (ii) a dimerization and docking domain (DDD) moiety of human protein kinase A regulatory subunit RIα, RIβ, RIIα and RIIα. (patentsencyclopedia.com)
  • 5. The fusion protein of claim 1, wherein the antibody or antigen-binding fragment thereof is chimeric, humanized or human. (patentsencyclopedia.com)
  • 9. A fusion protein comprising: (i) an antibody, an antigen-binding antibody fragment or a cytokine conjugated to (ii) an anchoring domain (AD) moiety of an A-kinase anchoring protein (AKAP). (patentsencyclopedia.com)
  • This heptavalent-KLH conjugate plus QS21 vaccine safely induced antibody responses against five of seven antigens. (aacrjournals.org)
  • Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)
  • In the absence of crosslinking, the antibody inhibits CD27-CD70 interaction.Applications Reported: This LG.3A10 antibody has been reported for use in flow cytometric analysis, and immunohistology staining of frozen tissue sections.Applications Tested: This LG.3A10 antibody has been tested by flow cytometric analysis of mouse splenocytes. (fishersci.co.uk)
  • CD59
  • Cell surface regulators of complement, 5I2 antigen, and CD59, in the rat eye and adnexal tissues. (arvojournals.org)
  • METHODS: After euthanasia of female Wistar rats, followed by orbital exenteration, eyelids and orbital tissue including the lacrimal gland were separated from the globes and immediately snap-frozen in liquid nitrogen at -70 degrees C. Tissues then were sectioned at -20 degrees C and examined immunohistochemically for 5I2 antigen and rat CD59. (arvojournals.org)
  • Corneal endothelial cells showed intense labeling for rat CD59 but not for 5I2 antigen. (arvojournals.org)
  • The retina showed labeling at multiple levels, with that of rat CD59 being more intense than that of 5I2 antigen. (arvojournals.org)
  • CONCLUSIONS: 5I2 antigen and rat CD59 are expressed in high levels and distributed similarly in the rat eye and lacrimal gland to DAF, MCP, and MIRL in the human eye and lacrimal gland. (arvojournals.org)
  • The constructs made in this work were subsequently used for cotransfection experiments together with BAC or PAC constructs carrying the genomic sequence of CD46 or CD59 to obtain either a human artificial chromosome (HAC) that carries several xenoprotective transgenes or multi-transgenic cells that express a battery of xenoprotective transgenes. (tum.de)
  • immune
  • This proposal is based on the novel finding that common marmosets, a species of New World primates that is prone to develop an MS-like immune-mediated CNS illness after immunization with myelin antigens, can be infected with HHV6. (dana.org)
  • A "two-hit" infection with HHV-6A appears to result in neurological deficits and pathologically, CNS inflammatory demyelination similar to human MS. Affected animals appear to develop immune reactivity to myelin antigens, indicating the possibility that mechanisms of mimicry may be involved in pathogenesis. (dana.org)
  • Possible cytotoxicity of lymphocytes from HHV6-infected animals towards antigen-sensitized targets and capacity for immune viral clearance or neutralization will be explored. (dana.org)
  • In the human body, a vast diversity of immune cells constantly patrols the blood stream and tissues to protect from invaders. (bloodjournal.org)
  • cancers
  • CD46 is an attractive target for a number of cancers but has yet to be exploited due to its role in healthy tissues," said Jay Lichter, Ph.D., President and CEO of Fortis Therapeutics. (businesswire.com)
  • ovarian
  • Five copies of a tissue microarray representing 339 cases of ovarian cancer which presented to Derby City General Hospital between 1982 and 1997 were made. (nottingham.ac.uk)
  • inflammation
  • Marie JC, Astier AL, Rivailler P, Rabourdin-Combe C, Wild TF, Horvat B: Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. (sysmex-flowcytometry.com)
  • normal
  • 3 However, many recommend that clinical investigation and intervention be initiated after two consecutive spontaneous abortions, especially if any of the following are coexistent: fetal heart activity was identified before any of the pregnancy losses, fetal karyotyping of pregnancy tissues revealed normal chromosome content, the woman is older than 35 years of age, or the couple also shows subfertility. (glowm.com)
  • found
  • At least fourteen different transcript variants encoding different isoforms have been found for CD46. (miltenyibiotec.com)
  • In mouse, CD27 has been found on nearly all thymocytes excluding a population of CD46-CD8- precursors. (fishersci.co.uk)
  • type
  • Type V collagen [col(V)], a cryptic antigen, becomes exposed during lung remodeling. (iupui.edu)
  • damage
  • The proposed research will consolidate these observations in marmosets and establish the requirements in exposure to HHV6 viruses for appearance of CNS autoimmune demyelinating disease (e.g., single or repeated exposure, variant A vs. variant B). Mechanistic studies using all laboratory and immunological methods relevant to marmoset EAE pathogenesis will be applied to understand the cause of CNS autoimmunity and the pathway(s) of tissue damage following exposure to HHV6. (dana.org)