• Plasminogen activator inhibitor type 1 deficiency. (medscape.com)
  • In brief, blood samples were collected at various time points during and after surgery, and levels of the following markers were obtained at each time point: prothrombin activation peptide F1.2, thrombin antithrombin complex (TAT), D-dimer (DD), active tissue plasminogen activator (active tPA), and active plasminogen activator inhibitor type 1 (active PAI-1). (hindawi.com)
  • 5. Quantitative real-time reverse transcription-PCR assay for urokinase plasminogen activator, plasminogen activator inhibitor type 1, and tissue metalloproteinase inhibitor type 1 gene expressions in primary breast cancer. (nih.gov)
  • and plasminogen activator inhibitor, type I in skull base chordoma. (nih.gov)
  • It acts as an enzyme to convert plasminogen into its active form plasmin, the major enzyme responsible for clot breakdown. (wikipedia.org)
  • Tissue-type plasminogen activator (tPA) is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. (psu.edu)
  • 9. The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network. (nih.gov)
  • NTF generation was abolished by serine-proteinase inhibitors, but not inhibitors of matrix metalloproteinases, and was not enhanced by the addition of plasminogen or plasmin. (nih.gov)
  • 6 It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. (drugbank.com)
  • The specificity of alteplase for plasminogen bound to fibrin allows this drug to act in a clot- or fibrin-specific manner, leading to low concentrations of circulating plasmin and a lower risk of hemorrhagic transformation. (drugbank.com)
  • Alteplase is a recombinant tissue plasminogen activator (rt-PA) that converts plasminogen to plasmin in a fibrin-dependent process. (drugbank.com)
  • At present, the only approved therapy for stroke is early reperfusion by intravenous injection of the thrombolytic agent, tissue-type plasminogen activator (tPA). (bb-c.fr)
  • Alteplase is the only drug licensed for acute ischemic stroke, and in this formulation, the thrombolytic agent recombinant tissue plasminogen activator (rtPA) is stabilized in a solution of L-arginine. (ox.ac.uk)
  • Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. (drugbank.com)
  • Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. (nih.gov)
  • To evaluate the efficacy and safety of intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA) in patients with acute ischemic stroke. (nih.gov)
  • We performed a randomized, double-blind trial of intravenous recombinant tissue plasminogen activator (t-PA) for ischemic stroke after recent pilot studies suggested that t-PA was beneficial when treatment was begun within three hours of the onset of stroke. (nih.gov)
  • Intravenous tissue plasminogen activator for acute ischemic stroke-feasibility, safety, and efficacy in the first year of clinical practice. (jamanetwork.com)
  • Alberts, MJ 2017, ' Stroke Treatment With Intravenous Tissue-Type Plasminogen Activator: More Proof That Time Is Brain ', Circulation , vol. 135, no. 2, pp. 140-142. (elsevierpure.com)
  • 6 , 7 Although some reports have described treatment with conventional intravenous tissue plasminogen activator (tPA) in the very elderly, 8 - 11 no large series has directly examined age-specific results of IA treatment in the elderly. (ajnr.org)
  • Background: We hypothesized that patients with clinically severe strokes but less severe early ischemic changes on brain CT (i.e., clinical-CT mismatch) may respond better to intravenous recombinant tissue plasminogen activator (i.v. rt-PA) within 3 h of symptom onset. (utmb.edu)
  • 4. The p75(NTR) metastasis suppressor inhibits urokinase plasminogen activator, matrix metalloproteinase-2 and matrix metalloproteinase-9 in PC-3 prostate cancer cells. (nih.gov)
  • 7. Role of hepatocyte growth factor/c-Met signaling in regulating urokinase plasminogen activator on invasiveness in human hepatocellular carcinoma: a potential therapeutic target. (nih.gov)
  • Another major advance was the clot-dissolving medicine tPA (for tissue plasminogen activator), the first treatment for acute ischemic stroke to receive Food and Drug Administration (FDA) approval. (nih.gov)
  • Initial clinical experience with IV tissue plasminogen activator for acute ischemic stroke: a multicenter survey. (jamanetwork.com)
  • Karbalai H, Demchuk AM, Hoyte KM, Klein GM, Feasby TE, Buchan AM. Effectiveness of tissue-type plasminogen activator for acute ischemic stroke: consequences of protocol violation. (jamanetwork.com)
  • Danish researchers describe enzyme that will become known as tissue plasminogen activator(tPA). (nih.gov)
  • However, we report the actual effect of rFVIIa on changes in hemostatic markers such as prothrombin activation peptide F1.2, thrombin antithrombin complex (TAT), D-dimer, tissue plasminogen activator (tPA), and plasminogen activator inhibitor (PAI) in a neonate after cardiopulmonary bypass. (hindawi.com)
  • The main treatment for an ischemic stroke is a medicine called tissue plasminogen activator (tPA). (nih.gov)
  • For an ischemic stroke, you may get a clot-dissolving medicine called tissue plasminogen activator (TPA). (healthwise.net)
  • The drug, called tissue plasminogen activator (tPA), was the first proven treatment for stroke. (nih.gov)
  • In the mid-90s, NIH research led to approval of the drug tissue-type plasminogen activator (tPA), which dissolves stroke-causing clots if given soon after symptoms appear. (nih.gov)
  • In 1996, the use of tissue-type plasminogen activator (tPA) was approved as acceptable treatment for ischemic strokes. (uic.edu)
  • A stroke occurs when the blood supply to brain tissue is blocked by a blood clot (ischemic stroke), or when a blood vessel in the brain ruptures (hemorrhagic stroke), causing brain cells to die and leading to functional impairments. (nih.gov)
  • The complexity of tissue-type plasminogen activator: can serine protease inhibitors help in stroke management? (bb-c.fr)
  • This type of medicine must be given within 3 hours after stroke symptoms start. (nih.gov)
  • In a study supported by the Food & Drug Administration, Dr. Carhuapoma and his colleagues are conducting a multicentered clinical trial of thrombolysis for intraventricular hemorrhage, the results of which will allow for the development of an effective treatment for intraventricular hemorrhage and demonstrate the safety and efficacy of thrombolysis with rtPA for that type of stroke. (hopkinsmedicine.org)
  • What causes a stroke depends on the type of stroke. (healthwise.net)
  • Ischemic strokes are the most common type of stroke. (healthwise.net)
  • There are two types of stroke: ischemic (say "iss-KEE-mick") strokes and hemorrhagic (say "heh-muh-RAW-jick") strokes. (healthwise.net)
  • The other type, called hemorrhagic stroke-is caused by a broken or leaking blood vessel in the brain. (nih.gov)
  • A common symptom in some types of hemorrhagic stroke is a very sudden and extremely painful headache. (nih.gov)
  • Alteplase is a recombinant form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli. (drugbank.com)
  • tPA can be manufactured using recombinant biotechnology techniques, producing types of recombinant tissue plasminogen activator (rtPA) such as alteplase, reteplase, and tenecteplase. (wikipedia.org)
  • Dr. Carhuapoma and his colleagues are investigating removal of an ICH with minimally invasive surgery and treatment with recombinant tissue plasminogen activator (rtPA). (hopkinsmedicine.org)
  • The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity. (ox.ac.uk)
  • 8. Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver. (nih.gov)
  • 15. Aspirin Inhibits IKK-β-mediated Prostate Cancer Cell Invasion by Targeting Matrix Metalloproteinase-9 and Urokinase-Type Plasminogen Activator. (nih.gov)
  • The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. (avivasysbio.com)
  • Autocrine regulation of growth stimulation in human epithelial ovarian carcinoma by serine-proteinase-catalysed release of the urinary-type-plasminogen-activator N-terminal fragment. (nih.gov)
  • Important biochemical constituents of the fibrinolytic system include tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1). (nih.gov)
  • ABSTRACT The aim of this study in 2006-08 was to determine the prevalence and risk factors of CVD in an Iranian population of patients with type 2 diabetes mellitus. (who.int)
  • A heart attack (myocardial infarction) occurs when blood flow to the heart muscle is blocked, and tissue death occurs from loss of oxygen, severely damaging a portion of the heart. (limamemorial.org)
  • The plasminogen activator/coagulase ( pla ) gene, located on plasmid pPCP1, is incorporated into most Y. pestis PCR assays, and in several studies it was the prime or sole marker ( 1 , 2 , 5 , 7 - 9 ). (cdc.gov)
  • The existence of a concatenated pla-rep sequence in rat tissue samples was confirmed by amplification of a PCR product from a primer targeting the pla gene, combined with a primer targeting the rep gene sequence that was acquired by using the genewalking procedure. (cdc.gov)
  • T and plasminogen activator inhibitor 1 4G/5G gene polymorphisms in central serous chorioretinopathy. (cdc.gov)
  • We successfully isolated primary hPDMSCs and CTBs, collected CM from these placental cells and sub-cultured placental tissue, and then evaluated the effects of the CM on a series of angiogenic processes in HUVECs in vitro. (biomedcentral.com)
  • The results showed that not only placental cells but also sub-cultured placental tissue, to some extent, promoted HUVEC angiogenesis in vitro by promoting proliferation, adhesion, migration, invasion, and tube formation. (biomedcentral.com)
  • CM obtained from placental cells (primary CTBs or hPDMSCs) or sub-cultured placental tissue contained proangiogenic factors and promoted HUVEC angiogenesis in vitro. (biomedcentral.com)
  • Tissue-type plasminogen activator, short name tPA, is a protein that facilitates the breakdown of blood clots. (wikipedia.org)
  • It is suggested that the term is restricted to proteins secreted from adipocytes, excluding signals released only by the other cell types (such as macrophages) in adipose tissue. (cambridge.org)
  • The parsimonious view is that the increased production of inflammatory cytokines and acute-phase proteins by adipose tissue in obesity relates primarily to localised events within the expanding fat depots. (cambridge.org)
  • Multidomain proteins of the extracellular matrix (ECM) play an important role in development and maintenance of cellular organization and in tissue repair. (embl-heidelberg.de)
  • 4 New thrombolytic agents derived from tissue plasminogen activator, such as desmoteplase , tenecteplase and reteplase , have also been developed. (drugbank.com)
  • Plasminogen activator inhibitor-1 (PAI-1) is a glycoprotein (molecular weight, 47 kDa) that is synthesized in endothelial cells, hepatocytes, and adipocytes. (medscape.com)
  • Intrapleural tissue plasminogen activator (t-PA) has emerged over the past several years as a treatment option for patients with complicated parapneumonic effusion that does not respond to medical management and drainage. (medscape.com)
  • Cite this: Intrapleural Tissue Plasminogen Activator for the Treatment of Parapneumonic Effusion - Medscape - Aug 01, 2010. (medscape.com)
  • The type of treatment you receive depends on what part of your brain is bleeding and how much. (nih.gov)
  • The high prevalence of CVD in Iranian patients with type 2 diabetes underscores the importance of better detection and treatment of metabolic risk factors of CVD in these patients. (who.int)
  • For any type of treatment involving an AVM, an angiogram may be needed to better identify the type of AVM. (stroke.org)
  • Does clinical-CT 'mismatch' predict early response to treatment with recombinant tissue plasminogen activator? (utmb.edu)
  • Throughout life, it continuously pumps blood enriched with oxygen and vital nutrients through a network of arteries to all tissues of the body. (limamemorial.org)
  • When an arteriovenous malformation (AVM) occurs, a tangle of blood vessels in the brain bypasses normal brain tissue and directly diverts blood from the arteries to the veins. (stroke.org)
  • It consists of a tangle of abnormal vessels connecting arteries and veins with no normal intervening brain tissue. (stroke.org)
  • We demonstrate that conditioning hiNPC with enzymatically-inactive tissue-type plasminogen activator (EI-tPA), prior to grafting into a T3 lesion site in a clinically relevant severe SCI model, significantly improves motor outcomes. (escholarship.org)
  • Lung and liver samples were available from all 17 rats, and leg tissue samples were available from 7 rats, 5 of which had positive peritoneal tissue test results. (cdc.gov)
  • 1. Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by host-derived urokinase-type plasminogen activator. (nih.gov)
  • 2. Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by hypoxia-inducible factor-1α. (nih.gov)
  • 3. Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling. (nih.gov)
  • 16. Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis. (nih.gov)
  • It is suggested that these events reflect hypoxia in parts of the growing adipose tissue mass in advance of angiogenesis, and involve the key controller of the cellular response to hypoxia, the transcription factor hypoxia inducible factor-1. (cambridge.org)
  • Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury. (escholarship.org)
  • In this study, primary cytotrophoblasts (CTBs) from early pregnancy and primary human placenta-derived mesenchymal stem cells (hPDMSCs) from different stages of pregnancy were selected as the cell research objects, and full-term placental tissue was selected as the tissue research object to detect the effects of their conditioned medium (CM) on human umbilical vein endothelial cell (HUVEC) angiogenesis. (biomedcentral.com)
  • Depending on the type of medicine you take, your provider may give you vitamin K to help stop bleeding. (nih.gov)
  • therefore, "weakened" blood vessels that direct blood away from normal brain tissue. (stroke.org)
  • Each time blood leaks into the brain, normal brain tissue is damaged. (stroke.org)
  • It depends on what type it is, the symptoms it may be causing and its location and size. (stroke.org)
  • There has been no systematic, comparative study on the roles of these two groups of placental cells and the whole placental tissue in the placental angiogenesis. (biomedcentral.com)
  • Furthermore, we measured the levels of angiogenic factors in the CM of placental cells or tissue by an angiogenesis antibody array. (biomedcentral.com)
  • The semiquantitative angiogenesis antibody array showed that 18 of the 43 angiogenic factors had obvious spots in placental cell-derived CM or sub-cultured placental tissue-derived CM, and the levels of 5 factors (including CXCL-5, GRO, IL-6, IL-8, and MCP-1) were the highest in sub-cultured placental tissue-derived CM. (biomedcentral.com)
  • Therefore, our research is helpful to better understand placental angiogenesis regulation and provides theoretical support for the clinical application of placental components, especially sub-cultured placental tissue-derived CM, in vascular tissue engineering and clinical treatments. (biomedcentral.com)
  • It is, however, unclear as to the extent to which adipose tissue contributes quantitatively to the elevated circulating levels of these factors in obesity and whether there is a generalised or local state of inflammation. (cambridge.org)
  • The percent of n-6 HUFA in tissue HUFA is also a marker of relative dietary intakes, reflecting known competitions among dietary n-3 and n-6 FA in maintaining levels of tissue HUFA (Lands et al, Biochim. (nih.gov)
  • Platelets are the main source of the circulating PAI11, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells. (thermofisher.com)