• Hidden copper toxicity occurs when high levels of copper are stored in various body tissues but have not yet been released to show up in the hair. (htmaexperts.com)
  • Someone with copper toxicity can have either high copper showing up in the hair or may have low or hidden copper. (htmaexperts.com)
  • 2004 ). One problem with cancers, especially HNSCCs, is the unpredictability of treatment outcomes, both in terms of tumor response and host toxicity. (researchsquare.com)
  • Results:Locoregional tumor response, acute and late toxicity, and compliance were the study's endpoints. (who.int)
  • On the other hands, researches have been conducted to find molecular markers for predicting the development of treatment-induced acute or chronic toxicity before initiation of treatment (Venkatesh et al. (researchsquare.com)
  • However, if doses of ascorbate are not provided to satisfy this potential draw on the nutrient, first local tissues involved in the disease, then the blood, and then the body in general become deplete of ascorbate (ANASCORBEMIA and ACUTE INDUCED SCURVY). (doctoryourself.com)
  • CAR-T therapy can induce rapid and durable clinical responses but is associated with unique acute toxicities. (nature.com)
  • Information is given on sources of depleted uranium exposure, the likely routes of acute and chronic intake, the potential health risks from both the radiological and chemical toxicity standpoints and future research needs. (who.int)
  • Acute toxicity was also evaluated. (bvsalud.org)
  • Moreover, no acute toxicity was detected with the use of PMF. (bvsalud.org)
  • Likewise, Ni 2+ has been demonstrated to be the toxic chemical species in the environment, and models have been developed that account for the influence of abiotic factors on the bioavailability and toxicity of Ni 2+ in different habitats. (mdpi.com)
  • To develop models that support site-specific risk assessment for nanoparticles (NPs), a better understanding of how NP transformation processes, bioavailability and toxicity are influenced by soil properties is needed. (nerc.ac.uk)
  • In this study, the influence of differing soil properties on the bioavailability and toxicity of zinc oxide (ZnO) NPs and ionic Zn to the earthworm Eisenia fetida was investigated. (nerc.ac.uk)
  • This mini-review focuses on the clinical applications of mIBG in neuroendocrine cancers and the differential roles of NET, OCT, and MATE transporters in mIBG disposition, response and toxicity. (aspetjournals.org)
  • The clinical use of mIBG as a radiopharmaceutical in cancer diagnosis and treatment can be further improved by taking a holistic approach considering mIBG transporters in both cancer and normal tissues. (aspetjournals.org)
  • Treatment-related toxicity is frequently a dose-limiting factor and represents a major challenge in clinical management of cancer. (aspetjournals.org)
  • PI3Kδ inhibitors are approved for the therapy of B cell malignancies, but their clinical use has been limited by unpredictable autoimmune toxicity, despite promising efficacy and evidence that toxicity is associated with improved clinical outcomes. (nature.com)
  • The evaluation of patients with possible toxicity from a local anesthetic should be guided by the clinical presentation. (medscape.com)
  • Body weight showed normal increments and none of the animals had any clinical signs of toxicity. (doaj.org)
  • Researchers from Rice University, University of Texas MD Anderson Cancer Center and spinoff company Nano3D Biosciences have shown that magnetic levitation can be a used to provide an environment for volumetric growing of tissue for research and one day maybe even for clinical use. (medgadget.com)
  • Vitamin D toxicity, or hypervitaminosis D is the toxic state of an excess of vitamin D. The normal range for blood concentration in adults is 20 to 50 nanograms per milliliter (ng/mL). (wikipedia.org)
  • Symptoms of vitamin D toxicity may include the following: Dehydration Vomiting Diarrhea Decreased appetite Irritability Constipation Fatigue Muscle weakness Metastatic calcification of the soft tissues Insomnia Symptoms of vitamin D toxicity appear several months after excessive doses of vitamin D are administered. (wikipedia.org)
  • It is possible that some of the symptoms of vitamin D toxicity are actually due to vitamin K depletion. (wikipedia.org)
  • Excessive exposure to sunlight poses no risk in vitamin D toxicity through overproduction of vitamin D precursor, cholecalciferol, regulating vitamin D production. (wikipedia.org)
  • For most people, vitamin D toxicity only occurs with vitamin D doses above 10,000 IU per day. (medlineplus.gov)
  • Thus, target tissue activation seems to play an important role in the tissue-selective toxicity, whereas differences in the rates of hepatic metabolism may be responsible for the species difference in olfactory toxicity. (aspetjournals.org)
  • sensitive to respiratory tract and hepatic toxicity from are not related to blood levels of styrene or styrene styrene. (cdc.gov)
  • mice developed severe liver toxicity, which probably tio is less than 1, while in mouse liver the ratio is about contributed to the cause of death. (cdc.gov)
  • in an inhalation study and only equivocal evidence of metabolism to SO is below the limit of detection in nearly all samples, and the most active sample of lung lung tumors in two of four chronic toxicity/oncogenicity was approximately 100-fold less active than mouse studies by gavage in mice (reviewed in Cruzan et al . (cdc.gov)
  • Systemic toxicity most often involves the central nervous system (CNS) or the cardiovascular system. (medscape.com)
  • See also Local Anesthetic Systemic Toxicity (LAST) Under Anesthesia . (medscape.com)
  • Skin, eye, and airway exposure to vapor sulfur mustard and skin and eye exposure to liquid mustard may cause systemic toxicity. (cdc.gov)
  • The recommended dosage of HYCAMTIN for injection is 1.5 mg/m² by intravenous infusion over 30 minutes daily for 5 consecutive days, starting on Day 1 of a 21-day cycle until disease progression or unacceptable toxicity. (globalrph.com)
  • Treatment is repeated every 2 weeks for up to 7 courses in the absence of disease progression and unacceptable toxicity. (knowcancer.com)
  • In addition to renal disease, cardiovascular effects, and reproductive toxicity, lead may cause irreversible neurologic damage. (cdc.gov)
  • Understanding the molecular mechanisms governing mIBG transport in cancer and normal cells is a critical step for developing strategies to optimize the efficacy of 131 I-mIBG while minimizing toxicity in normal tissues. (aspetjournals.org)
  • The facility offers a wide variety of histological studies, ranging from routine techniques and services to the development of new approaches (IHC, IF,…), experimental pathology studies, reports, and consultancy services (mouse phenotyping, animal models of disease, drug efficacy and non-GLP toxicity studies). (irbbarcelona.org)
  • Our case studies demonstrate anti-tumor efficacy with limited toxicity to normal tissues," Bauer added. (sciencedaily.com)
  • The platform will consist of a three-dimensional tissue engineering in-vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses, and integrated into a Machine Learning (ML) risk assessment tool. (europa.eu)
  • By introducing an in vitro cardiac system and ML models, ALTERNATIVE will provide a platform able to refine, reduce and replace the need for animal testing, providing close-to-real scenario information on toxicity and achieving a significant reduction of the associated direct and indirect costs. (europa.eu)
  • Neurocognitive and cardiac toxicity are severely impacting cancer survivors' quality of life. (unil.ch)
  • In parallel, g rowing evidence suggests that the long-term neurocognitive changes as well as cardiac toxicity induced by anti-cancer treatments might differ between the sexes in both human cancer patients and in rodent models. (unil.ch)
  • Memorial Sloan Kettering Cancer Center (MSK) researchers have discovered that innate immune signaling drives late cardiac toxicity after DNA-damaging cancer therapies. (mskcc.org)
  • Further, they found that suppressing this signaling pathway with an experimental STING antagonist effectively prevented cardiac toxicity in mouse models. (mskcc.org)
  • The researchers also identified the chemokine CXCL10 in circulating blood as a novel biomarker for radiation-induced cardiac toxicity. (mskcc.org)
  • Thymus tissue is obtained from donors less than or equal to 9 months of age undergoing cardiac surgery. (rxlist.com)
  • Thus, the combination of patient-derived primary cells with bioprinting technology here for the first time demonstrates superior performance in terms of mimicking human drug response in a known target organ at the tissue level. (organovo.com)
  • Microscopically assessed organ tissues did not reveal any abnormalities. (doaj.org)
  • Discontinue hydroxychloroquine if renal toxicity is suspected or demonstrated by tissue biopsy in any organ system. (nih.gov)
  • Coumarin was previously found to cause tissue-selective toxicity in the olfactory mucosa (OM) of rats and mice, with rats being the more sensitive species. (aspetjournals.org)
  • Numerous studies have demonstrated marked differ- fects on terminal bronchioles are seen, but effects in ences in toxicity between rats and mice to styrene ex- the nasal olfactory epithelium do occur, although to posure, especially by inhalation. (cdc.gov)
  • The PBPK model predicts that humans do not gener- toxicity, and nasal olfactory lesions. (cdc.gov)
  • An excess of vitamin D causes abnormally high blood concentrations of calcium, which can cause overcalcification of the bones, soft tissues, heart and kidneys. (wikipedia.org)
  • about 66% is found in the skeleton, 16% in the liver, 8% in the kidneys and 10% in other tissues. (who.int)
  • This can severely damage the kidneys, soft tissues, and bones over time. (medlineplus.gov)
  • In particular, human organic cation transporter 2 (hOCT2) and multidrug and toxin extrusion proteins 1 and 2-K (hMATE1/2-K) likely mediate renal secretion of mIBG, whereas hOCT1 and hOCT3 may contribute to mIBG uptake into normal tissues such as the liver, salivary glands, and heart. (aspetjournals.org)
  • Consider phospholipidosis as a possible cause of renal injury in patients with underlying connective tissue disorders. (nih.gov)
  • Trovafloxacin induced significant, dose-dependent toxicity at clinically relevant doses (≤ 4 μM). (organovo.com)
  • Large doses of lidocaine (up to 55 mg/kg, versus the conventional maximum of 4.5 mg/kg) are used for tumescent anesthesia, in which a dilute local anesthetic solution is injected into subcutaneous tissue until it becomes firm and tense. (medscape.com)
  • Severe radiation-induced lung toxicity, expected at normal lung absorbed doses of 25-27 Gy, is avoided, probably because most of the local electron dose is delivered to tumor tissue instead of to normal lung parenchyma. (snmjournals.org)
  • This was recognized to be a surrogate for red bone marrow absorbed dose and was intended to decrease the likelihood of severe marrow depression, the dose-limiting toxicity in radioiodine therapy of thyroid cancer. (snmjournals.org)
  • Bismuth Toxicity, Often Mild, Can Result in Severe Poisoning. (lww.com)
  • Naturally this led to severe toxicity, and the therapy could be given only by using rest periods between courses. (lww.com)
  • To review the salient features of the management of severe skin and soft tissue infections (SSTIs), including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis. (medscape.com)
  • Wilson's disease causes too much copper to collect in the liver, the brain, and other body tissues and organs. (healthline.com)
  • Their results, published in the Journal of Experimental Medicine on March 6, 2023, identify a targetable mechanism for one of the most challenging treatment-related late toxicities in cancer survivors. (mskcc.org)
  • Despite its selective uptake by neuroendocrine tumors, mIBG accumulates in several normal tissues and leads to tissue-specific radiation toxicities. (aspetjournals.org)
  • Along with estimating radiation dose values to certain critical organs, we have also proposed an MTD for 177Lu-EDTMP that correlated well with toxicity data. (nih.gov)
  • My group has been the first to develop FLASH-Radiotherapy, a novel modality of radiation therapy at ultra high dose rate that minimizes normal tissue toxicity but eradicates tumors. (unil.ch)
  • Determine the toxicity and response to cisplatin, paclitaxel and radiation therapy in these patients. (knowcancer.com)
  • The normal tissue toxicities of each patient undergoing radiation were monitored weekly. (who.int)
  • Emerging evidences suggest that the polyspecific organic cation transporters play important roles in systemic disposition and tissue-specific uptake of mIBG. (aspetjournals.org)
  • Hence, a major goal in cancer drug development and therapy is to increase tumor-specific drug uptake while reducing uptake into normal tissues to minimize toxicities. (aspetjournals.org)
  • These include producing energy, forming connective tissue, and helping your central nervous system (CNS) function. (healthline.com)
  • Identifies hidden toxicities and deficiencies when visible symptoms do not appear. (ufl.edu)
  • Prior phenotypic evaluation by CyTOF has identified increases in activated CD8 T cells with activation of Th17 T cells, as well as decreases in Tregs, particularly in patients with toxicity. (nature.com)
  • We further demonstrate directly using intracellular flow cytometry that autoimmune toxicity in patients is associated with higher absolute numbers of CD4 and CD8 T cells with Th17 differentiation in peripheral blood prior to therapy, and that gastrointestinal tissues from patients with active autoimmune complications of PI3Kδ inhibitors show infiltration with Th17 + T cells. (nature.com)
  • These same tissues show depletion of Tregs as compared to CLL patients without toxicity, suggesting that loss of Tregs may be permissive for Th17 activation to lead to autoimmune toxicity. (nature.com)
  • Variations in toxicity and response to therapy are observed among patients despite similar clinicopathologic characteristics which are attributed to single nucleotide polymorphisms (SNPs). (researchsquare.com)
  • Herein, we report the pharmacokinetics, dosimetry and toxicity analysis of 177Lu-EDTMP in patients (phase-0/I study). (nih.gov)
  • Only transient toxicity was observed in 14/21 patients, of which 6 had baseline toxicity. (nih.gov)
  • Beyond the MTD, a significantly higher number of patients displayed grade 3-4 toxicity. (nih.gov)
  • Determine the toxicity of amifostine in these patients. (knowcancer.com)
  • Rethymic ( allogeneic processed thymus tissue-agdc) is processed thymus tissue indicated for immune reconstitution in pediatric patients with congenital athymia. (rxlist.com)
  • Ces résultats semblent indiquer que l'utilisation de l'alun en tant qu'antiplaquettaire oral pourrait faire l'objet d'études complémentaires, en tenant compte des effets secondaires éventuels notamment chez les patients dont la fonction rénale est altérée. (who.int)
  • Skin and soft tissue infections (SSTIs) are a common reason for patients seeking inpatient and outpatient medical care with more than 14 million outpatient visits a year, [ 1 ] and almost 900 000 inpatient admissions in the United States. (medscape.com)
  • La plateforme consistera en un modèle in vitro tridimensionnel qui imite le tissu cardiaque humain, associé à un système de surveillance fiable à haut débit reposant sur des analyses multi-omiques et intégré à un outil d'évaluation des risques par apprentissage automatique. (europa.eu)
  • This composite shows 3-D cultures of four types of cells that Rice University scientists combined in vitro to create bronchiole lung tissue. (medgadget.com)
  • Notable human health toxicity effects identified from human and/or animal studies include respiratory cancer, non-cancer toxicity effects following inhalation, dermatitis, and reproductive effects. (mdpi.com)
  • This is mainly because existing liver models lack longevity and tissue-level complexity which limits their utility in predictive toxicology. (organovo.com)
  • Systems toxicology, therefore, aims at understanding and exploring the way that different biological components are orchestrated as an ensemble in cells, tissues, and organisms. (brill.com)
  • Understanding and targeting the mechanism of PI3Kδ-associated toxicity could allow us to more fully incorporate these agents into the CLL treatment paradigm and extend the duration of benefit from currently available therapies. (nature.com)
  • The mechanism involves an immune response against the patient's own tissues by autoantibodies (antibodies to self), most commonly antinuclear antibodies (ANA). (scienceblogs.com)
  • 2001). No other tumor types were increased in these toxicity in mice and rats, including mouse lung tu- studies in mice. (cdc.gov)
  • The toxicity of local and infiltration anesthetics can be local or systemic. (medscape.com)
  • Necrotizing fasciitis is a rapidly progressive inflammatory infection of the fascia, with secondary necrosis of the subcutaneous tissues. (medscape.com)
  • Earthworms exposed to ZnO_NPs survived higher Zn concentrations in the soils and had higher tissue concentrations compared with ionic Zn exposures, particularly in the high organic content calcareous soil. (nerc.ac.uk)
  • The aim of this study was to explore the role of target tissue biotransformation in OM-selective toxicity and the metabolic basis of the species differences in coumarin toxicity. (aspetjournals.org)
  • Differences in human toxicity potencies/potentials of different nickel chemical forms are correlated with the bioavailability of the Ni 2+ ion at target sites. (mdpi.com)
  • Systemic lupus erythematosus (SLE) is an autoimmune disease in which the body's immune system mistakenly attacks normal organs and healthy tissue. (scienceblogs.com)
  • It will be a new instrument to evaluate unpredictable toxicity due to synergistic effects of different chemicals, additionally worsened by the human ageing process. (europa.eu)
  • After completion of this educational activity, the reader should be able to discuss the major exposure routes for trichloroethylene, describe two potential environmental and occupational sources of exposure to trichloroethylene, state two reasons why trichloroethylene is a health hazard, describe factors contributing to trichloroethylene toxicity, identify evaluation and treatment protocols for persons exposed to trichloroethylene, and list two sources of information on trichloroethylene. (cdc.gov)
  • toxicity following styrene exposure. (cdc.gov)
  • By examining the SNPs, it is possible to make predictions about the patient's response to treatment or development of toxicity after treatment, and if necessary, make changes in the patient's treatment regimen. (researchsquare.com)
  • Whole rodent necropsy, tissue collection, gross examination with report. (irbbarcelona.org)
  • Objective: (1) Determine if sequential administration of standard chemotherapy (paclitaxel and cisplatin, P/C) with epigenetic drugs effectively targets ovarian cancer and limits toxicity to normal cells. (fortuneonline.org)
  • Modeling clinically relevant tissue responses using cell models poses a significant challenge for drug development, in particular for drug induced liver injury (DILI). (organovo.com)
  • Blood levels of the anesthetic may be measured, although blood levels may not correlate with toxicity or may not be obtained at a clinically useful time. (medscape.com)
  • The manufacturing process preserves the thymic epithelial cells and tissue structure and depletes most of the donor thymocytes from the tissue. (rxlist.com)
  • Together, these results demonstrate that 3D bioprinted liver tissues can both effectively model DILI and distinguish between highly related compounds with differential profile. (organovo.com)
  • Furthermore, of 13 human cytochrome P-450s (P-450s) examined, five (CYP1A1, CYP1A2, CYP2B6, CYP2E1, and CYP3A4) were active in the metabolic activation of coumarin, suggesting a potential risk of coumarin toxicity in humans. (aspetjournals.org)
  • Anemia, diseases of the musculoskeletal and connective tissues and other conditions accounted for the remaining 6 percent. (cdc.gov)
  • Neoplastic diseases are ones that cause abnormal tissue growth. (healthline.com)
  • In this study, we established and characterized novel bioprinted human liver tissue mimetics comprised of patient-derived hepatocytes and non-parenchymal cells in a defined architecture. (organovo.com)
  • Using the technique, the researchers were able to combine four tissue types found within lungs into a single whole that can be used to study how tissue reacts to toxins, drugs, or other stimuli. (medgadget.com)
  • Norepinephrine transporter, organic cation transporters, and multidrug and toxin extrusion proteins play differential roles in tumor targeting, systemic elimination, and accumulation in normal tissues. (aspetjournals.org)
  • Emerging evidences suggest that the polyspecific organic cation transporters are the major transporters driving the systemic elimination and tissue-specific disposition of mIBG in normal organs. (aspetjournals.org)
  • Our collective goal is to find innovative tools - pharmacological or technological - able to protect normal tissue and enhance tumor control. (unil.ch)
  • The attack of these antibodies against normal tissue does what immune activation does: It results in inflammation. (scienceblogs.com)
  • With traditional 2-D cultures, it is very difficult to culture cells at the air-liquid interface, which is what you'd prefer for toxicity testing," he said. (medgadget.com)
  • Thyroid hormones play a complex role in the toxicity of polychlorinated dibenzo-p-dioxins and furans and related compounds. (nih.gov)
  • Time courses and dose responses were determined for serum thyroxine (T4) and triiodothyronine (T3) levels, for 5'-DI activity in thyroid gland, liver and kidney, and for 5'-DII activity in brown adipose tissue (BAT). (nih.gov)
  • Soil testing and leaf tissue testing have different uses or purposes depending on the property or nutrient, so care must be taken to use the correct test when diagnosing citrus nutrition (Table 1). (ufl.edu)
  • Summary of the usefulness of soil testing and leaf tissue testing as citrus nutrient management tools. (ufl.edu)
  • Leaf tissue analysis is the quantitative determination of the total mineral nutrient concentrations in the leaf. (ufl.edu)