• The s-TMA functions as a biological filter to identify bona fide prognostic markers associated with survival group extremes (at least 18 months separate survival groups). (plos.org)
  • ROC curves were used to compare the four pathologic prognostic features (ROC area = 0.70) to three univariate molecular predictors (MUC1, MSLN, MUC2) of survival group (ROC area = 0.80, p = 0.07). (plos.org)
  • Several patient demographic factors, including marital status, have been demonstrated to have prognostic significance for survival in extremity soft tissue sarcoma (ESTS). (hindawi.com)
  • This work describes two projects investigating loss of proliferation control in soft tissue sarcoma, as a result of Hippo pathway deregulation, and mechanisms of survival under stress in glioblastoma, as a result of decreased microRNA-124 (miR-124) levels. (upenn.edu)
  • However, contamination by, or differentiation into, nonneural tissues can occur, can lead to proliferation of tissues within ventricular spaces, and may result in ventricular obstruction. (neurology.org)
  • Using the Gene Expression Omnibus (GEO) database, we identified up-regulated differentially expressed genes (DEGs) between tumor tissues and nontumor tissues in PDAC patients, enriched potential pathways/biological processes, and evaluated associations between up-regulated DEGs and PDAC outcomes. (bioscirep.org)
  • The span of viability of a tissue or an organ. (jove.com)
  • Accurate Prediction of Tissue Viability at Postoperative Day 7 Using Only Two Intraoperative Subsecond Near-Infrared Fluorescence Images. (harvard.edu)
  • Downregulation of p16(INK4a) is found in malignant progression, and is significantly correlated with reduced patient survival. (uni-muenchen.de)
  • Soft tissue sarcoma is a rare form of malignant tumor with approximately 2,000 cases in Japan and approximately 12,000 cases in the United States diagnosed each year. (eisai.com)
  • In conclusion, the up-regulation of BUB1B, CCNA2, CDC20, CDK1, and WEE1 in tumor tissues are associated with worse OS and DFS in PDAC and is correlated with advanced tumor stage and tumor development. (bioscirep.org)
  • Our results show that the combination chemotherapy did not improve overall survival," said study coordinator Ian Judson, MD, of the Royal Marsden Hospital in London, England. (oncologynurseadvisor.com)
  • While treatment of soft tissue sarcoma is focused on curative surgery, if the degree of malignancy is high, treatment then becomes a combination of chemotherapy and radiation therapy. (eisai.com)
  • Report about high dose chemotherapy and the possible development of second malignancy in children and young adults being treated for bone or soft tissue sarcoma. (dmoztools.net)
  • 5-year survival is only 51%, and has not changed significantly over the 12 years analysed. (ncin.org.uk)
  • Moreover, overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues was significantly associated with disease-free survival (DFS) in PDAC patients (Log rank P =0.00565, P =0.0357, P =0.00104, and P =0.00121, respectively). (bioscirep.org)
  • Significantly greater amounts of both 2- and 4-hydroxyestradiol, along with a marked increase of 16α-hydroxyestrone (OHE 1 ), were observed in cancer with respect to normal breast tissues. (aacrjournals.org)
  • The estrogen receptor status of tissues was determined by both ligand binding and immunohistochemical assays. (aacrjournals.org)
  • Our data imply that individual hydroxyestrogens may have a distinct role in the onset and the clinical progression of breast cancer, with greater 16αOHE 1 levels being in turn associated to cancer with respect to normal tissues and to a prolonged survival of breast cancer patients. (aacrjournals.org)
  • Clinical outcomes including local recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) were evaluated using the Kaplan-Meier estimate. (hindawi.com)
  • The main goal of our study was to assess estrogen contents of breast tumor tissues, having different estrogen receptor status, in relation to long-term follow-up of patients. (aacrjournals.org)
  • Static tissues such as muscle or bone will subtract out, however moving tissues such as blood will acquire a different phase since it moves constantly through the gradient, thus also giving its speed of the flow. (wikipedia.org)
  • The addition of olaratumab to doxorubicin dramatically improves survival in patients with advanced soft-tissue sarcoma, according to the results of a randomized phase Ib/II trial ( abstract 10501 ) presented at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, held May 29 to June 2, in Chicago. (cancernetwork.com)
  • We identify three factors (SERP1, TEAD1, and MAPK14) as direct miR-124 targets and partial effectors of cell survival under stress. (upenn.edu)
  • Kaplan-Meier curves of disease-specific survival for high-grade serous (HGSC) and endometrioid (EC) carcinomas, according to hormone receptor status. (nih.gov)
  • Based on the results of Study 309, Eisai intends to submit applications during the first half fiscal 2015 to the regulatory authorities in multiple countries including Japan, the United States and Europe seeking an expansion of the indication for eribulin to include soft tissue sarcoma. (eisai.com)
  • Eribulin has been designated as an orphan drug for the treatment of soft tissue sarcoma in the United States and Japan. (eisai.com)
  • For a patient to be eligible, tissue microarrays, clinical follow-up data, age at diagnosis, and tumour grade and stage had to be available. (nih.gov)
  • Since 1985, treatment of idiopathic Parkinson's disease (PD) by surgical transfer of adult or fetal chromaffin tissue or of fetal central neural tissue to the brains of afflicted patients has been attempted, with variable clinical results. (neurology.org)
  • Finally, post-transplant clinical improvement in symptoms of PD may be unrelated to survival of engrafted neurons. (neurology.org)
  • Concise Review: Understanding and leveraging cell metabolism to Enhance Mesenchymal Stem Cell Transplantation Survival in Tissue Engineering and Regenerative Medicine Applications. (stembook.org)
  • First, we demonstrate that the Hippo pathway is deregulated in soft tissue sarcoma patient samples, leading to overexpression of the Hippo effector YAP. (upenn.edu)
  • Despite major improvements in its diagnosis and treatment, PDAC remains an aggressive disease that carries a poor prognosis and a 5-year survival rate of approximately 8% in the United States [ 2 , 3 ]. (bioscirep.org)
  • A study population of 12,546 adult patients diagnosed with ESTS from 1991 to 2010 was identified from the SEER database, a large population-based registry, in order to determine whether overall survival had changed over this recent 20-year period. (hindawi.com)
  • Local recurrence in adult soft-tissue sarcoma: a randomized trial of brachytherapy. (springermedizin.de)
  • These results suggest that FABP4 and FABP5 have a critical role in the maintenance, longevity and function of CD8+ TRM cells, and suggest that CD8+ TRM cells use exogenous FFAs and their oxidative metabolism to persist in tissue and to mediate protective immunity. (ovid.com)
  • On the basis of these results, we hypothesize that low-volume resuscitation with HBOC-201 in a porcine model of controlled hemorrhage provides adequate tissue oxygenation to limit end-organ damage and allow for survival of the animal. (omicsonline.org)
  • Importantly, miR-124 ectopic expression results in increased survival in an in vivo orthotopic intracranial glioma model, suggesting that expression of miR-124, or inhibition of its downstream targets, is an attractive way of targeting glioblastoma cells residing in hypoxic/ischemic regions, and ultimately a method of investigating novel glioblastoma treatments. (upenn.edu)
  • In this study, we analysed a well characterised cohort of STS for p16(INK4a) expression and correlated the results with clinicopathological parameters including survival. (uni-muenchen.de)
  • The invasive soft tissue sarcoma morphology codes included within the analysis were agreed with the sarcoma SSCRG . (ncin.org.uk)
  • Comparison of survival times of mice inoculated with brain tissue from various neurological diseases. (docme.ru)
  • Am J Med 56:545-553, 1974 CornParison of Survival Tim& of Mice Inoculated with Brain Tissue from Various Neurological Diseases Leighton W. Greenham, PhD, and David B. Peacock, MB, ChB ~ ~ Mice inoculated intracerebrally before the age of 5 days with homogenates of autopsied brain tissue from patients with Creutzfeldt-Jakob (C-J), Alzheimer's, or Picks diseases showed highly significant decreases in life span when compared with sham-inoculated control mice. (docme.ru)
  • ASCO discussant Laurence Baker, DO, professor of medical oncology at the University of Michigan, noted the "dramatic difference in overall survival" seen with olaratumab, commenting that the PDGFRα monoclonal antibody "shows great promise," and that he is excited a phase III trial is planned. (cancernetwork.com)
  • Flow dependent MRA can be divided into different categories: There is phase-contrast MRA (PC-MRA) which utilizes phase differences to distinguish blood from static tissue and time-of-flight MRA (TOF MRA) which exploits that moving spins of the blood experience fewer excitation pulses than static tissue, e.g. when imaging a thin slice. (wikipedia.org)
  • One of the major concerns about fat transfer is long-term survival of the transplanted cells. (empowher.com)
  • CONCLUSION: Low-volume resuscitation with HBOC-201 provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhagic shock with no long-term organ dysfunction identified. (omicsonline.org)
  • Grafts, whether intraventricular or intraparenchymal, are capable of inciting host responses, which in turn may limit their long-term survival. (neurology.org)
  • The process of freezing causes ice crystals to form in the tissue, which in turn causes damage at the cellular level. (wikipedia.org)
  • Rewarming causes tissue damage through reperfusion injury, which involves vasodilation, swelling (edema), and poor blood flow (stasis). (wikipedia.org)
  • Learn how to determine the degree and the extent of damage to body tissues. (dmoztools.net)