Tissue specificities. Medical search. Frequent questions

Patient-collected vaginal swab specimens are equivalent in sensitivity and specificity to those collected by a clinician using NAATs ( 792 , 793 ), and this screening strategy is highly acceptable among women ( 794 , 795 ). (cdc.gov)
NAATs have been demonstrated to have improved sensitivity and specificity, compared with culture, for detecting C. trachomatis at rectal and oropharyngeal sites ( 553 , 800 - 804 ), and certain NAAT platforms have been cleared by FDA for these anatomic sites ( 805 ). (cdc.gov)
however, it has low sensitivity and specificity. (medscape.com)
Accuracy of specificity and degree of sensitivity by various methods are assessed. (uclahealth.org)
When both DSE and Thallium-201 are performed in the same patient, discordant results are often obtained In fact, in comparative studies where both techniques have been used prior to revascularisation procedures, the sensitivity, specificity and predictive value for the detection of viable myocardium have been found to differ. (escardio.org)
Indeed, comparative studies have been reported in which dysfunctional segments failing to respond to dobutamine (i.e., classified by dobutamine stress echocardiography as being non-viable) show thalium-201 uptake in redistribution, and are thus classified as viable by this test, highlighting the different sensitivity and specificity of both techniques. (escardio.org)
In addition, maximum diagnostic efficiency (sensitivity and specificity) is obtained for less viable tissue per segment with Tl-201 than for dobutamine echocardiography. (escardio.org)
In systematic reviews comparing VCTE TM to biopsy (as a gold standard) for the detection of severe liver fibrosis, the mean area under the ROC curve was 0.89 (95% CI, 0.88-0.91) (Tsochatzis et al, 2011, Friedrich-Rust et al, 2008) and the overall sensitivity and specificity were 82% (95% CI, 78-86%) and 86% (95% CI 0.80-0.91). (cdc.gov)
ABSTRACT A serological study was carried out in Tiaret province in western Algeria on 1032 cows distributed in 95 flocks to estimate the prevalence of Brucella infection and to compare the sensitivity and specificity of a range of agglutination tests. (who.int)

However, the factors leading to cell/tissues damage, as well as the mechanisms behind the observed organ specificity are mostly unknown. (lu.se)
Organ Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Organ Specificity" by people in Harvard Catalyst Profiles by year, and whether "Organ Specificity" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Organ Specificity" by people in Profiles. (harvard.edu)

A serum exchange was added in 1981, to check for anti-HLA antibody specificities. (uclahealth.org)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)

By unlocking the molecular mechanisms underpinning tissue specificity in tumours, the team would provide a foundation for rational interventions and therapeutic choices made by physicians and people with cancer throughout the patient journey. (cancergrandchallenges.org)
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function. (harvard.edu)
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
Symbols should not include tissue specificity and molecular weight designations. (jax.org)

Altered receptor-binding specificity of virus clade 2.3.4.4 H5 proteins might have contributed to emergence and spread of H5Nx viruses. (cdc.gov)
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (antibodies-online.com)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
Bioinformatics analysis revealed that several of the AS events could result in the production of novel tissue-specific proteins. (biomedcentral.com)
The antiserum further demonstrates specificity for proteins conjugated with MDI, but not other commonly used diisocyanate s. (cdc.gov)

Patients with inclusion body myositis (IBM) and controls were negative for Jo-1, PL-7, SRP, MDA5 and TIF1γ specificities in all assays. (bmj.com)

A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
The altered signaling interferes with the normal development of many organs and tissues, resulting in the characteristic features of cardiofaciocutaneous syndrome. (medlineplus.gov)
The increased signaling interferes with the normal development of many organs and tissues, resulting in the characteristic features of Noonan syndrome with multiple lentigines. (medlineplus.gov)

In addition, formalin fixed paraffin embedded tissue was obtained from eight patients with an earlier diagnosis of sarcoidosis who were still being followed up. (bmj.com)
Immunochemical studies with cytospun airway cells and formalin-fixed paraffin embedded lung tissue sections from mice intranasally exposed to MDI (as reversibly reactive glutathione conjugates, e.g. (cdc.gov)

Beyond the common features shared by all iNKT cells (including their CD1-restriction and innate-like properties), cells found in discrete tissues have distinct phenotypes and functions that critically modulate the outcome of immunity ( Crosby and Kronenberg, 2018 ). (elifesciences.org)

Central to the team's aims is the development of the first functional atlas of tissue specificity, a comprehensive map of the cellular networks that allow drivers to initiate cancers in certain tissues but not others. (cancergrandchallenges.org)
As a consequence, certain tissues might be more susceptible to loss of minor spliceosome function. (biomedcentral.com)

We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
The accuracy of these reagents was dependent upon local methods of assessing the specificities of the anti-HLA antibodies and the volumes made it difficult to distribute sufficient quantities for use by everyone who performed HLA testing. (uclahealth.org)

Immunoblot analysis of rat microsomes illustrated the male specificity of cytochrome P450h expression which extended to extrahepatic tissues including kidney and lung. (nih.gov)

Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)

In a study recently published in Nature Communications , SPECIFICANCER unlocks new information about the tissue specificity of KRAS - which, despite being one of the most commonly mutated cancer-driving genes (oncogenes), drives only a few cancer types: lung, colorectal, pancreatic and endometrial cancers, and myelomas. (cancergrandchallenges.org)
METHODS Fresh tissue samples (node or lung biopsy) taken from 23 patients with newly diagnosed sarcoidosis, 10 with other respiratory disease, and four patients with culture positive tuberculosis were analysed using PCR to amplify a 123 bp fragment of IS6110, the insertion element present in MTb, and nested PCR to further amplify an 85 bp sequence within the 123 bp product. (bmj.com)
The pathogenesis of diisocyanate -induced asthma, including the pathways by which the chemical is taken up and its distribution in exposed tissue, especially the lung, remains unclear. (cdc.gov)

By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)

Nonetheless, how signals from the tissue environment shape the iNKT cell population to best fit their function in their tissues of residency remains unclear. (elifesciences.org)

However, ZIKV can also be transmitted to other adult tissues, including the reproductive system, brain, eyes, and lymph nodes ( Figure 1 ). (encyclopedia.pub)
Expressed in many adult tissues. (abcam.com)

Given that the minor spliceosome is ubiquitously expressed, we hypothesized that these restricted phenotypes might be caused by the tissue-specific regulation of the minor spliceosome targets, i.e. minor intron-containing genes (MIGs). (biomedcentral.com)
These findings may shed light on the mechanism underlying tissue-specific phenotypes in diseases associated with minor spliceosome inactivation. (biomedcentral.com)
One way to explain this paradox of systemic minor spliceosome inhibition resulting in tissue-specific phenotypes would be that the MIGs are expressed, spliced and/or alternatively spliced in a tissue-specific manner. (biomedcentral.com)

The aim of this study was to collect prospectively tissue from a carefully characterised cohort of patients with newly diagnosed sarcoidosis in whom tuberculous infection or prior disease had been excluded and to use PCR to search for DNA sequences specific for MTb. (bmj.com)
Fresh tissue samples were prospectively collected from a cohort of 23 patients with newly diagnosed sarcoidosis all seen at one outpatient clinic at one hospital. (bmj.com)
2 3 Our aim was to compare a LB version with 16 specificities and an IP-based algorithm, as well as to describe clinical associations to autoantibody specificities in a cohort of patients classified as IIM. (bmj.com)

Within peripheral tissues iNKT cell recent thymic emigrants exhibit a different TCR repertoire than mature cells, suggesting that the iNKT population is shaped after arrival to the periphery. (elifesciences.org)
Effects of chondroitinase ABC on intrathecal and peripheral nerve tissue. (lu.se)

Transcription of endogenous C-type virus in resting and proliferating tissues of BALB/Mo mice. (microbiologyresearch.org)
Variations in hybridization of RNA from different mouse tissues and embryos to endogenous C-type virus DNA transcripts. (microbiologyresearch.org)
Selective transcription of homologous genomic sequences of N- and X-tropic endogenous retroviruses in BALB/C mouse tissues. (microbiologyresearch.org)

We discovered a positive correlation between genetic constraints, PPIs, and expression levels in all tissues. (qxmd.com)
The SPECIFICANCER team delves deeper into the biological laws that govern tissue specificity in cancer and reveals intricate webs of genetic interactions. (cancergrandchallenges.org)
Reasoning that these properties should cause each allele to behave differently, the team hypothesised that each must also interact with a distinct tissue-specific genetic network to drive cancer. (cancergrandchallenges.org)

We focused on four ApoA-I amyloidogenic variants and analyzed their cytotoxicity as well as their ability to alter redox homeostasis in cell lines from different tissues (liver, kidney, heart, skin). (lu.se)

Together, our work identified Bonus as a regulator of tissue-specific gene expression and revealed the importance of SUMOylation as a regulator of complex formation in the context of transcriptional repression. (elifesciences.org)

In preNAC biopsy tissues from a DCF-sensitive case, we demonstrated the presence of cells expressing mRNA for CXCL9, one of the prognosis-related DEGs. (bvsalud.org)

Differences in the exact size classes of virus-specific RNAs and, in their relative proportions were found to exist in the four different tissue types examined and no correlation between a specific RNA size-profile and the proliferating activity of a tissue could be detected. (microbiologyresearch.org)
Unlike linear RNAs, circRNAs require high conservation, have high stability and tissue specificity, and are not easily degraded by enonuclease [ 6 , 7 ]. (hindawi.com)

The concept of co-mutations not only extends our basic understanding of cancer genetics and tissue specificity - it could also transform our ability to predict how a person would respond to certain drugs," Kevin explains. (cancergrandchallenges.org)
Tissue-restricted inhibition of mTOR using chemical genetics. (harvard.edu)

RESULTS MTb DNA was not detected in any of the tissue samples from patients with sarcoidosis or other respiratory disease but was found in all four patients with tuberculosis. (bmj.com)
Some investigators have found evidence of MTb in tissues using the polymerase chain reaction (PCR) to amplify mycobacterial DNA or rRNA 6-8 but more recent studies have failed to identify such organisms in the majority of tissue samples from patients with sarcoidosis. (bmj.com)
This assay will have applications for water samples or fish tissue. (usda.gov)
Forty oral cancer tissue samples and paired adjacent normal tissues were collected from the Department of Oral and Maxillofacial Surgery, Shenzhen Hospital, Peking University (Shenzhen, China), from December 2016 to May 2017. (hindawi.com)
Tissue samples were stored at −80°C before use. (hindawi.com)
GSH-MDI) demonstrated the antiserum's ability to detect MDI in tissue samples. (cdc.gov)
Three isolates were identified from 105 blood samples from humans with brucellosis and 50 samples of milk and tissues from infected cows and they were all Brucella melitensis biovar 3. (who.int)

Most anatomical compartments, including mucosal surfaces and solid organs, host large populations of tissue-resident lymphocytes which are uniquely placed to provide local networks for immune surveillance and defence against infection ( Fan and Rudensky, 2016 ). (elifesciences.org)
Shin, H.Y. Tissue Specificity of Zika Virus Infection. (encyclopedia.pub)
Tissue Specificity of Zika Virus Infection" Encyclopedia , https://encyclopedia.pub/entry/27419 (accessed November 30, 2023). (encyclopedia.pub)
The primary target tissues of ZIKV infection have been recognized as the maternal placenta and fetal brain. (encyclopedia.pub)
Change in the condition of any one of the above factors or combination thereof can result in oral hard or soft tissue infection. (medscape.com)

Yes, mutational processes can contribute to tissue-specific alleles - but in most cases, there's something else in the tissue that is acting as a biological driver. (cancergrandchallenges.org)
The study of two cases of ductal carcinoma in situ in breast tissue supports the biological observation regarding the existence of a preferential intraductal invasion, and therefore a common origin, between the primary tumor and the gene amplification in the cell-nuclei lining the ductal structures in the breast. (nih.gov)
The primary method for detecting methyl parathion and metabolites in biological tissues is gas chromatography (GC) coupled with electron capture (ECD), flame photometric (FPD), or flame ionization detection (FID). (cdc.gov)
Table 7-1 summarizes the analytical methods used to detect methyl parathion and its metabolites in biological tissues and fluids. (cdc.gov)
4-Nitrophenol and the alkyl phosphate, dimethyl phosphate, are major metabolites that are frequently found in biological fluids and tissues following exposure. (cdc.gov)
For the analysis of 4-nitrophenol in biological tissues and fluids, EPA recommends extraction with benzene-ether and derivatization with hexamethyl disilizane prior to analysis by GC/ECD (EPA 1980d). (cdc.gov)

Therefore, we investigated the impact of ApoA-I variants on cell physiology and the mechanisms driving the observed tissue specificity. (lu.se)
The mechanisms underlying this tissue specificity in cancer remain mostly elusive. (cancergrandchallenges.org)
The Cancer Grand Challenges SPECIFICANCER team aims to clarify the complex mechanisms of tissue specificity, guided by an overarching philosophy that the tissue's pre-existing characteristics - including its epigenetics, microenvironment and cell-cell interactions - dictate whether a mutated gene can drive tumorigenesis. (cancergrandchallenges.org)

METHODS: Levels of VSNL expression in colorectal tumor tissues were analyzed using immunohistochemistry. (bvsalud.org)

Infoscitex, in collaboration with Dr. Cain at U-Idaho, will conduct evaluations to determine the relationship of bacteria concentration in water and tissue to the onset of disease in individual fish as well as to the time of propagation of the population. (usda.gov)

To our knowledge, this is the first demonstration of the prominent cell-type specificity of PMDs across normal, precursor, and malignant states," the researchers write. (genomeweb.com)

Three controls had either anti-Ku, anti-NXP2 or anti-Mi-2α by LB (mean 20 units), corresponding to a total diagnostic specificity of 99.7% ( table 1 ). (bmj.com)

How much are natural selection and gene characteristics, such as the number of protein-protein interactions (PPIs), tissue specificity (𝞽), and expression level, connected? (qxmd.com)
We observed that the variance of expression of tissue-specific genes seems not related to their level of selection constraints, which is the opposite of what is found on non-tissue-specific genes. (qxmd.com)
Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). (hindawi.com)
Its expression levels in tissues at various stages of OSCC were then explored, and the potential relationship between hsa_circ_001242 expression levels and patients' clinicopathological factors were investigated. (hindawi.com)
We then sought to address specificity of MIG expression, minor intron retention, and alternative splicing (AS) across mouse and human tissues. (biomedcentral.com)
We then analyzed the RNAseq data from eleven different mouse tissues, which revealed tissue-specific MIG expression and minor intron retention. (biomedcentral.com)

Intriguingly, the activating alleles (copies of the genes carrying mutations at these hotspots that drive tumorigenic KRAS ) vary significantly among these tissues. (cancergrandchallenges.org)

Insights into gene tissue specificity and protein-protein interactions in the context of purifying selection in humans. (qxmd.com)

If an intact cell membrane is considered to imply a live cell, then the detection of TL-201 in a given segment is indicative of tissue viability. (escardio.org)
In this sense, Thallium 201 requires less live tissue in each segment than DSE to diagnose viability. (escardio.org)

Avoid antibiotics and wound cultures in emergency department patients with uncomplicated skin and soft tissue abscesses after successful incision and drainage and with adequate medical follow-up. (aafp.org)

For example, BRAF is another oncogene with distinct patterns of tissue specificity. (cancergrandchallenges.org)

1971) found that GC/FPD provided better specificity. (cdc.gov)
and recall of stored tissues from donors found after donation to have been infected. (cdc.gov)

A higher specificity and selectivity aptamer based assay will provide US fish farmers and fish health laboratories with the ability to perform earlier detection of the onset of CWD or allow quantitative screening of broodstock in order to implement strategies that would limit vertical transmission to progeny. (usda.gov)

This suggests that unique tissue-specific factors (including local lipid antigens, cytokines and/or hormones) may shape the population of iNKT cells resident in those tissues, ultimately regulating local immune responses. (elifesciences.org)

They analyzed the whole-genome bisulfite sequencing profiles of 45 esophageal tumors, representing both the squamous cell carcinoma and adenocarcinoma subtypes, and matched nonmalignant tissue. (genomeweb.com)
Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types. (harvard.edu)
The Cell Exchange has helped laboratories to sharpen their skills and has monitored and published the development of tissue typing over the years. (uclahealth.org)
We first confirmed that hsa_circ_001242, which is located at chr10: 17157441-17168917 (Figure 1 ), was significantly downregulated in OSCC cell lines and OSCC tissues. (hindawi.com)

See related handout on skin and soft tissue infections , written by the authors of this article. (aafp.org)
Skin and soft tissue infections result from microbial invasion of the skin and its supporting structures. (aafp.org)
Skin and soft tissue infections (SSTIs) account for more than 14 million physician office visits each year in the United States, as well as emergency department visits and hospitalizations. (aafp.org)

Tissue homeostasis is critically dependent on the function of tissue-resident lymphocytes, including lipid-reactive invariant natural killer T (iNKT) cells. (elifesciences.org)
Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)
Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (antibodies-online.com)
Medical products of human origin are defined as substances that are derived wholly or in part from the human body and intended for clinical application.1 Source components in the human body range from organs, tissues, blood, cells and gametes to breast milk, hair, nails, urine and faeces. (who.int)
Nevertheless, the available guidance is somewhat fragmented and generally oriented towards a number of specific products (e.g. blood and organs/tissues/cells). (who.int)

Bone scintigraphic studies are highly sensitive but lack specificity. (medscape.com)
This rare disease causes the abnormal growth of new bone tissue on the surface of existing bones. (medlineplus.gov)
The mutations lead to the production of a version of the protein that is overactive, which increases RAS/MAPK signaling in bone tissue. (medlineplus.gov)

0.1 ppm) of methyl parathion in tissue, blood, and urine is GC/FPD for phosphorus (EPA 1980d). (cdc.gov)

Anatomy31

Organisms20

Diseases2

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes91

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science7

Health Care9

Sensitivity9

Organ specificity4

Antibody4

Molecular4

Proteins9

Assays1

Organs and tissues5

Formalin fixed paraffin embedded2

Modulate1

Certain tissues2

Antibodies2

Cytochrome1

Reactivity1

Lung3

Lymphoid1

Remains unclear1

Adult2

Phenotypes3

Cohort3

Peripheral2

Endogenous3

Genetic3

Liver1

Gene expression1

Biopsy1

RNAs2

Genetics2

Samples7

Infection5

Biological6

Mechanisms3

METHODS1

Bacteria1

Malignant1

Diagnostic1

Expression6

Genes1

Humans1

Viability2

Adequate1

Distinct1

Found2

Detection1

Antigens1

Cell4

Soft tissue3

Cells5

Bone3

Urine1