A comprehensive landscape of chromatin states for multiple mammalian tissues is essential for elucidating the molecular mechanism underlying regulatory variants on complex traits. (biomedcentral.com)
Our data provides a novel multi-tissues accessible chromatin landscape that serve as an important resource for interpreting regulatory sequences in tissue-specific and conserved biological functions, as well as regulatory variants of loci associated with complex traits in pigs. (biomedcentral.com)
Single CTCs from each individual display considerable heterogeneity, including expression of AR gene mutations and splicing variants. (uth.edu)
Homo sapiens , benefiting from new variants of the FADS2 gene, were able to adapt to this harsh environment, whereas Neanderthal man was unable to do so and became extinct. (ocl-journal.org)
Homo sapiens , avec l'avantage de nouveaux variants du gène FADS2, s'adapta à ce rigoureux environnement, mais l'Homme de Néandertal ne put le faire et disparut. (ocl-journal.org)
Mutations3
With the advent of cooking and new mutations producing even more FADS2 , the brain reached its maximum size in Homo neanderthalensis , in a food ecosystem that provided favorable quantities of α-Linolenic acid and DHA. (ocl-journal.org)
Un facteur stimulant : les mutations sur le gène FADS2 de la Δ6-désaturase, enzyme clé de la synthèse du DHA et de l'acide sapiénique. (ocl-journal.org)
Avec l'apport de la cuisson et de nouvelles mutations plus productives de FADS2, le volume cérébral a trouvé son apogée chez Homo neanderthalensis dans un écosystème alimentaire favorable en acide α-linolénique et DHA. (ocl-journal.org)
Homogenates9
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Wilms Tumor Protein (WT1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Wilms Tumor Protein (WT1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
Description: tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Proenkephalin (PENK) in samples from serum, plasma, tissue homogenates or other biological fluids. (stemcellcharter.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Proenkephalin (PENK) in serum, plasma, tissue homogenates and other biological fluids. (stemcellcharter.org)
Description: Quantitativesandwich ELISA kit for measuring Human Protein jagged-1 (JAG1) in samples from serum, plasma, tissue homogenates. (kits-elisa.com)
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Jagged 1 Protein (JAG1) in samples from tissue homogenates or other biological fluids. (kits-elisa.com)
Description: A sandwich quantitative ELISA assay kit for detection of Human Cyclin Dependent Kinase Inhibitor 3 (CDKN3) in samples from tissue homogenates or other biological fluids. (jemsec.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cyclin Dependent Kinase Inhibitor 3 (CDKN3) in Tissue homogenates and other biological fluids. (jemsec.com)
Biological1
We revealed tissue-specific regulatory elements which were associated with tissue-relevant biological functions. (biomedcentral.com)
Samples1
Samples that have “source name†set to “primary PCa tumor†were frozen primary prostate cancer tissue samples from patients with localized prostate cancer who underwent prostatectomy, that were then sectioned and microdissected for >70% tumor content. (uth.edu)
Distinct2
Moreover, the fatty acid composition of liver was clearly distinct from the remaining tissues involved in fatty acid metabolism of ruminants, as shown by Principal Components Analysis. (biomedcentral.com)
To better understand the distinct functions of yolk-sac-derived tissue-resident macrophages (TRMs) and bone-marrow-derived macrophages in homeostasis and disease, it is important to trace the ontogeny of these cells. (bvsalud.org)
Important role2
In ruminants, unsaturated dietary fatty acids are biohydrogenated in the rumen and are further metabolised in various tissues, including liver, which has an important role in lipid and lipoprotein metabolism. (biomedcentral.com)
Despite the predominant role of adipose tissue in ruminant's de novo fatty acid synthesis, the liver also plays an important role in ruminant lipid metabolism [ 1 ]. (biomedcentral.com)
Results1
Results indicate that DGAT1 , ELOVL2 , FADS1 and FADS2 genes influence the fatty acid composition of the liver the most. (biomedcentral.com)
Functions1
This organ carries out central metabolic functions in various aspects of lipid and lipoprotein metabolism, such as uptake, oxidation and metabolic conversion of non-esterified fatty acids (NEFA), synthesis of cholesterol and phospholipids, and formation and secretion of specific classes of lipoproteins [ 1 ]. (biomedcentral.com)