Tissue scaffolds vascular tissues. Medical search. Frequent questions

Thus, the long-term survival and function of 3D tissues depend on the rapid development of new blood vessels to provide nutrients and oxygen to cells in the center of the tissue grafts. (hindawi.com)
Tissue-engineered vascular grafts can grow and remodel and can therefore enable great advances in pediatric cardiovascular surgery. (medscape.com)
[ 3 ] Stenosis is the primary complication with tissue-engineered vascular grafts. (medscape.com)
He completed his PhD in biomedical engineering at Yale University as an NSF Graduate Research Fellow, where his dissertation work focused on the design of tissue engineered vascular grafts for use in the Fontan procedure. (stanford.edu)
Spontaneous reversal of stenosis in tissue-engineered vascular grafts. (stanford.edu)
Synthetic vascular grafts made from polymer materials are also available, although these are prone to infection and blood clotting, especially in smaller diameter vessels. (formlabs.com)
These tissue-engineered blood vessels, which ultimately would incorporate the patient's own cells to limit rejection, may be the best approach to generate vascular grafts that function in all respects like natural blood vessels. (benaroyaresearch.org)
The clinical demand for tissue-engineered vascular grafts is still rising, and there are many challenges that need to be overcome, in particular, to obtain functional small-diameter grafts. (bvsalud.org)
Several types of grafts can be used for vascular reconstruction. (medscape.com)
These can be divided into autologous tissue grafts, allografts, xenografts, alloplastic prostheses/artificial grafts, and tissue-engineered vascular grafts. (medscape.com)

The ideal vascular graft has yet to be developed, and all materials have advantages and disadvantages. (medscape.com)
He is also designing a small diameter tissue engineered vascular graft to treat cardiovascular diseases. (pitt.edu)
We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of a U.S. Food and Drug Administration (FDA)-approved clinical trial evaluating this graft in patients with single-ventricle cardiac anomalies. (stanford.edu)
This will allow for patient-specific vascular graft designs, improved surgical options and provides a unique testing platform for new vascular medical devices for those suffering from cardiovascular disease - which is currently the number one cause of death worldwide. (formlabs.com)
To promote healing of the vascular graft, the scaffolds are made from structural molecules found in natural connective tissues. (benaroyaresearch.org)
Currently, many naturally derived scaffold materials are mechanically weak, which requires that engineered vessels mature for months in culture before they are strong enough to graft safely. (benaroyaresearch.org)
The many advances made in cell culture, biomaterials, manufacturing techniques, and tissue engineering methods have led to various promising solutions for vascular graft production, with available options able to recapitulate both biological and mechanical properties of native blood vessels. (bvsalud.org)
In this review, the progress made in tissue-engineered vascular graft production is discussed. (bvsalud.org)

The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues and organs for repair or replacement. (mdpi.com)
Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)
Advances in 3D printing also offer exciting new opportunities for regenerative medicine, including incorporation of vascular scaffolds into bioengineered tissues and organs. (genomeweb.com)
The research in Dr. Vorp's lab focuses on the biomechanics, "mechanopathobiology," regenerative medicine, and tissue engineering of tubular tissues and organs, predominantly the vasculature. (pitt.edu)
In theory, repeating such print-and-culture cycle could generate complex tissue/organs with printed cells interlaced and connected with blood vessel networks to maintain long-term survival and functions. (nanowerk.com)
If damaged through injury or disease, most of our tissues and organs are unable to regenerate to their original state. (formlabs.com)
Tissue engineering refers to the development of technologies to grow replacement tissues and organs in the laboratory for use in treating injury and disease. (formlabs.com)
Methods of directly 3D printing with cells to form tissues and organs are being developed. (formlabs.com)
Broadly speaking, both terms refer to generating tissues, components of organs, and whole organs to repair or replace diseased, injured, or malfunctioning tissues. (embs.org)
Regenerative medicine is being driven by multiple factors: a shortage of organs available for transplantation, advances in biomaterials, a greater knowledge of the biological sciences, and a desire to produce functional replacement tissues. (embs.org)
Dr. McFetridge's primary research objective is to engineer viable 'living' tissue and organs for the repair and regeneration of diseased tissues. (ufl.edu)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)

He also serves as a Director of the Center for Vascular Remodeling and Regeneration, the Co-Director of the Center for Medical Innovation, the Acting Director of the University's GRID Institute, as well as the Director of the Vascular Bioengineering Laboratory. (pitt.edu)
The overall objectives of my research are to develop clinically translatable tissue regeneration and drug delivery strategies, and three-dimensional, in vitro human disease models using biologically-derived biomaterials. (wpi.edu)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
Biological scaffolding, either alone or in combination with cells for tissue regeneration, has the potential to revolutionize the repair of injured tissues and to replace tissues lost through disease and injury. (genengnews.com)
The expanded concept of regenerative medicine includes tissue engineering but also incorporates research on the regeneration of tissue directly in vivo, where the body uses its own systems to repair, replace, or regenerate function in damaged or diseased tissue with the help of exogenous cells, scaffolds, or biological factors. (embs.org)
Five weeks after implanting the scaffold, the tissue showed clear and significant regeneration of new vessels. (stanford.edu)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)

Here he also utilizes mesenchymal stem cells or their products incorporated in a biodegradable scaffold that undergoes substantial in vivo remodeling to develop a native-like blood vessel. (pitt.edu)

Angiogenesis is an important factor for tissue-engineered skin constructs. (hindawi.com)
In summary, compared with conventional methods, the novel 3D bioprinting system reported in this study offers a new strategy to print cells on complex-shaped vascular scaffolds and facilitate angiogenesis among post-printed cells, therefore enables long-term cell survival and demonstrates a feasible way to generate large-scale and functional artificial tissues/organs in vitro. (nanowerk.com)

The vast majority of the data on vascular reconstructive surgery in pediatric patients come from experience with access for hemodialysis, right ventricular outflow obstruction, middle aortic (midaortic) syndrome, renal artery occlusive disease and hypertension, and iatrogenic vascular trauma. (medscape.com)

This is accomplished through the integration of natural or synthetic scaffolds, cells, and biologically active molecules in concert with mechanical cues in in vitro preparations with subsequent implantation in vivo. (embs.org)
Improved recellularization of ex vivo vascular scaffolds using directed transport gradients," Biotechnology and Bioengineering . (ufl.edu)

Advances in the fields of stem cell biology, biomaterials, and tissue engineering over the last decades have brought the possibility of constructing tissue substitutes with a broad range of applications in reg. (biomedcentral.com)
In our lab we use precisely engineered, two-dimensional and three-dimensional constructs as model systems to study the effects of external internal (cell-generated) forces on cell behavior, matrix biochemistry, and the biomechanics of soft tissues and biomaterials. (wpi.edu)
3D bioprinting, which combines a 3D printer with bioinks (often containing cells and biomaterials) to fabricate tissue/organ-mimicking structures, is one of the most promising technologies for in vitro human organ generation. (nanowerk.com)
As a biomaterials scientist, his research focuses on developing biomaterials for implantable medical devices and tissue engineering templates and, specifically, on experimental and clinical work aimed at understanding biocompatibility phenomena [2], [3]. (embs.org)
It is one of a number of analysis and characterisation facilities within the Department, and is predominantly used by members of the Biomaterials and Tissue Engineering theme . (sheffield.ac.uk)

This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
The use of patient-specific induced pluripotent stem cells (iPSCs) in combination with bioengineering advances and genome editing offers unique opportunities for developing personalized disease models and tissues for regenerative medicine," the NIH said. (genomeweb.com)
The incidences of various esophageal diseases (e.g., congenital esophageal stenosis, tracheoesophageal fistula, esophageal atresia, esophageal cancer) are increasing, but esophageal tissue is difficult to be recovered because of its weak regenerative capability. (nature.com)
At McGowan Institute's "Symposium on Biologic Scaffolds for Regenerative Medicine" held recently in Boulder, CO, academic and industry scientists discussed topics ranging from peptide-based scaffolds for nerve tissue to tissue engineering via self assembly. (genengnews.com)
Medical researchers increasingly regard tissue engineering and regenerative medicine as potential game changers when it comes to repairing damage from disease or injury and restoring function. (embs.org)
To understand the progress made and challenges ahead for this combined field, IEEE Pulse sought out two experts: David F. Williams, former global president (2012-2015) of the Tissue Engineering and Regenerative Medicine International Society, and Roderic I. Pettigrew, founding director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (NIH) [1]. (embs.org)
How would you describe tissue engineering and regenerative medicine today? (embs.org)
Tissue engineering and regenerative medicine constitute a promising new field of medical research with the goal of generating or repairing human tissues, which in the coming years could transform clinical medicine. (embs.org)
Their activities led to the creation of the Tissue Engineering Society, which evolved to include international efforts in tissue engineering and in 2005 became the Tissue Engineering and Regenerative Medicine International Society. (embs.org)
Since that time, the terms tissue engineering and regenerative medicine , which have historical and nuanced distinctions, have become largely interchangeable among the broader scientific community. (embs.org)
As they report in their paper in Regenerative Medicine , the authors found that their delivery mechanism works-the cells placed next to the scaffold do in fact synthesize more growth factors. (stanford.edu)

However, the engineering of more complex tissues consisting of large 3D structures remains a critical challenge because the penetration of oxygen, which is required for cell survival, is limited by diffusion to a distance of approximately 150 to 200 mm from the nearest blood vessel. (hindawi.com)
To avoid the detrimental effects of biomaterial solidification, they also designed an oil-bath based cell printing system that allows the printed cells to blood vessel scaffolds via hydrophobicity, thus better maintaining cell activity and promoting the formation of cell-to-cell contact. (nanowerk.com)
Combining the six-axis robot-based bioprinter and oil-bath-based cell printing system, the researchers achieved a full range of cell printing on a complex-shaped blood vessel scaffold without causing cell damage or compromising cell proliferation and function. (nanowerk.com)
Furthermore, inspired by the natural organ developmental process, the team designed a repeated print-and-culture bioprinting strategy: after printing mono- or multi-layers of cells on the blood vessel scaffold, the printed cells would be cultured for certain intervals to induce the formation of cell-cell contact and new blood vessels, then the scaffold and already printed cells were subjected to a new round of bioprinting. (nanowerk.com)
To demonstrate the feasibility of such strategy, the researchers carried out bioprinting experiments using endothelial cell bioink and cardiomyocyte bioink on blood vessel scaffolds, and found that the printed endothelial cells formed intact endothelium as well as new blood vessels and capillaries with the assistance of angiogenic factors. (nanowerk.com)
Taking advantage of the extendibility of the six-axis robots, they further established a two-robot cooperation platform and accomplished simultaneous bioprinting of multiple types of cells on complex-shaped blood vessel scaffolds. (nanowerk.com)
For example, a tubular scaffold can be used to produce a blood vessel. (formlabs.com)
As an alternative to synthetic blood vessels, BRI is developing biologically based blood vessel replacements made from living cells seeded into prefabricated supports (scaffolds). (benaroyaresearch.org)
The collagen is formed into very thin, yet strong membranes that can be seeded with vascular smooth muscle cells and rolled into blood vessel-like tubes. (benaroyaresearch.org)
The researchers loaded mmRNA for a growth factor that promotes new blood vessel formation into a new, slow-releasing scaffold. (stanford.edu)

Using a biomaterial, like a scaffold, instead of a solution, could overcome these drawbacks. (stanford.edu)

However, a major discovery at BRI by the Wight Laboratory found that the molecule versican 3 (V3), found in natural connective tissue, can induce adult vascular smooth muscle cells to produce and assemble elastin. (benaroyaresearch.org)
To address this problem, the Vernon Laboratory at BRI has developed novel scaffolds made from the protein collagen - a major structural component of natural connective tissue. (benaroyaresearch.org)

The Wight Laboratory is developing new methods to produce V3 in a purified form, which will be tested for its ability to induce elastin production in engineered vessels containing vascular smooth muscle cells from adult sources. (benaroyaresearch.org)

In this regard, tissue engineers have sought to leverage native mechanotransduction pathways to enhance in vitro stem cell. (biomedcentral.com)
Tissue engineering has developed many paradigms and techniques on how to best integrate cells and extracellular matrix to create in vitro structures that replicate native tissue. (biomedcentral.com)
In vitro prevascularization can result in faster integration with the host vascular network [ 14 ]. (hindawi.com)
Soft tissue engineering for both clinical use and as novel 3D in vitro models for improved laboratory studies. (sheffield.ac.uk)

An additional benefit of scaffolds is that they closely mimic the structure of existing tissue, which helps tissue regenerate by giving newly growing cells a substrate to attach to. (stanford.edu)

Vascular reconstruction in pediatric patients requires a substantially different approach from that used in adults. (medscape.com)
Bovine pericardium has been used to fabricate conduits for vascular reconstruction. (medscape.com)
Dr. Freytes explained that bone reconstructions, such as craniofacial reconstruction, often involve "autologous tissue grafting, a method limited by harvesting difficulties, donor site morbidity, and the clinicians' ability to contour delicate 3-D shapes. (genengnews.com)
For their bone reconstruction model, the scientists generated anatomically shaped scaffolds in the exact shape of the human temperomandibular joint (TMJ) bone from decellularized trabecular bone using digitized clinical images, seeded with human mesenchymal stem cells, and cultured with interstitial flow of culture medium. (genengnews.com)
This article addresses the options and rationale behind choosing vascular reconstruction conduits in the pediatric population, as related to the most common circumstances requiring intervention. (medscape.com)

This series covers biophysical regulation of stem cell fate and function in the context of tissue development. (biomedcentral.com)
Stem cells reside within most tissues throughout the lifetimes of mammalian organisms. (biomedcentral.com)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
Approaches to scaffolding technology that were discussed at the meeting ranged in complexity from tissue repair products consisting of bovine type 1 collagen knee implants to the highly complex such as the use of whole acellular lung matrix (ACM) to support the development of engineered lung tissue from embryonic stem cells. (genengnews.com)
Tissue engineers working at the laboratory for stem cells and tissue engineering at Columbia University's Fu Foundation School of Engineering are applying a biomimetic approach to developing tissue replacements. (genengnews.com)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)

While many types of matrices have been successfully applied in the clinic, fundamental questions remain about how to combine and manipulate cells with scaffolding to generate functional tissue constructs that avoid immunogenicity. (genengnews.com)
Its experimental origins date back to the 1970s with cell seeding of biocompatible materials to generate new tissues. (embs.org)

Bioscaffolding materials may originate from multiple animal, tissue, and cell sources, as well as from synthetic polymers. (genengnews.com)

Skin tissue substitutes must readily adhere, have good physical and mechanical properties, and be nonantigenic [ 2 ]. (hindawi.com)
Scaffold choice, immunogenicity, degradation rate, toxicity of degradation products, host inflammatory responses, fibrous tissue formation due to scaffold degradation, and mechanical mismatches with the surrounding tissue are key issues that may affect the long-term behavior of the engineered tissue constructs and directly interfere with their primary biological functions [ 17 ]. (hindawi.com)
Understanding the mechanisms by which mechanical forces regulate the development and healing of connective tissues and the pathogenesis of disease is becoming one of the foremost problems at the intersection of biomechanics and cell biology-it has spawned the field of mechanobiology. (wpi.edu)
The ability of our biological tissues to adapt to their mechanical environment, and the ways in which our tissues are well suited for their own mechanical role within the body, is a constant source of wonder to me. (wpi.edu)
Millimeter-scale tissue rings are conducive to mechanical testing and serve as building blocks for tissue assembly. (jove.com)

Epithelial cells were then seeded on the fibrous sheet to assemble the bilayered tissue. (hindawi.com)
C. Two-robot cooperation platform (left) can simultaneously print different types of cells onto complex-shaped vascular scaffold (middle) to form patterned cell organization (right). (nanowerk.com)
By printing the mixture of endothelial cells and cardiomyocytes, researchers generated a piece of vascularized cardiac tissue, which maintained rhythmic beating and alive for at least 6 months. (nanowerk.com)
The tissues that make up our bodies are an intricate 3D arrangement of cells and structural proteins, but these are also highly variable, as everyone's body is unique. (formlabs.com)
An alternative approach is to direct the growth of cells into forming the required tissue in the lab. (formlabs.com)
To achieve this, the cells can be grown on a scaffold, which provides a template of the shape required. (formlabs.com)
The cells will multiply and cover the scaffold, taking its shape. (formlabs.com)
Over time, the scaffold breaks down, leaving the cells now arranged into the shape of the target tissue. (formlabs.com)
These scaffolds are then seeded with cells and matured in culture in the lab. (formlabs.com)
In addition, repair or replacement cells or tissues should not provoke immune reactions in the host. (genengnews.com)
Laser scanning confocal microscopy is a significant advance in the field of optical microscopy, primarily because it permits sample visualization deeper within living and fixed cells, tissues and other samples. (sheffield.ac.uk)
The 4x and 10x objectives can obtain images of cells grown on standard tissue culture well plates. (sheffield.ac.uk)
Smooth muscle cells seeded into ring-shaped agarose wells aggregate and contract to form robust three-dimensional (3D) tissues within 7 days. (jove.com)
New vessels develop in response to growth factors, which are molecules that signal to your tissue to create new cells. (stanford.edu)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

These are not able to accurately mimic the vessel architecture found in the body and place limitations on vascular surgeons. (formlabs.com)
Surgeons usually use ectopic conduit tissues including stomach and intestine, presumably inducing donor site morbidity and severe complications. (nature.com)
For traumatologists, intensivists, vascular surgeons, interventional radiologists, and cardiologists, the AIS and the pubic tubercle provide a relatively constant set of landmarks by which to gauge the course of the femoral artery or vein when central vascular access is required. (medscape.com)

For tumors that do not shrink or that impede daily life or for vascular trauma (0.6-2.0%), surgical intervention is necessary. (medscape.com)
John Dichiara, svp of clinical and regulatory affairs at ReGen Biologics, discussed the clinical performance of ReGen's collagen surgical mesh scaffold used for the reinforcement and repair of medial meniscus injuries. (genengnews.com)
Although these results were not statistically superior to partial meniscectomy which is one of the most successful orthopedic surgical procedures, Menaflex patients, DiChiara said, had the additional benefit of approximately 70% more tissue within the meniscus to potentially protect the articular surfaces from degradation. (genengnews.com)
[ 6 ] During surgical cases requiring more proximal exposure of the femoral vessels, this ligament can be divided to facilitate adequate vascular exposure. (medscape.com)

Porcine small-intestinal submucosa has been used to construct vascular conduits. (medscape.com)

He has several patents in the field of vascular bioengineering and was a co-founder of the start-up Neograft Technologies, Inc. (pitt.edu)
The following bioengineering laboratories are currently housed at the Center: Musculoskeletal Research Center, MSRC, (Dr. Savio Woo), Cardiovascular Systems Laboratory (Dr. Sanjeev Shroff), Bioengineering Methods and Applications Laboratory and BioTransport Laboratory (Dr. Jack Patzer), Vascular Bioengineering Laboratory (Dr. David Vorp), Cell Migration Laboratory (Dr. Partha Roy), Computational Biomechanics Laboratory (Dr. Spandan Maiti) , Orthopaedic Robotics Laboratory (Drs. Volker Musahl and Richard Debski) and Molecular Biological and Biophysical Core Facilities (Department). (pitt.edu)

Over the last few years, tremendous advances have been made towards producing tissue-engineered blood vessels, but researchers have only been able to construct simple straight tubes. (formlabs.com)

Mice lacking aggrecan or the metalloprotease ADAMTS1, which degrades proteoglycans, demonstrate their opposing roles in umbilical vascular dimorphism, including effects on SMC differentiation. (stanford.edu)
Secondly, scaffolds also allow the slow release of mmRNA, as the scaffold material slowly degrades over a period of weeks. (stanford.edu)

The most common such condition in children is vascular malformation (eg, arteriovenous malformation [AVM], cavernous malformation, or vein of Galen malformation). (medscape.com)
Even when the vessel is camouflaged by tissue in an obese patient or when there is no palpable femoral pulse in an underresuscitated trauma patient, the femoral vein may be successfully located in 90% of cases with this technique. (medscape.com)

To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)

Other vascular diseases in pediatric patients (eg, vascular tumors) require early clinical diagnosis and treatment. (medscape.com)

The two types of esophageal tissue derived-decellularized extracellular matrix bioinks can mimic the inherent components and composition of original tissues with layer specificity. (nature.com)

One classical approach to promoting vascularization is to decorate or supplement the scaffolds with proangiogenic factors such as VEGF, bFGF, and PDGF [ 8 ]. (hindawi.com)
Dr Pashneh-Tala uses a hybrid approach, in which 3D printing enables the production of tissue-engineering scaffolds for growing blood vessels with unique geometries. (formlabs.com)
This novel approach could also improve treatments for other disorders of soft tissue that have used gene therapy approaches in the past-cardiovascular, nervous, musculoskeletal, or otherwise. (stanford.edu)

Bone is a load-bearing tissue and physical forces play key roles in the development and maintenance of its structure. (biomedcentral.com)

There is also a need to provide vascular shunts for dialysis patients and replacements for blood vessels damaged or lost by trauma. (benaroyaresearch.org)

In this context, forces generated by actomyosin networks and those transmitted through focal adhesion (FA) complexes represent the key regulators of cellular behaviors in terms of cytoskeleton dynamism, cell adhesion, migration, differentiation, and tissue organization. (bvsalud.org)

Pediatric vascular disease consists of conditions that are caused by abnormal development of arteries, veins, or other blood vessels. (medscape.com)

In this study ( Bioactive Materials , 'A multi-axis robot-based bioprinting system supporting natural cell function preservation and cardiac tissue fabrication' ), the researchers creatively converted a six-axis robotic arm into a 3D bio-printer, enabling cell printing from all directions. (nanowerk.com)
These "bioprinting" techniques can reproduce the geometry of natural tissue. (formlabs.com)

Electrospinning was considered a promising technology because it can recapitulate microstructures mimicking the environment of the extracellular matrix (ECM) in native tissue. (nature.com)
Hydrogels obtained from decellularized tissues have a complex composition, comparable to the native extracellular environment, showing highly interesting characteristics for wound healing applications. (bvsalud.org)

Further, when they tested the scaffold in pigs with simulated PAD, they succeeded in helping to repair the damaged tissue. (stanford.edu)

Obesity, which is excessive expansion of white adipose tissue, is a major risk factor for several serious health issues, including diabetes, cardiovascular disease and cancer. (biomedcentral.com)
Tissue engineering holds great promise for the advancement of cardiovascular surgery as well as other medical fields. (medscape.com)
In their recent study, first author Tatiana Zaitseva, PhD, of Fibralign Corporation and Stanford Cardiovascular Institute-affiliated senior author Ngan Huang, PhD , report on a nanofibrillar scaffold they developed to help deliver mmRNA to limbs with PAD. (stanford.edu)

[ 2 ] Initial results with his techniques were disappointing because of the high rate of degeneration and vascular failure due to poor preservation methods, immunologic rejection, and inflammatory reactions that produced fibrosis, calcification, and aneurysms. (medscape.com)

Tissue engineering employs a combination of engineering, biology, and bioactive constructs to improve function by repairing, replacing, or regenerating tissue. (embs.org)

We will utilize techniques from engineering, chemistry and biology to address these research areas, including chemical modifications to alter drug-material interactions, small molecule and macromolecule conjugates to direct cell fate, and multi-cellular tissue/disease systems for paracrine signaling and direct cell-cell interactions. (wpi.edu)
This is where tissue engineering fits in. (formlabs.com)
The flexibility and precision of 3D printing as a manufacturing technique naturally lends itself to tissue engineering. (formlabs.com)
To date, vascular tissue engineering research has focused on producing straight vessels. (formlabs.com)
For this reason, electrospinning has been actively applied to esophagus tissue engineering. (nature.com)
The new grant at BRI funds progress toward two key goals of vascular engineering. (benaroyaresearch.org)
Due to the rising interest in materials with bioactive potentials, materials from natural sources have also recently gained more attention for vascular tissue engineering, and new strategies have been developed to solve the disadvantages related to their use. (bvsalud.org)
We highlight, in particular, the use of natural materials as scaffolds for vascular tissue engineering. (bvsalud.org)

The facility has: 1) a cell culture room that is equipped with tissue culture incubators, laminar flow hood, centrifuge and a microscope, 2) a wet lab which has equipment necessary to do protein biochemistry and molecular biology research, and 3) a microscopy room that houses an IX-71 Olympus research grade inverted microscope and live-cell Â image acquisition system. (pitt.edu)

This article outlines a versatile method to create cell-derived tissue rings by cellular self-assembly. (jove.com)

Here, analysis of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan dynamics as a determinant of these contrasting vascular responses. (stanford.edu)

Anatomy20

Organisms7

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes6

Technology, Industry, Agriculture12

Information Science2

Grafts10

Graft8

Organs14

Regeneration8

Biodegradable scaffold1

Angiogenesis2

Iatrogenic vascular trauma1

Vivo2

Biomaterials5

Regenerative11

Blood vessel10

Biomaterial1

Connective tissue2

Elastin1

Vitro4

Regenerate1

Reconstruction5

Stem8

Generate2

Synthetic polymers1

Mechanical5

Cells15

Surgeons3

Surgical4

Conduits1

Bioengineering2

Advances1

Degrades2

Vein2

Osteogenic1

Clinical1

Mimic1

Approach3

Bone1

Trauma1

Differentiation1

Pediatric1

Bioprinting2

Extracellular2

Repair1

Cardiovascular3

Methods1

Constructs1

Engineering8

Biology1

Cell1

Responses1