Tissue samples adult stem. Medical search. Frequent questions

Investigations of appropriate feeder cells concluded that a variety of cells could encourage development of germ cells such as Sertoli cells, Leydig cells and peritubular myoid cells but the most essential is Sertoli cells, but Leydig and peritubular myoid cells both contribute to the microenvironment that encourage stem cells to remain pluripotent and self renew in the testis. (wikipedia.org)
In the future, keratinocytes produced from pluripotent stem cells could be an alternative to adult stem cells in certain reconstructed tissue bio-engineering applications. (cea.fr)
Organoids can be derived from pluripotent stem cells (including embryonic stem cells or induced pluripotent stem cells) or neonatal or adult stem cells from healthy or diseased tissue. (technologynetworks.com)
He and his fellow researchers then used the snow leopard cells to create induced pluripotent stem (iPS) cells, also known as embryonic stem-like cells. (scientificamerican.com)
First year progress on grant ID1-06557, " Generation and Characterization of High-Quality, Footprint-Free Human Induced Pluripotent Stem Cell (iPSC) Lines From 3000 Donors to Investigate Multigenic Disease" has met all agreed-upon milestones. (ca.gov)
The goal of CIRM Grant ID1-06557 is to generate high quality induced pluripotent stem cells (iPSC) from blood and skin samples from 3000 donors, many of whom suffer from untreatable medical conditions, and place them in a Repository accessible to scientists around the world. (ca.gov)
Using genetically engineered human pluripotent stem cells, University of California San Diego School of Medicine researchers created a new type of cancer model to study in vivo how glioblastoma, the most common and aggressive form of brain cancer, develops and changes over time. (reachmd.com)
The experiment began with human pluripotent stem cells , which can become any cell in the human body if given the right chemical instructions. (livescience.com)
These are called induced pluripotent stem cells, and could be guided into developing the right types of organ cells when placed on the scaffold. (nbcnews.com)
To investigate underlying disease mechanisms, induced pluripotent stem cells (iPSCs) allow the generation of patient-derived neuronal cells in a dish. (biomedcentral.com)
Organoids are three-dimensional in vitro tissue cultures that are derived from pluripotent (embryonic or induced) adult stem cells or even patient-specific tissue samples. (inbirg.com)
Researchers in Pyle's lab and others around the world already have the capacity to generate skeletal muscle cells from human pluripotent stem cells - cells that have the ability to self-renew and to develop into any cell type in the body. (scienceblog.com)
To create this resource, the group gathered highly specific data about two different groups of skeletal muscle cells: those from the human body, ranging from the fifth week of embryonic development to middle age, and those derived from human pluripotent stem cells the researchers generated in the lab. (scienceblog.com)
For the pluripotent stem cell-derived muscle cells, the group evaluated cells created using their own unique method and the methods of several other groups. (scienceblog.com)
Leveraging the power of this technology and the Plath lab's bioinformatics expertise, the group identified the genetic signatures of various cell types from human tissues and pluripotent stem cells. (scienceblog.com)
This enabled the group to match the genetic signatures found in the pluripotent stem cell-derived muscle cells with their corresponding locations on the map of human muscle development. (scienceblog.com)
The group found that pluripotent stem cell-derived muscle cells produced by all the methods they tried resembled muscle progenitor cells at an early developmental state and did not align to adult muscle stem cells. (scienceblog.com)
In addition to pinning down the true maturity of the lab-produced cells, this analysis also provided details about the other cell types present in skeletal muscle tissue across development and in populations derived from human pluripotent stem cells. (scienceblog.com)
Martin Ma, MD/PhD student in the Kotton lab and first author of "Airway Stem Cell Reconstitution by Transplantation of Primary or Pluripotent Stem Cell-Derived Basal Cells. (bu.edu)
The induced pluripotent stem cells could offer new hope for unlocking the secrets of bipolar disorder. (bellenews.com)
Known as induced pluripotent stem cells , or iPSC , these, in turn, can be manipulated to develop into different types of body cells, including brain cells. (bellenews.com)
Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into forebrain neural progenitor cells. (lu.se)

The global mesenchymal stem cells market growth is primarily driven by the increasing demand for these stem cells as an effective treatment alternative for knee replacement in the recent past. (medgadget.com)
The research report titled Global Mesenchymal Stem Cells Market Growth (Status and Outlook) 2020-2025 released by MarketsandResearch.biz covers industry segment by applications, by type, regional outlook, market demand, latest trends, and industry share & revenue by manufacturers, company profiles, and growth forecasts - 2025. (tomeipowered.com)

SALL4 is a transcription factor that is important for development and embryonic stem cell properties. (confex.com)
Not only is adult stem cell research not controversial, it is strongly encouraged by those who raise objections to embryonic stem cell research. (voiceofsandiego.org)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

Vascular endothelial cells form the interface between recipient tissues and circulating alloreactive donor T cells after allogeneic stem cell transplantation. (nih.gov)

Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
Consequently, neural stem and progenitor cells have usually been studied retrospectively, based on their ability to form colonies in laboratory cell cultures. (elifesciences.org)
A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)
Focusing on muscle progenitor cells, which contribute to muscle formation before birth, and muscle stem cells, which contribute to muscle formation after birth and to regeneration from injury throughout life, the group mapped out how the cells' gene networks - which genes are active and inactive - change as the cells mature. (scienceblog.com)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

Koch said there's evidence that stem cells from cord blood are "younger" than bone marrow stem cells, which means they're capable of more divisions, and creating more diverse tissue types. (sciencedaily.com)
Next, we also assessed an expression level of SALL4A and SALL4A&B in 14 MDS patient bone marrow (BM) samples using Nanostring nCounter. (confex.com)
They knit new bone here, repair new heart tissue there. (voiceofsandiego.org)
Unlike the more well-known embryonic stem cells, adult stem cells have been proven to be useful for human medical treatments, such as bone marrow transplants, and they are already being used in veterinarian clinics across the country. (voiceofsandiego.org)
Mesenchymal stem cells are adult stem cells, which are traditionally found in the bone marrow. (medgadget.com)
Some techniques are being tested in simpler tissues , such as skin and bone. (nbcnews.com)
Researchers have printed ear, bone, and muscle tissue and transplanted it into animals, but it's going to be a while before this technique is perfected for humans. (nbcnews.com)
Therapy using stem cells from various sources, including those from bone marrow and umbilical cord, have been successfully used to treat a number of life-threatening diseases with good results, since 1988. (stemcellstransplantinstitute.com)
Degenerative disorders arise from degeneration or wear and tear of bone, cartilage, muscle, fat or any other tissue, cell or organ. (stemcellstransplantinstitute.com)
For example, adult stem cells in bone marrow can become red or white blood cells but can not become brain cells. (pediatricbrainfoundation.org)
Leukemia starts in blood-forming tissues such as the bone marrow. (medlineplus.gov)
Both tests involve removing a sample of bone marrow and bone. (medlineplus.gov)
In general, immunohistochemistry will be used for lymph node biopsies, flow cytometry will be used for peripheral blood and bone marrow samples. (who.int)

Human skin completely renews itself every month thanks to the presence of stem cells in the deepest layer, which generate all the upper layers of this tissue. (cea.fr)
We tested what native features have been preserved with a new culture protocol for adult human RPE. (arvojournals.org)
We cultured RPE from adult human eyes. (arvojournals.org)
Confluent monolayers of adult human RPE cultures exhibit characteristics of native RPE. (arvojournals.org)
28, 2021 Researchers have invented a new way to generate human cartilage tissue from stem cells. (sciencedaily.com)
Studies in murine models, as well as in human samples, have demonstrated that SALL4 is essential for leukemic cell survival and that SALL4 transgenic mice develop an MDS-like phenotype prior to transformation to AML, suggesting that SALL4 can be a driver of MDS/AML pathogenesis. (confex.com)
Research on human brain tissue samples showed that the virus was able to kill certain cells that traditional brain cancer treatments, such as chemotherapy, radiotherapy, and surgery, struggle to reach. (medicaldaily.com)
Researchers believe that the Zika virus won't damage the adult human brain because it has very few stem cells. (medicaldaily.com)
The project will investigate the age-related functional decline of hematopoiesis and dissect the role of Cdc42 in the rejuvenation of Human Hematopoietic Stem Cells (HSCs). (uni-ulm.de)
Using an array of different techniques, the team looked at cells, mouse models and samples from human patients. (sciencedaily.com)
1,2 Cancer organoids have been generated from a range of human cancer tissues and cell lines including colon, pancreas, prostate, liver, breast, bladder and lung. (technologynetworks.com)
To model this process, the FAL uses all the primary human cells involved in the liver, including hepatocyte cells, Kupffer cells, stellate cells and cells with liver disease (fibrosis), all derived from liver samples which are ethically sourced from hospitals in the East Midlands region. (frame.org.uk)
The FAL then produces 'scaffolding' from donated human liver tissue that has had the original cells removed. (frame.org.uk)
Epithelial tissue from both the rat BE model and human BE patients strongly expressed KLF5, CDX2, MUC2, and villin. (jcancer.org)
These models, or avatars as we call them, enable us to study human tumor development over long periods in vivo , which has not been feasible with patient-derived tissue samples which already harbor other genetic changes. (reachmd.com)
Human tissue samples do not allow for standardization in testing. (reachmd.com)
Taken together, this study clarified the effect of age on the content of human renal stem cells and determined the regulatory mechanism of hypoxia on renal stem cells. (bjbms.org)
Using human stem cells and a series of chemical switches, researchers grew stomachs measuring 0.1 inches (3 millimeters) in diameter, in lab dishes, according to a report published today (Oct. 29) in the journal Nature. (livescience.com)
The researchers used two kinds of stem cells - one group was derived from a human embryo that was made about 15 years ago, and the other was derived from adult human skin cells, using a technique that won the Nobel Prize for medicine in 2012. (livescience.com)
Bioprinters can build structures, like this 3D-printed ear, that look like human tissue and organs and even transplant them into animals. (nbcnews.com)
A lot of studies investigating human diseases look at blood samples rather than target tissues, because blood is much easier to collect. (futurity.org)
Mesenchymal stem cells (MSC) are multipotent cells which can be obtained from several adult and fetal tissues including human umbilical cord units. (escholarship.org)
Research by groups at the University of São Paulo and the State University of Campinas combined MRI scans of the brains of mild COVID-19 patients, analysis of brain tissue from people who died of the disease and experiments on human nerve cells infected in the laboratory. (fapesp.br)
An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle stem cells. (scienceblog.com)
So we set out to generate this map as a reference that our lab and others can use to compare the genetic signatures of the cells we are creating to those of real human skeletal muscle tissue. (scienceblog.com)
The group obtained 21 samples of human skeletal muscle tissue from their UCLA collaborators and from colleagues at the University of Southern California and the University of Tübingen in Germany. (scienceblog.com)
Human mesenchymal stem cells - current trends and future prospective. (tomeipowered.com)
The challenge has been to determine what these elements do and how they affect human tissues, given their abundant and repetitive presence in the human genome. (lu.se)
Johan Jakobsson, a professor at Lund University and research group leader at MultiPark and Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)
We observed that LINE-1s are highly expressed in the developing human brain and particularly in neurons in the adult human brain. (lu.se)
ABSTRACT The aim of this study was to determine the attitude of Saudi Arabians to research involving storage and use of human tissues from which genetic information may be derived and to assess their willingness to donate tissue samples to biobanks. (who.int)
The Saudi Biobank project includes human biological samples from participants aged 10-70 years and aims to conduct an extensive study on the influence of genes, environment and lifestyle in common diseases. (who.int)
The NGHA human sample donors should give zation for Medical Sciences (IOMS), has 4 large hospitals and 60 health cen- broad consent for use of samples rather in 2004 ( 7 ) is one of the references for tres (primary or secondary) with a total than specific consent for each research the Saudi Biobank governance. (who.int)
Overall, our findings highlight the importance of TEs as regulatory agents and their dynamic activity during development, adult life, and disease in the human brain. (lu.se)
Neuroscience focusing on human development and disease has long been hampered due to ethical rea¬sons, low tissue availability, and low translatability from animal models. (lu.se)
Secondly, we have developed an all-in-one vector-based strategy to convert adult human dermal fibroblasts directly from Huntington's disease (HD) patients and control individuals into induced neurons (iNs). (lu.se)

The differences between fetal and adult scars suggest the possibility of manipulating skin scarring outcomes. (rbcp.org.br)
both fetal and adult brain tissue samples. (lu.se)
To better understand how these repetitive genetic sequences influence brain development, researchers analyzed both fetal and adult brain tissue samples. (lu.se)

The researchers froze isolated testicle stem cells, while clinics are freezing whole tissue samples. (newscientist.com)
Researchers at the University of Guelph are hoping stem cells might provide the needed tissue replacements. (sciencedaily.com)
But scientists and researchers at an international biotechnology conference held in San Diego this month said that's because people often don't distinguish between adult and embryonic stem cells. (voiceofsandiego.org)
The researchers got similar results with samples from actual patients. (sciencedaily.com)
And the researchers have already accomplished the first step, creating embryonic stem-like cells from the tissue of an endangered adult snow leopard ( Panthera uncia ). (scientificamerican.com)
Other researchers have grown flat samples of gastric tissue, but few had successfully leapt into 3D territory, he said. (livescience.com)
Researchers have managed to grow beating heart tissue in the lab, but to keep a person alive, a transplanted heart must be strong enough to take over from the original. (nbcnews.com)
The researchers used a technique known as immunohistochemistry, a staining process in which antibodies act as markers of viral antigens or other components of the tissue analyzed. (fapesp.br)
The roadmap is critical for researchers who aim to develop muscle stem cells in the lab that can be used in regenerative cell therapies for devastating muscle diseases, including muscular dystrophies, and sarcopenia, the age-related loss of muscle mass and strength. (scienceblog.com)
This week, Pulmonary Center researchers from the Center for Regenerative Medicine (CReM) report their successes in developing new techniques to implant engineered cells into damaged lung tissue. (bu.edu)
googlead tip="vertical_mediu" aliniat="stanga"] The University of Michigan Health System researchers said stem cell could offer new hope for unlocking the secrets of bipolar disorder. (bellenews.com)
According to a University of Michigan Health System statement posted on its website on August 22, the new stem cell lines developed from the skin of adults living with bipolar disorder are providing researchers at the University of Michigan Health System an unprecedented opportunity to delve into the genetic and biological underpinnings of the devastating mood disorder. (bellenews.com)

The discoveries of a French research team from the CEA, INSERM and the University of Paris, produced in collaboration with I-Stem, the AFM-Téléthon laboratory, and the University of Évry, opens perspectives for regenerative cutaneous medicine, in particular for the bio-engineering of skin grafts for tissue reconstruction. (cea.fr)
This expansion phase involves a risk: it may be accompanied by a quantitative loss or degradation of stem cells, leading to a loss of regenerative potential. (cea.fr)
Every stem cell treatment should have the same conditions attached,"commented Professor Frank Barry, the coordinator of the project from the Regenerative Medicine Institute (REMEDI) at the National University of Ireland Galway. (eurostemcell.org)
This is a significant project for many reasons," Christoph Schuhmacher, Clinical Operations Director at the European Clinical Research Infrastructure Network ( ECRIN ) said, "primarily, it will advance regenerative medicine by providing validated clinical data to the field, but it will also coordinate consistent production of high-quality stem cells in multiple centres and look at the stem cell mechanism of action. (eurostemcell.org)
The company is using technology to harness the healing power of adult stem cells, one of the most misunderstood and promising areas of regenerative medicine and modern science. (voiceofsandiego.org)
The fat floats to the top as enzymes break down, and the regenerative stem cells - the healing stuff - that reside in the fat sink to the bottom. (voiceofsandiego.org)
In turn, the regenerative cells adjust themselves to help reconstruct the damaged tissue. (voiceofsandiego.org)
The regenerative stem cell therapy, science lingo for Vet-Stem's treatment, seems to be working. (voiceofsandiego.org)
Stem cells can be guided into becoming a specific type of cell allowing physicians trained in the field of regenerative medicine to use stem cells to repair diseased or damage tissue. (stemcellstransplantinstitute.com)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Nov. 26, 2019 The buildup of scar tissue makes recovery from torn rotator cuffs, jumper's knee, and other tendon injuries a painful, challenging process, often leading to secondary tendon ruptures. (sciencedaily.com)

In the adult body, proteins like HOXA5 regulate the body's stem cells to maintain both the identity and function of different tissues. (sciencedaily.com)
Although found in adults, children, and fetuses, adult stem cells are so called because they are specialized cells thought to be found in most of the body's tissues. (pediatricbrainfoundation.org)

From our perspective rigorous, objective and definitive proof about stem cell therapies can only emerge from carefully conducted, well-controlled, multicentre clinical trials. (eurostemcell.org)
The goal is to provide children with critical forms of heart disease samples of their own cells to enable future cell-based therapies for heart regeneration and replacement. (luriechildrens.org)
Because B cells are essential for the immune system attack of joint tissue in RA, therapies that target B cells have recently been used to combat the disease. (futurity.org)
Among the cell types that can be used for this purpose, mesenchymal stem cells (MSCs) are considered as promising source of stem cells in personalized cell-based therapies. (tomeipowered.com)
The new stem cell lines - among the first to be created by the A. Alfred Taubman Medical Research Institute Consortium for Stem Cell Therapies - were made from fibroblasts from skin samples donated by adult research volunteers both with and without bipolar disorder. (bellenews.com)
We often think of stems cells being used in therapies to treat disease, but this is a great example of stem cells' usefulness for studying the mechanisms of disease. (bellenews.com)

Participants were less willing to allow the use of tissue or organs from a deceased relative. (who.int)

Similar results were observed in Lin-CD34+CD38- hematopoietic stem cells, CD11b+ mature myeloid cells, CD19+ B cells, CD235+ erythroid cells. (confex.com)

Adipose tissue is taken from patients' abdomens using a minimally invasive liposuction procedure. (eurostemcell.org)
This tissue is processed and the cells (termed adipose derived mesenchymal stromal cells ) are grown, harvested and prepared for injection. (eurostemcell.org)
This study aimed to assess whether the use of adult stem cells from adipose tissue is beneficial to skin healing. (rbcp.org.br)
The adult stem cells used were autologous and were extracted from infraumbilical adipose tissue prior to abdominoplasty. (rbcp.org.br)
Skin healing results after implantation of adult stem cells derived from adipose tissue were satisfactory. (rbcp.org.br)
Mesenchymal stem cells (MSCs), or stromal stem cells, can differentiate into many different types of … In contrast, treatments that utilize MSCs from a patientâ s fat (adipose) sample have shown weak or unreliable responses. (tomeipowered.com)

Sample-specific meta-genomic assembled genomes (MAGs) were used as reference genomes to accurately identify the origin of RNA reads, and transcript ratios of genes with opposite transcription responses were compared to eliminate biases related to differences in organismal abundance, an approach hereafter named the "diametric ratio" method. (osti.gov)
We analyzed twenty fecal samples taken from four premature infants (4-6 time points from each infant), and found significantly higher diametric ratios of genes associated with low oxygen levels in samples of infants later diagnosed with NEC than in samples without NEC. (osti.gov)
The " browse " section allow users to view organoid samples and datasets with corresponding organoid culture information, differential genes, enriched functions/pathways, differential cell type markers, cell clustering, marker genes when available. (inbirg.com)
in this tissue they found upregulation of Wnt signaling-related genes compared to control tissues. (alzforum.org)

Obtaining cord blood samples is non-invasive and much easier than obtaining stem cells from an embryo. (sciencedaily.com)
Because there are no other reports on isolating stem cells from equine cord blood, Betts and Koch are eager to gather as much information as possible. (sciencedaily.com)
Already, they've succeeded in differentiating the cord blood stem cells into three different cell types including chondrocytes - the building blocks of cartilage. (sciencedaily.com)
However, they can also be parted from other available tissues including peripheral blood, cord blood, fallopian tube. (medgadget.com)
Working with a multidisciplinary team from Prentice Women's Hospital and the Heart Center at Lurie Children's , a new one-of-a-kind program, the Fontan Futures℠ Initiative, plans to help families expecting a child with only one ventricle save cord blood and heart tissue. (luriechildrens.org)
The Fontan Futures℠ Initiative will encompass a consent to obtain and retain otherwise discarded samples, specifically cord blood obtained at the time of delivery, and a blood sample and heart sample at the first open heart surgery. (luriechildrens.org)
Stem cell therapy is a type of treatment option that uses a patients' own stem cells or the stem cells from umbilical cord blood or tissue to repair and regenerate tissue. (stemcellstransplantinstitute.com)
We have recently shown that umbilical cord tissue (UC) is richer in MSC than umbilical cord blood (UCB) but their origin and characteristics in blood as compared to the cord remains unknown. (escholarship.org)
Adult stem cells are derived from adult tissue samples, and can also be derived from cord blood extracted after the birth of an infant. (pediatricbrainfoundation.org)

A CEA-Jacob team has just published a paper in which it demonstrates the central role of the transcription factor KLF4 in regulating the proliferation of epidermal stem cells and their ability to regenerate this tissue. (cea.fr)
Research has shown mesenchymal stem cells have the ability to regenerate damaged or injured tissue, modulate the immune system, decrease pro-inflammatory mediators, release growth factors, cytokines and chemokines that aid healing and in the formation of new blood vessels while suppressing inflammation. (stemcellstransplantinstitute.com)

Samples of brain tissue were also taken for molecular analysis. (cdc.gov)
Infection of astrocytes was confirmed by experiments using brain tissue from 26 patients who died of COVID-19. (fapesp.br)

This may explain why the infection is so destructive for growing fetuses, as they have high numbers of stem cells in their developing brains. (medicaldaily.com)
Past case studies have also shown that Zika has fewer effects on the adult brain than on fetuses' brains. (medicaldaily.com)

The Prechter Bipolar Genetic Repository already houses more than 1,500 genetic samples from people with bipolar disorder and healthy controls from studies at U-M along with collaborating sites: Johns Hopkins, Stanford, Cornell and Penn State. (bellenews.com)
Doctors examine a sample of blood to check for abnormalities and do genetic tests to confirm the diagnosis. (msdmanuals.com)

The answer came from vitamin A. This small chemical structure is called a retinoid, and it has been known to induce differentiation of stem cells in the skin. (sciencedaily.com)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)

15-17 Some healthy adults can carry the Pneumocystis fungus in their lungs without having symptoms, and it can spread to other people, including those with weakened immune systems. (cdc.gov)
PCP is diagnosed using a sample from a patient's lungs. (cdc.gov)
The studies, which outline the process of engineering lung stem cells and introducing them into injured lungs without need for immunosuppression, have been published in two new papers in Cell Stem Cell . (bu.edu)

The study , published May 11 in the peer-reviewed journal Cell Stem Cell, identified various cell types present in skeletal muscle tissues, from early embryonic development all the way to adulthood. (scienceblog.com)
MSCs make the different specialized cells found in the skeletal tissues. (tomeipowered.com)

1 Defined as a three-dimensional multicellular in vitro tissue construct, organoids are derived from cells that spontaneously self-organize into properly differentiated functional cell types to mimic at least some function of an organ. (technologynetworks.com)

tissue biopsies are routinely performed as part of cancer diagnosis, and a sample could be set aside to generate organoids. (technologynetworks.com)
Using cryopreserved Mouse Intestinal Organoids enables establishment of intestinal organoid cultures without the need to isolate intestinal crypts from primary tissue, eliminating the need for access to fresh mouse tissue and making it easy to standardize experimental starting materials. (stemcell.com)
Other types of sample are also integrated, including primary tissues and cell lines to enable comparisons to be made with organoids. (inbirg.com)

The potential of these cell is to heal the damaged tissue with no pain to the individual. (medgadget.com)
Once injected, stem cells are attracted to the site of injury and then change into the type of cell that is needed to repair or heal the damaged tissue. (stemcellstransplantinstitute.com)

They're using blood from the umbilical cord of horses as a source of stem cells. (sciencedaily.com)

Since neurosphere-forming cells can self-renew and differentiate into neurons and glia, the ability of cells to form neurospheres has generally been taken as evidence that they are stem cells. (elifesciences.org)
The power of stem cells is that they can differentiate into all the cell types in the body," Verma said in a prepared release . (scientificamerican.com)
Stem cells are a type of progenitor cell, or undifferentiated cell that have the ability to differentiate, or change, into specific and specialized cell types. (stemcellstransplantinstitute.com)
Mesenchymal Stem Cells Instruction Manual Product Description Mesenchymal Stem Cells (MSC), also termed Mesenchymal Stromal Cells, are self-renewing multipotent cells that can differentiate into a wide variety of cell types. (tomeipowered.com)

The study has shown that manipulation of KLF4 expression is also suitable for these cells, as reducing its expression in keratinocytes derived from embryonic stem cells (ESC) improves their proliferation capacity and their ability to reconstruct skin. (cea.fr)
He hopes further research will reveal more ways to reconstruct the tissue either at the injury site, or as a graft that can be surgically implanted. (sciencedaily.com)

Procedures for the shipping, infectious disease testing, and processing of donor samples were successfully implemented with the seven Tissue Collectors. (ca.gov)
Cellular Dynamics International (CDI) has continued to generate passage 5 iPSC lines from donor samples submitted to us by Tissue Collectors throughout the state of California. (ca.gov)
By the end of year three, we have generated iPSC clones from 1737 donor samples (out of 2670 received). (ca.gov)
Because of delays in receiving donor samples from our Tissue Collectors we have requested and received a one-year No Cost Extension to complete the activities associated with the grant by 30 November 2017. (ca.gov)
Hierarchical clustering based on protein-coding expression similarities grouped MSC according to their tissue location rather than original donor. (escholarship.org)

As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs) have emerged as a versatile and frequently utilized cell source in the fields of … MSC have been shown to differ-entiate in vitro into adipocytes, chon-drocytes, osteoblasts, myocytes, and ß-pancreatic islets cells. (tomeipowered.com)

This particular sample is from a recipient mouse that is more than two years post-transplantation. (bu.edu)
This article will explain what Haematopoietic stem cell transplantation (HSCT) involves, its benefits/risks, and how it may or may not be helpful for certain neurological conditions. (tomeipowered.com)
Treatment involves antibiotics to prevent infections, other drugs to help the immune system function better, and, if possible, stem cell transplantation. (msdmanuals.com)

Much of the team's research focuses on perfecting the technique for isolating, expanding and differentiating adult stem cells. (sciencedaily.com)
Reports about stem cell science have typically described the research as highly controversial business. (voiceofsandiego.org)
Increasing demand for better healthcare facilities, rising geriatric population across the globe, and continuous research and development activities in this area by the key players is expected to have a positive impact on the growth of Mesenchymal Stem Cells market. (medgadget.com)
Research has shown that young cardiac stem cells do a better job repairing injury than those from adult patients. (luriechildrens.org)
Over the years, as the children receive their surgical and medical care at Lurie Children's through the Single Ventricle Center for Excellence , the Fontan Futures℠ Initiative coordinator will periodically check in to update the families' contact information, track the development of heart failure symptoms, verify sample storage and inform families of clinical research opportunities nationwide that may be of interest. (luriechildrens.org)
Approach: Three key research areas (cancer research, autoimmune disease, and tissue and cell engineering) are considered to support the need for label-free microscopy to characterize heterogeneity and dynamics within biological systems. (bvsalud.org)
In particular, Cellular Dynamics International (CDI) has taken lease to approximately 5000 square feet of lab space at the Buck Institute for Research on Aging in Novato, CA. The majority of this space is located within the new CIRM-funded Stem Cell Research Building at the Buck Institute and was extensively reconfigured to meet the specific needs of this grant. (ca.gov)
We expect our results to provide a research basis for the treatment and clinical application of renal stem cells. (bjbms.org)
Thanks to a unique collaboration between the rheumatologists and orthopedic surgeons in the Center for Musculoskeletal Research, Anolik and her team were able to do studies in joint tissue collected during RA patient surgeries. (futurity.org)
Over the past few years, with an increased focus on research and development, a growing number of successful stem cell treatments have emerged and it has become one of the most exciting fields of medicine. (stemcellstransplantinstitute.com)
New research presented at the annual Society for Neuroscience meeting, held 13-17 November 2010 in San Diego, California, suggests that the deficiency stems from a vicious feedback loop that keeps progranulin expression in neurons low, even as neighboring microglia produce plenty of the protein. (alzforum.org)
Muscle loss due to aging or disease is often the result of dysfunctional muscle stem cells," said April Pyle, senior author of the paper and a member of the Broad Stem Cell Research Center. (scienceblog.com)
The Pyle lab collaborated with the lab of Kathrin Plath, a UCLA professor of biological chemistry and member of the Broad Stem Cell Research Center, to conduct high-throughput droplet-based single-cell RNA sequencing of all of the samples. (scienceblog.com)
Bipolar disorder: new hope from stem cell research. (bellenews.com)
But that is now changing because of the Prechter research program and advances in stem cell research. (bellenews.com)
However, initial research on the injection of stem cells shows promise with regard to efficacy and durability. (medscape.com)
Likewise, recent research has shown promise in the use of stem cells in periurethral injections. (medscape.com)
In a cross-sectional interview study of 1051 outpatients at a hospital in Riyadh city, 68.8% had a positive attitude towards biomedical research and 78.4% were willing to allow use of excess surgical tissues for research purposes. (who.int)
Logistic regression analysis found that predictors for a positive attitude to biomedical research and to use of tissue in research were: female sex, higher level of education, previous experience of blood testing and previous participation in health-related research. (who.int)
However, these research biobanks have Guidelines for Biomedical Research man biological samples and collect data created many new ethical challenges. (who.int)

As the liver has a remarkable capacity to regenerate, the FAL is also isolating the cells it believes are adult stem cells and is growing and differentiating these to produce hepatocytes. (frame.org.uk)
GH is needed for growth and has important effects on protein, lipids, and carbohydrate metabolism, which are accomplished directly as a result of GH binding to its receptor on target cells or indirectly primarily through insulinlike growth factor 1 (IGF-1), a hormone secreted from the liver and other tissues in response to GH. (medscape.com)

Cartilage is an exceptionally slow-healing tissue, and, until now, the missing or damaged tissue is often irreplaceable. (sciencedaily.com)
Biomedical sciences professor Dean Betts and doctoral candidate Thomas Koch are hoping to use stem cells to improve cartilage healing after joint injuries. (sciencedaily.com)
The younger stem cells may also be less prone to rejection when used to help heal cartilage in another body. (sciencedaily.com)
Or, are they populated by fate-restricted migratory tissue-specific adult stem cells from stump muscle, cartilage, and blood? (wisc.edu)

This map identifies the precise gene networks present in muscle progenitor and stem cells across development, which is essential to developing methods to generate these cells in a dish to treat muscle disorders. (scienceblog.com)
These cells could play an essential role in muscle cell maturation and could be critical to improving methods to generate and support muscle stem cells in a dish. (scienceblog.com)
The term 'mesenchymal stem cells' (MSCs) is most commonly used to describe multipotent self-renewing cells that can be differentiated in vitro to generate adipocytes, chondrocytes, and osteoblasts. (tomeipowered.com)

3) Because people with HIV-associated immunocompromise are at risk for severe manifestations of monkeypox, the HIV status of all sexually active adults and adolescents with suspected or confirmed monkeypox should be determined. (cdc.gov)

Medicine to prevent PCP is recommended for some people infected with HIV, stem cell transplant patients, and some solid organ transplant patients. (cdc.gov)

For instance, when a person is injured, stem cells come to the site of the injury and aid in healing damaged tissues. (sciencedaily.com)

In the trial, called ADIPOA2, patients who have not responded to standard therapy will be treated with stem cells derived from their own fatty tissue. (eurostemcell.org)

Mesenchymal stem cells (MSCs) naturally repair injured or diseased tissue, however, a person suffering from a severe injury or degenerative disease, may not have sufficient quantities of stem cells, or may not be able to release the stem cells quickly enough to repair the damaged tissue. (stemcellstransplantinstitute.com)
Mesenchymal stem cells (MSCs) are an example of tissue or 'adult' stem cells. (tomeipowered.com)
The original mesengenic process pathway (Figure 1) was hypothesized and fashioned … Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time. (tomeipowered.com)
The problem is what a mesenchymal stem cell (MSCs) is isn't always clearly defined, which has led to confusion in the scientific community, as well as public misunderstandings exploited by businesses marketing questionable cell-based treatments, the authors argue. (tomeipowered.com)
Properties of Mesenchymal … We found that … Platelets are known to enhance the wound-healing activity of mesenchymal stem cells (MSCs). (tomeipowered.com)
Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most promising means of allogeneic cell therapy. (tomeipowered.com)

Urethral bulking procedures are designed to treat stress urinary incontinence due to intrinsic sphincter deficiency by artificially inflating the submucosal tissues of the bladder neck and urethra. (medscape.com)

In fragment cultures, the testis is removed and fragments of tissue are cultured in supplemental media containing different growth factors to induce spermatogenesis and form functional gametes. (wikipedia.org)

Previous studies showed that renal stem cells can be directly induced into renal tubular epithelial cells to repair damaged tissue structures. (bjbms.org)

The results of the paper published in Nature Biomedical Engineering show that reducing the expression of the KLF4 gene during graft preparation promotes rapid expansion of functional stem cells1, without damaging their genomic stability. (cea.fr)
1. A single functional stem cell is able to regenerate the skin throughout a person's life. (cea.fr)
These molecular differences verified in tissue-specific MSC gene expression may reflect functional activities influenced by distinct niches and should be considered when developing clinical protocols involving MSC from different sources. (escholarship.org)
We knew that the muscle cells we were making in the lab were not as functional as the fully matured muscle stem cells found in humans," said Haibin Xi, first author of the new paper and an assistant project scientist in Pyle's lab. (scienceblog.com)
Could they be the key to producing and supporting mature and functional muscle stem cells in a dish? (scienceblog.com)

The expression profile of CIS cells was compared with microdissected gonocytes, oogonia, and cultured embryonic stem cells with and without genomic aberrations. (ku.dk)

The heart's stem cells work throughout life to slowly regenerate the heart, but these cells are unable to prevent eventual heart failure, especially for children born with only one ventricle. (luriechildrens.org)

Less-touted than the fiercely-debated embryonic stem cells, the adult version has the ability to morph into cells with special functions, such as the insulin-producing cells of the pancreas or the beating cells of the heart muscle. (voiceofsandiego.org)
Next steps include screening drugs, testing other mutations in adult and pediatric brain tumors as well as to evaluate if these approaches can model tumors in other tissues, such as the pancreas and lung," said Furnari. (reachmd.com)

First, we assessed an expression level of SALL4 using CyTOF in 10 MDS patients as compared with normal BM samples (N=5). (confex.com)
We observed that 12 out of 14 MDS patients had higher SALL4 expression levels as compared with control normal BM samples (N=3). (confex.com)
Patients are injected with stem cells originating from their own tissue samples and subsequent assessment for pain, stiffness and physical functioning is compared with results from patients treated with a placebo. (eurostemcell.org)
in both the self-assessment by the patients and the physicians' assessment, the results were significantly in favor of intervention with stem cells (P = 0.12 and P = 0.003, respectively). (rbcp.org.br)
This effect was even greater when study authors inspected B cells extracted from RA patients' joint fluid and tissue. (futurity.org)
These patients' immune systems attack their own joint tissue causing painful stiffness and swelling of the joints as well as erosion of the bones in the joint that can cause permanent damage. (futurity.org)
We investigated eight patients with acute GVHD and ten with chronic GVHD for signs of endothelial injury and microvessel loss by measurement of von Willebrand factor (vWF) in plasma and blood vessel density in biopsy samples taken from lesional skin. (nih.gov)
Perivascular CD8 T cell infiltrates in skin correlated with vWF plasma concentrations in patients with GVHD (p=0.01), and activated cytotoxic T lymphocytes and endothelial injury were present in these same samples. (nih.gov)
Une étude transversale comportant des entretiens a montré que 68,8 % des 1051 patients interrogés en consultation externe dans un hôpital de Riyad montraient une attitude positive au sujet de la recherche biomédicale. (who.int)

However, hypoxia is a recurring problem in these cultures where the low oxygen supply hinders the development and maturation of spermatids (significantly more in adult than immature testis tissues). (wikipedia.org)
Other challenges with this type of culture include maintaining the structure of the seminiferous tubules which makes it more difficult for longer-term cell cultures as the tissue structures can flatten out making it hard to work with. (wikipedia.org)
3D cultures use sponge, models or scaffolds that resemble the elements of the extracellular matrix to achieve a more natural spatial structure of the seminiferous tubules and to better represent the tissues and the interaction between different cell types in an ex vivo experiment. (wikipedia.org)

Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)

The content of CD133 + renal stem cells was the highest in the neonatal group and it decreased with the increase of age. (bjbms.org)

"We will be able to see if there are differences in how the neurons of a person with bipolar disorder make connections, determine how they respond to different medications and explore potential deficiencies in signaling pathways," explained Sue O'Shea, Ph.D., a professor of cell and developmental biology at the Medical School who leads the stem cell lab with Gary Smith, Ph.D, professor of obstetrics and gynecology. (bellenews.com)

Clinical data, blood, and tissue samples will be collected to establish a biorepository to facilitate the study of the natural history of MDS. (nih.gov)
Our hypothesis is that IV ganciclovir administered early in critical illness will effectively suppress CMV reactivation in CMV seropositive adults with sepsis-associated acute respiratory failure thereby leading to improved clinical outcomes. (nih.gov)
A large-scale clinical trial across six European countries will this year begin to test the use of adult stem cells as a treatment for knee osteoarthritis. (eurostemcell.org)
This database tracks clinical variables, patient associated biologic samples, contact information and patient-family preferences. (luriechildrens.org)
Phenomenal progress with 3D printed materials, advances in nanotechnology and clinical trials using stem cells strongly suggest that there are opportunities to treat heart failure. (luriechildrens.org)
Investigation on how to block or reverse the progress of renal tissue impairment is of great significance for clinical treatment. (bjbms.org)
In addition to sharing the knowledge between the different universities, confidential, coded DNA repository samples and clinical information will be made available to scientists worldwide to accelerate and share clinical breakthroughs in evaluating and treating bipolar disorder. (bellenews.com)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)

KLF4 is therefore a new molecular target for preserving the functionality of stem cells and making progress in the bio-engineering of skin grafts. (cea.fr)
This second, more extensive project builds on the earlier work and aims to further confirm safety, determine whether the treatment provides statistically significant improvement in patient condition and improve understanding of how adult stem cells work at the molecular level. (eurostemcell.org)
The effect and molecular mechanism of hypoxia-inducible factor 1-alpha (HIF-1α) on the proliferation and apoptosis of renal stem cells were also explored. (bjbms.org)
Liu H, Liu C, Qu Y. The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells. (bjbms.org)

A graft of stem cells or other materials could prompt regeneration of the diseased organ. (nbcnews.com)

To date, over 700 samples have been received from these Tissue Collectors and derivation of the first 50 patient-derived iPSC lines has been completed on schedule. (ca.gov)

These include creating a similar microenvironment to that of the testis as well as supporting endocrine and paracrine signalling, and ensuring survival of the somatic and germ cells from spermatogonial stem cells (SSCs) to mature spermatozoa. (wikipedia.org)

Nearly 800 of those treatments have been performed this year and 1,295 veterinarians are signed up to get credentialed to perform the stem cell therapy. (voiceofsandiego.org)

Testicular germ cell cancers in young adult men derive from a precursor lesion called carcinoma in situ (CIS) of the testis. (ku.dk)

Sometimes, a small sample of lung tissue (a biopsy) is used to diagnose PCP. (cdc.gov)

Anatomy64

Organisms13

Diseases19

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment61

Phenomena and Processes53

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science2

Named Groups1

Health Care5

Pluripotent22

Global mesenchymal stem cells market g2

Embryonic stem3

Allogeneic stem cell trans1

Progenitor cells6

Bone13

Human36

Fetal and adult3

Researchers12

Regenerative10

20191

Body's2

Therapies6

Organs1

Hematopoietic1

Adipose6

Genes4

Cord blood9

Ability to regenerate2

Brain tissue2

Fetuses2

Genetic2

Differentiation3

Lungs3

Skeletal2

Vitro tissue1

Organoids3

Heal the damaged tissue2

Umbilical1

Differentiate4

Reconstruct2

Donor5

Mesenchymal stromal1

Transplantation3

Research20

Liver2

Cartilage4

Generate3

Adolescents1

Cell transplant1

Healing damaged1

Cells derived1

MSCs6

Deficiency1

Induce1

Epithelial1

Functional5

Genomic1

Regenerate1

Pancreas2

Patients9

Cultures3

Unlike1

Neonatal1

Neurons1

Clinical8

Molecular4

Graft1

Patient-derived1

Germ cells1

Treatments1

Testicular1

Lung tissue1