Tissue remodeling wolff. Medical search. Frequent questions

Wolff's law states that bone tissue will adapt to stress placed on it. (mmaleech.com)
This physiologic response is known as Wolff's law, which states that bone remodels along lines of physiologic stress. (eastparkchiro.com)
Therefore, under normal circumstances, bone appears able to keep up with necessary repairs without manifesting clinically significant injury as it remodels in accordance with Wolff's law. (medscape.com)

1 Julius Wolff Institute, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany. (nih.gov)

The course should be of interest to graduate students, PhD candidates, post-doctoral fellows and young faculty members in the field of, e.g., bone: biomechanics, cell biology, tissue engineering and systems biology. (isbweb.org)
The study of biomechanics ranges from the inner workings of a cell to the movement and development of limbs, to the mechanical properties of soft tissue, and bones. (forensicarts.org)
Charité's Julius Wolff Centre for Biomechanics and Musculoskeletal Regeneration director Dr. Georg N. Duda said: "We assumed that bone regrowth would vary according to the stiffness of the implanted scaffold…Even after only three months, radiographic evidence showed that soft implants, produced faster bone growth in response to increased mechanical stimulation than stiffer implants. (nridigital.com)

Next, we propose a bone remodeling algorithm and we solve a two-dimensional femur problem by using the finite element method. (biomedcentral.com)
The femur can be remodeled in response to external loads to give greater bone matrix in regions that are subjected to higher levels of stress. (biomedcentral.com)
Sex differences in age‐related remodeling of the femur and tibia. (lievers.net)

Cortical remodeling is a long process. (mmaleech.com)
Minster J. Modelling of viscoelastic deformation of cortical bone tissue. (edu.pl)
A calibrated examiner performed linear and angular measurements (mandibular body length and height, mandibular lengths, ramus depth and height, mandibular base depth, mandibular head and gonial angle) on photographs, estimated bone density in the mandibular ramus region on digital radiographs and assessed the area of cortical and trabecular bone tissue in the second molar region, in 5-μm-thick serial cuts stained with Cason's Trichrome. (bvsalud.org)

From embryonic development to tissue regeneration and disease progression, the human body is continuously subject to mechanical stresses. (5dok.org)
By seeding macroporous collagen scaffolds and producing 3D micro tissues that mimic the healing process in soft tissues and early stage of bone regeneration, we study the mechanism of load transfer from Fibronectin to collagen and the influence of tissue tension on cell function and ECM growth, using Fluorescent Resonance Energy Transfer (FRET). (charite.de)
Bone, like muscle, is an adaptable tissue capable of repair, regeneration, and remodeling in response to environmental (particularly mechanical) signals. (medscape.com)
Bone remodelling and regeneration following trauma has been traditionally supported by scaffolds created from patient's bone cells with disappointingly variable levels of success. (nridigital.com)
The 3D printed titanium-mesh scaffold is filled with the patient's own bone tissue, growth factors and bone replacement material to help further promote bone regeneration. (nridigital.com)
This builds upon previous research into how stem cells could be used alongside tissue engineering techniques to advance bone regeneration. (nridigital.com)
The implants reconnected the severed spinal cord, encouraged tissue growth, and caused the regeneration of nerve cell extensions. (nridigital.com)
Building on the success of pulsed electromagnetic field therapy in bone tissue regeneration, scientists at Peking Union Medical College discovered the static magnetic field (SMF) treatment enhanced the strength of bone formation and remodelling in both human stem cells and an animal model. (nridigital.com)

In silico models have greatly contributed to the understanding of the influence of mechanics on tissue formation and resorption during the soft and hard callus phases. (nih.gov)
The net daily rate of apposition or resorption on a bone surface is determined by the difference between the actual stimulus and the tissue attractor state and can be modulated by other biologic factors. (lievers.net)
Metabolism of the bone, which results from the simultaneous processes of resorption and formation of new bone tissue, may depend on the presence and type of arthritis. (edu.pl)
We observed bone resorption and osteogenesis, which indicate normal homeostasis of the bone tissue. (edu.pl)
When bone is subjected to mechanical load, areas of tension and compression are generated in different regions, resulting in bone deposition and resorption as part of the remodeling process 7-8 . (bvsalud.org)

Therefore, FEA can predict adaptive bone remodeling after mechanical loading changes. (intechopen.com)
These adaptive changes are regulated by physiological process commonly called the bone remodeling. (biomedcentral.com)
Bone remodeling, I: theory of adaptive elasticity. (lievers.net)
Osteoregulatory nature of mechanical stimuli: function as a determinant for adaptive remodeling in bone. (lievers.net)
Our observations indicate an intense adaptive reorganization of bone tissue depending on external and internal factors, including biomechanical condition. (edu.pl)

Trabecular bone density and loading history: regulation of connective tissue biology by mechanical energy. (lievers.net)
Nicotine causes atrial fibrosis by blocking the activity of two micro-RNA (mi-R-133 and miR-590), which inhibits transforming growth factor (TGF)-β1 and TGF-β receptor type II, and thus blocks the modulators of connective tissue growth factor. (holisticly.com)
This qualification includes graduate chiropractic education in healthy and traumatically altered spinal morphology inclusive of osseous, connective tissue and neurological structure, function and pathology. (uschirodirectory.com)

The characteristic substances inside the extracellular matrix of soft tissue are the collagen, elastin and ground substance. (wikipedia.org)
With increasing tissue deformation the collagen is gradually stretched in the direction of deformation. (wikipedia.org)
In soft tissues, the collagen limits the deformation and protects the tissues from injury. (wikipedia.org)

Some evidence indicates that bone natural curvatures may restrict tissue deformation during mechanical load, so the bone tissue becomes more adapted and resistant to a normal pattern of strain distribution 8 . (bvsalud.org)

In physiological state soft tissues usually present residual stress that may be released when the tissue is excised. (wikipedia.org)

The bone remodels to fit the load as long as the forces are physiologic (not too much too soon). (umn.edu)
Therefore, it was hypothesized that mechanical load arising in the mandibular ramus during mastication would generate the physiologic stimulus for bone remodeling and mandibular growth. (bvsalud.org)

At small strains, elastin confers stiffness to the tissue and stores most of the strain energy. (wikipedia.org)
Soft tissues have the potential to undergo large deformations and still return to the initial configuration when unloaded, i.e. they are hyperelastic materials, and their stress-strain curve is nonlinear. (wikipedia.org)
Even though soft tissues have viscoelastic properties, i.e. stress as function of strain rate, it can be approximated by a hyperelastic model after precondition to a load pattern. (wikipedia.org)
S = S ( E , E ˙ ) → S = S ( E ) {\displaystyle \mathbf {S} =\mathbf {S} (\mathbf {E} ,{\dot {\mathbf {E} }})\quad \rightarrow \quad \mathbf {S} =\mathbf {S} (\mathbf {E} )} Despite the independence of strain rate, preconditioned soft tissues still present hysteresis, so the mechanical response can be modeled as hyperelastic with different material constants at loading and unloading. (wikipedia.org)
Here, we propose an in silico multi-tissue evolution model based on mechanical strain accumulation to investigate the mechanobiological regulation of bone remodeling during the late phase of healing. (nih.gov)
Our results suggest that the local strain accumulation can explain the fracture remodeling process and that this mechanobiological response is conserved among different mammal species. (nih.gov)

The soft tissues are also viscoelastic, incompressible and usually anisotropic. (wikipedia.org)
Some viscoelastic properties observable in soft tissues are: relaxation, creep and hysteresis. (wikipedia.org)

He could determine the position of the human center of gravity, calculate and measure inspired and expired air volumes, and showed that inspiration is muscle-driven and expiration is due to tissue elasticity. (forensicarts.org)

This stress has become increasingly recognized as one of the primary and essential factors controlling biological functions, ultimately affecting the function of the cells, tissues, and organs. (cambridgebookshop.co.uk)
Micro X-ray imaging is one such popular method as it provides a three- dimensional (3D) representation of organs and tissues. (chestervetclinic.com)

Therefore, FEA can assess the effects of stem geometry on bone remodeling after THA. (intechopen.com)
Khetan, S. & Burdick, J. A. Patterning network structure to spatially control cellular remodeling and stem cell fate within 3-dimensional hydrogels. (nature.com)

Hutmacher, D. W. Scaffolds in tissue engineering bone and cartilage. (nature.com)

When taut, these fibers produce a strong growth in tissue stiffness. (wikipedia.org)
Impact testing results showed that the stiffness and the damping resistance of a test subject's tissue are correlated with the mass, velocity, and size of the striking object. (wikipedia.org)
In addition to temporal changes in growth factor presentation, mechanical stiffness of tissues is also dynamically altered over time. (5dok.org)

As a living tissue, bone is able to optimize its structure by redistributing its density under the influence of external forces. (biomedcentral.com)
Since this publication of Wolff, many theories describing the redistributing of the bone density have been proposed [ 2 - 4 ]. (biomedcentral.com)
Additionally, it provides attenuation maps which can be related to mineral density variations within calcified tissues [11]. (chestervetclinic.com)

Functional adaptation in long bones: establishing in vivo values for surface remodeling rate coefficients. (lievers.net)

Although PDL and bone are two dissimilar tissues in physical and chemical properties, the continuity formed by blood vessels enables a flow of nutrients and maintains cellular activity responsible for PDL turnover and bone remodeling. (chestervetclinic.com)

Examples of ablative materials are described below, including spacecraft material for ascent and atmospheric reentry , ice and snow in glaciology , biological tissues in medicine and passive fire protection materials. (wikipedia.org)

Physical forces are increasingly recognized as major microenvironmental cues that control tensional homeostasis in tissues. (5dok.org)

The load bearing bone is a dynamic tissue and continuously adapts to changes in loads [1]. (chestervetclinic.com)

Osteoporosis (OP) is a skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to increased susceptibility to fractures (World Health Organization, 1994). (unm.edu)

The reorganization of bone tissue is closely associated with its metabolism and changes in its internal structure. (edu.pl)

Mathematical modeling and numerical solutions for functionally dependent bone remodeling. (lievers.net)

The ability of bone to remodel has tremendous clinical consequences. (medscape.com)
Considering that the mandible receives intense mechanical load during mastication, it may also be hypothesized that myofunctional alterations due to soft diet consistency would affect mandibular overall remodeling process with consequences on bone curvatures. (bvsalud.org)

Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. (cambridgebookshop.co.uk)
However, animal studies have shown that oxidative stress can alter heart tissue resulting in more arrhythmogenic events. (holisticly.com)

Development and growth superimposed with functional loads [4] causing posterior lengthening of the rat jaw [5] can contribute to PDL turnover, bone remodeling and load related modeling during the lifespan of a rat. (chestervetclinic.com)

This process, called bone remodeling, was formally developed later by Huiskes et al. (biomedcentral.com)
We aim to gain a better insight into the mechanism of force transmission from the cells to ECM and the long range signals resulting in growth and remodeling in the healing process. (charite.de)

Numerous studies in the field of mineralized tissues related to dental research have used the rat periodontium as a model to investigate adaptation of bone, PDL and root by applying many perturbations, predominantly disease [9] and extraneous loads [10]. (chestervetclinic.com)
In this study we present an overview of commonly used imaging methods to investigate calcified tissues and the PDL while addressing the plausible artifacts during specimen preparation, imaging and post processing of experimental data. (chestervetclinic.com)

Dear All, this is the second announcement for the CISM course on 'Bone Cell and Tissue Mechanics' that will be held in Udine (Italy) on June 22-26 in 2015. (isbweb.org)

In order to describe the mechanical response of soft tissues, several methods have been used. (wikipedia.org)
A time‐dependent approach for emulating bone modeling and remodeling in response to the daily loading history is presented. (lievers.net)

Soft tissue is all the tissue in the body that is not hardened by the processes of ossification or calcification such as bones and teeth. (wikipedia.org)

Healing begins with the self-organisation of cells in the wound to reestablish structured tissue and restore the mechanical stability and intrinsic pretension of the injured matrix lost through the injury. (charite.de)
Our aim is to decipher this independent organisation of fibroblasts, vascular precursors, immune cells and mechanical instability in the complex environment of the tissue. (charite.de)
When your cells and tissues aren't receiving the correct information they need, symptoms and disease are the likely result. (eastparkchiro.com)

Normally the soft tissue is very hydrated because of the ground substance. (wikipedia.org)
The fibroblasts are the most common cell responsible for the production of soft tissues' fibers and ground substance. (wikipedia.org)
Human soft tissue is highly deformable, and its mechanical properties vary significantly from one person to another. (wikipedia.org)
subjects with more soft tissue thickness tended to absorb the impacts with less aversion. (wikipedia.org)
Magnetic resonance imaging is a diagnostic imaging modality that is capable of demonstrating a wide variety of soft-tissue lesions with contrast resolution equal or superior to CT scanning in various parts of the body. (cms.gov)

The CTT is the most commonly used technique for treating NONFH, which is fulfilled by drilling a core tunnel from the lateral aspect of the greater trochanter, removing the necrotic bone tissue and implanting the bone. (biomedcentral.com)

The objective of the study was to assess, based on the morphological features and mineral composition of bone tissue, changes in the femoral head in various types of hip joint degeneration. (edu.pl)
The assessment of the morphological condition of the bone and the mineral composition of bone tissue took into account quantitative and qualitative relationships among the mineral components and bone matrix. (edu.pl)

We postulate that genotype, systemic metabolic conditions, and local tissue interactions establish the level of local tissue mechanical stimulation (attractor state) appropriate for the maintenance of bone tissue. (lievers.net)
Osteoporosis is a metabolic disease involving loss of bone tissue and the disorganization of bone structure. (eastparkchiro.com)

The structure of spongious bone tissue was analyzed in histological studies, with special attention paid to osteogenesis and osteoclastic processes and the advancement of degeneration. (edu.pl)
Bone is one tissue that will return to its original structure after damaged. (umn.edu)

Bone tissue formation and repair. (isbweb.org)

Since blood carries oxygen to all the tissues in the body, including the heart, a reduction in blood flow could lead to tissue death of the heart and organ damage. (holisticly.com)

2. Siemionow M, Arslan E. Ischemia/reperfusion injury: a review in relation to free tissue transfers. (scielo.br)

Tomography illustrated structural adaptation in the calcified tissue and, electron microscopy allowed to study it at a higher resolution. (chestervetclinic.com)
3. Mücke T, Rau A, Merezas A, Loeffelbein DJ, Wagenpfeil S, Mitchell DA, Wolff KD, Steiner T. Identification of perioperative risk factor by laser-doppler spectroscopy after free flap perfusion in the head and neck: a prospective clinical study. (scielo.br)
In this study, we show that contactin associates with Na v 1.3 in P0 brain tissue and interacts with both the N and C termini of Na v 1.3. (jneurosci.org)

This is because fat tissue has the ability to retain a very small amount of water, which explains the reduction of the body's water content. (articlesfactory.com)

Wolff's3

Julius Wolff Institute1

Biomechanics3

Femur3

Cortical3

Regeneration8

Resorption5

Adaptive5

Connective tissue3

Collagen3

Deformation1

Physiological1

Physiologic2

Strain6

Viscoelastic2

Elasticity1

Organs2

Stem2

Scaffolds1

Stiffness3

Density3

Vivo1

Cellular1

Biological1

Homeostasis1

Adapts1

Fractures1

Internal1

Mathematical1

Consequences2

Stress2

Causing posterior1

Process2

Investigate2

Mechanics1

Response2

Bones1

Cells3

Soft5

Commonly1

Mineral2

Metabolic2

Structure2

Formation1

Body1

Injury1

Study3

Ability1